{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:45:32Z","timestamp":1784897132606,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007409","name":"Chengde Medical University","doi-asserted-by":"publisher","award":["202611"],"award-info":[{"award-number":["202611"]}],"id":[{"id":"10.13039\/501100007409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["H2022406025"],"award-info":[{"award-number":["H2022406025"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003482","name":"Hebei Province Department of Education","doi-asserted-by":"publisher","award":["BJK2023001"],"award-info":[{"award-number":["BJK2023001"]}],"id":[{"id":"10.13039\/501100003482","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.intimp.2026.116169","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T19:31:58Z","timestamp":1767814318000},"page":"116169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["RNF19A facilitates gastric cancer progression by regulating the Hippo\/YAP axis"],"prefix":"10.1016","volume":"171","author":[{"given":"Yu","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiJun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116169_bb0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.intimp.2026.116169_bb0010","first-page":"264","article-title":"Current treatment and recent progress in gastric cancer","volume":"71","author":"Joshi","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.intimp.2026.116169_bb0015","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1006\/bbrc.2001.4414","article-title":"A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity","volume":"281","author":"Niwa","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2026.116169_bb0020","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1042\/BJ20140006","article-title":"RBR E3 ubiquitin ligases: new structures, new insights, new questions","volume":"458","author":"Spratt","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.intimp.2026.116169_bb0025","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1042\/BST20200237","article-title":"Chain reactions: molecular mechanisms of RBR ubiquitin ligases","volume":"48","author":"Cotton","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.intimp.2026.116169_bb0030","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/embr.201338166","article-title":"RBR E3-ligases at work","volume":"15","author":"Smit","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.intimp.2026.116169_bb0035","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.semcancer.2020.05.002","article-title":"RBR E3 ubiquitin ligases in tumorigenesis","volume":"67","author":"Wang","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.intimp.2026.116169_bb0040","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s40880-019-0421-5","article-title":"Post-translational modification of parkin and its research progress in cancer","volume":"39","author":"Ding","year":"2019","journal-title":"Cancer Commun. (Lond.)"},{"key":"10.1016\/j.intimp.2026.116169_bb0045","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/cam4.1324","article-title":"Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4","volume":"7","author":"Zhang","year":"2018","journal-title":"Cancer Med."},{"key":"10.1016\/j.intimp.2026.116169_bb0050","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/s41418-019-0400-z","article-title":"RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2","volume":"27","author":"Yang","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.intimp.2026.116169_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109250","article-title":"RBCK1 contributes to chemoresistance and stemness in colorectal cancer (CRC)","volume":"118","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2026.116169_bb0060","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1158\/0008-5472.CAN-09-2674","article-title":"RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor alpha and cyclin B1","volume":"70","author":"Gustafsson","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2026.116169_bb0065","doi-asserted-by":"crossref","first-page":"51174","DOI":"10.18632\/oncotarget.9433","article-title":"RNF216 contributes to proliferation and migration of colorectal cancer via suppressing BECN1-dependent autophagy","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.intimp.2026.116169_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034875","article-title":"Averaged differential expression for the discovery of biomarkers in the blood of patients with prostate cancer","volume":"7","author":"Bai","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.intimp.2026.116169_bb0075","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.1111\/jcmm.16674","article-title":"Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth","volume":"25","author":"Cheng","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.intimp.2026.116169_bb0080","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13062-024-00562-2","article-title":"RNF19A inhibits bladder cancer progression by regulating ILK ubiquitination and inactivating the AKT\/mTOR signalling pathway","volume":"19","author":"Deng","year":"2024","journal-title":"Biol. Direct"},{"key":"10.1016\/j.intimp.2026.116169_bb0085","first-page":"893","article-title":"The hippo signaling pathway in gastric cancer","volume":"55","author":"Cao","year":"2023","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.intimp.2026.116169_bb0090","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1146\/annurev-biochem-013118-111829","article-title":"The hippo pathway: biology and pathophysiology","volume":"88","author":"Ma","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.intimp.2026.116169_bb0095","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.molcel.2016.10.034","article-title":"Characterization of hippo pathway components by gene inactivation","volume":"64","author":"Plouffe","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.intimp.2026.116169_bb0100","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.devcel.2019.06.003","article-title":"The hippo signaling pathway in development and disease","volume":"50","author":"Zheng","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.intimp.2026.116169_bb0105","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nrc3458","article-title":"The hippo pathway and human cancer","volume":"13","author":"Harvey","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.intimp.2026.116169_bb0110","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.7150\/thno.46078","article-title":"Regulation of hippo\/YAP signaling and esophageal squamous carcinoma progression by an E3 ubiquitin ligase PARK2","volume":"10","author":"Zhou","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2026.116169_bb0115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neo.2019.12.001","article-title":"SHARPIN inhibits esophageal squamous cell carcinoma progression by modulating hippo signaling","volume":"22","author":"Zhang","year":"2020","journal-title":"Neoplasia"},{"key":"10.1016\/j.intimp.2026.116169_bb0120","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.7150\/jca.88102","article-title":"PRMT7 inhibits the proliferation and migration of gastric cancer cells by suppressing the PI3K\/AKT pathway via PTEN","volume":"14","author":"Wang","year":"2023","journal-title":"J. Cancer"},{"key":"10.1016\/j.intimp.2026.116169_bb0125","doi-asserted-by":"crossref","first-page":"21049","DOI":"10.1074\/jbc.271.35.21049","article-title":"The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain","volume":"271","author":"Creasy","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2026.116169_bb0130","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3748\/wjg.v22.i3.1279","article-title":"Emerging role of hippo pathway in gastric and other gastrointestinal cancers","volume":"22","author":"Kang","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2026.116169_bb0135","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41419-023-05568-8","article-title":"Hippo pathway dysregulation in gastric cancer: from helicobacter pylori infection to tumor promotion and progression","volume":"14","author":"Messina","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116169_bb0140","first-page":"9","article-title":"YAP\/TAZ as master regulators in cancer: modulation, function and therapeutic approaches","volume":"4","author":"Piccolo","year":"2023","journal-title":"Nat Cancer."},{"key":"10.1016\/j.intimp.2026.116169_bb0145","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.3748\/wjg.v20.i7.1694","article-title":"Cyr61\/CTGF\/Nov family proteins in gastric carcinogenesis","volume":"20","author":"Cheng","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2026.116169_bb0150","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.cellsig.2007.12.019","article-title":"Biosignaling of mammalian Ste20-related kinases","volume":"20","author":"Ling","year":"2008","journal-title":"Cell. Signal."},{"key":"10.1016\/j.intimp.2026.116169_bb0155","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.semcdb.2012.07.002","article-title":"Protein kinases of the hippo pathway: regulation and substrates","volume":"23","author":"Avruch","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2026.116169_bb0160","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12967-019-1869-4","article-title":"Analysis of the role of the hippo pathway in cancer","volume":"17","author":"Han","year":"2019","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2026.116169_bb0165","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2009.09.026","article-title":"Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene","volume":"16","author":"Zhou","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2026.116169_bb0170","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1002\/dvdy.21764","article-title":"Characterization of two Mst1-deficient mouse models","volume":"237","author":"Anguera","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.intimp.2026.116169_bb0175","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/emboj.2008.63","article-title":"A crucial role of WW45 in developing epithelial tissues in the mouse","volume":"27","author":"Lee","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2026.116169_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105395","article-title":"Smurf1 polyubiquitinates on K285\/K282 of the kinases Mst1\/2 to attenuate their tumor-suppressor functions","volume":"299","author":"Xu","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2026.116169_bb0185","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10238-018-00543-6","article-title":"TRAF6 regulates YAP signaling by promoting the ubiquitination and degradation of MST1 in pancreatic cancer","volume":"19","author":"Li","year":"2019","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.intimp.2026.116169_bb0190","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1007\/s00018-020-03650-4","article-title":"TRAF6-mediated ubiquitination of MST1\/STK4 attenuates the TLR4-NF-\u03baB signaling pathway in macrophages","volume":"78","author":"Roh","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2026.116169_bb0195","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2022.11255","article-title":"RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1","author":"Huang","year":"2022","journal-title":"Exp Ther Med."},{"key":"10.1016\/j.intimp.2026.116169_bb0200","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/cas.16134","article-title":"TRIM21 is critical in regulating hepatocellular carcinoma growth and response to therapy by altering the MST1\/YAP pathway","volume":"115","author":"Shu","year":"2024","journal-title":"Cancer Sci."},{"key":"10.1016\/j.intimp.2026.116169_bb0205","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13046-020-01553-7","article-title":"Cullin-7 (CUL7) is overexpressed in glioma cells and promotes tumorigenesis via NF-\u03baB activation","volume":"39","author":"Xu","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2026.116169_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molimm.2021.12.021","article-title":"RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1","volume":"143","author":"Yang","year":"2022","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2026.116169_bb0215","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.1038\/s41467-021-27048-3","article-title":"RNF19A-mediated ubiquitination of BARD1 prevents BRCA1\/BARD1-dependent homologous recombination","volume":"12","author":"Zhu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.116169_bb0220","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/cmi.2011.60","article-title":"Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance","volume":"9","author":"Jin","year":"2012","journal-title":"Cell. Mol. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926000123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926000123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:30:43Z","timestamp":1768998643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926000123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":44,"alternative-id":["S1567576926000123"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116169","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RNF19A facilitates gastric cancer progression by regulating the Hippo\/YAP axis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116169"}}