{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:22:56Z","timestamp":1775308976276,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272208"],"award-info":[{"award-number":["82272208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241039"],"award-info":[{"award-number":["82241039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102273"],"award-info":[{"award-number":["82102273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.intimp.2026.116350","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T04:17:53Z","timestamp":1770783473000},"page":"116350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tubular STING drives renal fibrosis via extracellular vesicle\u2013mediated activation of the SMO\/GLI-1 pathway"],"prefix":"10.1016","volume":"174","author":[{"given":"Dongxue","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinmeng","family":"Suo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinye","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2026.116350_bb0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-021-00284-z","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"9","key":"10.1016\/j.intimp.2026.116350_bb0010","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/ki.2011.339","article-title":"AKI in the ICU: definition, epidemiology, risk stratification, and outcomes","volume":"81","author":"Singbartl","year":"2012","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.intimp.2026.116350_bb0015","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1681\/ASN.2015010006","article-title":"Failed tubule recovery, AKI-CKD transition, and kidney disease progression","volume":"26","author":"Venkatachalam","year":"2015","journal-title":"J. American Society Nephrology\u202f: JASN."},{"issue":"12","key":"10.1016\/j.intimp.2026.116350_bb0020","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1681\/ASN.2021101286","article-title":"Activation of stimulator of IFN genes (STING) causes proteinuria and contributes to glomerular diseases","volume":"33","author":"Mitrofanova","year":"2022","journal-title":"J. Am. Society Nephrology\u202f: JASN."},{"issue":"2","key":"10.1016\/j.intimp.2026.116350_bb0025","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.kint.2024.10.021","article-title":"The critical role of endoplasmic reticulum stress and the stimulator of interferon genes (STING) pathway in kidney fibrosis","volume":"107","author":"Andrade-Silva","year":"2025","journal-title":"Kidney Int."},{"issue":"7","key":"10.1016\/j.intimp.2026.116350_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-05115-x","article-title":"The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages","volume":"13","author":"Wu","year":"2022","journal-title":"Cell Death Dis."},{"issue":"8","key":"10.1016\/j.intimp.2026.116350_bb0035","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41556-023-01185-x","article-title":"STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2","volume":"25","author":"Zhang","year":"2023","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116350_bb0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-06600-1","article-title":"STING contributes to lipopolysaccharide-induced tubular cell inflammation and pyroptosis by activating endoplasmic reticulum stress in acute kidney injury","volume":"15","author":"Cao","year":"2024","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.intimp.2026.116350_bb0045","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41556-022-00894-z","article-title":"A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis","volume":"24","author":"Zhang","year":"2022","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116350_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12203","article-title":"\u0392-catenin-controlled tubular cell-derived exosomes play a key role in fibroblast activation via the OPN-CD44 axis","volume":"11","author":"Chen","year":"2022","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.intimp.2026.116350_bb0055","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-025-04338-x","article-title":"Renal tubular epithelial cell-derived exosomal miR-330-3p plays a key role in fibroblast activation and renal fibrosis by regulating CREBBP","volume":"16","author":"Dai","year":"2025","journal-title":"Stem Cell Res. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2026.116350_bb0060","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.kint.2019.11.026","article-title":"Tubule-derived exosomes play a central role in fibroblast activation and kidney fibrosis","volume":"97","author":"Liu","year":"2020","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.intimp.2026.116350_bb0065","article-title":"Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies","volume":"8","author":"Jing","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2026.116350_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12316","article-title":"STAM transports STING oligomers into extracellular vesicles, down-regulating the innate immune response","volume":"12","author":"Liang","year":"2023","journal-title":"J. Extracell. Vesicles"},{"issue":"12","key":"10.1016\/j.intimp.2026.116350_bb0075","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/s41422-022-00731-w","article-title":"Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity","volume":"32","author":"Gao","year":"2022","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.intimp.2026.116350_bb0080","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.ajpath.2011.12.039","article-title":"Hedgehog-Gli pathway activation during kidney fibrosis","volume":"180","author":"Fabian","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"12","key":"10.1016\/j.intimp.2026.116350_bb0085","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.cmet.2022.09.026","article-title":"Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis","volume":"34","author":"Li","year":"2022","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.intimp.2026.116350_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/biom15060794","article-title":"Mechanisms of acute kidney injury-chronic kidney disease transition: unraveling maladaptive repair and therapeutic opportunities","volume":"15","author":"Xu","year":"2025","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.intimp.2026.116350_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-06638-1","article-title":"STING agonist diABZI enhances the cytotoxicity of T cell towards cancer cells","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.intimp.2026.116350_bb0100","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.celrep.2019.09.050","article-title":"Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury","volume":"29","author":"Maekawa","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2026.116350_bb0105","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.freeradbiomed.2023.08.025","article-title":"STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury","volume":"208","author":"Jin","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.116350_bb0110","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"issue":"13","key":"10.1016\/j.intimp.2026.116350_bb0115","doi-asserted-by":"crossref","DOI":"10.1172\/JCI165836","article-title":"Fibroblast expression of transmembrane protein smoothened governs microenvironment characteristics after acute kidney injury","volume":"134","author":"Gui","year":"2024","journal-title":"J. Clin. Invest."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926001943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926001943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:33:27Z","timestamp":1775306007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926001943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":23,"alternative-id":["S1567576926001943"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116350","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tubular STING drives renal fibrosis via extracellular vesicle\u2013mediated activation of the SMO\/GLI-1 pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116350","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116350"}}