{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:38:07Z","timestamp":1789148287025,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019370","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2022.13327"],"award-info":[{"award-number":["2022.13327"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.intimp.2025.116113","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T17:04:19Z","timestamp":1767114259000},"page":"116113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Early P2X7 receptor activation mitigates neonatal group B Streptococcus infection severity and long-term neurodevelopmental impairment"],"prefix":"10.1016","volume":"171","author":[{"given":"Sales","family":"Fialho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Quintas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Trieu-Cuot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2025.116113_bb0080","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"Fleischmann-Struzek","year":"2018","journal-title":"The Lancet Respiratory Medicine"},{"issue":"3","key":"10.1016\/j.intimp.2025.116113_bb0250","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/0884533617695243","article-title":"Sepsis: Current Definition, Pathophysiology, Diagnosis, and Management","volume":"32","author":"Taeb","year":"2017","journal-title":"Nutr Clin Pract"},{"key":"10.1016\/j.intimp.2025.116113_bb0265","series-title":"Global report on the epidemiology and burden of sepsis: current evidence, identifying gaps and future directions. (ISBN 978-92-4-001078-9). Geneva","author":"World Health Organization","year":"2020"},{"key":"10.1016\/j.intimp.2025.116113_bb0165","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fped.2018.00027","article-title":"Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventive Approaches","volume":"6","author":"Patras","year":"2018","journal-title":"Front Pediatr"},{"issue":"suppl_2","key":"10.1016\/j.intimp.2025.116113_bb0120","doi-asserted-by":"crossref","first-page":"S190","DOI":"10.1093\/cid\/cix663","article-title":"Neurodevelopmental Impairment in Children After Group B Streptococcal Disease Worldwide: Systematic Review and Meta-analyses","volume":"65","author":"Kohli-Lynch","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"2","key":"10.1016\/j.intimp.2025.116113_bb0050","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/MPG.0000000000000928","article-title":"Influence of Intrapartum Antibiotic Prophylaxis for Group B Streptococcus on Gut Microbiota in the First Month of Life","volume":"62","author":"Corvaglia","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.intimp.2025.116113_bb0180","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1542\/pir.2016-0127","article-title":"Group B Streptococcal Infections","volume":"38","author":"Randis","year":"2017","journal-title":"Pediatrics in review"},{"issue":"2","key":"10.1016\/j.intimp.2025.116113_bb0030","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pharmthera.2005.04.013","article-title":"Adenosine 5\u2019-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation","volume":"112","author":"Bours","year":"2006","journal-title":"Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.intimp.2025.116113_bb0040","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s11302-014-9427-2","article-title":"Purinergic signalling and immune cells","volume":"10","author":"Burnstock","year":"2014","journal-title":"Purinergic Signal"},{"issue":"9","key":"10.1016\/j.intimp.2025.116113_bb0075","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1074\/jbc.M113.545632","article-title":"Extracellular nucleotide catabolism by the Group B Streptococcus ectonucleotidase NudP increases bacterial survival in blood","volume":"289","author":"Firon","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2025.116113_bb0005","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bcp.2017.12.021","article-title":"The P2X7 receptor: A main player in inflammation","volume":"151","author":"Adinolfi","year":"2018","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.intimp.2025.116113_bb0055","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.immuni.2017.06.020","article-title":"The P2X7 Receptor in Infection and Inflammation","volume":"47","author":"Di Virgilio","year":"2017","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2025.116113_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010232","article-title":"Inherent P2X7 Receptors Regulate Macrophage Functions during Inflammatory Diseases","volume":"23","author":"Ren","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.intimp.2025.116113_bb0255","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3389\/fimmu.2018.00399","article-title":"Purinergic Regulation of Neutrophil Function","volume":"9","author":"Wang","year":"2018","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.intimp.2025.116113_bb0260","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1002\/eji.202249932","article-title":"P2X7 is expressed on human innate-like T lymphocytes and mediates susceptibility to ATP-induced cell death","volume":"52","author":"Winzer","year":"2022","journal-title":"Eur J Immunol"},{"issue":"5","key":"10.1016\/j.intimp.2025.116113_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096281","article-title":"Modulation of mouse embryonic stem cell proliferation and neural differentiation by the P2X7 receptor","volume":"9","author":"Glaser","year":"2014","journal-title":"PLoS One"},{"issue":"30","key":"10.1016\/j.intimp.2025.116113_bb0150","doi-asserted-by":"crossref","first-page":"7063","DOI":"10.1523\/JNEUROSCI.3104-16.2017","article-title":"Neuronal P2X7 Receptor: Involvement in Neuronal Physiology and Pathology","volume":"37","author":"Miras-Portugal","year":"2017","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.intimp.2025.116113_bb0235","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1046\/j.1471-4159.2002.00920.x","article-title":"Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus","volume":"81","author":"Sperlagh","year":"2002","journal-title":"J Neurochem"},{"issue":"Pt A","key":"10.1016\/j.intimp.2025.116113_bb0070","article-title":"Could P2X7 receptor be a potencial target in neonatal sepsis?","volume":"142","author":"Fialho","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2025.116113_bb0110","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.brainresbull.2018.12.008","article-title":"Regulation of P2X7 receptor expression and function in the brain","volume":"151","author":"Jimenez-Mateos","year":"2019","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.intimp.2025.116113_bb0200","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.semcdb.2018.12.001","article-title":"Purinergic signalling and brain development","volume":"95","author":"Rodrigues","year":"2019","journal-title":"Semin Cell Dev Biol"},{"issue":"22","key":"10.1016\/j.intimp.2025.116113_bb0090","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1111\/bph.14470","article-title":"P2X7 as a scavenger receptor for innate phagocytosis in the brain","volume":"175","author":"Gu","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.intimp.2025.116113_bb0245","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12974-025-03509-0","article-title":"The role of maternal infections in neurodevelopmental psychiatric disorders: focus on the P2X7\/NLRP3\/IL-1\u03b2 signalling pathway","volume":"22","author":"Szab\u00f3","year":"2025","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.intimp.2025.116113_bb0015","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1038\/s41467-018-05492-y","article-title":"A mouse model reproducing the pathophysiology of neonatal group B streptococcal infection","volume":"9","author":"Andrade","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.intimp.2025.116113_bb0065","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.1038\/s41598-019-42414-4","article-title":"A sensitive scoring system for the longitudinal clinical evaluation and prediction of lethal disease outcomes in newborn mice","volume":"9","author":"Fehlhaber","year":"2019","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.intimp.2025.116113_bb0020","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.intimp.2025.116113_bb0175","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2019"},{"key":"10.1016\/j.intimp.2025.116113_bb0105","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-1-60327-099-1_10","article-title":"Developmental Milestones in the Newborn Mouse","volume":"39","author":"Hill","year":"2008","journal-title":"Neuromethods"},{"issue":"3","key":"10.1016\/j.intimp.2025.116113_bb0205","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/2041-210X.12874","article-title":"ToxTrac: A fast and robust software for tracking organisms","volume":"9","author":"Rodriguez","year":"2018","journal-title":"Methods in Ecology and Evolution"},{"issue":"9","key":"10.1016\/j.intimp.2025.116113_bb0010","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.4049\/jimmunol.1301752","article-title":"TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis","volume":"191","author":"Andrade","year":"2013","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.intimp.2025.116113_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128431","article-title":"Group B streptococcal infection and activation of human astrocytes","volume":"10","author":"Stoner","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.intimp.2025.116113_bb0095","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrneurol.2015.13","article-title":"The role of inflammation in perinatal brain injury","volume":"11","author":"Hagberg","year":"2015","journal-title":"Nat Rev Neurol"},{"issue":"suppl_2","key":"10.1016\/j.intimp.2025.116113_bb0130","doi-asserted-by":"crossref","first-page":"S160","DOI":"10.1093\/cid\/cix656","article-title":"Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses","volume":"65","author":"Madrid","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.intimp.2025.116113_bb0185","doi-asserted-by":"crossref","first-page":"1268804","DOI":"10.3389\/fimmu.2023.1268804","article-title":"Dysregulated monocyte-derived macrophage response to Group B Streptococcus in newborns","volume":"14","author":"Ravi","year":"2023","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.intimp.2025.116113_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002363","article-title":"Inhibition of IL-10 production by maternal antibodies against Group B Streptococcus GAPDH confers immunity to offspring by favoring neutrophil recruitment","volume":"7","author":"Madureira","year":"2011","journal-title":"PLoS Pathog"},{"issue":"3","key":"10.1016\/j.intimp.2025.116113_bb0045","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101485R","article-title":"Nucleotide receptors mediate protection against neonatal sepsis and meningitis caused by alpha-hemolysin expressing Escherichia coli K1","volume":"36","author":"Chambers","year":"2022","journal-title":"FASEB J"},{"key":"10.1016\/j.intimp.2025.116113_bb0220","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fphar.2018.00052","article-title":"The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?","volume":"9","author":"Savio","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.intimp.2025.116113_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00862","article-title":"P2X7 Receptor Induces Tumor Necrosis Factor-\u03b1 Converting Enzyme Activation and Release to Boost TNF-\u03b1 Production [Original Research]","volume":"8","author":"Barber\u00e0-Cremades","year":"2017","journal-title":"Frontiers in Immunology"},{"issue":"4","key":"10.1016\/j.intimp.2025.116113_bb0215","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1159\/000371388","article-title":"The P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis","volume":"7","author":"Santana","year":"2015","journal-title":"J Innate Immun"},{"issue":"12","key":"10.1016\/j.intimp.2025.116113_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/cells12121570","article-title":"Brain Infection by Group B Streptococcus Induces Inflammation and Affects Neurogenesis in the Adult Mouse Hippocampus","volume":"12","author":"Segklia","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2025.116113_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.25276","article-title":"Selective vulnerability of hippocampal CA1 and CA3 pyramidal cells: What are possible pathomechanisms and should more attention be paid to the CA3 region in future studies?","volume":"102","author":"Einenkel","year":"2024","journal-title":"J Neurosci Res."},{"issue":"6","key":"10.1016\/j.intimp.2025.116113_bb0145","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/s41390-021-01405-w","article-title":"Serial plasma biomarkers of brain injury in infants with neonatal encephalopathy treated with therapeutic hypothermia","volume":"90","author":"McGowan","year":"2021","journal-title":"Pediatr Res"},{"issue":"5","key":"10.1016\/j.intimp.2025.116113_bb0160","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/pr.2015.280","article-title":"Association of brain injury and neonatal cytokine response during therapeutic hypothermia in newborns with hypoxic-ischemic encephalopathy","volume":"79","author":"Orrock","year":"2016","journal-title":"Pediatr Res"},{"issue":"11","key":"10.1016\/j.intimp.2025.116113_bb0035","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/jnen\/61.11.1013","article-title":"Broad expression of Toll-like receptors in the human central nervous system","volume":"61","author":"Bsibsi","year":"2002","journal-title":"J Neuropathol Exp Neurol"},{"issue":"6","key":"10.1016\/j.intimp.2025.116113_bb0100","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/jnc.14126","article-title":"Interleukin-10 release from astrocytes suppresses neuronal apoptosis via the TLR2\/NF\u03baB pathway in a neonatal rat model of hypoxic-ischemic brain damage","volume":"142","author":"He","year":"2017","journal-title":"J Neurochem"},{"issue":"1","key":"10.1016\/j.intimp.2025.116113_bb0125","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12974-016-0763-8","article-title":"Balancing the immune response in the brain: IL-10 and its regulation","volume":"13","author":"Lobo-Silva","year":"2016","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.intimp.2025.116113_bb0210","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bbi.2021.12.026","article-title":"Chronic IL-10 overproduction disrupts microglia-neuron dialogue similar to aging, resulting in impaired hippocampal neurogenesis and spatial memory","volume":"101","author":"Sanchez-Molina","year":"2022","journal-title":"Brain Behav Immun"},{"issue":"4","key":"10.1016\/j.intimp.2025.116113_bb0190","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/glia.23573","article-title":"Astrocyte-targeted IL-10 production decreases proliferation and induces a downregulation of activated microglia\/macrophages after PPT","volume":"67","author":"Recasens","year":"2019","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.intimp.2025.116113_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/cells14010054","article-title":"From Homeostasis to Neuroinflammation: Insights into Cellular and Molecular Interactions and Network Dynamics","volume":"14","author":"M\u00fcller","year":"2025","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2025.116113_bb0140","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/glia.22904","article-title":"Mechanism of microglia neuroprotection: Involvement of P2X7, TNFalpha, and valproic acid","volume":"64","author":"Masuch","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.intimp.2025.116113_bb0115","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1742-2094-8-62","article-title":"P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-\u03b1-mediated pathway in the rat hippocampus following status epilepticus","volume":"8","author":"Kim","year":"2011","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.intimp.2025.116113_bb0230","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2019.00240","article-title":"LPS-Induced Systemic Neonatal Inflammation: Blockage of P2X7R by BBG Decreases Mortality on Rat Pups and Oxidative Stress in Hippocampus of Adult Rats","volume":"13","author":"Silva","year":"2019","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"8","key":"10.1016\/j.intimp.2025.116113_bb0170","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/sj.bjp.0706815","article-title":"Differential effects of Gram-positive versus Gram-negative bacteria on NOSII and TNFalpha in macrophages: role of TLRs in synergy between the two","volume":"148","author":"Paul-Clark","year":"2006","journal-title":"Br J Pharmacol"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925021022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925021022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:55:36Z","timestamp":1778820936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925021022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":53,"alternative-id":["S1567576925021022"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.116113","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early P2X7 receptor activation mitigates neonatal group B Streptococcus infection severity and long-term neurodevelopmental impairment","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.116113","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116113"}}