{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:23:28Z","timestamp":1778621008183,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260547"],"award-info":[{"award-number":["82260547"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160452"],"award-info":[{"award-number":["82160452"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.intimp.2026.116202","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T13:58:14Z","timestamp":1768917494000},"page":"116202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["MAP3K19 promotes the progression of hypopharyngeal cancer by suppressing dendritic cell maturation through mediating NF-\u03baB activation and PD-L1 expression"],"prefix":"10.1016","volume":"172","author":[{"given":"Weidong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangyu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Tuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runjia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoming","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.intimp.2026.116202_bb0005","doi-asserted-by":"crossref","first-page":"105505","DOI":"10.1016\/j.esmoop.2025.105505","article-title":"Tislelizumab plus nab-paclitaxel and cisplatin as induction immunochemotherapy for organ preservation of locally advanced hypopharyngeal squamous cell carcinoma: a single-arm phase II trial","volume":"10","author":"Gui","year":"2025","journal-title":"ESMO Open"},{"issue":"2","key":"10.1016\/j.intimp.2026.116202_bb0010","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1158\/1078-0432.CCR-23-2398","article-title":"Induction Toripalimab and chemotherapy for organ preservation in locally advanced laryngeal and hypopharyngeal Cancer: a single-arm phase II clinical trial","volume":"30","author":"Ou","year":"2024","journal-title":"Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.intimp.2026.116202_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13102485","article-title":"Mechanisms of resistance to chemotherapy in hypopharyngeal carcinoma","volume":"13","author":"Lu","year":"2025","journal-title":"Biomedicines"},{"issue":"Pt B","key":"10.1016\/j.intimp.2026.116202_bb0020","article-title":"Spatial transcriptomics reveal tumor microenvironment and SLCO2A1 correlated with tumor suppression in hypopharyngeal squamous cell carcinoma","volume":"142","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116202_bb0025","first-page":"57","article-title":"Transcriptome analysis reveals the link between lncRNA-mRNA co-expression network and tumor immune microenvironment and overall survival in head and neck squamous cell carcinoma","volume":"13","author":"Zhong","year":"2020","journal-title":"BMC Med. Genet."},{"issue":"15","key":"10.1016\/j.intimp.2026.116202_bb0030","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1158\/1078-0432.CCR-19-1321","article-title":"Dendritic cells, the T-cell-inflamed tumor microenvironment, and immunotherapy treatment response","volume":"26","author":"Garris","year":"2020","journal-title":"Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.intimp.2026.116202_bb0035","doi-asserted-by":"crossref","first-page":"769","DOI":"10.7150\/jca.38785","article-title":"The effect of the tumor microenvironment and tumor-derived metabolites on dendritic cell function","volume":"11","author":"Lee","year":"2020","journal-title":"J. Cancer"},{"key":"10.1016\/j.intimp.2026.116202_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104980","article-title":"Tumor microenvironment-related dendritic cell deficiency: a target to enhance tumor immunotherapy","volume":"159","author":"Zhu","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.intimp.2026.116202_bb0045","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41423-023-00990-6","article-title":"Dendritic cell subsets in cancer immunity and tumor antigen sensing","volume":"20","author":"Del Prete","year":"2023","journal-title":"Cell. Mol. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116202_bb0050","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/his.13415","article-title":"A decreased peritumoral CD1a+ cell number predicts a worse prognosis in oral squamous cell carcinoma","volume":"72","author":"Jardim","year":"2018","journal-title":"Histopathology"},{"key":"10.1016\/j.intimp.2026.116202_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1414298","article-title":"Type I conventional dendritic cells and CD8(+) T cells predict favorable clinical outcome of head and neck squamous cell carcinoma patients","volume":"15","author":"Kirchner","year":"2024","journal-title":"Front. Immunol."},{"issue":"25","key":"10.1016\/j.intimp.2026.116202_bb0060","doi-asserted-by":"crossref","first-page":"8470","DOI":"10.1074\/jbc.RA119.012365","article-title":"The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells","volume":"295","author":"Hoang","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2026.116202_bb0065","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2262014","article-title":"A prognostic risk model of a novel oxidative stress-related signature predicts clinical prognosis and demonstrates immune relevancy in lung adenocarcinoma","volume":"2022","author":"Huang","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"13","key":"10.1016\/j.intimp.2026.116202_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310652","article-title":"CC chemokine 2 promotes ovarian Cancer progression through the MEK\/ERK\/MAP3K19 Signaling pathway","volume":"24","author":"Liu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116202_bb0075","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.cyto.2019.03.019","article-title":"Extracellular ATP activates P2X7R-NF-\u03baB (p65) pathway to promote the maturation of bone marrow-derived dendritic cells of mice","volume":"119","author":"Yu","year":"2019","journal-title":"Cytokine"},{"issue":"7","key":"10.1016\/j.intimp.2026.116202_bb0080","first-page":"681","article-title":"PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer","volume":"1","author":"Oh","year":"2020","journal-title":"Nat. Can."},{"issue":"3","key":"10.1016\/j.intimp.2026.116202_bb0085","first-page":"218","article-title":"Pharmacologic activation of \u0394133p53\u03b1 reduces cellular senescence in progeria patients-derived cells","volume":"7","author":"Joruiz","year":"2025","journal-title":"Aging Pathobiol. Ther."},{"issue":"5","key":"10.1016\/j.intimp.2026.116202_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154874","article-title":"MAP3K19 is a novel regulator of TGF-\u03b2 Signaling that impacts bleomycin-induced lung injury and pulmonary fibrosis","volume":"11","author":"Boehme","year":"2016","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.intimp.2026.116202_bb0095","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/s41419-020-03140-2","article-title":"PD-L1 degradation pathway and immunotherapy for cancer","volume":"11","author":"Gou","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116202_bb0100","article-title":"Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity","volume":"7","author":"Li","year":"2016","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.intimp.2026.116202_bb0105","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1093\/toxsci\/kfm178","article-title":"NF-kappaB plays a major role in the maturation of human dendritic cells induced by NiSO(4) but not by DNCB","volume":"99","author":"Ade","year":"2007","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116202_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdermsci.2005.11.004","article-title":"Differential role of MAPK signaling in human dendritic cell maturation and Th1\/Th2 engagement","volume":"42","author":"Nakahara","year":"2006","journal-title":"J. Dermatol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2026.116202_bb0115","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1007\/s10753-021-01478-z","article-title":"Benzoylaconine modulates LPS-induced responses through inhibition of toll-like receptor-mediated NF-kappaB and MAPK Signaling in RAW264.7 cells","volume":"44","author":"Zhou","year":"2021","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.intimp.2026.116202_bb0120","doi-asserted-by":"crossref","DOI":"10.1172\/JCI183656","article-title":"MAP3K1 mutations confer tumor immune heterogeneity in hormone receptor-positive HER2-negative breast cancer","volume":"135","author":"Cai","year":"2024","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.intimp.2026.116202_bb0125","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1172\/JCI84577","article-title":"Donor dendritic cell-derived exosomes promote allograft-targeting immune response","volume":"126","author":"Liu","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.intimp.2026.116202_bb0130","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.coi.2013.10.004","article-title":"Dendritic cells in tolerance and autoimmune diabetes","volume":"25","author":"Guerder","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.intimp.2026.116202_bb0135","first-page":"345","article-title":"STING-activating dendritic cell-targeted nanovaccines that evoke potent antigen cross-presentation for cancer immunotherapy","volume":"42","author":"Nguyen","year":"2024","journal-title":"Bioact. Mater."},{"issue":"6","key":"10.1016\/j.intimp.2026.116202_bb0140","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.survophthal.2016.12.010","article-title":"Management of high-risk corneal transplantation","volume":"62","author":"Di Zazzo","year":"2017","journal-title":"Surv. Ophthalmol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116202_bb0145","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.4049\/jimmunol.1600251","article-title":"Alloimmunity and tolerance in corneal transplantation","volume":"196","author":"Amouzegar","year":"2016","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116202_bb0150","doi-asserted-by":"crossref","first-page":"38","DOI":"10.31491\/APT.2022.06.084","article-title":"Research progress in the PD-1\/PD-L1 pathway and IL-17A in lymphomas","volume":"4","author":"Yang","year":"2022","journal-title":"Aging Pathobiol. Therapeutics"},{"key":"10.1016\/j.intimp.2026.116202_bb0155","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-981-13-9367-9_10","article-title":"NF-kappaB, IkappaB, and IKK: integral components of immune system Signaling","volume":"1172","author":"Mulero","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"12","key":"10.1016\/j.intimp.2026.116202_bb0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167169","article-title":"MAP3K19 is overexpressed in COPD and is a central mediator of cigarette smoke-induced pulmonary inflammation and lower airway destruction","volume":"11","author":"Boehme","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.intimp.2026.116202_bb0165","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1158\/1078-0432.CCR-11-0510","article-title":"Bexarotene via CBP\/p300 induces suppression of NF-\u03baB-dependent cell growth and invasion in thyroid cancer","volume":"18","author":"Cras","year":"2012","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.intimp.2026.116202_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104991","article-title":"REDD1-dependent GSK3beta dephosphorylation promotes NF-kappaB activation and macrophage infiltration in the retina of diabetic mice","volume":"299","author":"Sunilkumar","year":"2023","journal-title":"J. Biol. Chem."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926000457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926000457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:00:00Z","timestamp":1778619600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926000457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":34,"alternative-id":["S1567576926000457"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116202","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MAP3K19 promotes the progression of hypopharyngeal cancer by suppressing dendritic cell maturation through mediating NF-\u03baB activation and PD-L1 expression","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116202"}}