{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:38:26Z","timestamp":1793039906325,"version":"4.5.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173939"],"award-info":[{"award-number":["82173939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.intimp.2025.116120","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T16:25:03Z","timestamp":1767457503000},"page":"116120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Siraitiae Fructus ameliorates allergic asthma via \u201cgut-lung axis\u201d modulation: Th17\/Treg ratio rebalancing, TLR4\/MyD88\/NF-\u03baB pathway suppression, and T lymphocytes migration inhibition"],"prefix":"10.1016","volume":"171","author":[{"given":"Zongjin","family":"Pu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.116120_bb0005","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jaip.2025.01.006","article-title":"Relationships between chronic cough and asthma control and quality of life in patients with severe asthma: a 6-month longitudinal analysis","volume":"13","author":"Lee","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.intimp.2025.116120_bb0010","doi-asserted-by":"crossref","DOI":"10.15585\/mmwr.ss7005a1","article-title":"Asthma surveillance \u2014 United States, 2006\u20132018","volume":"70","author":"Pate","year":"2021","journal-title":"MMWR Surveill. Summ."},{"key":"10.1016\/j.intimp.2025.116120_bb0015","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2021.02.016","article-title":"The basic immunology of asthma","volume":"184","author":"Hammad","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2025.116120_bb0020","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrmicro2801","article-title":"The microbiology of asthma","volume":"10","author":"Edwards","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.intimp.2025.116120_bb0025","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev.physiol.010908.163200","article-title":"Immunobiology of asthma","volume":"71","author":"Hamid","year":"2009","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.intimp.2025.116120_bb0030","article-title":"Phytochemicals as treatment for allergic asthma: therapeutic effects and mechanisms of action","volume":"122","author":"Jasemi","year":"2024","journal-title":"Phytomed. Int. J. Phytother. Phytomed."},{"key":"10.1016\/j.intimp.2025.116120_bb0035","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01619-2023","article-title":"Airway remodelling in asthma and the epithelium: on the edge of a new era","volume":"63","author":"Varricchi","year":"2024","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.intimp.2025.116120_bb0040","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01585-2021","article-title":"European respiratory society guidelines for the diagnosis of asthma in adults","volume":"60","author":"Louis","year":"2022","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.intimp.2025.116120_bb0045","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S2213-2600(20)30052-7","article-title":"Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies","volume":"8","author":"Patrick","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.intimp.2025.116120_bb0050","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-58248-w","article-title":"A genome-wide cross-trait analysis characterizes the shared genetic architecture between lung and gastrointestinal diseases","volume":"16","author":"You","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.116120_bb0055","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.jaci.2016.05.049","article-title":"Histamine-secreting microbes are increased in the gut of adult asthma patients","volume":"138","author":"Barcik","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0060","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1111\/all.15691","article-title":"Adult asthma with symptomatic eosinophilic inflammation is accompanied by alteration in gut microbiome","volume":"78","author":"Gu","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2025.116120_bb0065","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2020.01.007","article-title":"The role of lung and gut microbiota in the pathology of asthma","volume":"52","author":"Barcik","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2025.116120_bb0070","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41467-018-03157-4","article-title":"Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by lactobacillus supplementation","volume":"9","author":"Durack","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.116120_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106243","article-title":"Salidroside suppresses group 2 innate lymphoid cell-mediated allergic airway inflammation by targeting IL-33\/ST2 axis","volume":"81","author":"Cai","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.116120_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124333","article-title":"Cordyceps militaris polysaccharide alleviates ovalbumin-induced allergic asthma through the Nrf2\/HO-1 and NF-\u03baB signaling pathways and regulates the gut microbiota","volume":"238","author":"Song","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.intimp.2025.116120_bb0085","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1039\/D1FO00194A","article-title":"Tetrahydrocurcumin alleviates allergic airway inflammation in asthmatic mice by modulating the gut microbiota","volume":"12","author":"Wu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2025.116120_bb0090","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1164\/rccm.200208-902SO","article-title":"Acute severe asthma","volume":"168","author":"McFadden","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2025.116120_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.800143","article-title":"A combined transcriptomic and proteomic approach to reveal the effect of mogroside V on OVA-induced pulmonary inflammation in mice","volume":"13","author":"Dou","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153682","article-title":"Mogroside V reduce OVA-induced pulmonary inflammation based on lung and serum metabolomics","volume":"91","author":"Liu","year":"2021","journal-title":"Phytomed"},{"key":"10.1016\/j.intimp.2025.116120_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.133593","article-title":"Screening of bioactive flavour compounds targeting muscarinic-3 acetylcholine receptor from siraitia grosvenorii and evaluation of their synergistic anti-asthmatic activity","volume":"395","author":"Zhao","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.intimp.2025.116120_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2025.106538","article-title":"Total saponins from Siraitiae Fructus alleviate lung and intestinal injuries in rats with acute lung injury and mice infected with the influenza virus by regulating cytokines and enhancing the mucosal barrier","volume":"68","author":"Pu","year":"2025","journal-title":"Food Biosci."},{"key":"10.1016\/j.intimp.2025.116120_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117227","article-title":"Xuanbai chengqi decoction alleviates acute lung injury by inhibiting NLRP3 inflammasome","volume":"319","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.116120_bb0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jchromb.2018.02.002","article-title":"The metabolism of a natural product mogroside V, in healthy and type 2 diabetic rats","volume":"1079","author":"Zhou","year":"2018","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.intimp.2025.116120_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153790","article-title":"Differential effect of polysaccharide and nonpolysaccharide components in sijunzi decoction on spleen deficiency syndrome and their mechanisms","volume":"93","author":"Ma","year":"2021","journal-title":"Phytomed"},{"key":"10.1016\/j.intimp.2025.116120_bb0130","first-page":"599","article-title":"Effects of dexamethasone on body fluid and electrolyte composition of rats","volume":"122","author":"Kenyon","year":"1990","journal-title":"Acta Endocrinol."},{"key":"10.1016\/j.intimp.2025.116120_bb0135","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.3390\/molecules25235739","article-title":"Determination and comparison of short-chain fatty acids in serum and colon content samples: alzheimer\u2019s disease rat as a case study","volume":"25","author":"Guo","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2025.116120_bb0140","article-title":"A comprehensive review of siraitia grosvenorii (swingle) C. Jeffrey: chemical composition, pharmacology, toxicology, status of resources development, and applications","volume":"15","author":"Huang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.116120_bb0145","doi-asserted-by":"crossref","first-page":"6850","DOI":"10.1021\/acs.jafc.4c00018","article-title":"Siraitia grosvenorii as a homologue of food and medicine: a review of biological activity, mechanisms of action, synthetic biology, and applications in future food","volume":"72","author":"Guo","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2025.116120_bb0150","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/08830185.2024.2431507","article-title":"Asthma research in mice: an overview of current models and their methodological variability","volume":"44","author":"Chen","year":"2025","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112410","article-title":"Anti-asthmatic effects of phlomis umbrosa turczaninow using ovalbumin induced asthma murine model and network pharmacology analysis","volume":"145","author":"Pak","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.116120_bb0160","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1398-9995.2012.02832.x","article-title":"Untangling asthma phenotypes and endotypes","volume":"67","author":"Agache","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2025.116120_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114067","article-title":"Coordinated regulation of eosinophil production and migration by glucocorticoids, prostaglandins, and cysteinyl-leukotrienes","volume":"148","author":"Vieira","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.116120_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123250","article-title":"The therapeutic effect of xuanbai chengqi decoction on chronic obstructive pulmonary disease with excessive heat in the lung and fu-organs based on gut and lung microbiota as well as metabolic profiles","volume":"1198","author":"Jiao","year":"2022","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.intimp.2025.116120_bb0175","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1067\/mai.2003.22","article-title":"Inflammatory cells in asthma: mechanisms and implications for therapy","volume":"111","author":"Hamid","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0180","first-page":"604","article-title":"Current understanding of TH2 cell differentiation and function, protein","volume":"2","author":"Li","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2025.116120_bb0185","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1183\/13993003.00536-2015","article-title":"Allergen-induced airway responses","volume":"46","author":"Gauvreau","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.intimp.2025.116120_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113476","article-title":"Hylocereus undatus flower extract suppresses OVA-induced allergic asthma in BALb\/c mice by reducing airway inflammation and modulating gut microbiota","volume":"153","author":"Liao","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.116120_bb0195","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.jaci.2013.02.016","article-title":"T cells in asthma: influences of genetics, environment, and T-cell plasticity","volume":"131","author":"Lloyd","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0200","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1398-9995.2011.02576.x","article-title":"Th17 cells: new players in asthma pathogenesis","volume":"66","author":"Cosmi","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2025.116120_bb0205","doi-asserted-by":"crossref","DOI":"10.1111\/imr.70011","article-title":"T1-T2 interplay in the complex immune landscape of severe asthma","volume":"330","author":"Gauthier","year":"2025","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2025.116120_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1429591","article-title":"Oleic acid attenuates asthma pathogenesis via Th1\/TH2 immune cell modulation, TLR3\/4-NF-\u03baB-related inflammation suppression, and intrinsic apoptotic pathway induction","volume":"15","author":"Lee","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0215","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1038\/s41467-021-25307-x","article-title":"CD11b+ lung dendritic cells at different stages of maturation induce Th17 or TH2 differentiation","volume":"12","author":"Izumi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.116120_bb0220","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1164\/rccm.201405-0859PP","article-title":"IL-17 in severe asthma. Where do we stand?","volume":"190","author":"Chesn\u00e9","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2025.116120_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2010.06.025","article-title":"The role of the T cell in asthma","volume":"126","author":"Robinson","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0230","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1398-9995.2009.01972.x","article-title":"Regulatory T cells in bronchial asthma","volume":"64","author":"Ryanna","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2025.116120_bb0235","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.jaci.2013.08.025","article-title":"Natural regulatory T cells in isolated early responders compared with dual responders with allergic asthma","volume":"133","author":"Kinoshita","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0240","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/all.12828","article-title":"Current and future biomarkers in allergic asthma","volume":"71","author":"Zissler","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2025.116120_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103594","article-title":"Interleukin-35 inhibits NETs to ameliorate Th17\/treg immune imbalance during the exacerbation of cigarette smoke exposed-asthma via gp130\/STAT3\/ferroptosis axis","volume":"82","author":"Tao","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.116120_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114483","article-title":"T helper 17 (Th17) cell responses to the gut microbiota in human diseases","volume":"161","author":"Sun","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.116120_bb0255","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41593-017-0059-z","article-title":"Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response","volume":"21","author":"Faraco","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2025.116120_bb0260","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.36","article-title":"Microbiota in T-cell homeostasis and inflammatory diseases","volume":"49","author":"Lee","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2025.116120_bb0265","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.954339","article-title":"Possible role of gut microbes and host\u2019s immune response in gut\u2013lung homeostasis","volume":"13","author":"Rastogi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0270","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13054-024-05006-x","article-title":"Gut-derived immune cells and the gut-lung axis in ARDS","volume":"28","author":"Ziaka","year":"2024","journal-title":"Crit. Care"},{"key":"10.1016\/j.intimp.2025.116120_bb0275","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.jaci.2020.01.044","article-title":"Altered gut microbiota by azithromycin attenuates airway inflammation in allergic asthma","volume":"145","author":"Park","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0280","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/cea.14089","article-title":"Microbiota associations with inflammatory pathways in asthma","volume":"52","author":"Wang","year":"2022","journal-title":"Clin. Exp. Allergy: J. Br. Soc. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115387","article-title":"Babao dan alleviates gut immune and microbiota disorders while impacting the TLR4\/MyD88\/NF-\u043aB pathway to attenuate 5-fluorouracil-induced intestinal injury","volume":"166","author":"Huang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.116120_bb0290","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.chom.2020.05.005","article-title":"Functional and genomic variation between human-derived isolates of lachnospiraceae reveals inter- and intra-species diversity","volume":"28","author":"Sorbara","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.intimp.2025.116120_bb0295","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01760-24","article-title":"Association of the gut microbiome and different phenotypes of COPD and asthma: a bidirectional mendelian randomization study","volume":"12","author":"Wang","year":"2024","journal-title":"Microbiol. Spectrum"},{"key":"10.1016\/j.intimp.2025.116120_bb0300","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nm.3444","article-title":"Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis","volume":"20","author":"Trompette","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2025.116120_bb0305","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/ijms22010065","article-title":"Butyrate and propionate restore the cytokine and house dust mite compromised barrier function of human bronchial airway epithelial cells","volume":"22","author":"Richards","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.116120_bb0310","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","article-title":"Short-chain fatty acids: linking diet, the microbiome and immunity","volume":"24","author":"Mann","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0315","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.2147\/JIR.S506688","article-title":"Role of the gut-lung microbiome axis in airway inflammation in OVA-challenged mice and the effect of azithromycin","volume":"18","author":"Zheng","year":"2025","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.intimp.2025.116120_bb0320","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12929-021-00711-z","article-title":"Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency","volume":"28","author":"Tang","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.intimp.2025.116120_bb0325","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.3390\/microorganisms10102066","article-title":"The changes in bacterial microbiome associated with immune disorder in allergic respiratory disease","volume":"10","author":"Lyu","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.intimp.2025.116120_bb0330","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.1038\/s41467-024-51209-9","article-title":"Gut-derived memory \u03b3\u03b4 T17 cells exacerbate sepsis-induced acute lung injury in mice","volume":"15","author":"Xie","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.116120_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113810","article-title":"Gut microbiota: a new insight into lung diseases","volume":"155","author":"Ma","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.116120_bb0340","doi-asserted-by":"crossref","DOI":"10.1067\/mai.2003.169","article-title":"The role of T lymphocytes in the pathogenesis of asthma","volume":"111","author":"Larch\u00e9","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.101333","article-title":"Immunologic mechanisms in asthma","volume":"46","author":"Boonpiyathad","year":"2019","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0350","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/thx.2010.140319","article-title":"Sarcoidosis is a Th1\/Th17 multisystem disorder","volume":"66","author":"Facco","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.intimp.2025.116120_bb0355","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2560019","article-title":"Regulatory roles of intestinal CD4+ T cells in inflammation and their modulation by the intestinal microbiota","volume":"17","author":"Ma","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.intimp.2025.116120_bb0360","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrmicro.2016.142","article-title":"Emerging pathogenic links between microbiota and the gut\u2013lung axis","volume":"15","author":"Budden","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.intimp.2025.116120_bb0365","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/s41423-023-01036-7","article-title":"Intricacies of TGF-\u03b2 signaling in treg and Th17 cell biology","volume":"20","author":"Wang","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0370","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/s41590-019-0451-9","article-title":"The influence of the microbiome on respiratory health","volume":"20","author":"Wypych","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0375","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jaci.2013.06.022","article-title":"Innate sensors of pathogen and stress: linking inflammation to obesity","volume":"132","author":"Jin","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0380","article-title":"Xiao-chai-hu-tang ameliorates tumor growth in cancer comorbid depressive symptoms via modulating gut microbiota-mediated TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"88","author":"Shao","year":"2021","journal-title":"Phytomed. Int. J. Phytother. Phytomed."},{"key":"10.1016\/j.intimp.2025.116120_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104603","article-title":"Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-\u03baB pathway","volume":"152","author":"Li","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2025.116120_bb0390","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1210\/er.2014-1100","article-title":"TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation","volume":"36","author":"Velloso","year":"2015","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.intimp.2025.116120_bb0395","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ni1488","article-title":"IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways","volume":"8","author":"Zhou","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2025.116120_bb0400","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1016\/j.jaip.2021.02.047","article-title":"The association of plasma IL-6 with measures of asthma morbidity in a moderate-severe pediatric cohort aged 6-18 years","volume":"9","author":"Permaul","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.intimp.2025.116120_bb0405","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12967-022-03337-3","article-title":"Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4\/NF-kB signaling pathway","volume":"20","author":"Wu","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2025.116120_bb0410","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.chom.2022.07.003","article-title":"Butyrate-producing Eubacterium rectale suppresses lymphomagenesis by alleviating the TNF-induced TLR4\/MyD88\/NF-\u03baB axis","volume":"30","author":"Lu","year":"2022","journal-title":"Cell Host Microbe"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925021095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925021095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T01:29:14Z","timestamp":1769131754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925021095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":82,"alternative-id":["S1567576925021095"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.116120","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Siraitiae Fructus ameliorates allergic asthma via \u201cgut-lung axis\u201d modulation: Th17\/Treg ratio rebalancing, TLR4\/MyD88\/NF-\u03baB pathway suppression, and T lymphocytes migration inhibition","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.116120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116120"}}