{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:23:25Z","timestamp":1786991005185,"version":"build-2736575974"},"reference-count":138,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.intimp.2026.116407","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:56:05Z","timestamp":1771671365000},"page":"116407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Dual roles of complement in cerebral amyloid angiopathy: A two-compartment framework across the blood\u2013brain barrier"],"prefix":"10.1016","volume":"175","author":[{"given":"Wu-meng","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-chang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang-hang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2026.116407_bb0005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10571-016-0334-7","article-title":"The science of vascular contributions to cognitive impairment and dementia (VCID): a framework for advancing research priorities in the cerebrovascular biology of cognitive decline","volume":"36","author":"Corriveau","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/alz.12366","article-title":"Prevalence of cerebral amyloid angiopathy: a systematic review and meta-analysis","volume":"18","author":"J\u00e4kel","year":"2022","journal-title":"Alzheimers Dement."},{"issue":"19","key":"10.1016\/j.intimp.2026.116407_bb0015","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1212\/01.wnl.0000435291.49598.54","article-title":"Neurovascular decoupling is associated with severity of cerebral amyloid angiopathy","volume":"81","author":"Peca","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.intimp.2026.116407_bb0020","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1038\/ncomms11934","article-title":"Early role of vascular dysregulation on late-onset Alzheimer\u2019s disease based on multifactorial data-driven analysis","volume":"7","author":"Iturria-Medina","year":"2016","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.intimp.2026.116407_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22042022","article-title":"The neurovascular unit dysfunction in Alzheimer\u2019s disease","volume":"22","author":"Soto-Rojas","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.intimp.2026.116407_bb0030","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13503","article-title":"Effects of cerebral amyloid angiopathy on the brain vasculome","volume":"21","author":"Deng","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2026.116407_bb0035","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1749-6632.1993.tb23043.x","article-title":"The C-terminus of the beta protein is critical in amyloidogenesis","volume":"695","author":"Jarrett","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3988\/jcn.2011.7.1.1","article-title":"Cerebral amyloid angiopathy: a systematic review","volume":"7","author":"Biffi","year":"2011","journal-title":"J. Clin. Neurol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116407_bb0045","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The cellular phase of Alzheimer\u2019s disease","volume":"164","author":"De Strooper","year":"2016","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.intimp.2026.116407_bb0050","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1161\/CIRCRESAHA.116.308426","article-title":"Vascular Cognitive Impairment","volume":"120","author":"Dichgans","year":"2017","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0055","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-023-00640-5","article-title":"Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer\u2019s disease","volume":"18","author":"Inoue","year":"2023","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0060","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways","volume":"16","author":"Greenberg","year":"2020","journal-title":"Nat. Rev. Neurol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116407_bb0065","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1093\/brain\/awac178","article-title":"Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline","volume":"145","author":"Rabin","year":"2022","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.intimp.2026.116407_bb0070","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.tins.2018.03.009","article-title":"Complement: the emerging architect of the developing brain","volume":"41","author":"Coulthard","year":"2018","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0075","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-025-00916-y","article-title":"The complement cascade in Alzheimer\u2019s disease: modern implications of an ancient immune protagonist","volume":"21","author":"Papavergi","year":"2025","journal-title":"Mol Neurodegener."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0080","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/cr.2009.139","article-title":"Complement and its role in innate and adaptive immune responses","volume":"20","author":"Dunkelberger","year":"2010","journal-title":"Cell Res."},{"issue":"12","key":"10.1016\/j.intimp.2026.116407_bb0085","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/ni.3858","article-title":"Novel mechanisms and functions of complement","volume":"18","author":"Hajishengallis","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2026.116407_bb0090","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fimmu.2015.00262","article-title":"Complement system part I - molecular mechanisms of activation and regulation","volume":"6","author":"Merle","year":"2015","journal-title":"Front. Immunol."},{"issue":"14","key":"10.1016\/j.intimp.2026.116407_bb0095","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM200104053441406","article-title":"Complement. First of two parts","volume":"344","author":"Walport","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"15","key":"10.1016\/j.intimp.2026.116407_bb0100","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJM200104123441506","article-title":"Complement. Second of two parts","volume":"344","author":"Walport","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.intimp.2026.116407_bb0105","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"issue":"5247","key":"10.1016\/j.intimp.2026.116407_bb0110","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.271.5247.348","article-title":"C3d of complement as a molecular adjuvant: bridging innate and acquired immunity","volume":"271","author":"Dempsey","year":"1996","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.intimp.2026.116407_bb0115","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.molmed.2008.09.009","article-title":"C1, MBL-MASPs and C1-inhibitor: novel approaches for targeting complement-mediated inflammation","volume":"14","author":"Beinrohr","year":"2008","journal-title":"Trends Mol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.116407_bb0120","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molimm.2004.02.005","article-title":"The human complement factor H: functional roles, genetic variations and disease associations","volume":"41","author":"Rodr\u00edguez de C\u00f3rdoba","year":"2004","journal-title":"Mol. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116407_bb0125","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nri2620","article-title":"Complement regulators and inhibitory proteins","volume":"9","author":"Zipfel","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116407_bb0130","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.4049\/jimmunol.144.9.3478","article-title":"The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9","volume":"144","author":"Rollins","year":"1990","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116407_bb0135","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1615\/CritRevImmunol.v19.i3.10","article-title":"Regulation of the complement membrane attack pathway","volume":"19","author":"Morgan","year":"1999","journal-title":"Crit. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116407_bb0140","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/s41593-019-0491-3","article-title":"Single-cell transcriptomic profiling of the aging mouse brain","volume":"22","author":"Ximerakis","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2026.116407_bb0145","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/bs.ai.2021.09.003","article-title":"Complement as a powerful \u201cinfluencer\u201d in the brain during development, adulthood and neurological disorders","volume":"152","author":"Petrisko","year":"2021","journal-title":"Adv. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116407_bb0150","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s41593-020-0672-0","article-title":"The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development","volume":"23","author":"Cong","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.intimp.2026.116407_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.100957","article-title":"The complement regulator Susd4 influences nervous-system function and neuronal morphology in mice","volume":"23","author":"Zhu","year":"2020","journal-title":"iScience"},{"issue":"7","key":"10.1016\/j.intimp.2026.116407_bb0160","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.4049\/jimmunol.176.7.4419","article-title":"CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues","volume":"176","author":"Kraus","year":"2006","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0165","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0006-291X(03)01555-9","article-title":"A novel giant gene CSMD3 encoding a protein with CUB and sushi multiple domains: a candidate gene for benign adult familial myoclonic epilepsy on human chromosome 8q23.3-q24.1","volume":"309","author":"Shimizu","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2026.116407_bb0170","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.molimm.2018.06.267","article-title":"Blood-brain barrier (BBB) and the complement landscape","volume":"102","author":"Alexander","year":"2018","journal-title":"Mol. Immunol."},{"issue":"8397","key":"10.1016\/j.intimp.2026.116407_bb0175","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0140-6736(84)90298-8","article-title":"Terminal component of complement (C9) in cerebrospinal fluid of patients with multiple sclerosis","volume":"2","author":"Morgan","year":"1984","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.intimp.2026.116407_bb0180","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.mvr.2007.10.004","article-title":"Human postmortem brain-derived cerebrovascular smooth muscle cells express all genes of the classical complement pathway: a potential mechanism for vascular damage in cerebral amyloid angiopathy and Alzheimer\u2019s disease","volume":"75","author":"Walker","year":"2008","journal-title":"Microvasc. Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.116407_bb0185","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0190","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/glia.22389","article-title":"The \u201cquad-partite\u201d synapse: microglia-synapse interactions in the developing and mature CNS","volume":"61","author":"Schafer","year":"2013","journal-title":"Glia"},{"issue":"6","key":"10.1016\/j.intimp.2026.116407_bb0195","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1042\/CS20230513","article-title":"The complement system in neurodegenerative diseases","volume":"138","author":"Nimmo","year":"2024","journal-title":"Clin. Sci. (Lond.)"},{"issue":"6","key":"10.1016\/j.intimp.2026.116407_bb0200","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/ana.24398","article-title":"Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus","volume":"77","author":"Michailidou","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.intimp.2026.116407_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/alz.093183","article-title":"Anti-amyloid immunotherapy for AD: a potential link between ARIA and Complement","volume":"20","author":"Bathini","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"14","key":"10.1016\/j.intimp.2026.116407_bb0210","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.molimm.2011.04.003","article-title":"Complement in the brain","volume":"48","author":"Veerhuis","year":"2011","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116407_bb0215","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1750-3639.2008.00133.x","article-title":"Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer\u2019s disease","volume":"18","author":"Weller","year":"2008","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0220","article-title":"Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model","volume":"14","author":"Hu","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.intimp.2026.116407_bb0225","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S1474-4422(14)70003-1","article-title":"Outcome markers for clinical trials in cerebral amyloid angiopathy","volume":"13","author":"Greenberg","year":"2014","journal-title":"Lancet Neurol."},{"issue":"21","key":"10.1016\/j.intimp.2026.116407_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12216792","article-title":"Anti-amyloid therapy, AD, and ARIA: untangling the role of CAA","volume":"12","author":"Sin","year":"2023","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.116407_bb0235","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00401-011-0801-7","article-title":"Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy","volume":"121","author":"Hawkes","year":"2011","journal-title":"Acta Neuropathol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116407_bb0240","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","article-title":"Clearance systems in the brain-implications for Alzheimer disease","volume":"11","author":"Tarasoff-Conway","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116407_bb0245","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2125.1989.tb03521.x","article-title":"Lisinopril dose-response relationship in essential hypertension","volume":"28","author":"Gomez","year":"1989","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0250","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"issue":"12","key":"10.1016\/j.intimp.2026.116407_bb0255","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI10498","article-title":"Clearance of Alzheimer\u2019s amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier","volume":"106","author":"Shibata","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2026.116407_bb0260","doi-asserted-by":"crossref","DOI":"10.1186\/2045-8118-8-21","article-title":"Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent","volume":"8","author":"Pascale","year":"2011","journal-title":"Fluids Barriers CNS"},{"issue":"4","key":"10.1016\/j.intimp.2026.116407_bb0265","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.4049\/jimmunol.151.4.2159","article-title":"Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9","volume":"151","author":"Tschopp","year":"1993","journal-title":"J. Immunol."},{"issue":"33","key":"10.1016\/j.intimp.2026.116407_bb0270","doi-asserted-by":"crossref","first-page":"E6962","DOI":"10.1073\/pnas.1701137114","article-title":"Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways","volume":"114","author":"Wojtas","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0275","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40478-018-0540-2","article-title":"Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer\u2019s disease","volume":"6","author":"Hondius","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0280","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-021-01303-6","article-title":"Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates","volume":"10","author":"Zellner","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0285","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140966","article-title":"Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging","volume":"131","author":"Propson","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.intimp.2026.116407_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110961","article-title":"Absence of microglia promotes diverse pathologies and early lethality in Alzheimer\u2019s disease mice","volume":"39","author":"Kiani Shabestari","year":"2022","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.intimp.2026.116407_bb0295","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1523\/JNEUROSCI.1967-16.2016","article-title":"Innate immunity stimulation via toll-like receptor 9 ameliorates vascular amyloid pathology in Tg-SwDI mice with associated cognitive benefits","volume":"37","author":"Scholtzova","year":"2017","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.intimp.2026.116407_bb0300","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/glia.22331","article-title":"Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar a\u03b2 by microglia","volume":"60","author":"Fu","year":"2012","journal-title":"Glia"},{"issue":"25","key":"10.1016\/j.intimp.2026.116407_bb0305","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1523\/JNEUROSCI.0829-08.2008","article-title":"Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia\/macrophage phenotype in amyloid precursor protein transgenic mice","volume":"28","author":"Maier","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2026.116407_bb0310","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1742-2094-6-35","article-title":"Expression of complement system components during aging and amyloid deposition in APP transgenic mice","volume":"6","author":"Reichwald","year":"2009","journal-title":"J. Neuroinflammation"},{"issue":"12","key":"10.1016\/j.intimp.2026.116407_bb0315","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.neurobiolaging.2005.09.043","article-title":"Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes","volume":"27","author":"Rogers","year":"2006","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.intimp.2026.116407_bb0320","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.neuron.2019.10.033","article-title":"Vasomotion as a driving force for Paravascular clearance in the awake mouse brain","volume":"105","author":"van Veluw","year":"2020","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.intimp.2026.116407_bb0325","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2990.2007.00926.x","article-title":"Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology","volume":"34","author":"Carare","year":"2008","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0330","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00401-018-1862-7","article-title":"Convective influx\/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways","volume":"136","author":"Albargothy","year":"2018","journal-title":"Acta Neuropathol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116407_bb0335","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.bbadis.2015.08.024","article-title":"Deposition of amyloid \u03b2 in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy","volume":"1862","author":"Keable","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"5\u20136","key":"10.1016\/j.intimp.2026.116407_bb0340","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000486091","article-title":"Complement activation in capillary cerebral amyloid angiopathy","volume":"44","author":"Matsuo","year":"2017","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"6","key":"10.1016\/j.intimp.2026.116407_bb0345","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s004010050944","article-title":"Distribution of a beta-associated proteins in cerebrovascular amyloid of Alzheimer\u2019s disease","volume":"96","author":"Verbeek","year":"1998","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.intimp.2026.116407_bb0350","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.27679","article-title":"Test of the \u2018glymphatic\u2019 hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma","volume":"6","author":"Smith","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.intimp.2026.116407_bb0355","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.40070","article-title":"Aquaporin-4-dependent glymphatic solute transport in the rodent brain","volume":"7","author":"Mestre","year":"2018","journal-title":"Elife"},{"issue":"3","key":"10.1016\/j.intimp.2026.116407_bb0360","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.neuroscience.2009.01.023","article-title":"Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer\u2019s disease","volume":"159","author":"Wilcock","year":"2009","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.intimp.2026.116407_bb0365","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1365-2990.2005.00652.x","article-title":"Cerebral amyloid angiopathy in a 95+ cohort: complement activation and apolipoprotein E (ApoE) genotype","volume":"31","author":"Tanskanen","year":"2005","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0370","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00401-025-02886-3","article-title":"CAA proteomics meta-analysis reveals novel targets, key players, and the effects of sex, APOE, and brain region in humans","volume":"149","author":"Varma","year":"2025","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0375","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00401-024-02767-1","article-title":"Differences in the cerebral amyloid angiopathy proteome in Alzheimer\u2019s disease and mild cognitive impairment","volume":"148","author":"Leitner","year":"2024","journal-title":"Acta Neuropathol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116407_bb0380","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/nan.12342","article-title":"Systems proteomic analysis reveals that clusterin and tissue inhibitor of metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy","volume":"43","author":"Manousopoulou","year":"2017","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0385","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s004019570001","article-title":"Early complement components in Alzheimer\u2019s disease brains","volume":"91","author":"Veerhuis","year":"1996","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0390","doi-asserted-by":"crossref","DOI":"10.1038\/s41597-021-01090-8","article-title":"Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis","volume":"8","author":"Haytural","year":"2021","journal-title":"Scientific Data"},{"issue":"4","key":"10.1016\/j.intimp.2026.116407_bb0395","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.ajpath.2011.01.006","article-title":"Complement 3 and factor h in human cerebrospinal fluid in Parkinson\u2019s disease, Alzheimer\u2019s disease, and multiple-system atrophy","volume":"178","author":"Wang","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116407_bb0400","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00702-012-0797-8","article-title":"Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer\u2019s disease","volume":"119","author":"Daborg","year":"2012","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0405","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/exnr.1999.7260","article-title":"Complement component C1q modulates the phagocytosis of Abeta by microglia","volume":"161","author":"Webster","year":"2000","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116407_bb0410","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/S0002-9440(10)63744-3","article-title":"The powerful neuroprotective action of C1-inhibitor on brain ischemia-reperfusion injury does not require C1q","volume":"164","author":"De Simoni","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2026.116407_bb0415","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/929803","article-title":"Mannose-binding lectin binds to amyloid \u03b2 protein and modulates inflammation","volume":"2012","author":"Larvie","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.intimp.2026.116407_bb0420","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.958121","article-title":"Proprotein convertases and the complement system","volume":"13","author":"Dob\u00f3","year":"2022","journal-title":"Front. Immunol."},{"issue":"29","key":"10.1016\/j.intimp.2026.116407_bb0425","doi-asserted-by":"crossref","first-page":"6457","DOI":"10.1523\/JNEUROSCI.0901-04.2004","article-title":"Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer\u2019s disease","volume":"24","author":"Fonseca","year":"2004","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.intimp.2026.116407_bb0430","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.neuron.2018.10.014","article-title":"Changes in the synaptic proteome in tauopathy and Rescue of tau-Induced Synapse Loss by C1q antibodies","volume":"100","author":"Dejanovic","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.intimp.2026.116407_bb0435","article-title":"Therapeutically targeting the classical complement pathway with antisense oligonucleotides in Alzheimer\u2019s disease","author":"Wang","year":"2024","journal-title":"bioRxiv"},{"issue":"5","key":"10.1016\/j.intimp.2026.116407_bb0440","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1111\/j.1471-4159.2008.05558.x","article-title":"Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer\u2019s disease","volume":"106","author":"Zhou","year":"2008","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.intimp.2026.116407_bb0445","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11910-016-0674-1","article-title":"Neuropsychological effects of cerebral amyloid angiopathy","volume":"16","author":"Schrag","year":"2016","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"Pt 13","key":"10.1016\/j.intimp.2026.116407_bb0450","first-page":"2903","article-title":"The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation","volume":"126","author":"Triantafilou","year":"2013","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.intimp.2026.116407_bb0455","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/brain\/awae278","article-title":"Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer\u2019s disease mouse model","volume":"148","author":"Zelek","year":"2025","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0460","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-022-01404-w","article-title":"Terminal complement pathway activation drives synaptic loss in Alzheimer\u2019s disease models","volume":"10","author":"Carpanini","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0465","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-019-0662-1","article-title":"Apolipoprotein E and clusterin inhibit the early phase of amyloid-\u03b2 aggregation in an in vitro model of cerebral amyloid angiopathy","volume":"7","author":"Endo","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0470","article-title":"The presence of circulating human apolipoprotein J reduces the occurrence of cerebral microbleeds in a transgenic mouse model with cerebral amyloid angiopathy","volume":"16","author":"Bonaterra-Pastra","year":"2024","journal-title":"Alzheimer\u2019s Research & Therapy"},{"issue":"5","key":"10.1016\/j.intimp.2026.116407_bb0475","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1212\/WNL.0b013e3182452b40","article-title":"Genetic variation at CR1 increases risk of cerebral amyloid angiopathy","volume":"78","author":"Biffi","year":"2012","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0480","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-022-02484-0","article-title":"A breakdown in microglial metabolic reprogramming causes internalization dysfunction of \u03b1-synuclein in a mouse model of Parkinson\u2019s disease","volume":"19","author":"Lu","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"6","key":"10.1016\/j.intimp.2026.116407_bb0485","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci14060601","article-title":"CD59 protects primary human cerebrovascular smooth muscle cells from cytolytic membrane attack complex","volume":"14","author":"Whinnery","year":"2024","journal-title":"Brain Sci."},{"issue":"20","key":"10.1016\/j.intimp.2026.116407_bb0490","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1523\/JNEUROSCI.20-20-07505.2000","article-title":"Deficiency of complement defense protein CD59 may contribute to neurodegeneration in Alzheimer\u2019s disease","volume":"20","author":"Yang","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2026.116407_bb0495","author":"Is ARIA an Inflammatory Reaction to Vascular Amyloid?"},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0500","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144348","article-title":"Complement C3a receptor-mediated vascular dysfunction: a complex interplay between aging and neurodegeneration","volume":"131","author":"Bhatia","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.intimp.2026.116407_bb0505","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1212\/WNL.36.3.395","article-title":"Oligoclonal immunoglobulin G in acute subarachnoid hemorrhage and stroke","volume":"36","author":"Tsementzis","year":"1986","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.intimp.2026.116407_bb0510","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s12975-013-0309-7","article-title":"Alzheimer\u2019s silent partner: cerebral amyloid angiopathy","volume":"5","author":"Cupino","year":"2014","journal-title":"Transl. Stroke Res."},{"issue":"7638","key":"10.1016\/j.intimp.2026.116407_bb0515","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.intimp.2026.116407_bb0520","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1523\/JNEUROSCI.2117-15.2016","article-title":"Astrocyte-microglia cross talk through complement activation modulates amyloid pathology in mouse models of Alzheimer\u2019s disease","volume":"36","author":"Lian","year":"2016","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.intimp.2026.116407_bb0525","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.celrep.2019.07.060","article-title":"Complement C3 Is activated in human AD brain and Is required for neurodegeneration in mouse models of amyloidosis and tauopathy","volume":"28","author":"Wu","year":"2019","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.intimp.2026.116407_bb0530","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/ana.25512","article-title":"Different microvascular alterations underlie microbleeds and microinfarcts","volume":"86","author":"van Veluw","year":"2019","journal-title":"Ann. Neurol."},{"issue":"22","key":"10.1016\/j.intimp.2026.116407_bb0535","first-page":"7994","article-title":"C5aR antagonist inhibits occurrence and progression of complement C5a induced inflammatory response of microglial cells through activating p38MAPK and ERK1\/2 signaling pathway","volume":"22","author":"Liu","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2026.116407_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.101340","article-title":"Complement dysregulation in the central nervous system during development and disease","volume":"45","author":"Lee","year":"2019","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.intimp.2026.116407_bb0545","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2019.07.050","article-title":"Chronic cerebral hypoperfusion activates the coagulation and complement cascades in Alzheimer\u2019s disease mice","volume":"416","author":"Shi","year":"2019","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.intimp.2026.116407_bb0550","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.neuron.2019.01.014","article-title":"Fibrinogen induces microglia-mediated spine elimination and cognitive impairment in an Alzheimer\u2019s disease model","volume":"101","author":"Merlini","year":"2019","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0555","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-023-00649-w","article-title":"Amyloid-\u03b2 (a\u03b2) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer\u2019s disease mice","volume":"18","author":"Taylor","year":"2023","journal-title":"Mol Neurodegener."},{"key":"10.1016\/j.intimp.2026.116407_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2021.117425","article-title":"Cerebral amyloid angiopathy and related inflammatory disorders","volume":"424","author":"Chwalisz","year":"2021","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0565","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/jamaneurol.2021.4161","article-title":"Amyloid-related imaging abnormalities in 2 phase 3 studies evaluating aducanumab in patients with early Alzheimer disease","volume":"79","author":"Salloway","year":"2022","journal-title":"JAMA Neurol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116407_bb0570","doi-asserted-by":"crossref","DOI":"10.1148\/rg.230009","article-title":"Amyloid-related imaging abnormalities in Alzheimer disease treated with anti-amyloid-\u03b2 therapy","volume":"43","author":"Agarwal","year":"2023","journal-title":"Radiographics"},{"issue":"10","key":"10.1016\/j.intimp.2026.116407_bb0575","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1016\/j.neurobiolaging.2015.06.028","article-title":"Cerebral amyloid angiopathy and its co-occurrence with Alzheimer\u2019s disease and other cerebrovascular neuropathologic changes","volume":"36","author":"Brenowitz","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"6286","key":"10.1016\/j.intimp.2026.116407_bb0580","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.intimp.2026.116407_bb0585","doi-asserted-by":"crossref","DOI":"10.1172\/JCI167501","article-title":"Complement C3aR depletion reverses HIF-1\u03b1-induced metabolic impairment and enhances microglial response to a\u03b2 pathology","volume":"133","author":"Gedam","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2026.116407_bb0590","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-015-0369-6","article-title":"Active immunization against complement factor C5a: a new therapeutic approach for Alzheimer\u2019s disease","volume":"12","author":"Landlinger","year":"2015","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.intimp.2026.116407_bb0595","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/alz.13682","article-title":"C5aR1 signaling promotes region- and age-dependent synaptic pruning in models of Alzheimer\u2019s disease","volume":"20","author":"Gomez-Arboledas","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0600","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1602\/neurorx.2.1.3","article-title":"The blood-brain barrier: bottleneck in brain drug development","volume":"2","author":"Pardridge","year":"2005","journal-title":"NeuroRx"},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0605","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood-brain barrier: structure, regulation, and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2026.116407_bb0610","article-title":"Practical considerations for infection prevention with the clinical use of complement inhibitors","volume":"Epub ahead of print","author":"Java","year":"2026","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"392","key":"10.1016\/j.intimp.2026.116407_bb0615","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf6295","article-title":"Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP\/PS1 mice","volume":"9","author":"Shi","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0620","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuron.2014.11.018","article-title":"NF\u03baB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer\u2019s disease","volume":"85","author":"Lian","year":"2015","journal-title":"Neuron"},{"issue":"Pt 1","key":"10.1016\/j.intimp.2026.116407_bb0625","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/brain\/awu316","article-title":"Structural network alterations and neurological dysfunction in cerebral amyloid angiopathy","volume":"138","author":"Reijmer","year":"2015","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.intimp.2026.116407_bb0630","doi-asserted-by":"crossref","first-page":"429","DOI":"10.14336\/AD.2019.0119","article-title":"Significance of complement system in ischemic stroke: a comprehensive review","volume":"10","author":"Ma","year":"2019","journal-title":"Aging Dis."},{"key":"10.1016\/j.intimp.2026.116407_bb0635","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-neuro-061010-113810","article-title":"The complement system: an unexpected role in synaptic pruning during development and disease","volume":"35","author":"Stephan","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"issue":"11","key":"10.1016\/j.intimp.2026.116407_bb0640","doi-asserted-by":"crossref","first-page":"6374","DOI":"10.4049\/jimmunol.167.11.6374","article-title":"Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for a beta on the C1q globular regions","volume":"167","author":"Tacnet-Delorme","year":"2001","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0645","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-51163-6","article-title":"C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer\u2019s disease mouse model","volume":"15","author":"Schartz","year":"2024","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.intimp.2026.116407_bb0650","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.4049\/jimmunol.0901005","article-title":"Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer\u2019s disease","volume":"183","author":"Fonseca","year":"2009","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0655","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-022-01416-6","article-title":"C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer\u2019s disease","volume":"10","author":"Gomez-Arboledas","year":"2022","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0660","doi-asserted-by":"crossref","DOI":"10.1177\/1759091416687871","article-title":"C5a increases the injury to primary neurons elicited by fibrillar amyloid beta","volume":"9","author":"Hernandez","year":"2017","journal-title":"ASN Neuro"},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0665","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12974-022-02539-2","article-title":"Modulation of C5a-C5aR1 signaling alters the dynamics of AD progression","volume":"19","author":"Carvalho","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"12","key":"10.1016\/j.intimp.2026.116407_bb0670","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225417","article-title":"C5aR agonist enhances phagocytosis of fibrillar and non-fibrillar a\u03b2 amyloid and preserves memory in a mouse model of familial Alzheimer\u2019s disease","volume":"14","author":"Panayiotou","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.intimp.2026.116407_bb0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110081","article-title":"The anaphylatoxin C5a: structure, function, signaling, physiology, disease, and therapeutics","volume":"118","author":"Ghosh","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116407_bb0680","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.bbi.2024.03.017","article-title":"Targeting terminal pathway reduces brain complement activation, amyloid load and synapse loss, and improves cognition in a mouse model of dementia","volume":"118","author":"Zelek","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.intimp.2026.116407_bb0685","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1093\/brain\/awaa425","article-title":"Gamma subunit of complement component 8 is a neuroinflammation inhibitor","volume":"144","author":"Kim","year":"2021","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.intimp.2026.116407_bb0690","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13195-019-0498-8","article-title":"Peripheral administration of human recombinant ApoJ\/clusterin modulates brain beta-amyloid levels in APP23 mice","volume":"11","author":"de Retana","year":"2019","journal-title":"Alzheimer\u2019s Res. Ther."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926002511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926002511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:14:44Z","timestamp":1777619684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926002511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":138,"alternative-id":["S1567576926002511"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116407","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual roles of complement in cerebral amyloid angiopathy: A two-compartment framework across the blood\u2013brain barrier","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116407","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116407"}}