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Med."},{"issue":"5","key":"10.1016\/j.intimp.2025.116109_bb0545","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1440-1711.2005.01371.x","article-title":"Dendritic cell dysfunction in cancer: A mechanism for immunosuppression","volume":"83","author":"Pinzon-Charry","year":"2005","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.intimp.2025.116109_bb0550","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1479-5876-10-19","article-title":"Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis","volume":"10","author":"Li","year":"2012","journal-title":"J. Transl. 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Rep."},{"issue":"4","key":"10.1016\/j.intimp.2025.116109_bb0640","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju016","article-title":"A prospective study of macrophage inhibitory cytokine-1 (MIC-1\/GDF15) and risk of colorectal cancer","volume":"106","author":"Mehta","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"issue":"3","key":"10.1016\/j.intimp.2025.116109_bb0645","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1053\/j.gastro.2015.05.038","article-title":"Association between plasma levels of macrophage inhibitory cytokine-1 before diagnosis of colorectal cancer and mortality","volume":"149","author":"Mehta","year":"2015","journal-title":"Gastroenterology"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2025.116109_bb0650","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cca.2008.12.008","article-title":"Upregulation and secretion of macrophage inhibitory cytokine-1 (MIC-1) in gastric cancers","volume":"401","author":"Baek","year":"2009","journal-title":"Clinica Chimica Acta; Int. J. Clin. 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