{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:20:52Z","timestamp":1775308852991,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2021-I2M-1-020"],"award-info":[{"award-number":["2021-I2M-1-020"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130109"],"award-info":[{"award-number":["82130109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473908"],"award-info":[{"award-number":["82473908"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.intimp.2026.116243","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:20:29Z","timestamp":1769044829000},"page":"116243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ginsenoside Rg1 ameliorates depression-like behaviors in mice by inhibiting astrocyte pyroptosis via Cx43-dependent restoration of mitophagy flux"],"prefix":"10.1016","volume":"172","author":[{"given":"Zan","family":"Xing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Mu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Feng","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"278","key":"10.1016\/j.intimp.2026.116243_bb0005","article-title":"New mechanisms of ginseng saponin-mediated anti-inflammatory action via targeting canonical inflammasome signaling pathways","volume":"5","author":"Yi","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"960","key":"10.1016\/j.intimp.2026.116243_bb0010","article-title":"Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress","volume":"5","author":"He","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116243_bb0015","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/s41401-025-01515-9","article-title":"Ginsenoside Rg1 alleviates chronic stress-induced depression in rats by targeting Cx43-YAP axis","volume":"46","author":"Wang","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"issue":"5","key":"10.1016\/j.intimp.2026.116243_bb0020","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/s41401-022-01022-1","article-title":"Ginsenoside Rg1 in neurological diseases: from bench to bedside","volume":"44","author":"Yang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2026.116243_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156186","article-title":"Ginsenoside Rg1 enriches gut microbial indole-3-acetic acid to alleviate depression-like behavior in mice via oxytocin signaling","volume":"135","author":"Yu","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0030","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3390\/ijms24010575","article-title":"Novel antidepressant mechanism of ginsenoside Rg1 in regulating the dysfunction of the glutamatergic system in astrocytes","volume":"24","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0035","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbamem.2017.05.008","article-title":"The connexin 43 C-terminus: a tail of many tales","volume":"1860","author":"Leithe","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0040","doi-asserted-by":"crossref","first-page":"7159","DOI":"10.1038\/s41598-017-07658-y","article-title":"Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0045","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s13018-024-04879-6","article-title":"Repetitive transcranial magnetic stimulation promotes motor function recovery in mice after spinal cord injury via regulation of the Cx43-autophagy loop","volume":"19","author":"Zhang","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.intimp.2026.116243_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114876","article-title":"Hydrogen mitigates brain injury by prompting NEDD4-CX43- mediated mitophagy in traumatic brain injury","volume":"379","author":"Wu","year":"2024","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0055","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12974-023-02964-x","article-title":"Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis","volume":"20","author":"Wu","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"995","key":"10.1016\/j.intimp.2026.116243_bb0060","article-title":"Linking depression and neuroinflammation: crosstalk between glial cells","author":"Yang","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0065","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12974-022-02492-0","article-title":"Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"6","key":"10.1016\/j.intimp.2026.116243_bb0070","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s11427-020-1815-6","article-title":"Microglia in depression: current perspectives","volume":"64","author":"Jia","year":"2021","journal-title":"Sci. China Life Sci."},{"issue":"7638","key":"10.1016\/j.intimp.2026.116243_bb0075","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0080","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1038\/s41467-023-40968-6","article-title":"Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels","volume":"14","author":"Novakovic","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0085","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of astroglia","volume":"98","author":"Verkhratsky","year":"2018","journal-title":"Physiol. Rev."},{"issue":"15","key":"10.1016\/j.intimp.2026.116243_bb0090","doi-asserted-by":"crossref","first-page":"6611","DOI":"10.7150\/thno.77455","article-title":"Kir6.1\/K-ATP channel in astrocytes is an essential negative modulator of astrocytic pyroptosis in mouse model of depression","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"issue":"8","key":"10.1016\/j.intimp.2026.116243_bb0095","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41419-019-1813-9","article-title":"The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression","volume":"10","author":"Shu","year":"2019","journal-title":"Cell Death Dis."},{"issue":"148","key":"10.1016\/j.intimp.2026.116243_bb0100","article-title":"Mogroside V ameliorates astrocyte inflammation induced by cerebral ischemia through suppressing TLR4\/TRADD pathway","author":"Chen","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"132","key":"10.1016\/j.intimp.2026.116243_bb0105","article-title":"Stress, pain, anxiety, and depression in endometriosis-targeting glial activation and inflammation","volume":"10","author":"Mokhtari","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"Pt 3","key":"10.1016\/j.intimp.2026.116243_bb0110","article-title":"Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPAR\u03b3 and STAT1 signaling","volume":"143","author":"Su","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116243_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109916","article-title":"NLRP3 inflammasome in depression: a review","volume":"117","author":"Roy","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116243_bb0120","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/s41590-023-01526-w","article-title":"Molecular mechanisms of gasdermin D pore-forming activity","volume":"24","author":"Devant","year":"2023","journal-title":"Nat. Immunol."},{"issue":"14","key":"10.1016\/j.intimp.2026.116243_bb0125","doi-asserted-by":"crossref","first-page":"1178662","DOI":"10.3389\/fimmu.2023.1178662","article-title":"Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors","volume":"18","author":"Dai","year":"2023","journal-title":"Front. Immunol."},{"issue":"20","key":"10.1016\/j.intimp.2026.116243_bb0130","article-title":"Efficient delivery of GSDMD-N mRNA by engineered extracellular vesicles induces Pyroptosis for enhanced immunotherapy","volume":"19","author":"Xing","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.intimp.2026.116243_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155083","article-title":"Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis","volume":"121","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.intimp.2026.116243_bb0140","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41593-025-01875-9","article-title":"CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model","volume":"28","author":"Kadowaki","year":"2025","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.intimp.2026.116243_bb0145","doi-asserted-by":"crossref","first-page":"610","DOI":"10.2174\/1570159X14666160229114755","article-title":"Mitochondrial dysfunction in depression","volume":"14","author":"Bansal","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.intimp.2026.116243_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102363","article-title":"Ginsenoside Rb1 inhibits astrocyte activation and promotes transfer of astrocytic mitochondria to neurons against ischemic stroke","volume":"54","author":"Ni","year":"2022","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0155","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12974-023-02715-y","article-title":"Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy","volume":"20","author":"Yang","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0160","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12185","article-title":"Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours","volume":"11","author":"Yu","year":"2022","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.intimp.2026.116243_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2025.173987","article-title":"Astrocyte gap junction dysfunction activates JAK2-STAT3 pathway to mediate inflammation in depression","volume":"252","author":"Yang","year":"2025","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.intimp.2026.116243_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.110871","article-title":"Improvement of astrocytic gap junction involves the anti-depressive effect of celecoxib through inhibition of NF-\u03baB","volume":"207","author":"Zheng","year":"2024","journal-title":"Brain Res. Bull."},{"issue":"9","key":"10.1016\/j.intimp.2026.116243_bb0175","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s41419-023-06116-0","article-title":"A small molecule 20C from Gastrodia elata inhibits \u03b1-synuclein aggregation and prevents progression of Parkinson\u2019s disease","volume":"14","author":"Peng","year":"2023","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.intimp.2026.116243_bb0180","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1080\/15548627.2023.2276639","article-title":"CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction","volume":"20","author":"Wang","year":"2024","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.intimp.2026.116243_bb0185","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/s41418-025-01475-x","article-title":"CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine","volume":"32","author":"Fan","year":"2025","journal-title":"Cell Death Differ."},{"issue":"46","key":"10.1016\/j.intimp.2026.116243_bb0190","doi-asserted-by":"crossref","first-page":"eabo2098","DOI":"10.1126\/sciadv.abo2098","article-title":"Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression","volume":"8","author":"Liu","year":"2022","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.intimp.2026.116243_bb0195","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s12035-023-03669-1","article-title":"Ketamine improves the glymphatic pathway by reducing the Pyroptosis of hippocampal astrocytes in the chronic unpredictable mild stress model","volume":"61","author":"Wen","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0200","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/s41467-025-56444-2","article-title":"ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.116243_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156095","article-title":"Naringenin alleviates intestinal ischemia\/reperfusion injury by inhibiting ferroptosis via targeting YAP\/STAT3 signaling axis","volume":"135","author":"Hou","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116243_bb0210","article-title":"Mitochondrial stress activates YAP\/TAZ through RhoA oxidation to promote liver injury","author":"Kwon","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116243_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101254","article-title":"PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation","volume":"26","author":"Lin","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2026.116243_bb0220","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.bbi.2024.04.036","article-title":"BGP-15 alleviates LPS-induced depression-like behavior by promoting mitophagy","volume":"119","author":"Liu","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"17","key":"10.1016\/j.intimp.2026.116243_bb0225","doi-asserted-by":"crossref","first-page":"1235241","DOI":"10.3389\/fnins.2023.1235241","article-title":"Targeting mitophagy for depression amelioration: a novel therapeutic strategy","volume":"6","author":"Xu","year":"2023","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.intimp.2026.116243_bb0230","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1001\/jamapsychiatry.2014.2427","article-title":"Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes","volume":"72","author":"Setiawan","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"10.1016\/j.intimp.2026.116243_bb0235","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/s41380-021-01312-w","article-title":"Dysregulation of mitochondrial dynamics, mitophagy and apoptosis in major depressive disorder: does inflammation play a role?","volume":"27","author":"Scaini","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0240","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/imr.12286","article-title":"Initiation and perpetuation of NLRP3 inflammasome activation and assembly","volume":"265","author":"Elliott","year":"2015","journal-title":"Immunol. Rev."},{"issue":"6","key":"10.1016\/j.intimp.2026.116243_bb0245","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1007\/s12975-025-01374-w","article-title":"Astrocyte-derived Exosomal GJA1-20 k targets Pink1-mediated mitophagy to attenuate traumatic brain injury","volume":"16","author":"Li","year":"2025","journal-title":"Transl. Stroke Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.116243_bb0250","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jamapsychiatry.2015.0071","article-title":"Large-scale network dysfunction in major depressive disorder: a Meta-analysis of resting-state functional connectivity","volume":"72","author":"Kaiser","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"10.1016\/j.intimp.2026.116243_bb0255","doi-asserted-by":"crossref","first-page":"25282","DOI":"10.1038\/srep25282","article-title":"Ginsenoside Rg1 promotes osteogenic differentiation of rBMSCs and healing of rat tibial fractures through regulation of GR-dependent BMP-2\/SMAD signaling","volume":"4","author":"Gu","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2026.116243_bb0260","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/cvr\/cvq300","article-title":"Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1","volume":"89","author":"Cheung","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116243_bb0265","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/21655979.2021.2005744","article-title":"Xiaoyao powder alleviates the hippocampal neuron damage in chronic unpredictable mild stress-induced depression model rats in hippocampus via connexin 43Cx43\/glucocorticoid receptor\/brain-derived neurotrophic factor signaling pathway","volume":"13","author":"Zhang","year":"2022","journal-title":"Bioengineered"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692600086X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692600086X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:30:03Z","timestamp":1775305803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692600086X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":53,"alternative-id":["S156757692600086X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116243","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ginsenoside Rg1 ameliorates depression-like behaviors in mice by inhibiting astrocyte pyroptosis via Cx43-dependent restoration of mitophagy flux","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116243","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116243"}}