{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:12:31Z","timestamp":1790651551432,"version":"4.1.0"},"reference-count":157,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.intimp.2025.116091","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T08:12:16Z","timestamp":1766563936000},"page":"116091","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Nickel-induced cardiotoxicity: immunopathogenesis, thromboinflammation, and a targeted nanotherapeutic strategy"],"prefix":"10.1016","volume":"170","author":[{"given":"Pegah","family":"Joghataie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Habibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Bahrampour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Danjeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Molaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Yousefi Chermehini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabnam","family":"Forouzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Zamanifard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farahnaz","family":"Nikdoust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.116091_bb0005","doi-asserted-by":"crossref","unstructured":"Genchi G, Carocci A, Lauria G, Sinicropi MS, Catalano A. Nickel: Human health and environmental toxicology. Int. J. Environ. Res. Public Health 2020;17(3).","DOI":"10.3390\/ijerph17030679"},{"key":"10.1016\/j.intimp.2025.116091_bb0010","article-title":"Review on high-energy beam repair of surface damages in Ni-based single crystal superalloys","volume":"109612","author":"Zhang","year":"2025","journal-title":"Eng. Fail. Anal."},{"key":"10.1016\/j.intimp.2025.116091_bb0015","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.fct.2012.09.007","article-title":"Efficacy of all-trans retinoid acid in preventing nickel induced cardiotoxicity in myocardial cells of rats","volume":"51","author":"Lou","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"8","key":"10.1016\/j.intimp.2025.116091_bb0020","first-page":"1678","article-title":"Unveiling cadmium-induced cardiotoxicity: mechanisms, challenges, and future perspectives: a narrative review","volume":"54","author":"Pouladzadeh","year":"2025","journal-title":"Iran. J. Public Health"},{"issue":"6","key":"10.1016\/j.intimp.2025.116091_bb0025","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/jat.4768","article-title":"The mechanism of bisphenol S-induced atherosclerosis elucidated based on network toxicology, molecular docking, and machine learning","volume":"45","author":"Guo","year":"2025","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.intimp.2025.116091_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111006","article-title":"Immunotoxicity of nickel: pathological and toxicological effects","volume":"203","author":"Guo","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.intimp.2025.116091_bb0035","doi-asserted-by":"crossref","first-page":"1529903","DOI":"10.3389\/fcvm.2024.1529903","article-title":"Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives","volume":"11","author":"Liu","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"issue":"2","key":"10.1016\/j.intimp.2025.116091_bb0040","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s12403-023-00579-4","article-title":"Environmental nickel exposure and cardiovascular disease in a nationally representative sample of U.S. adults","volume":"16","author":"Cheek","year":"2024","journal-title":"Exposure Health"},{"issue":"2","key":"10.1016\/j.intimp.2025.116091_bb0045","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1055\/s-0037-1614998","article-title":"Nickel enhances collagen-induced platelet activation acting by increasing the organization of the cytoskeleton","volume":"79","author":"Pulcinelli","year":"1998","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.intimp.2025.116091_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118668","article-title":"Nickel exposure induced endoplasmic reticulum stress by disturbing calcium homeostasis and triggered mitochondrial autophagy in domestic animal oocytes","volume":"302","author":"Zhong","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"9","key":"10.1016\/j.intimp.2025.116091_bb0055","doi-asserted-by":"crossref","first-page":"14500","DOI":"10.1002\/jcp.28292","article-title":"Strategies to inhibit arsenic trioxide-induced cardiotoxicity in acute promyelocytic leukemia","volume":"234","author":"Haybar","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2025.116091_bb0060","first-page":"1","article-title":"Environmental nickel exposure and cardiovascular disease in a nationally representative sample of U.S. adults","author":"Cheek","year":"2023","journal-title":"Expo Health."},{"issue":"8","key":"10.1016\/j.intimp.2025.116091_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12032-025-02860-9","article-title":"Ovarian cancer, neutrophil hitchhiking, and NETs: unraveling their role in pathogenesis and management","volume":"42","author":"Amirlatifi","year":"2025","journal-title":"Med. Oncol."},{"key":"10.1016\/j.intimp.2025.116091_bb0070","doi-asserted-by":"crossref","first-page":"6159","DOI":"10.1021\/ic5006693","article-title":"Redox chemistry of nickel(II) complexes supported by a series of noninnocent \u03b2-Diketiminate ligands","volume":"53","author":"Takaichi","year":"2014","journal-title":"Inorg. Chem."},{"issue":"12","key":"10.1016\/j.intimp.2025.116091_bb0075","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1002\/anie.201500404","article-title":"Nickel-catalyzed amination of aryl chlorides with ammonia or ammonium salts","volume":"54","author":"Green","year":"2015","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"20","key":"10.1016\/j.intimp.2025.116091_bb0080","doi-asserted-by":"crossref","first-page":"7394","DOI":"10.1039\/D4SC01253D","article-title":"The development of cage phosphine \u2018DalPhos\u2019 ligands to enable nickel-catalyzed cross-couplings of (hetero)aryl electrophiles","volume":"15","author":"Morrison","year":"2024","journal-title":"Chem. Sci."},{"key":"10.1016\/j.intimp.2025.116091_bb0085","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.015459","article-title":"Allosteric regulation of the nickel-responsive NikR transcription factor from helicobacter pylori","volume":"296","author":"Baksh","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.116091_bb0090","doi-asserted-by":"crossref","unstructured":"Kalamkar P, Gadgoli C, Girase G, Dalvi R, Dadrekar P, Karulkar N, et al. Novel biomarkers for detection of nephrotoxicity. Journal of renal Inj. Prev. 2024;13(3):e33294-e.","DOI":"10.34172\/jrip.2024.33294"},{"issue":"10","key":"10.1016\/j.intimp.2025.116091_bb0095","doi-asserted-by":"crossref","first-page":"12396","DOI":"10.3390\/molecules181012396","article-title":"The involvement of amino acid side chains in shielding the nickel coordination site: an NMR study","volume":"18","author":"Medici","year":"2013","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0100","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1557\/s43578-020-00059-4","article-title":"Corrosion of nickel and nickel\u2013phosphorous-coated AISI 430 in dry (Ar\u20133%H2) and humid hydrogen (Ar\u20133%H2\u20133%H2O) atmosphere","volume":"36","author":"King","year":"2021","journal-title":"J. Mater. Res."},{"issue":"3","key":"10.1016\/j.intimp.2025.116091_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ma12030407","article-title":"Corrosion of metallic biomaterials: a review","volume":"12","author":"Eliaz","year":"2019","journal-title":"Materials (Basel)"},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0110","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12989-017-0229-x","article-title":"Kinetics and dissolution of intratracheally administered nickel oxide nanomaterials in rats","volume":"14","author":"Shinohara","year":"2017","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.intimp.2025.116091_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127272","article-title":"Nickel chloride generates cytotoxic ROS that cause oxidative damage in human erythrocytes","volume":"80","author":"Sharma","year":"2023","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/toxics3010020","article-title":"Toxicity of glutathione-binding metals: a review of targets and mechanisms","volume":"3","author":"Rubino","year":"2015","journal-title":"Toxics"},{"issue":"7","key":"10.1016\/j.intimp.2025.116091_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159684","article-title":"Nickel release, ROS generation and toxicity of Ni and NiO Micro- and nanoparticles","volume":"11","author":"Latvala","year":"2016","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.intimp.2025.116091_bb0130","article-title":"Review and evaluation of the potential health effects of oxidic nickel nanoparticles","volume":"11","author":"More","year":"2021","journal-title":"Nanomaterials [Internet]"},{"key":"10.1016\/j.intimp.2025.116091_bb0135","doi-asserted-by":"crossref","first-page":"rbac040","DOI":"10.1093\/rb\/rbac040","article-title":"The interaction mechanism of nickel ions with L929 cells based on integrative analysis of proteomics and metabolomics data","volume":"9","author":"Zhang","year":"2022","journal-title":"Regen Biomater."},{"issue":"9","key":"10.1016\/j.intimp.2025.116091_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/biom12091283","article-title":"Effects of nickel at environmentally relevant concentrations on human corneal epithelial cells: oxidative damage and cellular apoptosis","volume":"12","author":"Zhang","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.intimp.2025.116091_bb0145","doi-asserted-by":"crossref","first-page":"1443749","DOI":"10.3389\/fmed.2024.1443749","article-title":"The neutrophil-lymphocyte ratio predicts all-cause and cardiovascular mortality among United States adults with COPD: results from NHANES 1999\u20132018","volume":"11","author":"Chen","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.intimp.2025.116091_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110525","article-title":"NF-\u03baB pathway activation during endothelial-to-mesenchymal transition in a rat model of doxorubicin-induced cardiotoxicity","volume":"130","author":"Xu","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"10","key":"10.1016\/j.intimp.2025.116091_bb0155","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3109\/08958378.2014.937882","article-title":"The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells","volume":"26","author":"Liberda","year":"2014","journal-title":"Inhal. Toxicol."},{"issue":"9","key":"10.1016\/j.intimp.2025.116091_bb0160","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s00018-012-1225-9","article-title":"Complex modulation of ca(v)3.1 T-type calcium channel by nickel","volume":"70","author":"Nosal","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2025.116091_bb0165","doi-asserted-by":"crossref","unstructured":"El-Din SB, ALfiky HAAA, Wahsh E, Badawy H, Seliem N, El Attar S, et al. Effect of garlic on sodium fluoride-induced hypertension and elevated cardiac enzymes in male albino rats. Immunopathologia Persa. 2025;11(2):e43763-e.","DOI":"10.34172\/ipp.2025.43763"},{"key":"10.1016\/j.intimp.2025.116091_bb0170","doi-asserted-by":"crossref","unstructured":"Schmid J, M\u00fcller B, Heppeler D, Gaynullina D, Kassmann M, Gagov H, et al. The Unexpected Role of Calcium-Activated Potassium Channels: Limitation of NO-Induced Arterial Relaxation. Journal of the American Heart Association.7(7):e007808.","DOI":"10.1161\/JAHA.117.007808"},{"issue":"9","key":"10.1016\/j.intimp.2025.116091_bb0175","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s00424-018-2151-y","article-title":"Calcium- and voltage-gated BK channels in vascular smooth muscle","volume":"470","author":"Dopico","year":"2018","journal-title":"Pflugers Arch."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0180","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/taap.1993.1125","article-title":"Interactions of cadmium and nickel with K channels of vascular smooth muscle","volume":"121","author":"Stockand","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"0","key":"10.1016\/j.intimp.2025.116091_bb0185","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1540\/jsmr.54.71","article-title":"Role of calcium channels and endothelial factors in nickel induced aortic hypercontraction in Wistar rats","volume":"54","author":"Wani","year":"2018","journal-title":"J. Smooth Muscle Res."},{"issue":"12","key":"10.1016\/j.intimp.2025.116091_bb0190","article-title":"Molecular mechanisms regulating vascular endothelial permeability","volume":"25","author":"Wakasugi","year":"2024","journal-title":"Int. J. Mol. Sci. [Internet]"},{"issue":"3","key":"10.1016\/j.intimp.2025.116091_bb0195","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00204-002-0427-6","article-title":"Nickel-induced oxidative stress and effect of antioxidants in human lymphocytes","volume":"77","author":"Chen","year":"2003","journal-title":"Arch. Toxicol."},{"issue":"4","key":"10.1016\/j.intimp.2025.116091_bb0200","first-page":"412","article-title":"Nickel, its adverse health effects & oxidative stress","volume":"128","author":"Das","year":"2008","journal-title":"Indian J. Med. Res."},{"issue":"5","key":"10.1016\/j.intimp.2025.116091_bb0205","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1039\/C6TX00197A","article-title":"Oxidative stress and inflammatory responses involved in dietary nickel chloride (NiCl(2))-induced pulmonary toxicity in broiler chickens","volume":"5","author":"Deng","year":"2016","journal-title":"Toxicol Res (Camb)."},{"key":"10.1016\/j.intimp.2025.116091_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtauto.2025.100309","article-title":"When the victim becomes the villain: platelets as drivers of immune dysregulation in ITP","volume":"11","author":"Farhid","year":"2025","journal-title":"Journal of Translational Autoimmunity."},{"issue":"2","key":"10.1016\/j.intimp.2025.116091_bb0215","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1515\/jbcpp-2017-0171","article-title":"Primary concept of nickel toxicity - an overview","volume":"30","author":"Das","year":"2018","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"issue":"23","key":"10.1016\/j.intimp.2025.116091_bb0220","doi-asserted-by":"crossref","first-page":"11659","DOI":"10.18632\/aging.102570","article-title":"Nickel induces inflammatory activation via NF-\u03baB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages","volume":"11","author":"Guo","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"7","key":"10.1016\/j.intimp.2025.116091_bb0225","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.2174\/1871530319666191205122249","article-title":"Nickel and oxidative stress: cell Signaling mechanisms and protective role of vitamin C","volume":"20","author":"Das","year":"2020","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"issue":"3","key":"10.1016\/j.intimp.2025.116091_bb0230","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.3892\/mmr.2015.3878","article-title":"Toxicity of nickel ions and comprehensive analysis of nickel ion-associated gene expression profiles in THP-1 cells","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2025.116091_bb0235","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1289\/ehp.1002508","article-title":"Long-term inhalation exposure to nickel nanoparticles exacerbated atherosclerosis in a susceptible mouse model","volume":"119","author":"Kang","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.intimp.2025.116091_bb0240","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3390\/genes4040583","article-title":"Nickel and epigenetic gene silencing","volume":"4","author":"Sun","year":"2013","journal-title":"Genes (Basel)"},{"issue":"6","key":"10.1016\/j.intimp.2025.116091_bb0245","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.3892\/or.2012.2057","article-title":"Molecular and genomic approach for understanding the gene-environment interaction between Nrf2 deficiency and carcinogenic nickel-induced DNA damage","volume":"28","author":"Kim","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.intimp.2025.116091_bb0250","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.taap.2017.05.029","article-title":"Nickel-induced HIF-1\u03b1 promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells","volume":"331","author":"Luczak","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2025.116091_bb0255","doi-asserted-by":"crossref","first-page":"34270","DOI":"10.1007\/s11356-022-24597-y","article-title":"The role of selenoprotein M in nickel-induced pyroptosis in mice spleen tissue via oxidative stress","volume":"30","author":"Ma","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"6","key":"10.1016\/j.intimp.2025.116091_bb0260","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1179\/1351000213Y.0000000055","article-title":"Ameliorating effects of troxerutin on nickel-induced oxidative stress in rats","volume":"18","author":"Elangovan","year":"2013","journal-title":"Redox Rep."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0265","doi-asserted-by":"crossref","first-page":"6688855","DOI":"10.1155\/2021\/6688855","article-title":"Antioxidant effect of Polygonatum sibiricum polysaccharides in D-galactose-induced heart aging mice","volume":"2021","author":"Ma","year":"2021","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.intimp.2025.116091_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.126366","article-title":"Metabolic modifications to Ni excess in L. minor: role of organic-, amino- and fatty acid profiles","volume":"251","author":"Sha","year":"2020","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.intimp.2025.116091_bb0275","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3892\/ijo.2013.2004","article-title":"Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells","volume":"43","author":"Yang","year":"2013","journal-title":"Int. J. Oncol."},{"issue":"16","key":"10.1016\/j.intimp.2025.116091_bb0280","doi-asserted-by":"crossref","first-page":"326","DOI":"10.21037\/atm.2017.06.27","article-title":"The role of reactive oxygen species in the pathophysiology of cardiovascular diseases and the clinical significance of myocardial redox","volume":"5","author":"Moris","year":"2017","journal-title":"Ann Transl Med."},{"key":"10.1016\/j.intimp.2025.116091_bb0285","doi-asserted-by":"crossref","unstructured":"Zhang X, Wei F, Fu H, Guo H. Characterisation of environmentally persistent free radicals and their contributions to oxidative potential and reactive oxygen species in sea spray and size-resolved ambient particles. Npj climate and atmospheric Science 2025;8(1):27.","DOI":"10.1038\/s41612-025-00911-6"},{"key":"10.1016\/j.intimp.2025.116091_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2022.104384","article-title":"NLRP3 inflammasome contributes to endothelial dysfunction in angiotensin II-induced hypertension in mice","volume":"143","author":"Li","year":"2022","journal-title":"Microvasc. Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0295","doi-asserted-by":"crossref","first-page":"R96","DOI":"10.1530\/VB-21-0010","article-title":"Interleukin role in the regulation of endothelial cell pathological activation","volume":"3","author":"Carbone","year":"2021","journal-title":"Vasc Biol."},{"issue":"9","key":"10.1016\/j.intimp.2025.116091_bb0300","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/trf.17061","article-title":"DAMPS and complement activation in platelet concentrates that induce adverse reactions in patients","volume":"62","author":"de Wit","year":"2022","journal-title":"Transfusion"},{"issue":"9","key":"10.1016\/j.intimp.2025.116091_bb0305","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1084\/jem.20120189","article-title":"Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release","volume":"209","author":"Venereau","year":"2012","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.intimp.2025.116091_bb0310","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1021\/acsnano.3c05847","article-title":"Multitargeted immunomodulatory therapy for viral myocarditis by engineered extracellular vesicles","volume":"18","author":"Pei","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0315","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.18295\/2075-0528.1648","article-title":"The role of damage-associated molecular patterns in human diseases: part I - promoting inflammation and immunity","volume":"15","author":"Land","year":"2015","journal-title":"Sultan Qaboos Univ. Med. J."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0320","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12933-025-02591-1","article-title":"The triglyceride\u2013glucose index and its obesity-related derivatives as predictors of all-cause and cardiovascular mortality in hypertensive patients: insights from NHANES data with machine learning analysis","volume":"24","author":"Li","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"issue":"3","key":"10.1016\/j.intimp.2025.116091_bb0325","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1165\/rcmb.2023-0428OC","article-title":"Identification of SNHG11 as a therapeutic target in pulmonary hypertension","volume":"72","author":"Li","year":"2025","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.intimp.2025.116091_bb0330","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/00984100150501169","article-title":"Effects of nickel chloride on human platelets: enhancement of lipid peroxidation, inhibition of aggregation and interaction with ascorbic acid","volume":"62","author":"Chen","year":"2001","journal-title":"J. Toxicol. Environ. Health A"},{"issue":"16","key":"10.1016\/j.intimp.2025.116091_bb0335","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1161\/01.CIR.102.16.1931","article-title":"P-selectin expression on platelets determines size and stability of platelet aggregates","volume":"102","author":"Merten","year":"2000","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.intimp.2025.116091_bb0340","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1080\/09537104.2018.1430358","article-title":"Measuring and interpreting platelet-leukocyte aggregates","volume":"29","author":"Finsterbusch","year":"2018","journal-title":"Platelets"},{"key":"10.1016\/j.intimp.2025.116091_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2025.104805","article-title":"Interplay between platelet and T lymphocyte after coronary artery bypass grafting (CABG): evidence for platelet mediated post-CABG immunomodulation","volume":"160","author":"Farhid","year":"2025","journal-title":"Microvasc. Res."},{"issue":"9","key":"10.1016\/j.intimp.2025.116091_bb0350","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41419-020-02985-x","article-title":"NLRP3 inflammasome in endothelial dysfunction","volume":"11","author":"Bai","year":"2020","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0355","doi-asserted-by":"crossref","first-page":"13069","DOI":"10.1038\/s41598-019-49253-3","article-title":"Platelet-leukocyte aggregate is associated with adverse events after surgical intervention for rheumatic heart disease","volume":"9","author":"Liu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.116091_bb0360","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fimmu.2015.00083","article-title":"The inflammatory role of platelets via their TLRs and Siglec receptors","volume":"6","author":"Cognasse","year":"2015","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2025.116091_bb0365","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00441-014-1809-9","article-title":"Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies","volume":"355","author":"Leick","year":"2014","journal-title":"Cell Tissue Res."},{"issue":"9","key":"10.1016\/j.intimp.2025.116091_bb0370","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1161\/01.STR.0000086466.32421.F4","article-title":"Endothelial and platelet activation in acute ischemic stroke and its etiological subtypes","volume":"34","author":"Cherian","year":"2003","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.intimp.2025.116091_bb0375","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0380","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.1038\/s41467-022-32946-1","article-title":"NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia","volume":"13","author":"Leung","year":"2022","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2025.116091_bb0385","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12308-017-0306-y","article-title":"Restoration of natural killer cell cytotoxicity in the suppressive tumor microenvironment: novel approaches to treat AML","volume":"10","author":"Hassani","year":"2017","journal-title":"J. Hematop."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0390","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/jat.4892","article-title":"Exploring the Diagnostic Potential of Core Targets of 6PPD and Its Metabolite 6PPD-Q in Cardiovascular Diseases: An Integrated Analysis Based on Network Toxicology, Molecular Docking, and In Vitro Validation","volume":"46","author":"Guo","year":"2026","journal-title":"J Appl Toxicol."},{"issue":"12","key":"10.1016\/j.intimp.2025.116091_bb0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0355-7","article-title":"Mitochondrial dysfunction and oxidative stress in heart disease","volume":"51","author":"Peoples","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2025.116091_bb0400","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.taap.2011.12.022","article-title":"Nickel (II)-induced cytotoxicity and apoptosis in human proximal tubule cells through a ROS- and mitochondria-mediated pathway","volume":"259","author":"Wang","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0405","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17010010","article-title":"Research advances on pathways of nickel-induced apoptosis","volume":"17","author":"Guo","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2025.116091_bb0410","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1016\/S0006-3495(99)77134-1","article-title":"Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H","volume":"77","author":"Lee","year":"1999","journal-title":"Biophys. J."},{"key":"10.1016\/j.intimp.2025.116091_bb0415","doi-asserted-by":"crossref","unstructured":"Guo H, Cui H, Peng X, Fang J, Zuo Z, Deng J, et al. Modulation of the PI3K\/Akt Pathway and Bcl-2 Family Proteins Involved in Chicken's Tubular Apoptosis Induced by Nickel Chloride (NiCl2). International Journal of Molecular Sciences [Internet]. 2015; 16(9):[22989\u20133011 pp.].","DOI":"10.3390\/ijms160922989"},{"key":"10.1016\/j.intimp.2025.116091_bb0420","unstructured":"Naghinezhad J, Alenabi A, Ayatollahi H, Sheikhi M, Sadeghian MH, Khoshnegah Z, et al. Expression of DR4, DR5, FAS, Caspase-8 and, DDIAS Genes in AML Patients. Med. J. Islam Repub. Iran 2023;37:68."},{"key":"10.1016\/j.intimp.2025.116091_bb0425","doi-asserted-by":"crossref","unstructured":"Zhang W, Lavine KJ, Epelman S, Evans SA, Weinheimer CJ, Barger PM, et al. Necrotic Myocardial Cells Release Damage-Associated Molecular Patterns That Provoke Fibroblast Activation In Vitro and Trigger Myocardial Inflammation and Fibrosis In Vivo. Journal of the American Heart Association.4(6):e001993.","DOI":"10.1161\/JAHA.115.001993"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2025.116091_bb0430","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11010-008-9803-8","article-title":"Oxidative stress mediates cardiac fibrosis by enhancing transforming growth factor-beta1 in hypertensive rats","volume":"317","author":"Zhao","year":"2008","journal-title":"Mol. Cell. Biochem."},{"issue":"10","key":"10.1016\/j.intimp.2025.116091_bb0435","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/s41401-024-01305-9","article-title":"A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis","volume":"45","author":"Wang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"issue":"12","key":"10.1016\/j.intimp.2025.116091_bb0440","doi-asserted-by":"crossref","first-page":"22093","DOI":"10.1002\/jcp.28772","article-title":"Ni-induced TGF-\u03b2 signaling promotes VEGF-a secretion via integrin \u03b23 upregulation","volume":"234","author":"Wu","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"2S","key":"10.1016\/j.intimp.2025.116091_bb0445","first-page":"470","volume":"28","author":"Determination Of Bacterial Profiles In Children With Otitis Media With Effusion And Adenoid Hypertrophy","year":"2025","journal-title":"Afr. J. Biomed. Res."},{"key":"10.1016\/j.intimp.2025.116091_bb0450","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.redox.2015.09.009","article-title":"Reciprocal regulation of TGF-\u03b2 and reactive oxygen species: a perverse cycle for fibrosis","volume":"6","author":"Liu","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.116091_bb0455","article-title":"Pivotal role of TGF-\u03b2\/Smad Signaling in cardiac fibrosis: non-coding RNAs as effectual players","volume":"7","author":"Saadat","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.intimp.2025.116091_bb0460","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2018.10.023","article-title":"Calcitonin gene-related peptide inhibits the cardiac fibroblasts senescence in cardiac fibrosis via up-regulating klotho expression","volume":"843","author":"Li","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2025.116091_bb0465","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1600-079X.2011.00906.x","article-title":"Nickel exposure induces oxidative damage to mitochondrial DNA in Neuro2a cells: the neuroprotective roles of melatonin","volume":"51","author":"Xu","year":"2011","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.intimp.2025.116091_bb0470","doi-asserted-by":"crossref","unstructured":"Li C, Meng X, Wang L, Dai X. Mechanism of action of non-coding RNAs and traditional Chinese medicine in myocardial fibrosis: focus on the TGF-\u03b2\/Smad signaling pathway. Front. Pharmacol. 2023;Volume 14\u20132023.","DOI":"10.3389\/fphar.2023.1092148"},{"key":"10.1016\/j.intimp.2025.116091_bb0475","doi-asserted-by":"crossref","unstructured":"Hoying JB, Yin M, Diebold R, Ormsby I, Becker A, Doetschman T. Transforming Growth Factor β1 Enhances Platelet Aggregation through a Non-transcriptional Effect on the Fibrinogen Receptor *. J. Biol. Chem. 1999;274(43):31008\u201313.","DOI":"10.1074\/jbc.274.43.31008"},{"issue":"9","key":"10.1016\/j.intimp.2025.116091_bb0480","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094492","article-title":"Blood platelets as an important but underrated circulating source of TGF\u03b2","volume":"22","author":"Karolczak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2025.116091_bb0485","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1007\/s12012-024-09924-8","article-title":"Potential player of platelet in the pathogenesis of cardiotoxicity: molecular insight and future perspective","volume":"24","author":"Amin","year":"2024","journal-title":"Cardiovasc. Toxicol."},{"issue":"2","key":"10.1016\/j.intimp.2025.116091_bb0490","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/path.4104","article-title":"The myofibroblast matrix: implications for tissue repair and fibrosis","volume":"229","author":"Klingberg","year":"2013","journal-title":"J. Pathol."},{"key":"10.1016\/j.intimp.2025.116091_bb0495","article-title":"Nanozyme-enhanced tyramine signal amplification probe for preamplification-free myocarditis-related miRNAs detection","volume":"503","author":"Li","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"2","key":"10.1016\/j.intimp.2025.116091_bb0500","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17020202","article-title":"Molecular mechanisms of nickel allergy","volume":"17","author":"Saito","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.intimp.2025.116091_bb0505","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.tcm.2010.02.005","article-title":"Mechanisms of cardiac fibrosis in inflammatory heart disease","volume":"19","author":"Kania","year":"2009","journal-title":"Trends Cardiovasc. Med."},{"issue":"20","key":"10.1016\/j.intimp.2025.116091_bb0510","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.010013","article-title":"Cardiac fibrosis in proteotoxic cardiac disease is dependent upon myofibroblast TGF -\u03b2 Signaling","volume":"7","author":"Bhandary","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.intimp.2025.116091_bb0515","article-title":"A two-way street \u2013 cellular metabolism and myofibroblast contraction. Npj","volume":"9(1):15","author":"Noom","year":"2024","journal-title":"Regen. Med."},{"issue":"11","key":"10.1016\/j.intimp.2025.116091_bb0520","first-page":"2609","article-title":"Diastolic heart failure: challenges of diagnosis and treatment","volume":"69","author":"Gutierrez","year":"2004","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.intimp.2025.116091_bb0525","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.2147\/DDDT.S282206","article-title":"Xanthohumol inhibits TGF-\u03b21-induced cardiac fibroblasts activation via mediating PTEN\/Akt\/mTOR signaling pathway","author":"Jiang","year":"2020","journal-title":"Drug Des. Devel. Ther."},{"issue":"5","key":"10.1016\/j.intimp.2025.116091_bb0530","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004567","article-title":"TGF-\u03b21 (transforming growth factor-\u03b21) plays a pivotal role in cardiac myofibroblast arrhythmogenicity","volume":"10","author":"Salvarani","year":"2017","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.intimp.2025.116091_bb0535","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112583","article-title":"Nickel induces autophagy via PI3K\/AKT\/mTOR and AMPK pathways in mouse kidney","volume":"223","author":"Yin","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.intimp.2025.116091_bb0540","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.toxrep.2023.04.010","article-title":"Disease-associated metabolic pathways affected by heavy metals and metalloid","volume":"10","author":"Haidar","year":"2023","journal-title":"Toxicol. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2025.116091_bb0545","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062952","article-title":"JNK and p38 inhibitors prevent transforming growth factor-\u03b21-induced myofibroblast Transdifferentiation in human graves\u2019 orbital fibroblasts","volume":"22","author":"Hou","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"104","key":"10.1016\/j.intimp.2025.116091_bb0550","first-page":"62","article-title":"PI3K\/AKT\/mTOR pathway in ATLL: from basic biology to preclinical study","volume":"3","author":"Naghinezhad","year":"2019","journal-title":"J Cell Mol Pharmacol."},{"issue":"18","key":"10.1016\/j.intimp.2025.116091_bb0555","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810546","article-title":"The role of matrix metalloproteinase in inflammation with a focus on infectious diseases","volume":"23","author":"Lee","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.116091_bb0560","article-title":"M2 macrophage exosome-derived lncRNA AK083884 protects mice from CVB3-induced viral myocarditis through regulating PKM2\/HIF-1\u03b1 axis mediated metabolic reprogramming of macrophages","volume":"69","author":"Zhang","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.116091_bb0565","article-title":"Identification of necroptosis and immune infiltration in heart failure through bioinformatics analysis","volume":"2465-81","author":"Zhu","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.intimp.2025.116091_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127272","article-title":"Nickel chloride generates cytotoxic ROS that cause oxidative damage in human erythrocytes","volume":"80","author":"Sharma","year":"2023","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"6","key":"10.1016\/j.intimp.2025.116091_bb0575","doi-asserted-by":"crossref","first-page":"223","DOI":"10.31083\/j.fbl2906223","article-title":"Endothelial cell dysfunction: onset, progression, and consequences","volume":"29","author":"Naderi-Meshkin","year":"2024","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"8","key":"10.1016\/j.intimp.2025.116091_bb0580","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9080915","article-title":"Recognition of oxidized lipids by macrophages and its role in atherosclerosis development","volume":"9","author":"Mushenkova","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.intimp.2025.116091_bb0585","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1179828","article-title":"The cell origins of foam cell and lipid metabolism regulated by mechanical stress in atherosclerosis","volume":"14","author":"Ouyang","year":"2023","journal-title":"Front. Physiol."},{"issue":"12","key":"10.1016\/j.intimp.2025.116091_bb0590","doi-asserted-by":"crossref","first-page":"22093","DOI":"10.1002\/jcp.28772","article-title":"Ni-induced TGF-\u03b2 signaling promotes VEGF-a secretion via integrin \u03b23 upregulation","volume":"234","author":"Wu","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.intimp.2025.116091_bb0595","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1124\/mol.117.110650","article-title":"Long noncoding RNA LINC00657 acting as a mir-590-3p sponge to facilitate low concentration oxidized low-density lipoprotein\u2013induced angiogenesis","volume":"93","author":"Bao","year":"2018","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2025.116091_bb0600","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.mcna.2023.04.004","article-title":"Atherosclerotic disease: pathogenesis and approaches to management","volume":"107","author":"Morrison","year":"2023","journal-title":"Med. Clin. North Am."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0605","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12944-025-02638-y","article-title":"Suppression effect of folate on poly-and perfluoroalkyl substance-induced alterations in lipids and the atherogenic index of plasma in adolescents","volume":"24","author":"Pan","year":"2025","journal-title":"Lipids Health Dis."},{"issue":"11","key":"10.1016\/j.intimp.2025.116091_bb0610","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.jfma.2014.03.007","article-title":"Nickel ions from a corroded cardiovascular stent induce monocytic cell apoptosis: proposed impact on vascular remodeling and mechanism","volume":"114","author":"Shih","year":"2015","journal-title":"J. Formos. Med. Assoc."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0615","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1040-8428(01)00214-1","article-title":"Nickel essentiality, toxicity, and carcinogenicity","volume":"42","author":"Denkhaus","year":"2002","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.intimp.2025.116091_bb0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114620","article-title":"Nanoparticles derived from naturally occurring metal chelators for theranostic applications","volume":"191","author":"Jung","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0625","doi-asserted-by":"crossref","first-page":"13851","DOI":"10.1038\/s41598-019-50027-0","article-title":"Nickel chelation therapy as an approach to combat multi-drug resistant enteric pathogens","volume":"9","author":"Benoit","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0630","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1038\/s41598-021-86060-1","article-title":"The nickel-chelator dimethylglyoxime inhibits human amyloid beta peptide in vitro aggregation","volume":"11","author":"Benoit","year":"2021","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2025.116091_bb0635","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1067\/mem.2003.72","article-title":"British anti-lewisite (dimercaprol): an amazing history","volume":"41","author":"Vilensky","year":"2003","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.intimp.2025.116091_bb0640","doi-asserted-by":"crossref","unstructured":"Yarahmadi S, Mehrjoo M, Asgharzadeh S, Pakravan S, Ahmadvand H, Babaeenezhad E. The combination effects of sodium selenite and vitamin E on renal ischemia-reperfusion injury in rats. Journal of renal Inj. Prev. 2024;14(2):e38400-e.","DOI":"10.34172\/jrip.2025.38400"},{"key":"10.1016\/j.intimp.2025.116091_bb0645","doi-asserted-by":"crossref","unstructured":"Aralapuram K, Shetty BC, Gurusiddaiah SC. A study on comparison of Tc-99m DTPA renal dynamic imaging with Mayo quadratic, Cockcroft-gault, MDRD, and CKD-EPI formulas for estimation of glomerular filtration rate among south Indian live-related kidney donors. Journal of renal Inj. Prev. 2024;13(4):e36310-e.","DOI":"10.34172\/jrip.2024.36310"},{"issue":"5","key":"10.1016\/j.intimp.2025.116091_bb0650","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051019","article-title":"EDTA chelation therapy for the treatment of neurotoxicity","volume":"20","author":"Fulgenzi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.116091_bb0655","doi-asserted-by":"crossref","unstructured":"Pourpashang P, Khayyat A, Ghasemi M, Rouzbahani S. Clinical significance of APOL1-mediated renal disease. Immunopathologia Persa. 2025;11(2):e43770-e.","DOI":"10.34172\/ipp.2025.43770"},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0660","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2369-7-5","article-title":"Protective effect of EDTA preadministration on renal ischemia","volume":"7","author":"Foglieni","year":"2006","journal-title":"BMC Nephrol."},{"issue":"11","key":"10.1016\/j.intimp.2025.116091_bb0665","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1080\/14740338.2021.1956460","article-title":"Safety profile of D-penicillamine: a comprehensive pharmacovigilance analysis by FDA adverse event reporting system","volume":"20","author":"Kumar","year":"2021","journal-title":"Expert Opin. Drug Saf."},{"issue":"2","key":"10.1016\/j.intimp.2025.116091_bb0670","doi-asserted-by":"crossref","first-page":"F321","DOI":"10.1152\/ajprenal.1990.258.2.F321","article-title":"D-penicillamine and the transport of L-cystine by rat and human renal cortical brush-border membrane vesicles","volume":"258","author":"Furlong","year":"1990","journal-title":"American Journal of Physiology-Renal Physiology."},{"issue":"2","key":"10.1016\/j.intimp.2025.116091_bb0675","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1464-410X.2006.06212.x","article-title":"Penicillamine administration reverses the inhibitory effect of hyperhomocysteinaemia on endothelium-dependent relaxation in the corpus cavernosum in the rabbit","volume":"98","author":"Koupparis","year":"2006","journal-title":"BJU Int."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0680","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1038\/s41598-021-83363-1","article-title":"Synthesis, characterization and heavy metal removal efficiency of nickel ferrite nanoparticles (NFN\u2019S)","volume":"11","author":"Khoso","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.116091_bb0685","first-page":"12","article-title":"Nano-revolution in heavy metal removal: engineered nanomaterials for cleaner water. Frontiers in environmental","author":"Karnwal","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.intimp.2025.116091_bb0690","first-page":"6","article-title":"Metal and metal oxide nanomaterials for heavy metal remediation: novel approaches for selective, regenerative, and scalable water treatment. Frontiers","author":"Olawade","year":"2024","journal-title":"Nanotechnology"},{"key":"10.1016\/j.intimp.2025.116091_bb0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpcs.2022.111089","article-title":"Carboxyl and thiol-functionalized magnetic nanoadsorbents for efficient and simultaneous removal of pb(II), cd(II), and Ni(II) heavy metal ions from aqueous solutions: studies of adsorption, kinetics, and isotherms","volume":"172","author":"Kothavale","year":"2023","journal-title":"J. Phys. Chem. Solid"},{"key":"10.1016\/j.intimp.2025.116091_bb0700","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2022.111007","article-title":"ICAM-1-targeted and antibacterial peptide modified polymeric nanoparticles for specific combating sepsis","volume":"222","author":"Pan","year":"2022","journal-title":"Mater. Des."},{"issue":"24","key":"10.1016\/j.intimp.2025.116091_bb0705","doi-asserted-by":"crossref","DOI":"10.3390\/ma14247500","article-title":"Heavy metal adsorption using magnetic nanoparticles for water purification: a critical review","volume":"14","author":"Liosis","year":"2021","journal-title":"Materials (Basel)"},{"issue":"11","key":"10.1016\/j.intimp.2025.116091_bb0710","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s41551-020-00637-1","article-title":"Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles","volume":"4","author":"Liu","year":"2020","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0715","article-title":"Nanoantioxidants: recent trends in antioxidant delivery applications","volume":"9","author":"Khalil","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2025.116091_bb0720","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114037","article-title":"Protective effect of methionine on the intestinal oxidative stress and microbiota change induced by nickel","volume":"244","author":"Wu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.intimp.2025.116091_bb0725","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/carcin\/bgx038","article-title":"Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells","volume":"38","author":"Scanlon","year":"2017","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0730","doi-asserted-by":"crossref","first-page":"16424","DOI":"10.1038\/s41598-023-43546-4","article-title":"Melatonin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles reduce inflammation, inhibit apoptosis and protect rat\u2019s liver from the hazardous effects of CCL4","volume":"13","author":"Farid","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.116091_bb0735","doi-asserted-by":"crossref","unstructured":"Shamay Y, Elkabets M, Li H, Shah J, Brook S, Wang F, et al. P-selectin is a nanotherapeutic delivery target in the tumor microenvironment. Sci. Transl. Med. 2016;8(345):345ra87.","DOI":"10.1126\/scitranslmed.aaf7374"},{"key":"10.1016\/j.intimp.2025.116091_bb0740","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1002\/tox.23550","article-title":"Investigation of nickel sulfate-induced cytotoxicity and underlying toxicological mechanisms in human umbilical vein endothelial cells through oxidative stress, inflammation, apoptosis, and MAPK signaling pathways","volume":"37","author":"Liu","year":"2022","journal-title":"Environ. Toxicol."},{"issue":"8","key":"10.1016\/j.intimp.2025.116091_bb0745","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14081614","article-title":"PEG spacer length substantially affects antibody-based nanocarrier targeting of dendritic cell subsets","volume":"14","author":"Br\u00fcckner","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.intimp.2025.116091_bb0750","doi-asserted-by":"crossref","first-page":"10045","DOI":"10.2147\/IJN.S479270","article-title":"Strategies for non-covalent attachment of antibodies to PEGylated nanoparticles for targeted drug delivery","volume":"19","author":"Ho","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.intimp.2025.116091_bb0755","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.2147\/IJN.S209820","article-title":"Co-loading antioxidant N-acetylcysteine attenuates cytotoxicity of iron oxide nanoparticles in hypoxia\/reoxygenation cardiomyocytes","volume":"14","author":"Shen","year":"2019","journal-title":"Int. J. Nanomedicine"},{"issue":"12","key":"10.1016\/j.intimp.2025.116091_bb0760","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019521","article-title":"Nanoparticle-mediated simultaneous targeting of mitochondrial injury and inflammation attenuates myocardial ischemia-reperfusion injury","volume":"10","author":"Ikeda","year":"2021","journal-title":"J. Am. Heart Assoc."},{"issue":"17","key":"10.1016\/j.intimp.2025.116091_bb0765","doi-asserted-by":"crossref","first-page":"10038","DOI":"10.1021\/la900966h","article-title":"Action at a distance: lengthening adhesion bonds with poly(ethylene glycol) spacers enhances mechanically stressed affinity for improved vascular targeting of microparticles","volume":"25","author":"Ham","year":"2009","journal-title":"Langmuir"},{"issue":"18","key":"10.1016\/j.intimp.2025.116091_bb0770","doi-asserted-by":"crossref","DOI":"10.3390\/polym16182606","article-title":"Recent applications of PLGA in drug delivery systems","volume":"16","author":"Yang","year":"2024","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.intimp.2025.116091_bb0775","doi-asserted-by":"crossref","unstructured":"Barenholz Y. Doxil\u00ae--the first FDA-approved nano-drug: lessons learned. J. Control. Release 2012;160(2):117\u201334.","DOI":"10.1016\/j.jconrel.2012.03.020"},{"issue":"49","key":"10.1016\/j.intimp.2025.116091_bb0780","doi-asserted-by":"crossref","first-page":"7534","DOI":"10.1039\/D3CC01082A","article-title":"A guide to functionalisation and bioconjugation strategies to surface-initiated polymer brushes","volume":"59","author":"Neri-Cruz","year":"2023","journal-title":"Chem. Commun. (Camb.)"},{"issue":"1","key":"10.1016\/j.intimp.2025.116091_bb0785","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15010236","article-title":"Superparamagnetic Iron oxide nanoparticles (SPION): from fundamentals to state-of-the-art innovative applications for Cancer therapy","volume":"15","author":"Vangijzegem","year":"2023","journal-title":"Pharmaceutics"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925020806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925020806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T12:15:22Z","timestamp":1767442522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925020806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":157,"alternative-id":["S1567576925020806"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.116091","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nickel-induced cardiotoxicity: immunopathogenesis, thromboinflammation, and a targeted nanotherapeutic strategy","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.116091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116091"}}