{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:44:04Z","timestamp":1792154644487,"version":"4.4.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.intimp.2026.116458","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:47:10Z","timestamp":1773132430000},"page":"116458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Danggui Sini decoction attenuates intervertebral disc degeneration by regulating ferroptosis in nucleus pulposus cells via the GJA1\/cGAS\/STING signaling axis"],"prefix":"10.1016","volume":"176","author":[{"given":"Shuang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116458_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100978","article-title":"Intervertebral disc ageing and degeneration: the antiapoptotic effect of oestrogen","volume":"57","author":"Yang","year":"2020","journal-title":"Ageing Res. Rev."},{"issue":"5","key":"10.1016\/j.intimp.2026.116458_bb0010","first-page":"2683","article-title":"Necrosulfonamide (NSA) protects intervertebral disc degeneration via necroptosis and apoptosis inhibition","volume":"24","author":"Zhang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2026.116458_bb0015","unstructured":"Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 354 Diseases and Injuries for 195 Countries and Territories, 1990\u20132017: A Systematic Analysis for the Global Burden of Disease Study 2017, Lancet (London, England) vol. 392(10159) (2018) 1789\u20131858."},{"issue":"3","key":"10.1016\/j.intimp.2026.116458_bb0020","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.arr.2007.08.001","article-title":"The cell biology of intervertebral disc aging and degeneration","volume":"6","author":"Zhao","year":"2007","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.intimp.2026.116458_bb0025","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/15548627.2024.2395797","article-title":"Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration","volume":"21","author":"Cheng","year":"2025","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.intimp.2026.116458_bb0030","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s11658-025-00802-x","article-title":"PPAR\u03b3-Axl axis ameliorates intervertebral disc degeneration by activating PI3K\/AKT-mediated autophagy to suppress ferroptosis","volume":"30","author":"Sun","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"5","key":"10.1016\/j.intimp.2026.116458_bb0035","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.intimp.2026.116458_bb0040","article-title":"Polydopamine nanoparticles targeting ferroptosis mitigate intervertebral disc degeneration via reactive oxygen species depletion, iron ions chelation, and GPX4 ubiquitination suppression","volume":"10","author":"Yang","year":"2023","journal-title":"Advanced Science (Weinheim, Baden-Wurttemberg, Germany)"},{"issue":"1","key":"10.1016\/j.intimp.2026.116458_bb0045","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41413-024-00317-9","article-title":"Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx","volume":"12","author":"Xiang","year":"2024","journal-title":"Bone Res."},{"issue":"9","key":"10.1016\/j.intimp.2026.116458_bb0050","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cGAS-STING signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116458_bb0055","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1172\/JCI128190","article-title":"Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy","volume":"130","author":"Himelman","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2026.116458_bb0060","doi-asserted-by":"crossref","first-page":"11649","DOI":"10.2147\/CMAR.S235500","article-title":"GJA1 is a prognostic biomarker and correlated with immune infiltrates in colorectal Cancer","volume":"12","author":"Hu","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116458_bb0065","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s40478-018-0642-x","article-title":"GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis","volume":"6","author":"Kajiwara","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116458_bb0070","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13018-022-03044-1","article-title":"MiR-206 improves intervertebral disk degeneration by targeting GJA1","volume":"17","author":"Zhou","year":"2022","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.intimp.2026.116458_bb0075","doi-asserted-by":"crossref","first-page":"2061071","DOI":"10.1155\/2023\/2061071","article-title":"miR-1 inhibits the Ferroptosis of chondrocyte by targeting CX43 and alleviates osteoarthritis progression","volume":"2023","author":"Zhou","year":"2023","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.intimp.2026.116458_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156034","article-title":"Integrated metabolomics and lipidomics investigation of the mechanism of Danggui Sini decoction on improving lipid homeostasis in primary dysmenorrhea","volume":"135","author":"Ren","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116458_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155740","article-title":"Danggui Sini decoction normalizes the intestinal microbiota and serum metabolite levels to treat sciatica","volume":"132","author":"Di","year":"2024","journal-title":"Phytomedicine"},{"issue":"22","key":"10.1016\/j.intimp.2026.116458_bb0090","first-page":"2473","article-title":"Clinical efficacy of Danggui Sini decoction in the treatment of lumbar disc herniation","volume":"27","author":"Lin","year":"2018","journal-title":"Mod J Integr Tradit Chin West Med"},{"issue":"18","key":"10.1016\/j.intimp.2026.116458_bb0095","first-page":"2868","article-title":"Clinical efficacy analysis of Danggui Sini decoction in patients with lumbar disc herniation","volume":"32","author":"Lu","year":"2021","journal-title":"Mod Diagn Treat"},{"issue":"12","key":"10.1016\/j.intimp.2026.116458_bb0100","first-page":"165","article-title":"Applications of Danggui Sini decoction in orthopedics and traumatology","volume":"21","author":"Zhou","year":"2019","journal-title":"J. Liaoning Univ. Tradit. Chin. Med."},{"issue":"7","key":"10.1016\/j.intimp.2026.116458_bb0105","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s11306-016-1050-5","article-title":"Serum metabolomics for early diagnosis of esophageal squamous cell carcinoma by UHPLC-QTOF\/MS","volume":"12","author":"Wang","year":"2016","journal-title":"Metabolomics"},{"key":"10.1016\/j.intimp.2026.116458_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178250","article-title":"Asperosaponin VI alleviates intervertebral disc degeneration by suppressing nucleus pulposus cell pyroptosis through modulation of the NF-\u03baB\/NLRP3 signaling pathway","volume":"1007","author":"Chen","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116458_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118735","article-title":"Melastoma dodecandrum lour. protects against cerebral ischemia-reperfusion injury by ameliorating oxidative stress and endoplasmic reticulum stress","volume":"336","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116458_bb0120","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.18632\/aging.204641","article-title":"Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats","volume":"15","author":"Cheon","year":"2023","journal-title":"Aging (Albany NY)"},{"issue":"4","key":"10.1016\/j.intimp.2026.116458_bb0125","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/humrep\/deaa363","article-title":"Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis","volume":"36","author":"Li","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.intimp.2026.116458_bb0130","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jot.2024.12.002","article-title":"Humanin reduces nucleus pulposus cells ferroptosis to alleviate intervertebral disc degeneration: An in vitro and in vivo study","volume":"50","author":"Zhu","year":"2025","journal-title":"Journal of orthopaedic translation"},{"issue":"12","key":"10.1016\/j.intimp.2026.116458_bb0135","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.7150\/ijms.95170","article-title":"Connexin43 overexpression promoted ferroptosis and increased myocardial vulnerability to ischemia-reperfusion injury in type 1 diabetic mice","volume":"21","author":"Yang","year":"2024","journal-title":"Int. J. Med. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2026.116458_bb0140","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.joca.2019.07.016","article-title":"Multiscale and multimodal structure-function analysis of intervertebral disc degeneration in a rabbit model","volume":"27","author":"Ashinsky","year":"2019","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.intimp.2026.116458_bb0145","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.actbio.2017.02.043","article-title":"Micromechanical anisotropy and heterogeneity of the meniscus extracellular matrix","volume":"54","author":"Li","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.intimp.2026.116458_bb0150","doi-asserted-by":"crossref","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminform."},{"key":"10.1016\/j.intimp.2026.116458_bb0155","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"D1","key":"10.1016\/j.intimp.2026.116458_bb0160","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","volume":"49","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.116458_bb0165","doi-asserted-by":"crossref","first-page":"331","DOI":"10.21037\/atm-22-1009","article-title":"Seven ferroptosis-specific expressed genes are considered as potential biomarkers for the diagnosis and treatment of cigarette smoke-induced chronic obstructive pulmonary disease","volume":"10","author":"Lin","year":"2022","journal-title":"Annals of translational medicine"},{"issue":"11","key":"10.1016\/j.intimp.2026.116458_bb0170","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1002\/jor.25281","article-title":"Similarity and difference between aging and puncture-induced intervertebral disc degeneration","volume":"40","author":"He","year":"2022","journal-title":"J. Orthop. Res."},{"issue":"3","key":"10.1016\/j.intimp.2026.116458_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188890","article-title":"GPX4: the hub of lipid oxidation, ferroptosis, disease and treatment","volume":"1878","author":"Liu","year":"2023","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"5","key":"10.1016\/j.intimp.2026.116458_bb0180","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.joca.2025.02.778","article-title":"Elevated expression of Piezo1 activates the cGAS-STING pathway in chondrocytes by releasing mitochondrial DNA","volume":"33","author":"Sun","year":"2025","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.intimp.2026.116458_bb0185","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3233\/BMR-181208","article-title":"Reliability of pressure pain threshold to discriminate individuals with neck and low back pain","volume":"34","author":"Zicarelli","year":"2021","journal-title":"J. Back Musculoskelet. Rehabil."},{"issue":"46","key":"10.1016\/j.intimp.2026.116458_bb0190","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000031516","article-title":"Efficacy and safety of Chinese herbal medicine Danggui Sini decoction for knee osteoarthritis: a protocol for systematic review and meta-analysis","volume":"101","author":"Zhou","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.intimp.2026.116458_bb0195","doi-asserted-by":"crossref","first-page":"1347021","DOI":"10.3389\/fendo.2024.1347021","article-title":"Discussion on the mechanism of Danggui Sini decoction in treating diabetic foot based on network pharmacology and molecular docking and verification of the curative effect by meta-analysis","volume":"15","author":"Ni","year":"2024","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.intimp.2026.116458_bb0200","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13020-024-00929-7","article-title":"Danggui Sini decoction alleviates oxaliplatin-induced peripheral neuropathy by regulating gut microbiota and potentially relieving neuroinflammation related metabolic disorder","volume":"19","author":"Chen","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.intimp.2026.116458_bb0205","doi-asserted-by":"crossref","first-page":"5165075","DOI":"10.1155\/2021\/5165075","article-title":"Pharmacological mechanism of Danggui-Sini formula for intervertebral disc degeneration: a network pharmacology study","volume":"2021","author":"Wang","year":"2021","journal-title":"Biomed. Res. Int."},{"issue":"9","key":"10.1016\/j.intimp.2026.116458_bb0210","doi-asserted-by":"crossref","first-page":"E520","DOI":"10.1097\/BRS.0000000000002953","article-title":"Secreted factors from intervertebral disc cells and infiltrating macrophages promote degenerated intervertebral disc catabolism","volume":"44","author":"Yang","year":"2019","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"10.1016\/j.intimp.2026.116458_bb0215","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.3390\/ijms23031715","article-title":"The proteolysis of ECM in intervertebral disc degeneration","volume":"23","author":"Liang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"20","key":"10.1016\/j.intimp.2026.116458_bb0220","doi-asserted-by":"crossref","first-page":"9938","DOI":"10.3390\/ijms26209938","article-title":"Understanding the microenvironment of intervertebral disc degeneration: a comprehensive review of pathophysiological insights and therapeutic implications","volume":"26","author":"Z\u0105bek","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116458_bb0225","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.cca.2015.06.023","article-title":"MMPs and ADAMTSs in intervertebral disc degeneration","volume":"448","author":"Wang","year":"2015","journal-title":"Clin. Chim. Acta"},{"issue":"Pt A","key":"10.1016\/j.intimp.2026.116458_bb0230","article-title":"Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1\/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by Duhuo Jisheng decoction","volume":"124","author":"Guo","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116458_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157405","article-title":"Duhuo Jisheng decoction alleviates intervertebral disc degeneration via the acacetin-mediated MAPK1\/HMOX1 axis by inhibiting nucleus pulposus cell pyroptosis","volume":"148","author":"Yu","year":"2025","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.intimp.2026.116458_bb0240","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116458_bb0245","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jot.2025.07.001","article-title":"Oxidative stress activates YAP\/TEAD1\/NCOA4 axis to promote ferroptosis of endplate chondrocytes and aggravate intervertebral disc degeneration","volume":"54","author":"Wang","year":"2025","journal-title":"Journal of orthopaedic translation"},{"key":"10.1016\/j.intimp.2026.116458_bb0250","article-title":"The STAT3\/S100A6\/P53\/SLC7A11 axis mediates intervertebral disc degeneration by regulating ferroptosis in nucleus pulposus cells and the metabolism of the extracellular matrix","author":"Yang","year":"2025","journal-title":"The Spine J."},{"key":"10.1016\/j.intimp.2026.116458_bb0255","doi-asserted-by":"crossref","first-page":"1219840","DOI":"10.3389\/fcell.2023.1219840","article-title":"The role of ferroptosis in intervertebral disc degeneration","volume":"11","author":"Fan","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2026.116458_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157113","article-title":"Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the exosome-mediated miR-19b-3p\/ACSL4 axis","volume":"146","author":"Feng","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116458_bb0265","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.freeradbiomed.2025.10.295","article-title":"Glutarate ameliorates intervertebral disc degeneration by regulating ferroptosis through Nrf2 glutarylation","volume":"242","author":"Yu","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2026.116458_bb0270","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jare.2024.12.028","article-title":"The role of cGAS-STING signaling pathway in ferroptosis","volume":"76","author":"Ding","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.intimp.2026.116458_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102691","article-title":"cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases","volume":"105","author":"Wang","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2026.116458_bb0280","doi-asserted-by":"crossref","first-page":"5835","DOI":"10.2147\/DDDT.S521397","article-title":"cGAS-STING targeting offers novel therapeutic opportunities in liver diseases","volume":"19","author":"Wang","year":"2025","journal-title":"Drug Des. Devel. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.116458_bb0285","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10565-025-10051-5","article-title":"cGAS-STING targeting offers novel therapeutic regimen in sepsis-associated organ dysfunction","volume":"41","author":"Yu","year":"2025","journal-title":"Cell Biol. Toxicol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116458_bb0290","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12974-025-03563-8","article-title":"cGAS-STING signaling in brain aging and neurodegeneration: molecular links and therapeutic perspectives","volume":"22","author":"Li","year":"2025","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.intimp.2026.116458_bb0295","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s12276-023-00965-7","article-title":"Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.116458_bb0300","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/iej.13636","article-title":"The induction of inflammation by the cGAS-STING pathway in human dental pulp cells: a laboratory investigation","volume":"55","author":"Tian","year":"2022","journal-title":"Int. Endod. J."},{"issue":"2","key":"10.1016\/j.intimp.2026.116458_bb0305","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s12276-022-00729-9","article-title":"Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis","volume":"54","author":"Zhang","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"5","key":"10.1016\/j.intimp.2026.116458_bb0310","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.joca.2025.02.771","article-title":"EZH2 inhibits senescence-associated inflammation and attenuates intervertebral disc degeneration by regulating the cGAS\/STING pathway via H3K27me3","volume":"33","author":"Zheng","year":"2025","journal-title":"Osteoarthr. Cartil."},{"issue":"45","key":"10.1016\/j.intimp.2026.116458_bb0315","doi-asserted-by":"crossref","first-page":"73055","DOI":"10.18632\/oncotarget.12197","article-title":"The C-terminal domain of connexin43 modulates cartilage structure via chondrocyte phenotypic changes","volume":"7","author":"Gago-Fuentes","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.intimp.2026.116458_bb0320","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.joca.2014.03.017","article-title":"Connexin43 hemichannels mediate small molecule exchange between chondrocytes and matrix in biomechanically-stimulated temporomandibular joint cartilage","volume":"22","author":"Zhang","year":"2014","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.intimp.2026.116458_bb0325","doi-asserted-by":"crossref","first-page":"C1254","DOI":"10.1152\/ajpcell.01166.2000","article-title":"IL-1beta-induced production of metalloproteinases by synovial cells depends on gap junction conductance","volume":"282","author":"Kolomytkin","year":"2002","journal-title":"Am. J. Physiol. Cell Physiol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926003024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926003024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:12:27Z","timestamp":1790838747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926003024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":65,"alternative-id":["S1567576926003024"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116458","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Danggui Sini decoction attenuates intervertebral disc degeneration by regulating ferroptosis in nucleus pulposus cells via the GJA1\/cGAS\/STING signaling axis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116458"}}