{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T03:01:31Z","timestamp":1789354891864,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070210"],"award-info":[{"award-number":["82070210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.intimp.2026.116265","type":"journal-article","created":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T15:47:23Z","timestamp":1769960843000},"page":"116265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Autophagy-driven CCL7+ monocyte terminal differentiation program fuels CD8+ T cell\u2013mediated cardiac injury in Sepsis"],"prefix":"10.1016","volume":"173","author":[{"given":"Xueyi","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolei","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116265_bb0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for Sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.intimp.2026.116265_bb0010","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41569-020-00492-2","article-title":"Pathophysiology of sepsis-induced cardiomyopathy","volume":"18","author":"Hollenberg","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.intimp.2026.116265_bb0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.21037\/jtd.2018.11.74","article-title":"Improving clinical outcomes in sepsis and multiple organ dysfunction through precision medicine","volume":"11","author":"Mehta","year":"2019","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.intimp.2026.116265_bb0020","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1161\/CIRCULATIONAHA.117.032821","article-title":"Beclin-1-dependent autophagy protects the heart during Sepsis","volume":"138","author":"Sun","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2026.116265_bb0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11886-020-01277-2","article-title":"Sepsis-induced cardiomyopathy: a comprehensive review","volume":"22","author":"L'Heureux","year":"2020","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.intimp.2026.116265_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/cells11182833","article-title":"Septic cardiomyopathy: from pathophysiology to the clinical setting","volume":"11","author":"Carbone","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.116265_bb0035","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2022.12773","article-title":"Cardiomyocyte death in sepsis: mechanisms and regulation (review)","volume":"26","author":"Zhang","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2026.116265_bb0040","first-page":"30","article-title":"Pathophysiology of sepsis-induced myocardial dysfunction","volume":"3","author":"Lv","year":"2016","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.intimp.2026.116265_bb0045","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3892\/etm.2016.3071","article-title":"Clinical application: restoration of immune homeostasis by autophagy as a potential therapeutic target in sepsis","volume":"11","author":"Zhang","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.intimp.2026.116265_bb0050","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.21037\/jtd.2016.11.17","article-title":"Monocytes and macrophages in cardiac injury and repair","volume":"9","author":"Sager","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.intimp.2026.116265_bb0055","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1182\/blood-2011-08-372383","article-title":"Induction of autophagy is essential for monocyte-macrophage differentiation","volume":"119","author":"Zhang","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2026.116265_bb0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41587-021-01033-z","article-title":"Differential abundance testing on single-cell data using k-nearest neighbor graphs","volume":"40","author":"Dann","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.intimp.2026.116265_bb0065","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41587-020-0605-1","article-title":"Cell type prioritization in single-cell data","volume":"39","author":"Skinnider","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.intimp.2026.116265_bb0070","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/JLB.5MA0721-825R","article-title":"Dynamic changes in human single-cell transcriptional signatures during fatal sepsis","volume":"110","author":"Qiu","year":"2021","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2026.116265_bb0075","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.3389\/fimmu.2018.03063","article-title":"CCL7 is a negative regulator of cutaneous inflammation following Leishmania major infection","volume":"9","author":"Ford","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116265_bb0080","article-title":"Endothelial-derived CCL7 promotes macrophage polarization and aggravates septic acute lung injury via CCR1-mediated STAT1 Succinylation","volume":"12","author":"Li","year":"2025","journal-title":"Adv Sci (Weinh)."},{"key":"10.1016\/j.intimp.2026.116265_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2024.04.011","article-title":"Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy","volume":"42","author":"van Elsas","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2026.116265_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111122","article-title":"Low shear stress induces macrophage infiltration and aggravates aneurysm wall inflammation via CCL7\/CCR1\/TAK1\/ NF-\u03baB axis","volume":"117","author":"Wei","year":"2024","journal-title":"Cell. Signal."},{"key":"10.1016\/j.intimp.2026.116265_bb0095","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1161\/CIRCRESAHA.116.307474","article-title":"Aging and autophagy in the heart","volume":"118","author":"Shirakabe","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.intimp.2026.116265_bb0100","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/cvr\/cvz233","article-title":"Comprehensive autophagy evaluation in cardiac disease models","volume":"116","author":"Kaludercic","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.intimp.2026.116265_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.923066","article-title":"Dysregulated autophagy-related genes in septic cardiomyopathy: comprehensive bioinformatics analysis based on the human transcriptomes and experimental validation","volume":"9","author":"Zou","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.intimp.2026.116265_bb0110","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.intimp.2026.116265_bb0115","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2119\/2007-00130.Flierl","article-title":"Molecular events in the cardiomyopathy of sepsis","volume":"14","author":"Flierl","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.intimp.2026.116265_bb0120","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"Ccl2-induced regulatory T cells balance inflammation through macrophage polarization during liver reconstitution","volume":"11","author":"Wang","year":"2024","journal-title":"Adv Sci (Weinh)."},{"key":"10.1016\/j.intimp.2026.116265_bb0125","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41423-023-01013-0","article-title":"The chemokine monocyte chemoattractant protein-1\/CCL2 is a promoter of breast cancer metastasis","volume":"20","author":"Yoshimura","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.intimp.2026.116265_bb0130","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.116265_bb0135","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.immuni.2018.10.005","article-title":"Developmental and functional heterogeneity of monocytes","volume":"49","author":"Guilliams","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2026.116265_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109909","article-title":"SPI1-mediated autophagy of peripheral blood monocyte cells as a mechanism for sepsis based on single-cell RNA sequencing","volume":"117","author":"Xie","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116265_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.946832","article-title":"Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis","volume":"13","author":"Wen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116265_bb0150","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1038\/s12276-024-01344-6","article-title":"The MCP-3\/Ccr3 axis contributes to increased bone mass by affecting osteoblast and osteoclast differentiation","volume":"56","author":"Kim","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2026.116265_bb0155","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s12276-024-01168-4","article-title":"Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2\/7-CCR2 signaling pathway","volume":"56","author":"Tian","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2026.116265_bb0160","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1038\/s41380-024-02826-9","article-title":"Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine","volume":"30","author":"Tanabe","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.intimp.2026.116265_bb0165","article-title":"CCL7 promotes macrophage polarization and synovitis to exacerbate rheumatoid arthritis","volume":"28","author":"Chen","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.intimp.2026.116265_bb0170","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.3389\/fimmu.2019.02759","article-title":"More than just attractive: how CCL2 influences myeloid cell behavior beyond chemotaxis","volume":"10","author":"Gschwandtner","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116265_bb0175","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.4049\/jimmunol.1701618","article-title":"Sepsis-induced T cell Immunoparalysis: the ins and outs of impaired T cell immunity","volume":"200","author":"Jensen","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2026.116265_bb0180","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.116265_bb0185","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s42255-022-00715-5","article-title":"TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis","volume":"5","author":"Zhang","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.intimp.2026.116265_bb0190","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI29919","article-title":"Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites","volume":"117","author":"Tsou","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2026.116265_bb0195","doi-asserted-by":"crossref","first-page":"22123","DOI":"10.1074\/jbc.270.38.22123","article-title":"Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha\/Rantes, is also a functional receptor for MCP3","volume":"270","author":"Ben-Baruch","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2026.116265_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0249142","article-title":"Deficiency in CCR2 increases susceptibility of mice to infection with an intracellular pathogen, Francisella tularensis LVS, but does not impair development of protective immunity","volume":"16","author":"Kurtz","year":"2021","journal-title":"PloS one."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926001086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926001086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:21:23Z","timestamp":1776770483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926001086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":40,"alternative-id":["S1567576926001086"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116265","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy-driven CCL7+ monocyte terminal differentiation program fuels CD8+ T cell\u2013mediated cardiac injury in Sepsis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116265"}}