{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:53:26Z","timestamp":1776772406296,"version":"3.51.2"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009020","name":"University of South China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009020","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.intimp.2026.116248","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T16:51:59Z","timestamp":1769619119000},"page":"116248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Treponema pallidum lipoprotein Tp0768 promotes H3K18 Lactylation modification to target PTK2 and enhance endothelial permeability"],"prefix":"10.1016","volume":"173","author":[{"given":"Yue","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liena","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jirong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feijun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopeng","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangquan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.intimp.2026.116248_bb0005","doi-asserted-by":"crossref","first-page":"247","DOI":"10.15585\/mmwr.mm6810a4","article-title":"Risk Factors for Congenital Syphilis Transmitted from Mother to Infant - Suzhou, China, 2011-2014","volume":"68","author":"Wang","year":"2019","journal-title":"MMWR Morb. Mortal Wkly. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2026.116248_bb0010","first-page":"64","article-title":"Bottleneck and Spread of Treponema Pallidum","volume":"20","author":"Hofer","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116248_bb0015","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s15010-022-01939-z","article-title":"Investigation of the Immune Escape Mechanism of Treponema Pallidum","volume":"51","author":"Tang","year":"2023","journal-title":"Infection"},{"issue":"7","key":"10.1016\/j.intimp.2026.116248_bb0020","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/sextrans-2020-054706","article-title":"Effect of Syphilis Infection on Hiv Acquisition: A Systematic Review and Meta-Analysis","volume":"97","author":"Wu","year":"2021","journal-title":"Sex. Transm. Infect."},{"issue":"1","key":"10.1016\/j.intimp.2026.116248_bb0025","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s40471-018-0138-z","article-title":"An Update on the Global Epidemiology of Syphilis","volume":"5","author":"Kojima","year":"2018","journal-title":"Curr. Epidemiol. Rep."},{"issue":"8","key":"10.1016\/j.intimp.2026.116248_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011594","article-title":"Treponema Pallidum Promoted Microglia Apoptosis and Prevented Itself from Clearing by Human Microglia Via Blocking Autophagic Flux","volume":"19","author":"Hu","year":"2023","journal-title":"PLoS Pathog."},{"issue":"10","key":"10.1016\/j.intimp.2026.116248_bb0035","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.tcb.2020.08.004","article-title":"Tight Junction Structure and Function Revisited","volume":"30","author":"Otani","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.intimp.2026.116248_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.109485","article-title":"Endothelial Tight Junctions and Their Regulatory Signaling Pathways in Vascular Homeostasis and Disease","volume":"66","author":"Cong","year":"2020","journal-title":"Cell. Signal."},{"issue":"12","key":"10.1016\/j.intimp.2026.116248_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/cells11121935","article-title":"Regulation and Dysregulation of Endothelial Permeability During Systemic Inflammation","volume":"11","author":"Hellenthal","year":"2022","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.intimp.2026.116248_bb0050","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.molmed.2020.11.006","article-title":"Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies","volume":"27","author":"Claesson-Welsh","year":"2021","journal-title":"Trends Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.116248_bb0055","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1161\/ATVBAHA.119.313545","article-title":"Interference with Esam (Endothelial Cell-Selective Adhesion Molecule) Plus Vascular Endothelial-Cadherin Causes Immediate Lethality and Lung-Specific Blood Coagulation","volume":"40","author":"Duong","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116248_bb0060","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/0271678X20904687","article-title":"Tight Junctions in the Blood-Brain Barrier Promote Edema Formation and Infarct Size in Stroke - Ambivalent Effects of Sealing Proteins","volume":"41","author":"Winkler","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"3","key":"10.1016\/j.intimp.2026.116248_bb0065","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1083\/jcb.67.3.863","article-title":"Segmental Differentiations of Cell Junctions in the Vascular Endothelium. The Microvasculature","volume":"67","author":"Simionescu","year":"1975","journal-title":"J. Cell Biol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116248_bb0070","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/ncb1752","article-title":"Endothelial Adherens Junctions Control Tight Junctions by Ve-Cadherin-Mediated Upregulation of Claudin-5","volume":"10","author":"Taddei","year":"2008","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116248_bb0075","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1083\/jcb.201404140","article-title":"Zo-1 Controls Endothelial Adherens Junctions, Cell-Cell Tension, Angiogenesis, and Barrier Formation","volume":"208","author":"Tornavaca","year":"2015","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116248_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijmm.2022.151553","article-title":"Treponema Pallidum Tp0751 Alters the Expression of Tight Junction Proteins by Promoting Bend3 Cell Apoptosis and Il-6 Secretion","volume":"312","author":"Lu","year":"2022","journal-title":"Int J Med Microbiol"},{"issue":"1","key":"10.1016\/j.intimp.2026.116248_bb0085","doi-asserted-by":"crossref","first-page":"2382236","DOI":"10.1080\/22221751.2024.2382236","article-title":"Treponema Pallidum Protein Tp0136 Promotes Angiogenesis to Facilitate the Dissemination of Treponema Pallidum","volume":"13","author":"Li","year":"2024","journal-title":"Emerg Microbes Infect"},{"issue":"1","key":"10.1016\/j.intimp.2026.116248_bb0090","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41418-021-00841-9","article-title":"Lactate Promotes Macrophage Hmgb1 Lactylation, Acetylation, and Exosomal Release in Polymicrobial Sepsis","volume":"29","author":"Yang","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.intimp.2026.116248_bb0095","article-title":"Lactate Induces Vascular Permeability Via Disruption of Ve-Cadherin in Endothelial Cells During Sepsis","volume":"8(17):eabm8965","author":"Yang","year":"2022","journal-title":"Sci. Adv."},{"issue":"7958","key":"10.1016\/j.intimp.2026.116248_bb0100","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/s41586-023-05939-3","article-title":"Lactate Regulates Cell Cycle by Remodelling the Anaphase Promoting Complex","volume":"616","author":"Liu","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2026.116248_bb0105","doi-asserted-by":"crossref","first-page":"6429","DOI":"10.1038\/ncomms7429","article-title":"Integrin \u03921 Controls Ve-Cadherin Localization and Blood Vessel Stability","volume":"6","author":"Yamamoto","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116248_bb0110","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1096\/fj.201800841R","article-title":"Matrix Stiffness Regulates Vascular Integrity through Focal Adhesion Kinase Activity","volume":"33","author":"Wang","year":"2019","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.intimp.2026.116248_bb0115","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1083\/jcb.201307067","article-title":"Inhibition of Endothelial Fak Activity Prevents Tumor Metastasis by Enhancing Barrier Function","volume":"204","author":"Jean","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.intimp.2026.116248_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.134126","article-title":"The Fak\/Occludin\/Zo-1 Complex Is Critical for Cadmium-Induced Testicular Damage by Disruption of the Integrity of the Blood-Testis Barrier in Chickens","volume":"470","author":"Li","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"4","key":"10.1016\/j.intimp.2026.116248_bb0125","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1165\/rcmb.2012-0100TR","article-title":"Human Epidermal Growth Factor Receptor Signaling in Acute Lung Injury","volume":"47","author":"Finigan","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116248_bb0130","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nrc3792","article-title":"Fak in Cancer: Mechanistic Findings and Clinical Applications","volume":"14","author":"Sulzmaier","year":"2014","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2026.116248_bb0135","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.devcel.2011.11.002","article-title":"Vegf-Induced Vascular Permeability Is Mediated by Fak","volume":"22","author":"Chen","year":"2012","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.intimp.2026.116248_bb0140","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/mmi.15010","article-title":"Treponema Pallidum Lipoprotein Tp0768 Promotes the Migration\u00a0and Adhesion of Thp-1 Cells to Vascular Endothelial Cells through Stress of the Endoplasmic Reticulum and the Nf-\u039ab\/Hif-1\u03b1 Pathway","volume":"119","author":"Zhou","year":"2023","journal-title":"Mol. Microbiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116248_bb0145","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00253-020-11018-8","article-title":"Recombinant Treponema Pallidum Protein Tp0768 Promotes Proinflammatory Cytokine Secretion of Macrophages through Er Stress and Ros\/Nf-\u039ab Pathway","volume":"105","author":"Li","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116248_bb0150","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/jleuko\/qiae114","article-title":"Treponema Pallidum Recombinant Protein Tp0768 Enhances the Ability of Huvecs to Promote Neutrophil Chemotaxis through the Tlr2\/Er Stress Signaling Pathway","volume":"116","author":"Cao","year":"2024","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2026.116248_bb0155","article-title":"Cardiovascular Dysfunction in Covid-19: Association between Endothelial Cell Injury and Lactate","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2026.116248_bb0160","doi-asserted-by":"crossref","DOI":"10.1093\/jmcb\/mjac073","article-title":"Histone Lactylation Driven by Mros-Mediated Glycolytic Shift Promotes Hypoxic Pulmonary Hypertension","volume":"14","author":"Chen","year":"2023","journal-title":"J. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116248_bb0165","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pharmthera.2013.12.003","article-title":"The Role of Fak in Tumor Metabolism and Therapy","volume":"142","author":"Zhang","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"13","key":"10.1016\/j.intimp.2026.116248_bb0170","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1158\/1078-0432.CCR-18-0263","article-title":"Zip4 Promotes Pancreatic Cancer Progression by Repressing Zo-1 and Claudin-1 through a Zeb1-Dependent Transcriptional Mechanism","volume":"24","author":"Liu","year":"2018","journal-title":"Clin. Cancer Res."},{"issue":"49","key":"10.1016\/j.intimp.2026.116248_bb0175","doi-asserted-by":"crossref","first-page":"19623","DOI":"10.1073\/pnas.1111414108","article-title":"P-Glycoprotein Regulates Blood-Testis Barrier Dynamics Via Its Effects on the Occludin\/Zonula Occludens 1 (Zo-1) Protein Complex Mediated by Focal Adhesion Kinase (Fak)","volume":"108","author":"Su","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.intimp.2026.116248_bb0180","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1182\/blood-2002-06-1887","article-title":"The Role of the Endothelium in Severe Sepsis and Multiple Organ Dysfunction Syndrome","volume":"101","author":"Aird","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2026.116248_bb0185","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-pathol-012615-044506","article-title":"Disorders of Vascular Permeability","volume":"11","author":"Park-Windhol","year":"2016","journal-title":"Annu. Rev. Pathol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116248_bb0190","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1161\/ATVBAHA.107.161521","article-title":"Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis","volume":"29","author":"Gaengel","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.intimp.2026.116248_bb0195","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1498","article-title":"Hyperglycolysis in Endothelial Cells Drives Endothelial Injury and Microvascular Alterations in Peritoneal Dialysis","volume":"13","author":"Si","year":"2023","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.intimp.2026.116248_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104292","article-title":"Ablation of Endothelial Pfkfb3 Protects Mice from Acute Lung Injury in Lps-Induced Endotoxemia","volume":"146","author":"Wang","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116248_bb0205","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1038\/s41467-020-17402-2","article-title":"Lactate Released by Inflammatory Bone Marrow Neutrophils Induces Their Mobilization Via Endothelial Gpr81 Signaling","volume":"11","author":"Khatib-Massalha","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116248_bb0210","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13059-024-03308-5","article-title":"A Feedback Loop Driven by H3k9 Lactylation and Hdac2 in Endothelial Cells Regulates Vegf-Induced Angiogenesis","volume":"25","author":"Fan","year":"2024","journal-title":"Genome Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116248_bb0215","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s44321-024-00025-1","article-title":"Lactylation-Driven Fto Targets Cdk2 to Aggravate Microvascular Anomalies in Diabetic Retinopathy","volume":"16","author":"Chen","year":"2024","journal-title":"EMBO Mol Med"},{"issue":"11","key":"10.1016\/j.intimp.2026.116248_bb0220","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1016\/j.cell.2025.03.048","article-title":"Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory","volume":"188","author":"Ziogas","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2026.116248_bb0225","article-title":"Histone lactylation mediates maternal cadmium exposure-induced liver fibrosis in male offspring","volume":"24","author":"Wang","year":"2025","journal-title":"Ecotoxicol Environ Saf. Published online October"},{"key":"10.1016\/j.intimp.2026.116248_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110602","article-title":"Class I histone deacetylases catalyze lysine lactylation","author":"Gonzatti","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2026.116248_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110795","article-title":"Sirtuin 6 is a histone delactylase","author":"Nickel","year":"2025","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.intimp.2026.116248_bb0240","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1083\/jcb.201108120","article-title":"Vinculin Associates with Endothelial Ve-Cadherin Junctions to Control Force-Dependent Remodeling","volume":"196","author":"Huveneers","year":"2012","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116248_bb0245","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm2593","article-title":"Environmental Sensing through Focal Adhesions","volume":"10","author":"Geiger","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"38","key":"10.1016\/j.intimp.2026.116248_bb0250","doi-asserted-by":"crossref","first-page":"36661","DOI":"10.1074\/jbc.M301253200","article-title":"Vascular Endothelial Growth Factor Regulates Focal Adhesion Assembly in Human Brain Microvascular Endothelial Cells through Activation of the Focal Adhesion Kinase and Related Adhesion Focal Tyrosine Kinase","volume":"278","author":"Avraham","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2026.116248_bb0255","first-page":"54","article-title":"Reactive Oxygen Species Increased Focal Adhesion Kinase Production in Pulmonary Microvascular Endothelial Cells","volume":"47","author":"Yang","year":"2004","journal-title":"Proc. West. Pharmacol. Soc."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926000913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926000913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:20:11Z","timestamp":1776770411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926000913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":51,"alternative-id":["S1567576926000913"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116248","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treponema pallidum lipoprotein Tp0768 promotes H3K18 Lactylation modification to target PTK2 and enhance endothelial permeability","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116248","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116248"}}