{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:38:10Z","timestamp":1793385490766,"version":"4.5.0"},"reference-count":385,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100031545","name":"Central University of Rajasthan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.intimp.2026.116285","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T19:17:54Z","timestamp":1769714274000},"page":"116285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Unrevealing role of TLRs\/NLRP receptors in halting Alzheimer's neuroinflammation: Current progress and existing therapies"],"prefix":"10.1016","volume":"173","author":[{"given":"Shubham","family":"Upadhayay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116285_bb0005","first-page":"51","article-title":"Global and regional projections of the economic burden of Alzheimer's disease and related dementias from 2019 to 2050: a value of statistical life approach","author":"Nandi","year":"2022","journal-title":"EClinicalMedicine"},{"issue":"12","key":"10.1016\/j.intimp.2026.116285_bb0010","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/alz.12362","article-title":"Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020\u20132060)","volume":"17","author":"Rajan","year":"2021","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.intimp.2026.116285_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.742408","article-title":"Alzheimer\u2019s disease: an update and insights into pathophysiology","volume":"14","author":"Abubakar","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0020","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","volume":"7","author":"Knopman","year":"2021","journal-title":"Alzheimer disease. Nature reviews Disease primers"},{"key":"10.1016\/j.intimp.2026.116285_bb0025","article-title":"Synaptic basis of Alzheimer\u2019s disease: Focus on synaptic amyloid beta","volume":"65","author":"John","year":"2021","journal-title":"P-tau and mitochondria. Ageing research reviews"},{"issue":"12","key":"10.1016\/j.intimp.2026.116285_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115052","article-title":"Microglia degrade Alzheimer\u2019s amyloid-beta deposits extracellularly via digestive exophagy","volume":"43","author":"Jacquet","year":"2024","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0035","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.1038\/s41598-021-84579-x","article-title":"Contrast enhanced X-ray computed tomography imaging of amyloid plaques in Alzheimer disease rat model on lab based micro CT system","volume":"11","author":"Kavkova","year":"2021","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb0040","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/s41591-023-02505-2","article-title":"Emerging diagnostics and therapeutics for Alzheimer disease","volume":"29","author":"Self","year":"2023","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb0045","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0050","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41398-021-01602-5","article-title":"Staging tau pathology with tau PET in Alzheimer\u2019s disease: a longitudinal study","volume":"11","author":"Chen","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0055","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuron.2020.09.042","article-title":"High-contrast in vivo imaging of tau pathologies in Alzheimer\u2019s and non-Alzheimer\u2019s disease tauopathies","volume":"109","author":"Tagai","year":"2021","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0060","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41392-023-01484-7","article-title":"Amyloid \u03b2-based therapy for Alzheimer\u2019s disease: challenges, successes and future","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2026.116285_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120861","article-title":"Alzheimer's disease failed clinical trials","volume":"306","author":"Asher","year":"2022","journal-title":"Life Sci."},{"issue":"19","key":"10.1016\/j.intimp.2026.116285_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202300328","article-title":"Failure, success, and future direction of Alzheimer drugs targeting amyloid-\u03b2 cascade: pros and cons of chemical and biological modalities","volume":"24","author":"Kim","year":"2023","journal-title":"ChemBioChem"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3233\/JAD-200840","article-title":"Investigating the spatial associations between amyloid-\u03b2 deposition, grey matter volume, and neuroinflammation in Alzheimer\u2019s disease","volume":"80","author":"Jorge","year":"2021","journal-title":"J. Alzheimer's Dis"},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb0080","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/10408363.2023.2187342","article-title":"Beyond the amyloid hypothesis: how current research implicates autoimmunity in Alzheimer\u2019s disease pathogenesis","volume":"60","author":"Chatanaka","year":"2023","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.intimp.2026.116285_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2025.102736","article-title":"Advanced Biomarkers: Beyond Amyloid and Tau: Emerging Non-Traditional Biomarkers for Alzheimer\u2019s Diagnosis and Progression","volume":"108","author":"Afrin","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2026.116285_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102535","article-title":"Decoding paradoxical links of cytokine markers in cognition: Cross talk between physiology, inflammaging, and Alzheimer\u2019s disease-related cognitive decline","volume":"101","author":"Khan","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2026.116285_bb0095","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cytogfr.2024.08.004","article-title":"Inflamm-ageing: how cytokines and nutrition shape the trajectory of ageing","volume":"82","author":"Coperchini","year":"2025","journal-title":"Cytokine Growth Factor Rev."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0100","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1038\/s41598-025-88526-y","article-title":"Alzheimer\u2019s disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function","volume":"15","author":"Yamakawa","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.116285_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2025.102843","article-title":"Gut-Brain Relationship in Dementia and Alzheimer\u2019s Disease: Impact on Stress and Immunity","volume":"111","author":"Mukherjee","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2026.116285_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.crphar.2022.100149","article-title":"Role of pro-inflammatory cytokines in Alzheimer's disease and neuroprotective effects of pegylated self-assembled nanoscaffolds","volume":"4","author":"Rani","year":"2023","journal-title":"Current research in pharmacology and drug discovery"},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb0115","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3109\/08923973.2012.705292","article-title":"The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis","volume":"34","author":"Azizi","year":"2012","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.intimp.2026.116285_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102548","article-title":"Inflammatory signaling pathways in Alzheimer's disease: mechanistic insights and possible therapeutic interventions","volume":"104","author":"Almutary","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2026.116285_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2025.102838","article-title":"The Evolution of Alzheimer\u2019s Disease: From Mitochondria to Microglia","volume":"111","author":"Yang","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2026.116285_bb0130","first-page":"1","article-title":"Neuroinflammation in Alzheimer disease","author":"Heneka","year":"2024","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0135","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41593-021-00951-0","article-title":"Microglia contribute to the propagation of A\u03b2 into unaffected brain tissue","volume":"25","author":"d\u2019Errico","year":"2022","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0140","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s12974-022-02679-5","article-title":"Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-\u03b2 and tau pathology in Alzheimer\u2019s disease","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0145","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-023-02853-3","article-title":"Tau and neuroinflammation in Alzheimer\u2019s disease: interplay mechanisms and clinical translation","volume":"20","author":"Chen","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0150","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-022-02565-0","article-title":"Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer\u2019s disease","volume":"19","author":"Singh","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0155","doi-asserted-by":"crossref","first-page":"17423","DOI":"10.1038\/s41598-024-67177-5","article-title":"Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer\u2019s disease","volume":"14","author":"Liang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.116285_bb0160","article-title":"Recent advances in the molecular signaling pathways of Substance P in Alzheimer's disease: Link to neuroinflammation associated with toll-like receptors","volume":"733","author":"Gurram","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb0165","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.tips.2022.05.004","article-title":"Toll-like receptor-mediated neuroinflammation: relevance for cognitive dysfunctions","volume":"43","author":"Squillace","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0170","first-page":"7924199","article-title":"Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer\u2019s Disease","volume":"2022","author":"Wu","year":"2022","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.intimp.2026.116285_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2023.105625","article-title":"Neurotropin alleviates cognitive impairment by inhibiting TLR4\/MyD88\/NF-\u03baB inflammation signaling pathway in mice with vascular dementia","volume":"171","author":"Zou","year":"2023","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0180","doi-asserted-by":"crossref","first-page":"3263446","DOI":"10.1155\/2022\/3263446","article-title":"Baicalin mitigates the neuroinflammation through the TLR4\/MyD88\/NF-\u03baB and MAPK pathways in LPS-stimulated BV-2 microglia","volume":"2022","author":"Li","year":"2022","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0185","doi-asserted-by":"crossref","first-page":"11368","DOI":"10.1038\/s41598-025-96456-y","article-title":"Microglial TLR4-Lyn kinase is a critical regulator of neuroinflammation, A\u03b2 phagocytosis, neuronal damage, and cell survival in Alzheimer\u2019s disease","volume":"15","author":"Islam","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0190","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s10753-022-01730-0","article-title":"Role of NLRP3 inflammasome and its inhibitors as emerging therapeutic drug candidate for Alzheimer\u2019s disease: a review of mechanism of activation, regulation, and inhibition","volume":"46","author":"Sharma","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2026.116285_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154695","article-title":"Essential oil of Acorus tatarinowii Schott inhibits neuroinflammation by suppressing NLRP3 inflammasome activation in 3\u00d7 Tg-AD transgenic mice","volume":"112","author":"Xu","year":"2023","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13064-025-00210-z","article-title":"Autophagy and apoptosis in Alzheimer\u2019s disease-associated neurons","volume":"20","author":"Cui","year":"2025","journal-title":"Discover Neuroscience"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0205","doi-asserted-by":"crossref","first-page":"8942","DOI":"10.1038\/s41598-023-35945-4","article-title":"Elevated GRO-\u03b1 and IL-18 in serum and brain implicate the NLRP3 inflammasome in frontotemporal dementia","volume":"13","author":"Lok","year":"2023","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb0210","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70404","article-title":"An integrated view of the relationships between amyloid, tau, and inflammatory pathophysiology in Alzheimer's disease","volume":"21","author":"Arnsten","year":"2025","journal-title":"Alzheimers Dement."},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb0215","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.3390\/biomedicines11092394","article-title":"Concordant and discordant cerebrospinal fluid and plasma cytokine and chemokine responses in mild cognitive impairment and early-stage Alzheimer\u2019s disease","volume":"11","author":"de la Monte","year":"2023","journal-title":"Biomedicines"},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb0220","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.3390\/ph15081008","article-title":"Neuroprotective effects of phytochemicals against aluminum chloride-induced Alzheimer\u2019s disease through ApoE4\/LRP1, wnt3\/\u03b2-catenin\/gsk3\u03b2, and TLR4\/NLRP3 pathways with physical and mental activities in a rat model","volume":"15","author":"Hamdan","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.intimp.2026.116285_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108488","article-title":"Fluoxetine ameliorates Alzheimer's disease progression and prevents the exacerbation of cardiovascular dysfunction of socially isolated depressed rats through activation of Nrf2\/HO-1 and hindering TLR4\/NLRP3 inflammasome signaling pathway","volume":"104","author":"Abu-Elfotuh","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb0230","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.molmed.2022.05.008","article-title":"Staging of Alzheimer\u2019s disease: past, present, and future perspectives","volume":"28","author":"Therriault","year":"2022","journal-title":"Trends Mol. Med."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb0235","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s43587-023-00404-2","article-title":"Towards a future where Alzheimer\u2019s disease pathology is stopped before the onset of dementia","volume":"3","author":"van der Flier","year":"2023","journal-title":"Nature aging"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0240","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41392-023-01486-5","article-title":"Role of neuroinflammation in neurodegeneration development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0245","doi-asserted-by":"crossref","first-page":"26580","DOI":"10.1038\/s41598-024-78204-w","article-title":"Activation of glial cells induces proinflammatory properties in brain capillary endothelial cells in vitro","volume":"14","author":"Burkhart","year":"2024","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.intimp.2026.116285_bb0250","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1038\/s41380-023-02242-5","article-title":"The role of glial autophagy in Alzheimer\u2019s disease","volume":"28","author":"Litwiniuk","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb0255","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/s41593-024-01664-w","article-title":"Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer\u2019s disease","volume":"27","author":"Huang","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2026.116285_bb0260","doi-asserted-by":"crossref","first-page":"1053680","DOI":"10.3389\/fphar.2023.1053680","article-title":"Regulatory role of the endocannabinoid system on glial cells toward cognitive function in Alzheimer\u2019s disease: A systematic review and meta-analysis of animal studies","volume":"14","author":"Kamaruzzaman","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb0265","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/s43587-023-00424-y","article-title":"Human microglia show unique transcriptional changes in Alzheimer\u2019s disease","volume":"3","author":"Prater","year":"2023","journal-title":"Nature Aging"},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114216","article-title":"Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer\u2019s disease mouse model, as revealed by spatial transcriptomics","volume":"43","author":"Mallach","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2026.116285_bb0275","first-page":"1","article-title":"Spatial proteomics of Alzheimer\u2019s disease-specific human microglial states","author":"Mrdjen","year":"2025","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb0280","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s43587-024-00630-2","article-title":"The path to next-generation disease-modifying immunomodulatory combination therapies in Alzheimer\u2019s disease","volume":"4","author":"Sarazin","year":"2024","journal-title":"Nature Aging"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0285","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s42003-024-06615-6","article-title":"Naringenin ameliorates amyloid-\u03b2 pathology and neuroinflammation in Alzheimer\u2019s disease","volume":"7","author":"Zhu","year":"2024","journal-title":"Communications Biology"},{"issue":"10","key":"10.1016\/j.intimp.2026.116285_bb0290","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.it.2024.08.008","article-title":"Emerging roles of astrocytes as immune effectors in the central nervous system","volume":"45","author":"Fisher","year":"2024","journal-title":"Trends Immunol"},{"issue":"6640","key":"10.1016\/j.intimp.2026.116285_bb0295","doi-asserted-by":"crossref","DOI":"10.1126\/science.abo7649","article-title":"Transforming the understanding of brain immunity","volume":"380","author":"Castellani","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.intimp.2026.116285_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2023.578180","article-title":"Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation","volume":"383","author":"Biswas","year":"2023","journal-title":"J. Neuroimmunol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb0305","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1007\/s12035-023-03845-3","article-title":"Epigallocatechin gallate modulates microglia phenotype to suppress pro-inflammatory signalling cues and inhibit phagocytosis","volume":"61","author":"Regan","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0310","doi-asserted-by":"crossref","first-page":"14405","DOI":"10.1038\/s41598-024-64872-1","article-title":"Metabolic flexibility ensures proper neuronal network function in moderate neuroinflammation","volume":"14","author":"Chausse","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0315","doi-asserted-by":"crossref","first-page":"10634","DOI":"10.1038\/s41467-024-54779-w","article-title":"Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer\u2019s Disease","volume":"15","author":"Balig\u00e1cs","year":"2024","journal-title":"Nat. Commun."},{"issue":"7953","key":"10.1016\/j.intimp.2026.116285_bb0320","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41586-023-05788-0","article-title":"Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy","volume":"615","author":"Chen","year":"2023","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0325","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/s41467-023-37304-3","article-title":"An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer\u2019s disease","volume":"14","author":"Lau","year":"2023","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb0330","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s12264-022-00992-w","article-title":"The structure and function of glial networks: Beyond the neuronal connections","volume":"39","author":"Peng","year":"2023","journal-title":"Neurosci. Bull."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb0335","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.14336\/AD.2023.1017","article-title":"Coupling of Alzheimer\u2019s disease genetic risk factors with viral susceptibility and inflammation","volume":"15","author":"Cao","year":"2024","journal-title":"Aging Dis."},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb0340","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.tins.2023.03.005","article-title":"Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer\u2019s disease","volume":"46","author":"Young-Pearse","year":"2023","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0345","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb0350","doi-asserted-by":"crossref","first-page":"7296","DOI":"10.1007\/s12035-025-04715-w","article-title":"Research progress in the molecular mechanism of NLRP3 inflammasome in alzheimer\u2019s disease and regulation by natural plant products","volume":"62","author":"Zu","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb0355","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11011-025-01631-9","article-title":"Microglial activation as a hallmark of neuroinflammation in Alzheimer\u2019s disease","volume":"40","author":"Ebrahimi","year":"2025","journal-title":"Metab. Brain Dis."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0360","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/13872877241313223","article-title":"Microglial polarization in Alzheimer's disease: Mechanisms, implications, and therapeutic opportunities","volume":"104","author":"Yang","year":"2025","journal-title":"J. Alzheimer's Dis"},{"key":"10.1016\/j.intimp.2026.116285_bb0365","first-page":"1","article-title":"Microglial mechanisms drive amyloid-\u03b2 clearance in immunized patients with Alzheimer\u2019s disease","author":"van Olst","year":"2025","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb0370","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1177\/13872877251335572","article-title":"Role of astroglia and microglia in Alzheimer's disease and multiple therapeutic interventions","volume":"105","author":"Li","year":"2025","journal-title":"J. Alzheimer's Dis"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0375","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00401-024-02790-2","article-title":"Inflammatory aspects of Alzheimer\u2019s disease","volume":"148","author":"Botella Lucena","year":"2024","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb0380","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s43440-024-00613-5","article-title":"Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases","volume":"76","author":"Sharma","year":"2024","journal-title":"Pharmacol. Rep."},{"issue":"15","key":"10.1016\/j.intimp.2026.116285_bb0385","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18554","article-title":"Microglial modulation as a therapeutic strategy in Alzheimer's disease: Focus on microglial preconditioning approaches","volume":"28","author":"Yassaghi","year":"2024","journal-title":"J. Cell. Mol. Med."},{"issue":"10","key":"10.1016\/j.intimp.2026.116285_bb0390","first-page":"3574","article-title":"Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's disease","volume":"168","author":"Jha","year":"2024","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb0395","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1007\/s10787-024-01534-8","article-title":"The role of IL-1 family of cytokines in the pathogenesis and therapy of Alzheimer\u2019s disease","volume":"32","author":"Li","year":"2024","journal-title":"Inflammopharmacology"},{"issue":"s1","key":"10.1016\/j.intimp.2026.116285_bb0400","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.3233\/JAD-230064","article-title":"Betaine mitigates amyloid-\u03b2-associated neuroinflammation by suppressing the NLRP3 and NF-\u03baB signaling pathways in microglial cells","volume":"94","author":"Zhang","year":"2023","journal-title":"J. Alzheimer's Dis"},{"key":"10.1016\/j.intimp.2026.116285_bb0405","doi-asserted-by":"crossref","first-page":"1444716","DOI":"10.3389\/fnagi.2024.1444716","article-title":"The impact of physical exercise on neuroinflammation mechanism in Alzheimer\u2019s disease","volume":"16","author":"Hu","year":"2024","journal-title":"Front. Aging Neurosci."},{"issue":"11","key":"10.1016\/j.intimp.2026.116285_bb0410","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.1007\/s00210-024-03188-3","article-title":"Oxidative stress\u2013mediated neuroinflammation in Alzheimer\u2019s disease","volume":"397","author":"Firdous","year":"2024","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0415","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s11658-023-00462-9","article-title":"The NLRP3 inflammasome: contributions to inflammation-related diseases","volume":"28","author":"Chen","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb0420","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s11626-023-00818-7","article-title":"Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease","volume":"59","author":"Guo","year":"2023","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"10.1016\/j.intimp.2026.116285_bb0425","first-page":"1","article-title":"Decoding NLRP3 Inflammasome Activation in Alzheimer\u2019s Disease: A Focus on Receptor Dynamics","author":"Maurya","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0430","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41392-023-01628-9","article-title":"Astrocytes in human central nervous system diseases: a frontier for new therapies","volume":"8","author":"Verkhratsky","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb0435","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41582-023-00822-1","article-title":"Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration","volume":"19","author":"Patani","year":"2023","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0440","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neuron.2024.12.010","article-title":"Astrocytes in aging","volume":"113","author":"Labarta-Bajo","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.intimp.2026.116285_bb0445","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-neuro-112723-035356","article-title":"Astrocytes as Key Regulators of Neural Signaling in Health and Disease","volume":"48","author":"Won","year":"2025","journal-title":"Annu. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0450","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s12276-023-01148-0","article-title":"Pathological phenotypes of astrocytes in Alzheimer\u2019s disease","volume":"56","author":"Kim","year":"2024","journal-title":"Exp. Mol. Med."},{"issue":"18","key":"10.1016\/j.intimp.2026.116285_bb0455","doi-asserted-by":"crossref","first-page":"13880","DOI":"10.3390\/ijms241813880","article-title":"Astrocytes as neuroimmunocytes in Alzheimer\u2019s disease: A biochemical tool in the neuron\u2013glia crosstalk along the pathogenetic pathways","volume":"24","author":"Stanca","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb0460","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1038\/s41380-023-02061-8","article-title":"Revisiting the critical roles of reactive astrocytes in neurodegeneration","volume":"28","author":"Qian","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb0465","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s11064-022-03820-9","article-title":"Inhibition of A1 astrocytes and activation of A2 astrocytes for the treatment of spinal cord injury","volume":"48","author":"Wang","year":"2023","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0470","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/ana.26797","article-title":"Altered brain energy metabolism related to astrocytes in Alzheimer's disease","volume":"95","author":"Hirata","year":"2024","journal-title":"Ann. Neurol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb0475","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1038\/s41591-023-02380-x","article-title":"Astrocyte reactivity influences amyloid-\u03b2 effects on tau pathology in preclinical Alzheimer\u2019s disease","volume":"29","author":"Bellaver","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2026.116285_bb0480","doi-asserted-by":"crossref","first-page":"1196413","DOI":"10.3389\/fphar.2023.1196413","article-title":"Alzheimer\u2019s disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy?","volume":"14","author":"Melchiorri","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb0485","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3390\/cells14030168","article-title":"Modulating Neuroinflammation as a Prospective Therapeutic Target in Alzheimer\u2019s Disease","volume":"14","author":"Lee","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.116285_bb0490","series-title":"The NLRP3-P2X7 Axis and Cytokine Crosstalk in Alzheimer's Disease: Mechanisms, Implications, and Therapeutic Opportunities","author":"Kurmi","year":"2025"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0495","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41583-022-00641-1","article-title":"Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders","volume":"24","author":"Brandebura","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb0500","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1007\/s10571-023-01365-1","article-title":"Roles of ApoE4 on the pathogenesis in Alzheimer\u2019s disease and the potential therapeutic approaches","volume":"43","author":"Sun","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2026.116285_bb0505","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.630502","article-title":"APOE and Alzheimer\u2019s disease: from lipid transport to physiopathology and therapeutics","volume":"15","author":"Husain","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2026.116285_bb0510","doi-asserted-by":"crossref","first-page":"1096206","DOI":"10.3389\/fnagi.2023.1096206","article-title":"White matter injury, cholesterol dysmetabolism, and APP\/Abeta dysmetabolism interact to produce Alzheimer\u2019s disease (AD) neuropathology: A hypothesis and review","volume":"15","author":"Sharp","year":"2023","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0515","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41420-025-02600-y","article-title":"The multifaceted roles of apolipoprotein E4 in Alzheimer\u2019s disease pathology and potential therapeutic strategies","volume":"11","author":"Chen","year":"2025","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.intimp.2026.116285_bb0520","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The amyloid-\u03b2 pathway in Alzheimer\u2019s disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"issue":"12","key":"10.1016\/j.intimp.2026.116285_bb0525","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/s41593-020-00735-y","article-title":"Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer\u2019s disease via H2O2\u2212 production","volume":"23","author":"Chun","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"10","key":"10.1016\/j.intimp.2026.116285_bb0530","doi-asserted-by":"crossref","first-page":"5404","DOI":"10.3390\/ijms23105404","article-title":"Transgenic mouse models of Alzheimer\u2019s disease: an integrative analysis","volume":"23","author":"Sanchez-Varo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0535","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12974-021-02117-y","article-title":"Pharmacological ablation of astrocytes reduces A\u03b2 degradation and synaptic connectivity in an ex vivo model of Alzheimer\u2019s disease","volume":"18","author":"Davis","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0540","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40478-024-01745-8","article-title":"Astrocytic accumulation of tau fibrils isolated from Alzheimer\u2019s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment","volume":"12","author":"Eltom","year":"2024","journal-title":"Acta neuropathologica communications"},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb0545","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1002\/glia.23981","article-title":"Reactive astrocytes as treatment targets in Alzheimer's disease\u2014systematic review of studies using the APPswePS1dE9 mouse model","volume":"69","author":"Smit","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.intimp.2026.116285_bb0550","doi-asserted-by":"crossref","first-page":"1421076","DOI":"10.3389\/fimmu.2024.1421076","article-title":"Spotlight on pro-inflammatory chemokines: regulators of cellular communication in cognitive impairment","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb0555","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s12031-022-02047-1","article-title":"Role of Chemokines in the Development and Progression of Alzheimer\u2019s Disease","volume":"72","author":"Wojcieszak","year":"2022","journal-title":"J. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb0560","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/cells8020184","article-title":"Astrocytes maintain glutamate homeostasis in the CNS by controlling the balance between glutamate uptake and release","volume":"8","author":"Mahmoud","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.116285_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2023.105551","article-title":"Mutant Tau protein-induced abnormalities in the Na+-dependent glutamine translocation and recycling and their impact on astrocyte-neuron integrity in vitro","volume":"168","author":"Sidoryk-W\u0119grzynowicz","year":"2023","journal-title":"Neurochem. Int."},{"issue":"12","key":"10.1016\/j.intimp.2026.116285_bb0570","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/1071576021000049890","article-title":"Amyloid \u03b2-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain","volume":"36","author":"Allan Butterfield","year":"2002","journal-title":"A review. Free radical research"},{"issue":"11","key":"10.1016\/j.intimp.2026.116285_bb0575","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/bkcs.12390","article-title":"Potent therapeutic targets for treatment of Alzheimer's disease: Amyloid degrading enzymes","volume":"42","author":"Choi","year":"2021","journal-title":"Bulletin of the Korean Chem. Society"},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb0580","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12031-025-02379-8","article-title":"Glial Cells in Alzheimer\u2019s Disease: Pathogenic Mechanisms and Therapeutic Frontiers","volume":"75","author":"Sil","year":"2025","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.intimp.2026.116285_bb0585","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.2147\/DDDT.S380612","article-title":"The role of Traditional Chinese Medicine Natural Products in \u03b2-amyloid deposition and tau protein hyperphosphorylation in Alzheimer\u2019s disease","author":"Yan","year":"2023","journal-title":"Drug Design, Development and Therapy"},{"issue":"12","key":"10.1016\/j.intimp.2026.116285_bb0590","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1021\/acsptsci.4c00400","article-title":"Neprilysin-mediated amyloid beta clearance and its therapeutic implications in neurodegenerative disorders","volume":"7","author":"Saxena","year":"2024","journal-title":"ACS Pharmacology & Translational Science"},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb0595","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12640-020-00284-z","article-title":"Liquiritigenin decreases A\u03b2 levels and ameliorates cognitive decline by regulating microglia M1\/M2 transformation in AD mice","volume":"39","author":"Du","year":"2021","journal-title":"Neurotox. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0600","doi-asserted-by":"crossref","first-page":"14305","DOI":"10.1038\/s41598-024-65248-1","article-title":"The impact of astrocytic NF-\u03baB on healthy and Alzheimer\u2019s disease brains","volume":"14","author":"Jong Huat","year":"2024","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb0605","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/1073858419848293","article-title":"Brain injury\u2013mediated neuroinflammatory response and Alzheimer\u2019s disease","volume":"26","author":"Kempuraj","year":"2020","journal-title":"Neuroscientist"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0610","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41392-025-02178-y","article-title":"Deep insight into cytokine storm: from pathogenesis to treatment","volume":"10","author":"Nie","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb0615","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s10787-019-00580-x","article-title":"Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer\u2019s disease","volume":"27","author":"Kaur","year":"2019","journal-title":"Inflammopharmacology"},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb0620","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.2353\/ajpath.2009.090418","article-title":"Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid \u03b2 neurotoxicity in in vitro and in vivo models of Alzheimer\u2019s disease","volume":"175","author":"Doi","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2026.116285_bb0625","series-title":"Aging and amyloid \u03b2 oligomers enhance TLR4 expression, LPS-induced Ca 2 responses, and neuron cell death in cultured rat hippocampal neurons","author":"Calvo-Rodr\u00edguez","year":"2017"},{"key":"10.1016\/j.intimp.2026.116285_bb0630","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.606986","article-title":"Lipopolysaccharide Preparation Derived From Porphyromonas gingivalis Induces a Weaker Immuno-Inflammatory Response in BV-2 Microglial Cells Than Escherichia coli by Differentially Activating TLR2\/4-Mediated NF-\u03baB\/STAT3 Signaling Pathways","volume":"11","author":"Qiu","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb0635","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s12031-018-1249-1","article-title":"Prestimulation of microglia through TLR4 pathway promotes interferon beta expression in a rat model of Alzheimer\u2019s disease","volume":"67","author":"Yousefi","year":"2019","journal-title":"J. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0640","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-022-00557-6","article-title":"Emerging principles of cytokine pharmacology and therapeutics","volume":"22","author":"Saxton","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb0645","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/s41590-022-01267-2","article-title":"The complex role of tumor-infiltrating macrophages","volume":"23","author":"Christofides","year":"2022","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb0650","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2026.116285_bb0655","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41573-024-01026-y","article-title":"Targeting cytokine networks in neuroinflammatory diseases","volume":"23","author":"Becher","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0660","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41392-021-00658-5","article-title":"Inflammation and tumor progression: signaling pathways and targeted intervention","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"12","key":"10.1016\/j.intimp.2026.116285_bb0665","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/s41590-019-0466-2","article-title":"Interferon target-gene expression and epigenomic signatures in health and disease","volume":"20","author":"Barrat","year":"2019","journal-title":"Nat. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116285_bb0670","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.714","article-title":"The interaction of innate immune and adaptive immune system","volume":"5","author":"Wang","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.intimp.2026.116285_bb0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.109884","article-title":"New mechanism of neuroinflammation in Alzheimer's disease: the activation of NLRP3 inflammasome mediated by gut microbiota","volume":"100","author":"Shen","year":"2020","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"11","key":"10.1016\/j.intimp.2026.116285_bb0680","doi-asserted-by":"crossref","first-page":"7741","DOI":"10.1007\/s12035-019-1638-7","article-title":"The role of neuronal NLRP1 inflammasome in Alzheimer\u2019s disease: bringing neurons into the neuroinflammation game","volume":"56","author":"Yap","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2026.116285_bb0685","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.016395","article-title":"TNF-\u03b1\u2013mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer\u2019s disease pathology in young Trem2R47H rats","volume":"296","author":"Ren","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb0690","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/14728222.2020.1738391","article-title":"Alzheimer\u2019s disease: microglia targets and their modulation to promote amyloid phagocytosis and mitigate neuroinflammation","volume":"24","author":"Anwar","year":"2020","journal-title":"Expert Opin. Ther. Targets"},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb0695","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s11481-023-10090-x","article-title":"Low-dose IL-2 treatment rescues cognitive deficits by repairing the Imbalance between Treg and Th17 cells at the Middle Alzheimer\u2019s Disease Stage","volume":"18","author":"Yuan","year":"2023","journal-title":"J. NeuroImmune Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0700","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13195-023-01323-5","article-title":"Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer\u2019s phenotypes without blocking peripheral T cell IL-2 response","volume":"15","author":"Stallings","year":"2023","journal-title":"Alzheimer's Res. Ther."},{"issue":"7869","key":"10.1016\/j.intimp.2026.116285_bb0705","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41586-021-03734-6","article-title":"Astrocytic interleukin-3 programs microglia and limits Alzheimer\u2019s disease","volume":"595","author":"McAlpine","year":"2021","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb0710","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41593-018-0296-9","article-title":"Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE","volume":"22","author":"Parhizkar","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0715","first-page":"4754195","article-title":"Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K\/Akt\/GSK-3\u03b2 Pathway in Experimental Models of Alzheimer\u2019s Disease","volume":"2020","author":"Yang","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2026.116285_bb0720","doi-asserted-by":"crossref","first-page":"1400533","DOI":"10.3389\/fimmu.2024.1400533","article-title":"The impact of interleukin-6 (IL-6) and mesenchymal stem cell-derived IL-6 on neurological conditions","volume":"15","author":"Kerkis","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116285_bb0725","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbi.2023.06.027","article-title":"Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers\u2013in cognitively unimpaired older adults","volume":"113","author":"Capogna","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0730","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/13872877241298973","article-title":"Investigating interleukin-8 in Alzheimer's disease: A comprehensive review","volume":"103","author":"Righi","year":"2025","journal-title":"J. Alzheimer's Dis"},{"key":"10.1016\/j.intimp.2026.116285_bb0735","first-page":"1","article-title":"Dietary plant-derived lectins induce oxidative stress, metabolic dysfunction, apoptosis and neuroinflammation in mice brain","author":"Zhgenti","year":"2025","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.intimp.2026.116285_bb0740","doi-asserted-by":"crossref","first-page":"1582119","DOI":"10.3389\/fimmu.2025.1582119","article-title":"Gut Microbiota-Driven Neuroinflammation in Alzheimer's Disease: From Mechanisms to Therapeutic Opportunities","volume":"16","author":"Lei","year":"2025","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0745","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s11033-022-07951-8","article-title":"The role of transforming growth factor \u03b21\/Smad pathway in Alzheimer\u2019s disease inflammation pathology","volume":"50","author":"Yang","year":"2023","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0750","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12974-023-02751-8","article-title":"TGF-\u03b21 signalling in Alzheimer\u2019s pathology and cytoskeletal reorganization: a specialized Tau perspective","volume":"20","author":"Kapoor","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"23","key":"10.1016\/j.intimp.2026.116285_bb0755","doi-asserted-by":"crossref","first-page":"9036","DOI":"10.3390\/ijms21239036","article-title":"Danger-sensing\/patten recognition receptors and neuroinflammation in Alzheimer\u2019s disease","volume":"21","author":"Chiarini","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116285_bb0760","doi-asserted-by":"crossref","first-page":"1161850","DOI":"10.3389\/fphar.2023.1161850","article-title":"Revisiting the neuroinflammation hypothesis in Alzheimer\u2019s disease: A focus on the druggability of current targets","volume":"14","author":"Wong-Guerra","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0765","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s42269-019-0227-2","article-title":"Toll-like receptors activation, signaling, and targeting: an overview","volume":"43","author":"El-Zayat","year":"2019","journal-title":"Bull. Natl. Res. Cent."},{"key":"10.1016\/j.intimp.2026.116285_bb0770","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.102818","article-title":"Gegen Qinlian Decoction improves Alzheimer's disease through TLR4\/NF-\u03baB\/NLRP3 pathway","volume":"95","author":"Zhang","year":"2025","journal-title":"Tissue Cell"},{"key":"10.1016\/j.intimp.2026.116285_bb0775","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3389\/fphys.2017.00508","article-title":"Inhibition of toll-like receptor signaling as a promising therapy for inflammatory diseases: a journey from molecular to nano therapeutics","volume":"8","author":"Gao","year":"2017","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0780","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s42269-019-0227-2","article-title":"Toll-like receptors activation, signaling, and targeting: an overview","volume":"43","author":"El-Zayat","year":"2019","journal-title":"Bull. Natl. Res. Cent."},{"key":"10.1016\/j.intimp.2026.116285_bb0785","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fimmu.2013.00248","article-title":"Sweeten PAMPs: role of sugar complexed PAMPs in innate immunity and vaccine biology","volume":"4","author":"Mahla","year":"2013","journal-title":"Front. Immunol."},{"issue":"6640","key":"10.1016\/j.intimp.2026.116285_bb0790","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/41131","article-title":"A human homologue of the Drosophila Toll protein signals activation of adaptive immunity","volume":"388","author":"Medzhitov","year":"1997","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0795","article-title":"Current views of Toll-like receptor signaling pathways","volume":"2010","author":"Yamamoto","year":"2010","journal-title":"Gastroenterol. Res. Pract."},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb0800","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nri3713","article-title":"Assembly and localization of Toll-like receptor signalling complexes","volume":"14","author":"Gay","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.116285_bb0805","series-title":"Seminars in immunology","article-title":"PRR-signaling pathways: learning from microbial tactics","author":"Sellge","year":"2015"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0810","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/08830185.2017.1380200","article-title":"Toll-like receptors: significance, ligands, signaling pathways, and functions in mammals","volume":"37","author":"Vidya","year":"2018","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.116285_bb0815","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3389\/fimmu.2014.00313","article-title":"Toll-like receptor 4 in inflammation and angiogenesis: a double-edged sword","volume":"5","author":"Murad","year":"2014","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0820","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2009.08.010","article-title":"Toll-like receptor signaling in cell proliferation and survival","volume":"49","author":"Li","year":"2010","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0825","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","volume":"30","author":"Kumar","year":"2011","journal-title":"Int. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0830","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40035-021-00271-0","article-title":"TLR2 and TLR4 in Parkinson\u2019s disease pathogenesis: the environment takes a toll on the gut","volume":"10","author":"Gorecki","year":"2021","journal-title":"Translational Neurodegeneration"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0835","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12974-022-02496-w","article-title":"The role of Toll-like receptors and neuroinflammation in Parkinson\u2019s disease","volume":"19","author":"Heidari","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116285_bb0840","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fcimb.2012.00167","article-title":"The function of TLR2 during staphylococcal diseases","volume":"2","author":"Fournier","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb0845","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.addr.2007.12.004","article-title":"TLR9 as a key receptor for the recognition of DNA","volume":"60","author":"Kumagai","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb0850","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4196\/kjpp.2014.18.3.225","article-title":"The protective role of TLR3 and TLR9 ligands in human pharyngeal epithelial cells infected with influenza A virus","volume":"18","author":"Han","year":"2014","journal-title":"The Korean journal of physiology & pharmacology: official journal of the Korean Physiological Society and the Korean Society of Pharmacology"},{"key":"10.1016\/j.intimp.2026.116285_bb0855","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.3389\/fimmu.2019.01000","article-title":"Regulation of toll-like receptor (TLR) signaling pathway by polyphenols in the treatment of age-linked neurodegenerative diseases: focus on TLR4 signaling","volume":"10","author":"Azam","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116285_bb0860","first-page":"1","article-title":"Beyond Neuroinflammation: Microglia at the Crossroads of Amyloid, Tau, and Neurodegeneration in Alzheimer\u2019s Disease","author":"Ebrahimi","year":"2025","journal-title":"Neurol. Sci."},{"issue":"15","key":"10.1016\/j.intimp.2026.116285_bb0865","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3390\/cells14151161","article-title":"Parkinson\u2019s Disease: Bridging Gaps, Building Biomarkers, and Reimagining Clinical Translation","volume":"14","author":"Tanaka","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.116285_bb0870","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3389\/fnmol.2019.00314","article-title":"Inflammatory role of TLR-MyD88 signaling in multiple sclerosis","volume":"12","author":"Zheng","year":"2020","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0875","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12974-021-02137-8","article-title":"Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke","volume":"18","author":"Xu","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"11","key":"10.1016\/j.intimp.2026.116285_bb0880","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1093\/brain\/awl249","article-title":"Role of toll-like receptor signalling in A\u03b2 uptake and clearance","volume":"129","author":"Tahara","year":"2006","journal-title":"Brain"},{"issue":"19","key":"10.1016\/j.intimp.2026.116285_bb0885","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1021\/acschemneuro.0c00029","article-title":"TLR4\/MyD88\/NF-\u03baB signaling in the rostral ventrolateral medulla is involved in the depressor effect of candesartan in stress-induced hypertensive rats","volume":"11","author":"Yang","year":"2020","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0890","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00109-016-1474-4","article-title":"Interaction between gut microbiota and toll-like receptor: from immunity to metabolism","volume":"95","author":"Yiu","year":"2017","journal-title":"J. Mol. Med."},{"issue":"1-2","key":"10.1016\/j.intimp.2026.116285_bb0895","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2014.01.014","article-title":"Biological role of Toll-like receptor-4 in the brain","volume":"268","author":"Trotta","year":"2014","journal-title":"J. Neuroimmunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb0900","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tins.2011.02.005","article-title":"Toll-like receptor signaling in neural plasticity and disease","volume":"34","author":"Okun","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.intimp.2026.116285_bb0905","series-title":"Toll-like receptors in Alzheimer\u2019s disease: a therapeutic perspective. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders)","first-page":"1542","volume":"13(9)","author":"EGambuzza","year":"2014"},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb0910","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1007\/s11064-019-02748-x","article-title":"Imbalance of microglial TLR4\/TREM2 in LPS-treated APP\/PS1 transgenic mice: a potential link between Alzheimer\u2019s disease and systemic inflammation","volume":"44","author":"Zhou","year":"2019","journal-title":"Neurochem. Res."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb0915","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.3233\/JAD-171160","article-title":"TLR4 gene expression and pro-inflammatory cytokines in Alzheimer\u2019s disease and in response to hippocampal deafferentation in rodents","volume":"63","author":"Miron","year":"2018","journal-title":"J. Alzheimer's Dis"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0920","doi-asserted-by":"crossref","first-page":"31895","DOI":"10.1038\/srep31895","article-title":"HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer\u2019s disease","volume":"6","author":"Fujita","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.116285_bb0925","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.molimm.2021.12.018","article-title":"Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer\u2019s disease","volume":"142","author":"Ruganzu","year":"2022","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2026.116285_bb0930","series-title":"Effect of Peripheral Inflammation on Neuroinflammation, Cognition, and Alzheimer-Like Pathology in C57BL\/6 Mice","author":"Eid","year":"2025"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0935","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12974-017-0802-0","article-title":"Aging and amyloid \u03b2 oligomers enhance TLR4 expression, LPS-induced Ca2+ responses, and neuron cell death in cultured rat hippocampal neurons","volume":"14","author":"Calvo-Rodr\u00edguez","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116285_bb0940","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbi.2016.10.012","article-title":"Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by \u03b2-amyloid oligomers in an acute mouse model of Alzheimer\u2019s disease","volume":"60","author":"Balducci","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"39","key":"10.1016\/j.intimp.2026.116285_bb0945","doi-asserted-by":"crossref","first-page":"35499","DOI":"10.1021\/acsomega.3c04855","article-title":"Comprehensive review of nutraceuticals against cognitive decline associated with Alzheimer\u2019s disease","volume":"8","author":"Reza-Zald\u00edvar","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.intimp.2026.116285_bb0950","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fncel.2019.00022","article-title":"Amyloid \u03b2 oligomers increase ER-mitochondria Ca2+ cross talk in young hippocampal neurons and exacerbate aging-induced intracellular Ca2+ remodeling","volume":"13","author":"Calvo-Rodriguez","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.intimp.2026.116285_bb0955","first-page":"66","article-title":"Lipopolysaccharide-induced memory impairment in rats: a model of Alzheimer's disease","author":"Zakaria","year":"2017","journal-title":"Physiol. Res."},{"key":"10.1016\/j.intimp.2026.116285_bb0960","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fcimb.2017.00318","article-title":"Secretory products of the human GI tract microbiome and their potential impact on Alzheimer's disease (AD): detection of lipopolysaccharide (LPS) in AD hippocampus","volume":"7","author":"Zhao","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2026.116285_bb0965","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3389\/fnagi.2017.00407","article-title":"Lipopolysaccharide (LPS) accumulates in neocortical neurons of Alzheimer\u2019s disease (AD) brain and impairs transcription in human neuronal-glial primary co-cultures","volume":"9","author":"Zhao","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb0970","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1002\/ptr.8461","article-title":"Gastrodin Ameliorates Tau Pathology and BBB Dysfunction in 3xTg-AD Transgenic Mice by Regulating the ADRA1\/NF-\u03baB\/NLRP3 Pathway to Reduce Neuroinflammation","volume":"39","author":"Li","year":"2025","journal-title":"Phytother. Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb0975","doi-asserted-by":"crossref","first-page":"5921","DOI":"10.3390\/ijms24065921","article-title":"Dietary protection against cognitive impairment, neuroinflammation and oxidative stress in Alzheimer\u2019s disease animal models of lipopolysaccharide-induced inflammation","volume":"24","author":"Decandia","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116285_bb0980","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3389\/fimmu.2020.00724","article-title":"TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in Alzheimer's disease","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb0985","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s42003-020-0792-9","article-title":"Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death","volume":"3","author":"Hughes","year":"2020","journal-title":"Communications biology"},{"key":"10.1016\/j.intimp.2026.116285_bb0990","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cbi.2014.01.012","article-title":"Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia","volume":"212","author":"Jeong","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.intimp.2026.116285_bb0995","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.602508","article-title":"TLR4 targeting as a promising therapeutic strategy for Alzheimer disease treatment","volume":"14","author":"Zhou","year":"2020","journal-title":"Front. Neurosci."},{"issue":"10","key":"10.1016\/j.intimp.2026.116285_bb1000","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1021\/acsptsci.4c00457","article-title":"Demystifying the role of neuroinflammatory mediators as biomarkers for diagnosis, prognosis, and treatment of Alzheimer\u2019s disease: a review","volume":"7","author":"Doke","year":"2024","journal-title":"ACS Pharmacology & Translational Science"},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb1005","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.pharep.2019.02.016","article-title":"Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling","volume":"71","author":"Ahuja","year":"2019","journal-title":"Pharmacol. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1010","article-title":"Biglycan Expression Promotes \u03b2-Amyloid-Induced Microglial Activation via TLR2 in Mouse Cell Culture Model","volume":"67","author":"Duan","year":"2021","journal-title":"Clin. Lab."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb1015","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1254\/jphs.13031FP","article-title":"Xanthoceraside inhibits pro-inflammatory cytokine expression in A\u03b225-35\/IFN-\u03b3-stimulated microglia through the TLR2 receptor, MyD88, nuclear factor-\u03baB, and mitogen-activated protein kinase signaling pathways","volume":"122","author":"Qi","year":"2013","journal-title":"J. Pharmacol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13041-024-01118-1","article-title":"The duality of amyloid-\u03b2: its role in normal and Alzheimer\u2019s disease states","volume":"17","author":"Azargoonjahromi","year":"2024","journal-title":"Molecular Brain"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1025","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40035-018-0139-3","article-title":"Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer\u2019s disease\u2013conformist, nonconformist, and realistic prospects for AD pathogenesis","volume":"7","author":"Li","year":"2018","journal-title":"Translational neurodegeneration"},{"issue":"22","key":"10.1016\/j.intimp.2026.116285_bb1030","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1523\/JNEUROSCI.1146-08.2008","article-title":"Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid \u03b21\u201342 and delay the cognitive decline in a mouse model of Alzheimer's disease","volume":"28","author":"Richard","year":"2008","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1035","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12974-018-1281-7","article-title":"Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of \u03b2-amyloid","volume":"15","author":"Rubio-Araiz","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb1040","doi-asserted-by":"crossref","first-page":"10425","DOI":"10.1096\/fj.201900527R","article-title":"Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP\/PS1 mice","volume":"33","author":"Sheng","year":"2019","journal-title":"FASEB J."},{"issue":"1-2","key":"10.1016\/j.intimp.2026.116285_bb1045","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jns.2011.11.032","article-title":"Increased expressions of TLR2 and TLR4 on peripheral blood mononuclear cells from patients with Alzheimer's disease","volume":"315","author":"Zhang","year":"2012","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1050","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1755-5949.2011.00245.x","article-title":"Systemic and central immunity in Alzheimer's disease: therapeutic implications","volume":"18","author":"Butchart","year":"2012","journal-title":"CNS neuroscience & therapeutics"},{"issue":"40","key":"10.1016\/j.intimp.2026.116285_bb1055","doi-asserted-by":"crossref","first-page":"6152","DOI":"10.2174\/1381612822666160907093807","article-title":"The gut-brain axis, including the microbiome, leaky gut and bacterial translocation: mechanisms and pathophysiological role in Alzheimer\u2019s disease","volume":"22","author":"Kohler","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.intimp.2026.116285_bb1060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2022.04.007","article-title":"TLR4 deletion improves cognitive brain function and structure in aged mice","volume":"492","author":"Fei","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2026.116285_bb1065","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bbi.2020.10.004","article-title":"Toll-like receptor-2 gene knockout results in neurobehavioral dysfunctions and multiple brain structural and functional abnormalities in mice","volume":"91","author":"Hu","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb1070","doi-asserted-by":"crossref","DOI":"10.1093\/toxres\/tfaf031","article-title":"Coenzyme Q10 alleviates AlCl3 and D-galactose induced Alzheimer via modulating oxidative burden and TLR-4\/MAPK pathways and regulation microRNA in rat brain","volume":"14","author":"Nawar","year":"2025","journal-title":"Toxicology Research"},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb1075","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neulet.2010.12.008","article-title":"Association between late-onset Alzheimer's disease and microsatellite polymorphisms in intron II of the human toll-like receptor 2 gene","volume":"489","author":"Wang","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb1080","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.3892\/mmr.2015.3968","article-title":"A single nucleotide polymorphism in primary-microRNA-146a reduces the expression of mature microRNA-146a in patients with Alzheimer's disease and is associated with the pathogenesis of Alzheimer's disease","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2026.116285_bb1085","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.expneurol.2018.07.016","article-title":"Increased expression of toll-like receptor 3, an anti-viral signaling molecule, and related genes in Alzheimer's disease brains","volume":"309","author":"Walker","year":"2018","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13195-023-01186-w","article-title":"Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer\u2019s disease in APP\/PS1 mouse","volume":"15","author":"Wang","year":"2023","journal-title":"Alzheimer's Res. Ther."},{"key":"10.1016\/j.intimp.2026.116285_bb1095","first-page":"1","article-title":"Late-Stage Activation of Toll-like receptor 3 Alleviates Cognitive Impairment and Neuropathology in an Alzheimer\u2019s Disease Mouse Model","author":"Zhu","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1100","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12035-014-8995-z","article-title":"Immunomodulatory effect of toll-like receptor-3 ligand poly I: C on cortical spreading depression","volume":"53","author":"Ghaemi","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.intimp.2026.116285_bb1105","first-page":"8342","article-title":"Neuroinflammation in Alzheimer\u2019s disease: chemokines produced by astrocytes and chemokine receptors","volume":"7","author":"Liu","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.intimp.2026.116285_bb1110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155065","article-title":"Ginsenoside-Re inhibits experimental autoimmune encephalomyelitis as a mouse model of multiple sclerosis by downregulating TLR4\/MyD88\/NF-\u03baB signaling pathways","volume":"122","author":"Oh","year":"2024","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb1115","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/ptr.8006","article-title":"Acteoside ameliorates learning and memory impairment in APP\/PS1 transgenic mice by increasing A\u03b2 degradation and inhibiting tau hyperphosphorylation","volume":"38","author":"Gao","year":"2024","journal-title":"Phytother. Res."},{"issue":"1-2","key":"10.1016\/j.intimp.2026.116285_bb1120","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jneuroim.2009.05.018","article-title":"Synergy of TRIF-dependent TLR3 and MyD88-dependent TLR7 in up-regulating expression of mouse FPR2, a promiscuous G-protein-coupled receptor, in microglial cells","volume":"213","author":"Chen","year":"2009","journal-title":"J. Neuroimmunol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116285_bb1125","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1177\/0960327118755256","article-title":"Thymoquinone alleviates the experimentally induced Alzheimer\u2019s disease inflammation by modulation of TLRs signaling","volume":"37","author":"Abulfadl","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"issue":"32","key":"10.1016\/j.intimp.2026.116285_bb1130","doi-asserted-by":"crossref","first-page":"13415","DOI":"10.1074\/jbc.M117.784983","article-title":"Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration","volume":"292","author":"Shmuel-Galia","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"6725","key":"10.1016\/j.intimp.2026.116285_bb1135","doi-asserted-by":"crossref","DOI":"10.1126\/science.adk7844","article-title":"Tlr7 drives sex differences in age-and Alzheimer\u2019s disease\u2013related demyelination","volume":"386","author":"Lopez-Lee","year":"2024","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.intimp.2026.116285_bb1140","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1038\/s41380-023-02166-0","article-title":"Mutated Toll-like receptor 9 increases Alzheimer\u2019s disease risk by compromising innate immunity protection","volume":"28","author":"Cacace","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1145","first-page":"101","article-title":"Amyloid \u03b2 and Tau Alzheimer\u2019s disease related pathology is reduced by Toll-like receptor 9 stimulation","volume":"2","author":"Scholtzova","year":"2014","journal-title":"Acta neuropathologica communications"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1150","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1186\/1742-2094-10-101","article-title":"Toll-like receptor 9 promoter polymorphism is associated with decreased risk of Alzheimer\u2019s disease in Han Chinese","volume":"10","author":"Wang","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116285_bb1155","doi-asserted-by":"crossref","unstructured":"Zhang, M.-j., et al., NLRP1 inflammasome in neurodegenerative disorders: From pathology to therapies. Cytokine Growth Factor Rev., 2024. 80: p. 138-155.","DOI":"10.1016\/j.cytogfr.2024.10.004"},{"key":"10.1016\/j.intimp.2026.116285_bb1160","doi-asserted-by":"crossref","first-page":"1122586","DOI":"10.3389\/fimmu.2023.1122586","article-title":"The role of NOD-like receptors in innate immunity","volume":"14","author":"Almeida-da-Silva","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb1165","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-\u03b2","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"issue":"16","key":"10.1016\/j.intimp.2026.116285_bb1170","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3390\/cells13161365","article-title":"Implication of the LRR Domain in the Regulation and Activation of the NLRP3 Inflammasome","volume":"13","author":"Cescato","year":"2024","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1175","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb1180","doi-asserted-by":"crossref","first-page":"673","DOI":"10.26502\/acbr.50170279","article-title":"Translational and clinical significance of DAMPs, PAMPs, and PRRs in trauma-induced inflammation","volume":"6","author":"Rai","year":"2022","journal-title":"Archives of clinical and biomedical research"},{"issue":"24","key":"10.1016\/j.intimp.2026.116285_bb1185","doi-asserted-by":"crossref","first-page":"13397","DOI":"10.3390\/ijms222413397","article-title":"Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-I-like receptors (RLRs) in innate immunity. TLRs, NLRs, and RLRs ligands as immunotherapeutic agents for hematopoietic diseases","volume":"22","author":"Wicherska-Paw\u0142owska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb1190","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1007\/s12264-023-01023-y","article-title":"NLRP3 inflammasome-mediated neuroinflammation and related mitochondrial impairment in Parkinson\u2019s disease","volume":"39","author":"Han","year":"2023","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.intimp.2026.116285_bb1195","first-page":"1","article-title":"Mitochondrial dysfunction and NLRP3 inflammasome activation in drug-resistant epilepsy: emerging insights and mitochondrial-targeted therapeutic strategies","author":"Khedpande","year":"2025","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1200","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1152\/physrev.00009.2014","article-title":"NOD-like receptors: versatile cytosolic sentinels","volume":"95","author":"Motta","year":"2015","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1205","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12974-025-03360-3","article-title":"Innate immune sensors and regulators at the blood brain barrier: focus on toll-like receptors and inflammasomes as mediators of neuro-immune crosstalk and inflammation","volume":"22","author":"Acioglu","year":"2025","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116285_bb1210","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.894298","article-title":"Focus on the role of the NLRP3 inflammasome in multiple sclerosis: pathogenesis, diagnosis, and therapeutics","volume":"15","author":"Cui","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.intimp.2026.116285_bb1215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fnint.2020.00037","article-title":"Key mechanisms and potential targets of the NLRP3 inflammasome in neurodegenerative diseases","volume":"14","author":"Guan","year":"2020","journal-title":"Front. Integr. Neurosci."},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb1220","doi-asserted-by":"crossref","first-page":"e2984","DOI":"10.1038\/cddis.2017.390","article-title":"Lytic cell death induced by melittin bypasses pyroptosis but induces NLRP3 inflammasome activation and IL-1\u03b2 release","volume":"8","author":"Mart\u00edn-S\u00e1nchez","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116285_bb1225","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108719","article-title":"Mitochondrial DNA in NLRP3 inflammasome activation","volume":"108","author":"Qiu","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"43","key":"10.1016\/j.intimp.2026.116285_bb1230","article-title":"Regulation of \u03b1-synuclein homeostasis and inflammasome activation by microglial autophagy. Science","volume":"8","author":"Choi","year":"2022","journal-title":"Advances"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1235","article-title":"Collaborative action of toll-like and NOD-like receptors as modulators of the inflammatory response to pathogenic bacteria","volume":"2014","author":"Oviedo-Boyso","year":"2014","journal-title":"Mediat. Inflamm."},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb1240","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00898-19","article-title":"NOD1 and NOD2 activation by diverse stimuli: a possible role for sensing pathogen-induced endoplasmic reticulum stress","volume":"88","author":"Kuss-Duerkop","year":"2020","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb1245","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4110\/in.2017.17.2.77","article-title":"Mitochondrial control of innate immunity and inflammation","volume":"17","author":"Jin","year":"2017","journal-title":"Immune Netw."},{"issue":"12","key":"10.1016\/j.intimp.2026.116285_bb1250","article-title":"From inflammatory signaling to neuronal damage: Exploring NLR inflammasomes in ageing neurological disorders","volume":"10","author":"Zhang","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.intimp.2026.116285_bb1255","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fncel.2019.00073","article-title":"The potential role of the NLRP3 inflammasome activation as a link between mitochondria ROS generation and neuroinflammation in postoperative cognitive dysfunction","volume":"13","author":"Wei","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.intimp.2026.116285_bb1260","doi-asserted-by":"crossref","first-page":"1305933","DOI":"10.3389\/fimmu.2023.1305933","article-title":"Immunological dimensions of neuroinflammation and microglial activation: Exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression","volume":"14","author":"Fornari Laurindo","year":"2024","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116285_bb1265","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41583-018-0055-7","article-title":"Inflammasome signalling in brain function and neurodegenerative disease","volume":"19","author":"Heneka","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb1270","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116285_bb1275","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.tibs.2025.07.007","article-title":"How interactions between oxidized DNA and the NLRP3 inflammasome fuel inflammatory disease","volume":"50","author":"Lackner","year":"2025","journal-title":"Trends Biochem. Sci."},{"issue":"30","key":"10.1016\/j.intimp.2026.116285_bb1280","doi-asserted-by":"crossref","first-page":"25030","DOI":"10.1074\/jbc.M112.378323","article-title":"Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity","volume":"287","author":"Finger","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1285","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1038\/ncomms4209","article-title":"Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation","volume":"5","author":"Van Opdenbosch","year":"2014","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb1290","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/prot.24287","article-title":"Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1","volume":"81","author":"Jin","year":"2013","journal-title":"Proteins: Structure, Function, and Bioinformatics"},{"key":"10.1016\/j.intimp.2026.116285_bb1295","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.863774","article-title":"NLRP1 inflammasomes: a potential target for the treatment of several types of brain injury","volume":"13","author":"Mi","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb1300","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/00207454.2013.833510","article-title":"Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease","volume":"124","author":"Cai","year":"2014","journal-title":"Int. J. Neurosci."},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb1305","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3390\/biom14030302","article-title":"Increased NLRP1 mRNA and protein expression suggests inflammasome activation in the dorsolateral prefrontal and medial orbitofrontal cortex in schizophrenia","volume":"14","author":"\u0160pani\u0107 Popova\u010dki","year":"2024","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb1310","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/WAD.0b013e318231a8ac","article-title":"NALP1\/NLRP1 genetic variants are associated with Alzheimer disease","volume":"26","author":"Pontillo","year":"2012","journal-title":"Alzheimer Dis. Assoc. Disord."},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb1315","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/08916934.2013.768617","article-title":"Polymorphisms in NLRP1 gene and susceptibility to autoimmune thyroid disease","volume":"46","author":"Alkhateeb","year":"2013","journal-title":"Autoimmunity"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1320","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13024-016-0088-1","article-title":"The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer\u2019s disease","volume":"11","author":"Saresella","year":"2016","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1325","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12993-021-00185-x","article-title":"NLRP1 inflammasome involves in learning and memory impairments and neuronal damages during aging process in mice","volume":"17","author":"Sun","year":"2021","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.intimp.2026.116285_bb1330","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.freeradbiomed.2023.05.011","article-title":"Chronic hypoxia of endothelial cells boosts HIF-1\u03b1-NLRP1 circuit in Alzheimer's disease","volume":"204","author":"Jung","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb1335","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41418-021-00881-1","article-title":"Therapeutic potential of Nlrp1 inflammasome, Caspase-1, or Caspase-6 against Alzheimer disease cognitive impairment","volume":"29","author":"Flores","year":"2022","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1340","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12993-023-00209-8","article-title":"Inhibition of NLRP1 inflammasome improves autophagy dysfunction and A\u03b2 disposition in APP\/PS1 mice","volume":"19","author":"Li","year":"2023","journal-title":"Behav. Brain Funct."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1345","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10571-025-01579-5","article-title":"Pyroptosis in Alzheimer's Disease: Mechanisms and Therapeutic Potential","volume":"45","author":"Tang","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.intimp.2026.116285_bb1350","doi-asserted-by":"crossref","DOI":"10.4103\/1673-5374.391311","article-title":"NLRP3\/1-mediated pyroptosis: beneficial clues for the development of novel therapies for Alzheimer\u2019s disease","volume":"19","author":"Hu","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2026.116285_bb1355","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cytogfr.2024.10.004","article-title":"NLRP1 inflammasome in neurodegenerative disorders: From pathology to therapies","volume":"80","author":"Zhang","year":"2024","journal-title":"Cytokine Growth Factor Rev."},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb1360","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"64","key":"10.1016\/j.intimp.2026.116285_bb1365","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abj3859","article-title":"NLRP3 inflammasome activation triggers gasdermin D-independent inflammation","volume":"6","author":"Wang","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.intimp.2026.116285_bb1370","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.3389\/fimmu.2020.01595","article-title":"The NLRP3 inflammasome and its role in T1DM","volume":"11","author":"Sun","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1375","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41392-023-01687-y","article-title":"The role of inflammasomes in human diseases and their potential as therapeutic targets","volume":"9","author":"Yao","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb1380","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3233\/JAD-210268","article-title":"NLRP3 Inflammasome: A Starring Role in Amyloid-\u03b2- and Tau-Driven Pathological Events in Alzheimer's Disease","volume":"83","author":"Van Zeller","year":"2021","journal-title":"J. Alzheimer's Dis"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1385","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s11658-023-00462-9","article-title":"The NLRP3 inflammasome: contributions to inflammation-related diseases","volume":"28","author":"Chen","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb1390","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1124\/pharmrev.122.000629","article-title":"Pharmacological Inhibition of the NLRP3 Inflammasome: Structure, Molecular Activation, and Inhibitor-NLRP3 Interaction","volume":"75","author":"Ma","year":"2023","journal-title":"Pharmacol. Rev."},{"issue":"13","key":"10.1016\/j.intimp.2026.116285_bb1395","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"16","key":"10.1016\/j.intimp.2026.116285_bb1400","article-title":"Monocyte NLRP3-IL-1\u03b2 Hyperactivation Mediates Neuronal and Synaptic Dysfunction in Perioperative Neurocognitive Disorder","volume":"9","author":"Chen","year":"2022","journal-title":"Adv Sci (Weinh)"},{"issue":"13","key":"10.1016\/j.intimp.2026.116285_bb1405","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1016\/j.celrep.2017.12.018","article-title":"The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity","volume":"21","author":"Schneider","year":"2017","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1410","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s44400-025-00011-5","article-title":"Post-symptomatic NLRP3 inhibition rescues cognitive impairment and mitigates amyloid and tau driven neurodegeneration. npj","volume":"1","author":"Auger","year":"2025","journal-title":"Dementia"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1415","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12974-024-03325-y","article-title":"Chemerin-9 is neuroprotective in APP\/PS1 transgenic mice by inhibiting NLRP3 inflammasome and promoting microglial clearance of A\u03b2","volume":"22","author":"Zhang","year":"2025","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116285_bb1420","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2025.138300","article-title":"Masitinib attenuates neuropathological changes in acrolein-induced sAD mouse model via NF-\u03baB\/NLRP3\/Caspase-1 signaling pathway","volume":"862","author":"Jia","year":"2025","journal-title":"Neurosci. Lett."},{"issue":"7964","key":"10.1016\/j.intimp.2026.116285_bb1425","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41586-023-06120-6","article-title":"Myelin dysfunction drives amyloid-\u03b2 deposition in models of Alzheimer's disease","volume":"618","author":"Depp","year":"2023","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1430","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s40478-023-01593-y","article-title":"DHCR24 reverses Alzheimer's disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice","volume":"11","author":"Zhang","year":"2023","journal-title":"Acta Neuropathol Commun"},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb1435","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jgr.2025.02.002","article-title":"Korean black ginseng extract alleviates Alzheimer's disease-related cognitive impairment by activating the Nrf2\/HO-1 pathway and suppressing the p38 MAPK\/NF-\u03baB\/STAT3 pathways and NLRP3 inflammasome via TLR2 and TLR4 modulation","volume":"49","author":"Ha","year":"2025","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.intimp.2026.116285_bb1440","first-page":"1","article-title":"NLRP3 inflammasome in neuroinflammation and central nervous system diseases","author":"Xu","year":"2025","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1445","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/mi.2009.124","article-title":"The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis","volume":"3","author":"Lavelle","year":"2010","journal-title":"Mucosal Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb1450","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/intimm\/dxp017","article-title":"The roles of TLRs, RLRs and NLRs in pathogen recognition","volume":"21","author":"Kawai","year":"2009","journal-title":"Int. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb1455","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2016.03.046","article-title":"Inflammasome Complexes: Emerging Mechanisms and Effector Functions","volume":"165","author":"Rathinam","year":"2016","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1460","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41467-024-44990-0","article-title":"Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1\u03b2 production","volume":"15","author":"Molina-L\u00f3pez","year":"2024","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb1465","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2025.105903","article-title":"Dysregulation of inflammasomes in autoinflammatory diseases","volume":"92","author":"Hou","year":"2025","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.intimp.2026.116285_bb1470","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fimmu.2014.00099","article-title":"DAMP-Mediated Activation of NLRP3-Inflammasome in Brain Sterile Inflammation: The Fine Line between Healing and Neurodegeneration","volume":"5","author":"Rubartelli","year":"2014","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb1475","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.it.2011.05.004","article-title":"NLRP3 inflammasomes link inflammation and metabolic disease","volume":"32","author":"De Nardo","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.intimp.2026.116285_bb1480","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.796867","article-title":"The impact of systemic inflammation on Alzheimer\u2019s disease pathology","volume":"12","author":"Xie","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb1485","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/cns.13086","article-title":"Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP 3 inflammasomes and TLR 4\/NF-\u03baB signaling pathway","volume":"25","author":"Jin","year":"2019","journal-title":"CNS Neuroscience & Therapeutics"},{"issue":"11","key":"10.1016\/j.intimp.2026.116285_bb1490","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23116354","article-title":"Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4\/NF-\u03baB Signaling","volume":"23","author":"Zhao","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116285_bb1495","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109994","article-title":"Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1\/NF-\u03baB pathway in a triple transgenic mouse model","volume":"118","author":"Xie","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116285_bb1500","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172857","article-title":"Geniposidic acid ameliorates spatial learning and memory deficits and alleviates neuroinflammation via inhibiting HMGB-1 and downregulating TLR4\/2 signaling pathway in APP\/PS1 mice","volume":"869","author":"Zhou","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb1505","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/cns.13086","article-title":"Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4\/NF-\u03baB signaling pathway","volume":"25","author":"Jin","year":"2019","journal-title":"CNS Neurosci Ther"},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb1510","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s11064-020-03198-6","article-title":"Platycodin D Inhibits \u03b2-Amyloid-Induced Inflammation and Oxidative Stress in BV-2 Cells Via Suppressing TLR4\/NF-\u03baB Signaling Pathway and Activating Nrf2\/HO-1 Signaling Pathway","volume":"46","author":"Zhang","year":"2021","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1515","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12017-022-08717-y","article-title":"Phenylethanoid Glycosides of Cistanche Improve Learning and Memory Disorders in APP\/PS1 Mice by Regulating Glial Cell Activation and Inhibiting TLR4\/NF-\u03baB Signaling Pathway","volume":"25","author":"Wang","year":"2023","journal-title":"NeuroMolecular Med."},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb1520","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0286086","article-title":"Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer's disease mice via suppressing TLR4 signaling pathway through the gut-brain axis","volume":"18","author":"Su","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2026.116285_bb1525","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110037","article-title":"Dihydromyricetin suppresses inflammatory injury in microglial cells to improve neurological behaviors of Alzheimer's disease mice via the TLR4\/MD2 signal","volume":"118","author":"Pei","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116285_bb1530","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104713","article-title":"The S1P receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases A\u03b2 clearance in 5XFAD mice","volume":"94","author":"Zhu","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.intimp.2026.116285_bb1535","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116190","article-title":"Sinomenine regulates the cholinergic anti-inflammatory pathway to inhibit TLR4\/NF-\u03baB pathway and protect the homeostasis in brain and gut in scopolamine-induced Alzheimer's disease mice","volume":"171","author":"Ni","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb1540","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1002\/ptr.8219","article-title":"Pomegranate polyphenol punicalin ameliorates lipopolysaccharide-induced memory impairment, behavioral disorders, oxidative stress, and neuroinflammation via inhibition of TLR4-NF-\u043aB pathway","volume":"38","author":"Chen","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2026.116285_bb1545","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.110006","article-title":"Edaravone Dexborneol ameliorates the cognitive deficits of APP\/PS1 mice by inhibiting TLR4\/MAPK signaling pathway via upregulating TREM2","volume":"255","author":"Wang","year":"2024","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.intimp.2026.116285_bb1550","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149019","article-title":"Neuroprotective effect of emodin on A\u03b2(25-35)-induced cytotoxicity in PC12 cells involves Nrf2\/GPX4 and TLR4\/p-NF-\u03baB\/NLRP3 pathways","volume":"1841","author":"Xia","year":"2024","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb1555","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1177\/13872877251329439","article-title":"Semaglutide improves cognitive function and neuroinflammation in APP\/PS1 transgenic mice by activating AMPK and inhibiting TLR4\/NF-\u03baB pathway","volume":"105","author":"Zhai","year":"2025","journal-title":"J. Alzheimer's Dis"},{"key":"10.1016\/j.intimp.2026.116285_bb1560","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.biopha.2018.10.201","article-title":"Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4\/MyD88\/NF-\u03baB pathway in rats","volume":"111","author":"Zhou","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb1565","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/kjm2.12797","article-title":"miR-107-5p ameliorates neurological damage, oxidative stress, and immune responses in mice with Alzheimer's disease by suppressing the Toll-like receptor 4 (TLR4)\/nuclear factor-kappaB(NF-\u03baB) pathway","volume":"40","author":"Hu","year":"2024","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb1570","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/15376516.2024.2329653","article-title":"Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: possible involvement of toll-like receptor 4","volume":"34","author":"Saxena","year":"2024","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.intimp.2026.116285_bb1575","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118651","article-title":"Notopterygium incisum roots extract (NRE) alleviates neuroinflammation pathology in Alzheimer's disease through TLR4-NF-\u03baB pathway","volume":"335","author":"Zhu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2026.116285_bb1580","doi-asserted-by":"crossref","first-page":"1443552","DOI":"10.3389\/fphar.2024.1443552","article-title":"Kojic acid reverses LPS-induced neuroinflammation and cognitive impairment by regulating the TLR4\/NF-\u03baB signaling pathway","volume":"15","author":"Ali","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"Pt 1","key":"10.1016\/j.intimp.2026.116285_bb1585","article-title":"Extract of Tinospora sinensis alleviates LPS-induced neuroinflammation in mice by regulating TLR4\/NF-\u03baB\/NLRP3 signaling pathway","volume":"337","author":"Xie","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb1590","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2174\/0118715273337232241121113048","article-title":"Anti-neuroinflammatory and Neuroprotective Effects of T-006 on Alzheimer's Disease Models by Modulating TLR4-Mediated MyD88\/ NF-\u03baB Signaling","volume":"24","author":"Chen","year":"2025","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb1595","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s11011-025-01672-0","article-title":"Mechanistic study on ligustilide modulation of the TLR4\/NF-\u03baB pathway in ameliorating Scopolamine-Induced cognitive impairment","volume":"40","author":"Zhang","year":"2025","journal-title":"Metab. Brain Dis."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb1600","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/cns.14082","article-title":"Aurantiamide suppresses the activation of NLRP3 inflammasome to improve the cognitive function and central inflammation in mice with Alzheimer's disease","volume":"29","author":"Shen","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.intimp.2026.116285_bb1605","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156928","article-title":"Ciliatoside A attenuates neuroinflammation in Alzheimer's disease by activating mitophagy and inhibiting NLRP3 inflammasome activation","volume":"145","author":"Guo","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116285_bb1610","doi-asserted-by":"crossref","first-page":"1662336","DOI":"10.3389\/fphar.2025.1662336","article-title":"Cistanche tubulosa glycosides ameliorate cognitive decline in APP\/PS1 mice via modulation of gut microbiota and fatty acid metabolism: insights from multi-omics and experimental validation","volume":"16","author":"Hou","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116285_bb1615","series-title":"Repositioning Canagliflozin for Mitigation of Aluminium Chloride-Induced Alzheimer's Disease: Involvement of TXNIP\/NLRP3 Inflammasome Axis, Mitochondrial Dysfunction, and SIRT1\/HMGB1 Signalling. Medicina (Kaunas)","volume":"60(11)","author":"Elariny","year":"2024"},{"issue":"10","key":"10.1016\/j.intimp.2026.116285_bb1620","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/jdi.14292","article-title":"Calpeptin improves the cognitive function in Alzheimer's disease-like complications of diabetes mellitus rats by regulating TXNIP\/NLRP3 inflammasome","volume":"15","author":"Qiao","year":"2024","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.intimp.2026.116285_bb1625","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116993","article-title":"Design, synthesis, and pharmacological characterization of sulfonylurea-based NLRP3 inhibitors: Towards an effective therapeutic strategy for Alzheimer's disease","volume":"280","author":"Lyu","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.intimp.2026.116285_bb1630","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177875","article-title":"The potential mitigating effect of febuxostat alone or with donepezil on scopolamine-induced Alzheimer's disease in rats: The role of TXNIP\/NLRP3 inflammasome signaling pathway","volume":"1002","author":"Taha","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116285_bb1635","doi-asserted-by":"crossref","first-page":"1617564","DOI":"10.3389\/fonc.2025.1617564","article-title":"NAP1L5 in acute myeloid leukemia: a prognostic biomarker and potential therapeutic target","volume":"15","author":"Wang","year":"2025","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb1640","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/bph.17373","article-title":"Dihydro-resveratrol ameliorates NLRP3 inflammasome-mediated neuroinflammation via Bnip3-dependent mitophagy in Alzheimer's disease","volume":"182","author":"Tao","year":"2025","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116285_bb1645","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149236","article-title":"Emoxypine succinate modulates behavioral and molecular responses in zebrafish model of iron Overload-Induced neuroinflammation via CDK5\/GSK3- \u03b2 and NLRP3 inflammasome pathway","volume":"1846","author":"Bagwe Parab","year":"2025","journal-title":"Brain Res."},{"key":"10.1016\/j.intimp.2026.116285_bb1650","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbi.2023.11.031","article-title":"MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer's disease","volume":"116","author":"Naeem","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2026.116285_bb1655","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148687","article-title":"Ellis extract attenuates memory impairment in rats with Alzheimer's disease by suppressing NLRP3 inflammasome","volume":"1824","author":"Wang","year":"2024","journal-title":"Brain Res."},{"key":"10.1016\/j.intimp.2026.116285_bb1660","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2023.102260","article-title":"Salvianolic acid B exerts protective effects against A\u03b2-induced neuroinflammation through the inhibition of NLRP3 inflammasome activation and switching of M1\/M2 polarization","volume":"85","author":"Zhao","year":"2023","journal-title":"Tissue Cell"},{"issue":"19","key":"10.1016\/j.intimp.2026.116285_bb1665","doi-asserted-by":"crossref","first-page":"10237","DOI":"10.18632\/aging.205072","article-title":"Ginkgolide attenuates memory impairment and neuroinflammation by suppressing the NLRP3\/caspase-1 pathway in Alzheimer's disease","volume":"15","author":"Liu","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.intimp.2026.116285_bb1670","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110287","article-title":"Parthenolide alleviates microglia-mediated neuroinflammation via MAPK\/TRIM31\/NLRP3 signaling to ameliorate cognitive disorder","volume":"120","author":"Fan","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116285_bb1675","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2023.112192","article-title":"Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease","volume":"177","author":"Karaji","year":"2023","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.intimp.2026.116285_bb1680","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110181","article-title":"The potential effects of festidinol treatment against the NLRP3 inflammasome and pyroptosis in D-galactose and aluminum chloride-induced Alzheimer's-like pathology in mouse brain","volume":"119","author":"Wongpun","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116285_bb1685","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154801","article-title":"Myricetin improves pathological changes in 3\u00d7Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway","volume":"115","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.intimp.2026.116285_bb1690","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s10787-023-01201-4","article-title":"Chrysophanol exerts a protective effect against A\u03b2(25-35)-induced Alzheimer's disease model through regulating the ROS\/TXNIP\/NLRP3 pathway","volume":"31","author":"Zhang","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2026.116285_bb1695","doi-asserted-by":"crossref","first-page":"8099459","DOI":"10.1155\/2022\/8099459","article-title":"Melatonin Ameliorates the Progression of Alzheimer's Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome Activity","volume":"2022","author":"Fan","year":"2022","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1700","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s12951-022-01524-4","article-title":"Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition","volume":"20","author":"Ruan","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.intimp.2026.116285_bb1705","first-page":"27(8)","article-title":"Eriodictyol and Homoeriodictyol Improve Memory Impairment in A\u03b2(25-35)-Induced Mice by Inhibiting the NLRP3 Inflammasome","author":"Guo","year":"2022","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb1710","first-page":"540","article-title":"miR-212-3p attenuates neuroinflammation of rats with Alzheimer's disease via regulating the SP1\/BACE1\/NLRP3\/Caspase-1 signaling pathway","volume":"22","author":"Nong","year":"2022","journal-title":"Bosn J Basic Med Sci"},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb1715","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11011-021-00886-2","article-title":"Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease","volume":"37","author":"Shao","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.intimp.2026.116285_bb1720","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106263","article-title":"CSB6B prevents \u03b2-amyloid-associated neuroinflammation and cognitive impairments via inhibiting NF-\u03baB and NLRP3 in microglia cells","volume":"81","author":"Yan","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb1725","doi-asserted-by":"crossref","first-page":"7053","DOI":"10.1002\/jcb.27023","article-title":"Pterostilbene inhibits amyloid-\u03b2-induced neuroinflammation in a microglia cell line by inactivating the NLRP3\/caspase-1 inflammasome pathway","volume":"119","author":"Li","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1730","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1124\/mol.110.068064","article-title":"TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules","volume":"79","author":"Matsunaga","year":"2011","journal-title":"Mol. Pharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb1735","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1007\/s10753-024-02028-z","article-title":"Resatorvid (TAK-242) ameliorates ulcerative colitis by modulating macrophage polarization and T helper cell balance via TLR4\/JAK2\/STAT3 signaling pathway","volume":"47","author":"Huang","year":"2024","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb1740","doi-asserted-by":"crossref","first-page":"178160","DOI":"10.1016\/j.ejphar.2025.178160","article-title":"Resatorvid as a Promising Neuroprotective Agent in Pentylenetetrazol-Kindling Rat Model: Suppressing Neuroinflammation and Enhancing Cognitive and Motor Functions","volume":"1006","author":"Zidan","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116285_bb1745","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107368","article-title":"TAK-242 ameliorates olfactory dysfunction in a mouse model of allergic rhinitis by inhibiting neuroinflammation in the olfactory bulb","volume":"92","author":"Lv","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116285_bb1750","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3389\/fnins.2020.00444","article-title":"Inhibition of TLR4 induces M2 microglial polarization and provides neuroprotection via the NLRP3 inflammasome in Alzheimer\u2019s disease","volume":"14","author":"Cui","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2026.116285_bb1755","first-page":"1","article-title":"The mechanism of Yizhi Qingxin formula to improve neuroinflammation in Alzheimer\u2019s disease by regulating the TLR4\/NF-\u03baB\/NLRP3 pathway","author":"Chen","year":"2025","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"5","key":"10.1016\/j.intimp.2026.116285_bb1760","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.21037\/jtd-23-360","article-title":"TAK-242 protects against oxygen-glucose deprivation and reoxygenation-induced injury in brain microvascular endothelial cells and alters the expression pattern of lncRNAs","volume":"15","author":"Kong","year":"2023","journal-title":"J Thorac Dis"},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb1765","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.3390\/cells9071655","article-title":"Regorafenib regulates AD pathology, neuroinflammation, and dendritic spinogenesis in cells and a mouse model of AD","volume":"9","author":"Han","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1770","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s12974-018-1340-0","article-title":"TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity","volume":"15","author":"Moser","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb1775","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1097\/CCM.0b013e3181e7c5c9","article-title":"A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis","volume":"38","author":"Rice","year":"2010","journal-title":"Crit. Care Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb1780","doi-asserted-by":"crossref","DOI":"10.1177\/1559325818761455","article-title":"The neuroprotective effects of thymoquinone: a review","volume":"16","author":"Farkhondeh","year":"2018","journal-title":"Dose-response"},{"key":"10.1016\/j.intimp.2026.116285_bb1785","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fnagi.2018.00016","article-title":"Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease","volume":"10","author":"Cascella","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.intimp.2026.116285_bb1790","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153324","article-title":"Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1\u201342 infused rat model","volume":"79","author":"Elibol","year":"2020","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb1795","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bbrc.2012.11.139","article-title":"Thymoquinone protects cultured rat primary neurons against amyloid \u03b2-induced neurotoxicity","volume":"433","author":"Alhebshi","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb1800","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/01616412.2018.1441776","article-title":"Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes","volume":"40","author":"Abulfadl","year":"2018","journal-title":"Neurol. Res."},{"key":"10.1016\/j.intimp.2026.116285_bb1805","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.biopha.2018.01.047","article-title":"Thymoquinone activates MAPK pathway in hippocampus of streptozotocin-treated rat model","volume":"99","author":"Dalli","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.intimp.2026.116285_bb1810","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/24750573.2019.1673945","article-title":"Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the A \u03b2 (1\u201342)-infused rat model of Alzheimer's disease","volume":"29","author":"Elibol","year":"2019","journal-title":"Psychiatry and Clinical Psychopharmacology"},{"issue":"6","key":"10.1016\/j.intimp.2026.116285_bb1815","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1002\/ptr.8200","article-title":"Neuroprotective and anti-inflammatory effects of curcumin in Alzheimer's disease: targeting neuroinflammation strategies","volume":"38","author":"Azzini","year":"2024","journal-title":"Phytother. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1820","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3390\/ijms22010196","article-title":"Curcumin and its derivatives as theranostic agents in Alzheimer\u2019s disease: The implication of nanotechnology","volume":"22","author":"Shabbir","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116285_bb1825","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.neulet.2015.03.045","article-title":"Curcumin inhibits A\u03b2-induced microglial inflammatory responses in vitro: Involvement of ERK1\/2 and p38 signaling pathways","volume":"594","author":"Shi","year":"2015","journal-title":"Neurosci. Lett."},{"issue":"18","key":"10.1016\/j.intimp.2026.116285_bb1830","doi-asserted-by":"crossref","first-page":"8947","DOI":"10.1111\/jcmm.16855","article-title":"Curcumin improves memory deficits by inhibiting HMGB1-RAGE\/TLR4-NF-\u03baB signalling pathway in APPswe\/PS1dE9 transgenic mice hippocampus","volume":"25","author":"Han","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb1835","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1093\/jpp\/rgaf034","article-title":"Curcuma longa L. extract and residue prevent Alzheimer\u2019s disease in mice by regulating microglia and TLR4\/NF-\u03ba B signaling pathway","volume":"77","author":"Xu","year":"2025","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1840","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: lessons learned from clinical trials","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J."},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb1845","doi-asserted-by":"crossref","DOI":"10.1016\/j.tjpad.2025.100248","article-title":"Targeting cognitive aging with curcumin supplementation: A systematic review and meta-analysis","volume":"12","author":"Yu","year":"2025","journal-title":"The Journal of Prevention of Alzheimer's Disease"},{"issue":"13","key":"10.1016\/j.intimp.2026.116285_bb1850","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.3390\/nu14132647","article-title":"Bioavailability of hesperidin and its aglycone hesperetin\u2014compounds found in citrus fruits as a parameter conditioning the pro-health potential (neuroprotective and antidiabetic activity)\u2014mini-review","volume":"14","author":"Wdowiak","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2026.116285_bb1855","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2024.106206","article-title":"Comprehensive review of Hesperetin: Advancements in pharmacokinetics, pharmacological effects, and novel formulations","volume":"179","author":"Song","year":"2024","journal-title":"Fitoterapia"},{"key":"10.1016\/j.intimp.2026.116285_bb1860","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103428","article-title":"A\u03b21-42 promotes microglial activation and apoptosis in the progression of AD by binding to TLR4","volume":"78","author":"Dou","year":"2024","journal-title":"Redox Biol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb1865","doi-asserted-by":"crossref","first-page":"6293","DOI":"10.1007\/s12035-019-1512-7","article-title":"Hesperetin confers neuroprotection by regulating Nrf2\/TLR4\/NF-\u03baB signaling in an A\u03b2 mouse model","volume":"56","author":"Ikram","year":"2019","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb1870","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3390\/antiox10071003","article-title":"Hesperetin nanocrystals improve mitochondrial function in a cell model of early Alzheimer disease","volume":"10","author":"Babylon","year":"2021","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.intimp.2026.116285_bb1875","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3390\/brainsci13081144","article-title":"Involvement of Nrf2 activation and NF-kB pathway inhibition in the antioxidant and anti-inflammatory effects of hesperetin in activated BV-2 microglial cells","volume":"13","author":"Evans","year":"2023","journal-title":"Brain Sciences"},{"issue":"7","key":"10.1016\/j.intimp.2026.116285_bb1880","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1007\/s11011-023-01250-2","article-title":"Hesperetin attenuates cognitive dysfunction via SIRT6\/NLRP3 pathway in scopolamine-induced mice","volume":"38","author":"Jing","year":"2023","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.intimp.2026.116285_bb1885","article-title":"Effects of hesperetin on dimethylsulphoxide induced cognitive dysfunction mediated through oxidative stress marker and neuroinflammation in hippocampus","volume":"8","author":"Yadav","year":"2023","journal-title":"Pharmacological Research-Modern Chinese Medicine"},{"key":"10.1016\/j.intimp.2026.116285_bb1890","doi-asserted-by":"crossref","first-page":"1425731","DOI":"10.3389\/fphar.2024.1425731","article-title":"Mitigating neurodegenerative diseases: the protective influence of baicalin and baicalein through neuroinflammation regulation","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116285_bb1895","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bbr.2016.05.052","article-title":"The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer\u2019s disease","volume":"311","author":"Gu","year":"2016","journal-title":"Behav. Brain Res."},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb1900","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/jnr.23244","article-title":"Baicalein reduces \u03b2-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer's disease transgenic mouse model","volume":"91","author":"Zhang","year":"2013","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1905","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12944-018-0797-2","article-title":"Baicalin reduces blood lipids and inflammation in patients with coronary artery disease and rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial","volume":"17","author":"Hang","year":"2018","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.intimp.2026.116285_bb1910","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.2147\/NDT.S117469","article-title":"Baicalein improves behavioral dysfunction induced by Alzheimer\u2019s disease in rats","author":"Zhou","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"9","key":"10.1016\/j.intimp.2026.116285_bb1915","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1021\/jm401006s","article-title":"Toll-like receptor 4 (TLR4) modulation by synthetic and natural compounds: an update: miniperspective","volume":"57","author":"Peri","year":"2014","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2026.116285_bb1920","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2552\/aaa03e","article-title":"Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance","volume":"15","author":"Hermann","year":"2018","journal-title":"J. Neural Eng."},{"issue":"1","key":"10.1016\/j.intimp.2026.116285_bb1925","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s13195-023-01330-6","article-title":"A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice","volume":"15","author":"Balu","year":"2023","journal-title":"Alzheimer's Res. Ther."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926001281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926001281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:21:12Z","timestamp":1776770472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926001281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":385,"alternative-id":["S1567576926001281"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116285","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unrevealing role of TLRs\/NLRP receptors in halting Alzheimer's neuroinflammation: Current progress and existing therapies","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116285","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116285"}}