{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:01:59Z","timestamp":1784354519848,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.intimp.2025.116073","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:21:01Z","timestamp":1766517661000},"page":"116073","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["20(S)-PPD-HSA NPs enhance the recovery of intramedullary and extramedullary hematopoiesis in cyclophosphamide-treated mice through activation of the FGFR1\/ERK pathway"],"prefix":"10.1016","volume":"170","author":[{"given":"Dalei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaying","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2025.116073_bb0005","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0889-8588(05)70344-0","article-title":"Chemotherapy and neutropenia","volume":"10","author":"Kim","year":"1996","journal-title":"Hematol. Oncol. Clin. North Am."},{"issue":"19","key":"10.1016\/j.intimp.2025.116073_bb0010","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1039\/C8DT00838H","article-title":"The side effects of platinum-based chemotherapy drugs: a review for chemists","volume":"47","author":"Oun","year":"2018","journal-title":"Dalton Trans."},{"issue":"1\u20133","key":"10.1016\/j.intimp.2025.116073_bb0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejphar.2012.07.050","article-title":"Improvement of ginsenoside Rg1 on hematopoietic function in cyclophosphamide-induced myelosuppression mice","volume":"695","author":"Xu","year":"2012","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.116073_bb0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27263-y","article-title":"Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution","volume":"12","author":"Termini","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.116073_bb0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.lfs.2015.01.002","article-title":"Echinacoside improves hematopoietic function in 5-FU-induced myelosuppression mice","volume":"123","author":"Wang","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2025.116073_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112087","article-title":"Dammarane-type leads panaxadiol and protopanaxadiol for drug discovery: biological activity and structural modification","volume":"189","author":"Wang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.intimp.2025.116073_bb0035","doi-asserted-by":"crossref","first-page":"5738694","DOI":"10.1155\/2016\/5738694","article-title":"Anticancer activities of protopanaxadiol- and protopanaxatriol-type ginsenosides and their metabolites","volume":"2016","author":"Chen","year":"2016","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"10","key":"10.1016\/j.intimp.2025.116073_bb0040","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1002\/ptr.7938","article-title":"20(S)- protopanaxadiol saponins isolated from Panax notoginseng target the binding of HMGB1 to TLR4 against inflammation in experimental ulcerative colitis","volume":"37","author":"Chen","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2025.116073_bb0045","doi-asserted-by":"crossref","unstructured":"Cao Y, Liu B, Li W, et al. Protopanaxadiol manipulates gut microbiota to promote bone marrow hematopoiesis and enhance immunity in cyclophosphamide-induced immunosuppression mice. MedComm (2020). 2023;4(2):e222.","DOI":"10.1002\/mco2.222"},{"issue":"4","key":"10.1016\/j.intimp.2025.116073_bb0050","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.3390\/ijms24044081","article-title":"Human serum albumin: from molecular aspects to biotechnological applications","volume":"24","author":"di Masi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.116073_bb0055","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1080\/10717544.2022.2111479","article-title":"Human serum albumin-based nanoparticles alter raloxifene administration and improve bioavailability","volume":"29","author":"Yang","year":"2022","journal-title":"Drug Deliv."},{"issue":"10","key":"10.1016\/j.intimp.2025.116073_bb0060","doi-asserted-by":"crossref","first-page":"5125","DOI":"10.1021\/acs.molpharmaceut.3c00409","article-title":"Human serum albumin nanoparticles as a carrier of 20(S)-protopanaxadiol via intramuscular injection to alleviate cyclophosphamide-induced myelosuppression","volume":"20","author":"Liu","year":"2023","journal-title":"Mol. Pharm."},{"issue":"9","key":"10.1016\/j.intimp.2025.116073_bb0065","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1182\/blood-2011-11-393991","article-title":"FGF signaling facilitates postinjury recovery of mouse hematopoietic system","volume":"120","author":"Zhao","year":"2012","journal-title":"Blood"},{"issue":"18","key":"10.1016\/j.intimp.2025.116073_bb0070","doi-asserted-by":"crossref","first-page":"10496","DOI":"10.3390\/ijms231810496","article-title":"TTYH3 modulates bladder Cancer proliferation and metastasis via FGFR1\/H-Ras\/A-Raf\/MEK\/ERK pathway","volume":"23","author":"Biswas","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2025.116073_bb0075","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1007\/s00018-020-03630-8","article-title":"FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1\/BRAF\/MEK\/ERK","volume":"78","author":"Chen","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2025.116073_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.redox.2017.08.003","article-title":"Carnosine attenuates cyclophosphamide-induced bone marrow suppression by reducing oxidative DNA damage","volume":"14","author":"Deng","year":"2018","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.116073_bb0085","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2023.2239035","article-title":"Chemotherapy-induced neutropenia elicits metastasis formation in mice by promoting proliferation of disseminated tumor cells","volume":"12","author":"Russo","year":"2023","journal-title":"Oncoimmunology"},{"issue":"13_Supplement","key":"10.1016\/j.intimp.2025.116073_bb0090","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1158\/1538-7445.AM2018-4805","article-title":"Abstract 4805: plinabulin ameliorates chemotherapy-induced neutropenia: mechanistic insights","volume":"78","author":"Ghosh","year":"2018","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.116073_bb0095","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1016\/j.jhep.2022.11.032","article-title":"G-CSF exacerbates liver injury in a mouse model of autoimmune hepatitis","volume":"79","author":"Shen","year":"2023","journal-title":"J. Hepatol."},{"issue":"19","key":"10.1016\/j.intimp.2025.116073_bb0100","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.3390\/molecules27196733","article-title":"Erdafitinib inhibits tumorigenesis of human lung adenocarcinoma A549 by inducing S-phase cell-cycle arrest as a CDK2 inhibitor","volume":"27","author":"Meng","year":"2022","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.intimp.2025.116073_bb0105","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1158\/2159-8290.CD-13-0070","article-title":"Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors","volume":"3","author":"Morris","year":"2013","journal-title":"Cancer Discov."},{"issue":"3","key":"10.1016\/j.intimp.2025.116073_bb0110","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3390\/mi11030305","article-title":"Nitric oxide and a conditioned medium affect the hematopoietic development in a microfluidic mouse embryonic stem cell\/OP9 co-cultivation system","volume":"11","author":"Sato","year":"2020","journal-title":"Micromachines (Basel)"},{"issue":"5","key":"10.1016\/j.intimp.2025.116073_bb0115","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s11626-022-00693-8","article-title":"Extramedullary hematopoiesis: mesenchymal stromal cells from spleen provide an in vitro niche for myelopoiesis","volume":"58","author":"Petvises","year":"2022","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.intimp.2025.116073_bb0120","doi-asserted-by":"crossref","first-page":"9896142","DOI":"10.1155\/2018\/9896142","article-title":"In vitro murine Hematopoiesis supported by Signaling from a splenic stromal cell line","volume":"2018","author":"Lim","year":"2018","journal-title":"Stem Cells Int."},{"issue":"10","key":"10.1016\/j.intimp.2025.116073_bb0125","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1158\/2326-6066.CIR-14-0058","article-title":"A feasibility study of cyclophosphamide, trastuzumab, and an allogeneic GM-CSF-secreting breast tumor vaccine for HER2+ metastatic breast cancer","volume":"2","author":"Chen","year":"2014","journal-title":"Cancer Immunol. Res."},{"issue":"7","key":"10.1016\/j.intimp.2025.116073_bb0130","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1177\/2472555218777968","article-title":"A multiplexed screening assay to evaluate chemotherapy-induced myelosuppression using healthy peripheral blood and bone marrow","volume":"23","author":"Javarappa","year":"2018","journal-title":"SLAS Discov."},{"issue":"1","key":"10.1016\/j.intimp.2025.116073_bb0135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00262-021-02959-8","article-title":"Lenalidomide enhances the efficacy of anti-BCMA CAR-T treatment in relapsed\/refractory multiple myeloma: a case report and revies of the literature","volume":"71","author":"Zhao","year":"2022","journal-title":"Cancer Immunol. Immunother."},{"issue":"9","key":"10.1016\/j.intimp.2025.116073_bb0140","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201350","article-title":"Amelioration of cyclophosphamide-induced myelosuppression during treatment to rats with breast cancer through low-intensity pulsed ultrasound","volume":"40","author":"Wang","year":"2020","journal-title":"Biosci. Rep."},{"issue":"23","key":"10.1016\/j.intimp.2025.116073_bb0145","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1056\/NEJMc1709258","article-title":"Long-term effects of G-CSF therapy in cyclic neutropenia","volume":"377","author":"Dale","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.intimp.2025.116073_bb0150","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1023\/A:1008362120909","article-title":"Docetaxel and epirubicin plus G-CSF mobilize hematopoietic progenitors in breast cancer","volume":"10","author":"Pierelli","year":"1999","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2025.116073_bb0155","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2184.2005.00329.x","article-title":"Effect of stem cell mobilization with cyclophosphamide plus granulocyte colony-stimulating factor on morphology of haematopoietic organs in mice","volume":"38","author":"Szumilas","year":"2005","journal-title":"Cell Prolif."},{"issue":"1","key":"10.1016\/j.intimp.2025.116073_bb0160","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12943-022-01628-3","article-title":"A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML","volume":"21","author":"Cai","year":"2022","journal-title":"Mol. Cancer"},{"issue":"26","key":"10.1016\/j.intimp.2025.116073_bb0165","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1182\/blood-2015-10-674465","article-title":"A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells","volume":"127","author":"Wang","year":"2016","journal-title":"Blood"},{"issue":"24","key":"10.1016\/j.intimp.2025.116073_bb0170","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.3390\/jcm10245831","article-title":"Extramedullary Hematopoiesis of the Liver and Spleen","volume":"10","author":"Cenariu","year":"2021","journal-title":"J. Clin. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925020624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925020624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T12:18:47Z","timestamp":1767442727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925020624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":34,"alternative-id":["S1567576925020624"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.116073","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"20(S)-PPD-HSA NPs enhance the recovery of intramedullary and extramedullary hematopoiesis in cyclophosphamide-treated mice through activation of the FGFR1\/ERK pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.116073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116073"}}