{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:56:59Z","timestamp":1790841419524,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.intimp.2026.116467","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T03:20:36Z","timestamp":1772853636000},"page":"116467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Leonurine ameliorates hypoxic pulmonary hypertension by inhibiting cross-talk between neutropHils and endothelial cells via SERPINB3 targeting"],"prefix":"10.1016","volume":"176","author":[{"given":"Huantian","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feitian","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixing","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116467_bb0005","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S1474-4422(24)00369-7","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the global burden of disease study 2021","volume":"23","author":"Collaborators","year":"2024","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.intimp.2026.116467_bb0010","article-title":"Pulmonary hypertension","volume":"10","author":"Mocumbi","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.intimp.2026.116467_bb0015","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1186\/s12931-024-02994-w","article-title":"Survival, morbidity, and quality of life in pulmonary arterial hypertension patients: a systematic review of outcomes reported by population-based observational studies","volume":"25","author":"Reinders","year":"2024","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2026.116467_bb0020","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.03957-2020","article-title":"Endothelial cells in the pathogenesis of pulmonary arterial hypertension","volume":"58","author":"Evans","year":"2021","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.intimp.2026.116467_bb0025","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.yjmcc.2024.10.004","article-title":"Panorama of artery endothelial cell dysfunction in pulmonary arterial hypertension","volume":"197","author":"Shen","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.intimp.2026.116467_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121879","article-title":"Cerebellin-2 promotes endothelial-mesenchymal transition in hypoxic pulmonary hypertension rats by activating NF-kappaB\/HIF-1alpha\/Twist1 pathway","volume":"328","author":"Wang","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2026.116467_bb0035","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1164\/rccm.201207-1323CI","article-title":"High-altitude medicine","volume":"186","author":"West","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2026.116467_bb0040","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1002\/ptr.8199","article-title":"Current insights and future perspectives of flavonoids: a promising antihypertensive approach","volume":"38","author":"Harahap","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2026.116467_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154329","article-title":"Luteolin ameliorates hypoxia-induced pulmonary hypertension via regulating HIF-2alpha-Arg-NO axis and PI3K-AKT-eNOS-NO signaling pathway","volume":"104","author":"Ji","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116467_bb0050","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41586-020-2922-4","article-title":"A molecular cell atlas of the human lung from single-cell RNA sequencing","volume":"587","author":"Travaglini","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2026.116467_bb0055","doi-asserted-by":"crossref","first-page":"14714","DOI":"10.1038\/s41598-021-94163-y","article-title":"Single-cell transcriptomic profile of human pulmonary artery endothelial cells in health and pulmonary arterial hypertension","volume":"11","author":"Asosingh","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.116467_bb0060","article-title":"Neutrophil-endothelium interaction mediated by S100A9 promotes pulmonary vascular remodeling during pulmonary hypertension","volume":"12","author":"Guo","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.intimp.2026.116467_bb0065","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1093\/cvr\/cvab296","article-title":"Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension","volume":"118","author":"Rodor","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.intimp.2026.116467_bb0070","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.immuni.2021.07.012","article-title":"Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation","volume":"54","author":"Reglero-Real","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2026.116467_bb0075","first-page":"614","article-title":"Research progress on the role of leonurine in inflammation-related diseases","volume":"51","author":"Jia-wei","year":"2024","journal-title":"Fudan Univ. J. Med. Sci."},{"key":"10.1016\/j.intimp.2026.116467_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154519","article-title":"Leonurine attenuates angiotensin II-induced cardiac injury and dysfunction via inhibiting MAPK and NF-kappaB pathway","volume":"108","author":"Shen","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116467_bb0085","doi-asserted-by":"crossref","unstructured":"Shi X, Zhang J, Hu X, et al., Leonurine attenuates obesity-related vascular dysfunction and inflammation, Antioxidants (Basel). 11 (2022).","DOI":"10.3390\/antiox11071338"},{"key":"10.1016\/j.intimp.2026.116467_bb0090","article-title":"Dan-Shen-yin granules prevent hypoxia-induced pulmonary hypertension via STAT3\/HIF-1alpha\/VEGF and FAK\/AKT signaling pathways","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116467_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157058","article-title":"Integrated transcriptome and metabolome analysis reveals the therapeutic mechanism of Huang-qi-Si-Wu-tang in experimental pulmonary arterial hypertension","volume":"145","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116467_bb0100","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ejphar.2010.08.056","article-title":"Leonurine (SCM-198) improves cardiac recovery in rat during chronic infarction","volume":"649","author":"Liu","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116467_bb0105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.freeradbiomed.2012.10.555","article-title":"Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4","volume":"54","author":"Liu","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2026.116467_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/cells11111724","article-title":"Leonurine protects bone mesenchymal stem cells from oxidative stress by activating Mitophagy through PI3K\/Akt\/mTOR pathway","volume":"11","author":"Zhao","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.116467_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156401","article-title":"Syringin inhibits the crosstalk between macrophages and fibroblast-like synoviocytes to treat rheumatoid arthritis via PDE4","volume":"138","author":"Cong","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116467_bb0120","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1164\/rccm.202006-2467OC","article-title":"Hypoxia increases the potential for neutrophil-mediated endothelial damage in chronic obstructive pulmonary disease","volume":"205","author":"Lodge","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2026.116467_bb0125","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1016\/j.apsb.2022.12.002","article-title":"Alleviating experimental pulmonary hypertension via co-delivering FoxO1 stimulus and apoptosis activator to hyperproliferating pulmonary arteries","volume":"13","author":"Li","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.intimp.2026.116467_bb0130","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s43450-024-00573-0","article-title":"Shionone exhibits anti-inflammatory and antiproliferative effects in pulmonary arterial endothelial cells and smooth muscle cells via SIRT1 in pulmonary arterial hypertension","volume":"34","author":"Jiang","year":"2024","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.intimp.2026.116467_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152230","article-title":"Schisandrin a induces osteoblast differentiation to treat glucocorticoid-induced osteoporosis through activating Wnt pathway","volume":"776","author":"Ai","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2026.116467_bb0140","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1080\/15548627.2023.2179781","article-title":"Narirutin activates TFEB (transcription factor EB) to protect against acetaminophen-induced liver injury by targeting PPP3\/calcineurin","volume":"19","author":"Fang","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.intimp.2026.116467_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115020","article-title":"S100a8 inhibitor Paquinimod attenuates coal dust-induced pulmonary fibrosis via blocking neutrophils-S100a8-Tlr4-macrophages signaling axis","volume":"161","author":"Du","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116467_bb0150","doi-asserted-by":"crossref","unstructured":"Lee J, Park JS, Jun JA, et al., Inhibitory effect of Paquinimod on a murine model of neutrophilic asthma induced by ovalbumin with complete Freund's adjuvant, Can. Respir. J. 2021 (2021) 8896108.","DOI":"10.1155\/2021\/9795069"},{"key":"10.1016\/j.intimp.2026.116467_bb0155","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163841","article-title":"SCCA1\/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production","volume":"133","author":"Chen","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2026.116467_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155976","article-title":"Parthenolide attenuates hypoxia-induced pulmonary hypertension through inhibiting STAT3 signaling","volume":"134","author":"Yao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116467_bb0165","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12872-023-03304-w","article-title":"Meta-analysis of differences in neutrophil to lymphocyte ratio between hypertensive and non-hypertensive individuals","volume":"23","author":"Sarejloo","year":"2023","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.intimp.2026.116467_bb0170","article-title":"The neutrophil-to-lymphocyte ratio as a diagnostic and prognostic biomarker in pulmonary hypertension: a systematic review","volume":"42","author":"Khanzadeh","year":"2025","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"10.1016\/j.intimp.2026.116467_bb0175","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.hlc.2022.02.007","article-title":"Immune cells in pulmonary arterial hypertension","volume":"31","author":"Ni","year":"2022","journal-title":"Heart Lung Circ."},{"key":"10.1016\/j.intimp.2026.116467_bb0180","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/bib\/bbab026","article-title":"Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients","volume":"22","author":"Taz","year":"2021","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.intimp.2026.116467_bb0185","doi-asserted-by":"crossref","first-page":"1618772","DOI":"10.3389\/fmed.2025.1618772","article-title":"A review on clinical implications of S100 proteins in lung diseases","volume":"12","author":"Raveendran","year":"2025","journal-title":"Front Med (Lausanne)."},{"key":"10.1016\/j.intimp.2026.116467_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203046","article-title":"Crucial role of RAGE in inappropriate increase of smooth muscle cells from patients with pulmonary arterial hypertension","volume":"13","author":"Nakamura","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.intimp.2026.116467_bb0195","doi-asserted-by":"crossref","first-page":"eadu6425","DOI":"10.1126\/scitranslmed.adu6425","article-title":"Sine oculis homeobox 1 drives endothelial dysfunction in preclinical pulmonary arterial hypertension","volume":"18","author":"Liu","year":"2026","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.intimp.2026.116467_bb0200","article-title":"The role of immune cells and inflammation in pulmonary hypertension: mechanisms and implications","volume":"15","author":"Zhao","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116467_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102721","article-title":"Deficiency of S100 calcium binding protein A9 attenuates vascular dysfunction in aged mice","volume":"63","author":"Zhao","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2026.116467_bb0210","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-023-02594-0","article-title":"Deficiency of S100A8\/A9 attenuates pulmonary microvascular leakage in septic mice","volume":"24","author":"Yu","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2026.116467_bb0215","doi-asserted-by":"crossref","unstructured":"Li C, Gao P, Zhuang F, et al., Inhibition of ALOX12-12-HETE alleviates lung ischemia-reperfusion injury by reducing endothelial Ferroptosis-mediated neutrophil extracellular trap formation, Research (Wash D C). 7 (2024) 0473.","DOI":"10.34133\/research.0473"},{"key":"10.1016\/j.intimp.2026.116467_bb0220","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bbrc.2020.03.088","article-title":"Neutrophil-derived exosome from systemic sclerosis inhibits the proliferation and migration of endothelial cells","volume":"526","author":"Li","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2026.116467_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116621","article-title":"NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1\/HS and downstream pathways","volume":"175","author":"Fei","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2026.116467_bb0230","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-025-02932-9","article-title":"Vascular smooth muscle cell metabolic reprogramming and phenotypic remodeling in atherosclerosis","volume":"12","author":"Fu","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.intimp.2026.116467_bb0235","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12931-024-02813-2","article-title":"Neutrophil extracellular traps promote proliferation of pulmonary smooth muscle cells mediated by CCDC25 in pulmonary arterial hypertension","volume":"25","author":"Sun","year":"2024","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2026.116467_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102037","article-title":"Susceptibility to COPD: differential proteomic profiling after acute smoking","volume":"9","author":"Franciosi","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.intimp.2026.116467_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26072832","article-title":"Impaired SERPIN-protease balance in the peripheral lungs of stable COPD patients","volume":"26","author":"Di Stefano","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116467_bb0250","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12014-019-9226-4","article-title":"Quantitative proteomic characterization of lung tissue in idiopathic pulmonary fibrosis","volume":"16","author":"Tian","year":"2019","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.intimp.2026.116467_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16142579","article-title":"SerpinB3: a multifaceted player in health and disease-review and future perspectives","volume":"16","author":"Cagnin","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.intimp.2026.116467_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167582","article-title":"MMP8-mediated vascular remodeling in pulmonary hypertension","volume":"1871","author":"Deng","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.intimp.2026.116467_bb0265","doi-asserted-by":"crossref","first-page":"8714","DOI":"10.1074\/jbc.M408092200","article-title":"Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase\/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury","volume":"280","author":"Zhang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2026.116467_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104935","article-title":"Adaptive evolution and divergence of SERPINB3: a young duplicate in great apes","volume":"9","author":"Gomes","year":"2014","journal-title":"PloS One"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926003115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926003115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:09:58Z","timestamp":1790838598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926003115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":54,"alternative-id":["S1567576926003115"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116467","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leonurine ameliorates hypoxic pulmonary hypertension by inhibiting cross-talk between neutropHils and endothelial cells via SERPINB3 targeting","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116467"}}