{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:19:33Z","timestamp":1775308773075,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,22]],"date-time":"2027-01-22T00:00:00Z","timestamp":1800576000000},"content-version":"am","delay-in-days":327,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003993","name":"Ministry of Agriculture Forestry and Fisheries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003993","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005946","name":"Hokkaido University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005946","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009951","name":"Toyo University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009951","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007173","name":"Bio-oriented Technology Research Advancement Institution","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.intimp.2026.116244","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:20:29Z","timestamp":1769044829000},"page":"116244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lactiplantibacillus plantarum K4\u20139 strain stimulates antitumor immune responses through the activation of dendritic cells and CD8+ T cells"],"prefix":"10.1016","volume":"172","author":[{"given":"Haruka","family":"Aso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumie","family":"Niitsuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroka","family":"Sasahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyebin","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsunori","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiga","family":"Yunoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Ohtake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemitsu","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.intimp.2026.116244_bb0005","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1471-4906(01)01896-8","article-title":"The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunity","volume":"22","author":"Wang","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.intimp.2026.116244_bb0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.immunol.25.022106.141548","article-title":"Effector and memory CTL differentiation","volume":"25","author":"Williams","year":"2007","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116244_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.0105-2896.2004.00142.x","article-title":"Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens","volume":"199","author":"Heath","year":"2004","journal-title":"Immunol. Rev."},{"issue":"2","key":"10.1016\/j.intimp.2026.116244_bb0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.immuni.2004.07.017","article-title":"The immunobiology of cancer immunosurveillance and immunoediting","volume":"21","author":"Dunn","year":"2004","journal-title":"Immunity"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2026.116244_bb0025","article-title":"On the origin of cancer metastasis","volume":"18","author":"Seyfried","year":"2013","journal-title":"Crit. Rev. Oncog."},{"issue":"24","key":"10.1016\/j.intimp.2026.116244_bb0030","doi-asserted-by":"crossref","first-page":"6325","DOI":"10.1158\/0008-5472.CAN-12-2027","article-title":"Role of chemokines and chemokine receptors in shaping the effector phase of the antitumor immune response","volume":"72","author":"Franciszkiewicz","year":"2012","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.intimp.2026.116244_bb0035","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1271\/bbb.90058","article-title":"Orally administered Lactobacillus paracasei KW3110 induces in vivo IL-12 production","volume":"73","author":"Ichikawa","year":"2009","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"8","key":"10.1016\/j.intimp.2026.116244_bb0040","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1073\/pnas.0500098102","article-title":"Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization","volume":"102","author":"Mohamadzadeh","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116244_bb0045","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4142\/jvs.2004.5.1.41","article-title":"Immunomodulatory and antitumor effects in vivo by the cytoplasmic fraction of Lactobacillus casei and Bifidobacterium longum","volume":"5","author":"Lee","year":"2004","journal-title":"J. Vet. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2026.116244_bb0050","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jcmgh.2021.06.001","article-title":"Lactobacillus rhamnosus GG orchestrates an antitumor immune response","volume":"12","author":"Owens","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116244_bb0055","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1264\/jsme2.ME19003","article-title":"Characterization of microbiota that influence immunomodulatory effects of fermented Brassica rapa L","volume":"34","author":"Sandagdorj","year":"2019","journal-title":"Microbes Environ."},{"issue":"2","key":"10.1016\/j.intimp.2026.116244_bb0060","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1574-695X.2011.00903.x","article-title":"Heat-killed Lactobacillus gasseri TMC0356 protects mice against influenza virus infection by stimulating gut and respiratory immune responses","volume":"64","author":"Kawase","year":"2012","journal-title":"FEMS Immunology & Medical Microbiology"},{"issue":"8","key":"10.1016\/j.intimp.2026.116244_bb0065","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1111\/cas.15397","article-title":"IFN-\u03b1\/\u03b2-mediated NK2R expression is related to the malignancy of colon cancer cells","volume":"113","author":"Xiang","year":"2022","journal-title":"Cancer Sci."},{"key":"10.1016\/j.intimp.2026.116244_bb0070","series-title":"Oncology Meets Immunology: The Cancer-Immunity Cycle, Immunity","first-page":"1","volume":"39(1)","author":"Chen","year":"2013"},{"issue":"5","key":"10.1016\/j.intimp.2026.116244_bb0075","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.immuni.2021.01.012","article-title":"Chemokines and the immune response to cancer","volume":"54","author":"Ozga","year":"2021","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.intimp.2026.116244_bb0080","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41577-020-0306-5","article-title":"A guide to cancer immunotherapy: from T cell basic science to clinical practice","volume":"20","author":"Waldman","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116244_bb0085","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116244_bb0090","doi-asserted-by":"crossref","first-page":"759","DOI":"10.2174\/1566524033479366","article-title":"Regulation of dendritic cell function through toll-like receptors","volume":"3","author":"Kaisho","year":"2003","journal-title":"Curr. Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.116244_bb0095","doi-asserted-by":"crossref","first-page":"803","DOI":"10.4049\/jimmunol.176.2.803","article-title":"CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes","volume":"176","author":"Jang","year":"2006","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116244_bb0100","first-page":"1020","article-title":"Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs, Blood","volume":"118","author":"Rehm","year":"2011","journal-title":"J. American Soc. Hematology"},{"issue":"11","key":"10.1016\/j.intimp.2026.116244_bb0105","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.4049\/jimmunol.1004036","article-title":"A new subset of CD103+ CD8\u03b1+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity","volume":"186","author":"Fujimoto","year":"2011","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116244_bb0110","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"issue":"21","key":"10.1016\/j.intimp.2026.116244_bb0115","doi-asserted-by":"crossref","first-page":"15319","DOI":"10.1074\/jbc.R700009200","article-title":"Toll-like receptors and type I interferons*","volume":"282","author":"Uematsu","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.intimp.2026.116244_bb0120","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/eji.200323797","article-title":"Sousa, toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8\u03b1+ DC correlates with unresponsiveness to imidazoquinolines","volume":"33","author":"Edwards","year":"2003","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116244_bb0125","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/cdd.2014.134","article-title":"New insights into IL-12-mediated tumor suppression","volume":"22","author":"Tugues","year":"2015","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.intimp.2026.116244_bb0130","doi-asserted-by":"crossref","first-page":"1868122","DOI":"10.1080\/2162402X.2020.1868122","article-title":"Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12","volume":"10","author":"Li","year":"2021","journal-title":"Oncoimmunology"},{"issue":"9","key":"10.1016\/j.intimp.2026.116244_bb0135","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1084\/jem.20041964","article-title":"A type I interferon autocrine\u2013paracrine loop is involved in toll-like receptor-induced interleukin-12p70 secretion by dendritic cells","volume":"201","author":"Gautier","year":"2005","journal-title":"J. Exp. Med."},{"issue":"12","key":"10.1016\/j.intimp.2026.116244_bb0140","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1158\/2326-6066.CIR-18-0766","article-title":"IL6 modulates the immune status of the tumor microenvironment to facilitate metastatic colonization of colorectal cancer cells","volume":"7","author":"Toyoshima","year":"2019","journal-title":"Cancer Immunol. Res."},{"issue":"5","key":"10.1016\/j.intimp.2026.116244_bb0145","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.4049\/jimmunol.1200994","article-title":"CD4+ T cell-dependent IFN-\u03b3 production by CD8+ effector T cells in mycobacterium tuberculosis infection","volume":"189","author":"Bold","year":"2012","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116244_bb0150","first-page":"2494","article-title":"Identification of a distant T-bet enhancer responsive to IL-12\/Stat4 and IFN\u03b3\/Stat1 signals, Blood","volume":"110","author":"Yang","year":"2007","journal-title":"J. American Society Hematol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116244_bb0155","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1186\/s12967-023-04775-3","article-title":"The expanding Pandora\u2019s toolbox of CD8+ T cell: from transcriptional control to metabolic firing","volume":"21","author":"Wu","year":"2023","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.intimp.2026.116244_bb0160","first-page":"932","article-title":"Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses, Blood","volume":"122","author":"Nizzoli","year":"2013","journal-title":"J. American Soc. Hematol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116244_bb0165","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/JLB.5AB0720-446RR","article-title":"CCR7+ dendritic cells sorted by binding of CCL19 show enhanced ag-presenting capacity and antitumor potency","volume":"111","author":"Burgoyne","year":"2022","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116244_bb0170","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccell.2016.06.003","article-title":"Critical role for CD103+\/CD141+ dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma","volume":"30","author":"Roberts","year":"2016","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.intimp.2026.116244_bb0175","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1002\/1521-4141(200206)32:6<1792::AID-IMMU1792>3.0.CO;2-0","article-title":"Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells: dependence on the release from persistent TCR-triggering and requirement for IFN-\u03b3 stimulation","volume":"32","author":"Nakajima","year":"2002","journal-title":"Eur. J. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2026.116244_bb0180","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.4049\/jimmunol.167.12.6877","article-title":"A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5","volume":"167","author":"Iwasaki","year":"2001","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116244_bb0185","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1502376","article-title":"Chemoattractant receptors BLT1 and CXCR3 regulate antitumor immunity by facilitating CD8+ T cell migration into tumors","volume":"197","author":"Chheda","year":"2016","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116244_bb0190","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1158\/0008-5472.CAN-08-2281","article-title":"Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment","volume":"69","author":"Harlin","year":"2009","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.intimp.2026.116244_bb0195","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/icb.2010.158","article-title":"CXCR3 ligands: redundant, collaborative and antagonistic functions","volume":"89","author":"Groom","year":"2011","journal-title":"Immunol. Cell Biol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116244_bb0200","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00262-022-03338-7","article-title":"Cxcr3 constrains pancreatic cancer dissemination through instructing T cell fate","volume":"72","author":"Burrack","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"issue":"11","key":"10.1016\/j.intimp.2026.116244_bb0205","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri3307","article-title":"Transcriptional control of effector and memory CD8+ T cell differentiation","volume":"12","author":"Kaech","year":"2012","journal-title":"Nat. Rev. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926000871?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926000871?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:28:38Z","timestamp":1775305718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926000871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":41,"alternative-id":["S1567576926000871"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116244","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactiplantibacillus plantarum K4\u20139 strain stimulates antitumor immune responses through the activation of dendritic cells and CD8+ T cells","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116244","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116244"}}