{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:51:02Z","timestamp":1783147862922,"version":"3.54.6"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770527"],"award-info":[{"award-number":["81770527"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171700"],"award-info":[{"award-number":["82171700"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.intimp.2026.116323","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:33:45Z","timestamp":1770482025000},"page":"116323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["IGF-1 ameliorates the blood brain barrier disruption induced by the neonatal hypoxia-ischemia"],"prefix":"10.1016","volume":"173","author":[{"given":"Rui","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116323_bb0005","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fncel.2017.00078","article-title":"Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges","volume":"11","author":"Millar","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.intimp.2026.116323_bb0010","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0140-6736(05)71048-5","article-title":"4 million neonatal deaths: when? Where? Why?","volume":"365","author":"Lawn","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2026.116323_bb0015","doi-asserted-by":"crossref","first-page":"e1621","DOI":"10.1542\/peds.2006-1522","article-title":"Increasing prevalence of cerebral palsy among very preterm infants: a population-based study","volume":"118","author":"Vincer","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.intimp.2026.116323_bb0020","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jamapediatrics.2014.3269","article-title":"Hypoxic-ischemic encephalopathy: a review for the clinician","volume":"169","author":"Douglas-Escobar","year":"2015","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.intimp.2026.116323_bb0025","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41420-024-02014-2","article-title":"Regulated cell death in hypoxic-ischaemic encephalopathy: recent development and mechanistic overview","volume":"10","author":"Wu","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.intimp.2026.116323_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115356","article-title":"Potential pharmacological target of tight junctions to improve the BBB permeability in neonatal hypoxic-ischemic encephalopathy diseases","volume":"207","author":"Paz","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116323_bb0035","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.neuroimage.2018.07.057","article-title":"Neonatal brain injury and aberrant connectivity","volume":"185","author":"Smyser","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.intimp.2026.116323_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.03.004","article-title":"Angioneurins \u2013 key regulators of blood\u2013brain barrier integrity during hypoxic and ischemic brain injury","volume":"178","author":"Kunze","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.intimp.2026.116323_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1242936","article-title":"Early-stage effect of HIBD on neuro-motor function and organic composition of neurovascular units in neonatal rats","volume":"17","author":"Mo","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2026.116323_bb0050","first-page":"717","article-title":"Pathophysiology of the Neuroregulation of growth hormone secretion in experimental animals and the human","volume":"19","author":"Giustina","year":"1998","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.intimp.2026.116323_bb0055","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.3390\/ijms18112441","article-title":"Neurotrophic and neuroregenerative effects of GH\/IGF1","volume":"18","author":"Bianchi","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116323_bb0060","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fnins.2016.00052","article-title":"IGF-I: a key growth factor that regulates neurogenesis and synaptogenesis from embryonic to adult stages of the brain","volume":"10","author":"Nieto-Est\u00e9vez","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2026.116323_bb0065","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11357-006-9009-5","article-title":"Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice","volume":"28","author":"Sun","year":"2006","journal-title":"Age (Dordr.)"},{"key":"10.1016\/j.intimp.2026.116323_bb0070","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3390\/cells11040666","article-title":"Research progress on neuroprotection of insulin-like growth factor-1 towards glutamate-induced neurotoxicity","volume":"11","author":"Ge","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.116323_bb0075","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neubiorev.2016.01.001","article-title":"The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders","volume":"63","author":"Costales","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.intimp.2026.116323_bb0080","article-title":"Neuroprotection of IGF-1 in neonatal hypoxic-ischemic brain injury through downregulation of FoXO3a-PUMA pathway","volume":"19","author":"Tang","year":"2026","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.intimp.2026.116323_bb0085","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/jcbfm.2009.75","article-title":"Postischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke","volume":"29","author":"Zhu","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.intimp.2026.116323_bb0090","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.intimp.2026.116323_bb0095","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000085978","article-title":"Perinatal hypoxic-ischemic brain damage: evolution of an animal model","volume":"27","author":"Vannucci","year":"2005","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.intimp.2026.116323_bb0100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1089\/neu.1996.13.557","article-title":"An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficits","volume":"13","author":"Chen","year":"1996","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.intimp.2026.116323_bb0105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s12031-019-01326-8","article-title":"Oxygen-glucose deprivation\/reoxygenation induces human brain microvascular endothelial cell hyperpermeability via VE-cadherin internalization: roles of RhoA\/ROCK2","volume":"69","author":"Chen","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.intimp.2026.116323_bb0110","doi-asserted-by":"crossref","first-page":"7298","DOI":"10.1007\/s12035-015-9583-6","article-title":"bFGF protects against blood-brain barrier damage through junction protein regulation via PI3K-Akt-Rac1 pathway following traumatic brain injury","volume":"53","author":"Wang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2026.116323_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2025.100737","article-title":"Photoacoustic imaging detects cerebrovascular pathological changes in sepsis","volume":"44","author":"Wang","year":"2025","journal-title":"Photoacoustics"},{"key":"10.1016\/j.intimp.2026.116323_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1142644","article-title":"New insights on the cardiovascular effects of IGF-1","volume":"14","author":"Macvanin","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.intimp.2026.116323_bb0125","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ghir.2019.01.002","article-title":"IGF-1 and cardiovascular disease","volume":"45","author":"Higashi","year":"2019","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.intimp.2026.116323_bb0130","doi-asserted-by":"crossref","DOI":"10.3171\/CASE2523","article-title":"Managing malignant middle cerebral artery infarction with open scalp incision and partial hemispherectomy: illustrative case","volume":"10","author":"Olivares","year":"2025","journal-title":"J. Neurosurg. Case Lessons"},{"key":"10.1016\/j.intimp.2026.116323_bb0135","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11357-019-00065-3","article-title":"Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice","volume":"41","author":"Farias Quipildor","year":"2019","journal-title":"Geroscience"},{"key":"10.1016\/j.intimp.2026.116323_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/cns.70714","article-title":"Impaired WNT3\/IGF-1 signaling in dorsal dentate gyrus contributes to chronic pain-related cognitive impairment","volume":"31","author":"An","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2026.116323_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101245","article-title":"Insulin-like growth factors: ligands, binding proteins, and receptors","volume":"52","author":"LeRoith","year":"2021","journal-title":"Mol Metab."},{"key":"10.1016\/j.intimp.2026.116323_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1190869","article-title":"Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field","volume":"15","author":"Du","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.intimp.2026.116323_bb0155","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/01.CIR.101.6.660","article-title":"Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart","volume":"101","author":"Fujio","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2026.116323_bb0160","article-title":"Insulin-like growth factor-1 in myocardial ischemia-reperfusion injury: a review","volume":"103","author":"Yan","year":"2024","journal-title":"Medicine"},{"key":"10.1016\/j.intimp.2026.116323_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.intimp.2026.116323_bb0170","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nn.4288","article-title":"Pericytes of the neurovascular unit: key functions and signaling pathways","volume":"19","author":"Sweeney","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2026.116323_bb0175","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12390","article-title":"IGF-1 promotes angiogenesis in endothelial cells\/adipose-derived stem cells co-culture system with activation of PI3K\/Akt signal pathway","volume":"50","author":"Lin","year":"2017","journal-title":"Cell Prolif."},{"key":"10.1016\/j.intimp.2026.116323_bb0180","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/acel.12372","article-title":"IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging","volume":"14","author":"Toth","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2026.116323_bb0185","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/intimm\/dxaa008","article-title":"Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells","volume":"32","author":"Naito","year":"2020","journal-title":"Int. Immunol."},{"key":"10.1016\/j.intimp.2026.116323_bb0190","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.15252\/embj.201696150","article-title":"Endothelial cell metabolism in health and disease: impact of hypoxia","volume":"36","author":"Wong","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2026.116323_bb0195","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrm3176","article-title":"Molecular control of endothelial cell behaviour during blood vessel morphogenesis","volume":"12","author":"Herbert","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.intimp.2026.116323_bb0200","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jb\/mvs136","article-title":"Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases","volume":"153","author":"Shibuya","year":"2013","journal-title":"J. Biochem."},{"key":"10.1016\/j.intimp.2026.116323_bb0205","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s12079-016-0352-8","article-title":"VEGF-A\/VEGFR2 signaling network in endothelial cells relevant to angiogenesis","volume":"10","author":"Abhinand","year":"2016","journal-title":"J. Cell Commun Signal."},{"key":"10.1016\/j.intimp.2026.116323_bb0210","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","article-title":"Role of PFKFB3-driven glycolysis in vessel sprouting","volume":"154","author":"De Bock","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2026.116323_bb0215","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuint.2015.10.006","article-title":"PFKFB3-mediated glycolysis is involved in reactive astrocyte proliferation after oxygen-glucose deprivation\/reperfusion and is regulated by Cdh1","volume":"91","author":"Lv","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.intimp.2026.116323_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232072","article-title":"Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia","volume":"15","author":"Cohen","year":"2020","journal-title":"PloS One"},{"key":"10.1016\/j.intimp.2026.116323_bb0225","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12240","article-title":"Glycolytic regulation of cell rearrangement in angiogenesis","volume":"7","author":"Cruys","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.116323_bb0230","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2174\/1570161115666170105124038","article-title":"Vascular endothelial growth factor (VEGF) signaling in tumour vascularization: potential and challenges","volume":"15","author":"Siveen","year":"2017","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116323_bb0235","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12974-025-03468-6","article-title":"NLRP3 activation induces BBB disruption and neutrophil infiltration via CXCR2 signaling in the mouse brain","volume":"22","author":"Lee","year":"2025","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116323_bb0240","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1172\/JCI24726","article-title":"Akt1\/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis","volume":"115","author":"Ackah","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2026.116323_bb0245","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.ejcb.2011.03.005","article-title":"Overexpression of osteopontin induces angiogenesis of endothelial progenitor cells via the av\u03b23\/PI3K\/AKT\/eNOS\/NO signaling pathway in glioma cells","volume":"90","author":"Wang","year":"2011","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.intimp.2026.116323_bb0250","doi-asserted-by":"crossref","first-page":"10602","DOI":"10.1038\/s41598-017-10894-x","article-title":"Interleukin-33 promotes inflammation-induced lymphangiogenesis via ST2\/TRAF6-mediated Akt\/eNOS\/NO signalling pathway","volume":"7","author":"Han","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.116323_bb0255","doi-asserted-by":"crossref","first-page":"14882","DOI":"10.3390\/ijms241914882","article-title":"The IGF1 signaling pathway: from basic concepts to therapeutic opportunities","volume":"24","author":"Werner","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116323_bb0260","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1158\/1078-0432.CCR-07-4879","article-title":"The type 1 insulin-like growth factor receptor pathway","volume":"14","author":"Chitnis","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2026.116323_bb0265","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1649453","article-title":"Activating CD137 signaling promotes sprouting angiogenesis via increased VEGFA secretion and the VEGFR2\/Akt\/eNOS pathway","volume":"2020","author":"Li","year":"2020","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.intimp.2026.116323_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117418","article-title":"Traditional Chinese medicine formula, Sanwujiao granule, attenuates ischemic stroke by promoting angiogenesis through early administration","volume":"321","author":"Zhou","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2026.116323_bb0275","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.expneurol.2014.10.017","article-title":"The role of the nitric oxide pathway in brain injury and its treatment \u2014 from bench to bedside","volume":"263","author":"Garry","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2026.116323_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114193","article-title":"Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation","volume":"43","author":"Ye","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2026.116323_bb0285","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13045-020-00904-3","article-title":"Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy","volume":"13","author":"Hua","year":"2020","journal-title":"J. Hematol. Oncol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926001670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926001670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:18:30Z","timestamp":1776770310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926001670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":57,"alternative-id":["S1567576926001670"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116323","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IGF-1 ameliorates the blood brain barrier disruption induced by the neonatal hypoxia-ischemia","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116323","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116323"}}