{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:57:31Z","timestamp":1790841451088,"version":"4.1.0"},"reference-count":282,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ90014"],"award-info":[{"award-number":["2025JJ90014"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014978","name":"Hunan University of Chinese Medicine","doi-asserted-by":"publisher","award":["2025CX173"],"award-info":[{"award-number":["2025CX173"]}],"id":[{"id":"10.13039\/501100014978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014978","name":"Hunan University of Chinese Medicine","doi-asserted-by":"publisher","award":["2025CX072"],"award-info":[{"award-number":["2025CX072"]}],"id":[{"id":"10.13039\/501100014978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.intimp.2026.116487","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:31:29Z","timestamp":1773084689000},"page":"116487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lysosomal functions in the osteoimmune microenvironment: a novel perspective in osteoporosis research"],"prefix":"10.1016","volume":"176","author":[{"given":"Chang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianguang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116487_bb0005","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-081250","article-title":"Advances in the management of osteoporosis","volume":"390","author":"Hoong","year":"2025","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41514-025-00269-2","article-title":"Global epidemiology and burden of osteoporosis among postmenopausal women: insights from the Global Burden of Disease Study 2021","volume":"11","author":"Liang","year":"2025","journal-title":"NPJ Aging"},{"key":"10.1016\/j.intimp.2026.116487_bb0015","article-title":"The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3803\/EnM.2021.1369","article-title":"Discontinuing Denosumab: can it be done safely? A review of the literature","volume":"37","author":"Tay","year":"2022","journal-title":"Endocrinol. Metab. (Seoul)"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0025","doi-asserted-by":"crossref","DOI":"10.1186\/s40360-023-00657-y","article-title":"Medication-induced osteonecrosis of the jaw: a review of cases from the Food and Drug Administration adverse event reporting system (FAERS)","volume":"24","author":"Ahdi","year":"2023","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.intimp.2026.116487_bb0030","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.semcdb.2021.05.014","article-title":"Interaction between bone and immune cells: implications for postmenopausal osteoporosis","volume":"123","author":"Fischer","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"issue":"14","key":"10.1016\/j.intimp.2026.116487_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202500858","article-title":"Influence of hypoxia on a biomaterial model of the bone marrow perivascular niche","volume":"14","author":"Thompson","year":"2025","journal-title":"Adv. Healthc. Mater."},{"issue":"23","key":"10.1016\/j.intimp.2026.116487_bb0040","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.182418","article-title":"Dynamic transcriptome analysis of osteal macrophages identifies a distinct subset with senescence features in experimental osteoporosis","volume":"9","author":"Nishida","year":"2024","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.intimp.2026.116487_bb0045","first-page":"C977","article-title":"Calcium released by osteoclastic resorption stimulates autocrine\/paracrine activities in local osteogenic cells to promote coupled bone formation","volume":"322","author":"Ahmed","year":"2022","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0050","doi-asserted-by":"crossref","DOI":"10.1186\/s41232-024-00360-3","article-title":"Cell fusion dynamics: mechanisms of multinucleation in osteoclasts and macrophages","volume":"44","author":"Sabe","year":"2024","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.intimp.2026.116487_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2022.116540","article-title":"Cytokine-mediated immunomodulation of osteoclastogenesis","volume":"164","author":"Zhou","year":"2022","journal-title":"Bone"},{"issue":"45","key":"10.1016\/j.intimp.2026.116487_bb0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2425366122","article-title":"The RANK\/RANKL axis controls vascular dynamics in the bone marrow","volume":"122","author":"Kaneko","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"23","key":"10.1016\/j.intimp.2026.116487_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262311642","article-title":"Immune-guided bone healing: the role of osteoimmunity in tissue engineering approaches","volume":"26","author":"Muna\u00f2","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116487_bb0070","article-title":"Membrane transport proteins in osteoclasts: the ins and outs. Front cell","volume":"9","author":"Ribet","year":"2021","journal-title":"Dev. Biol."},{"key":"10.1016\/j.intimp.2026.116487_bb0075","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85214","article-title":"Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity","volume":"13","author":"Yu","year":"2024","journal-title":"Elife"},{"issue":"24","key":"10.1016\/j.intimp.2026.116487_bb0080","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1016\/j.cell.2023.09.027","article-title":"Nutrient-regulated control of lysosome function by signaling lipid conversion","volume":"186","author":"Ebner","year":"2023","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.intimp.2026.116487_bb0085","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.immuni.2024.03.021","article-title":"25-hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages","volume":"57","author":"Xiao","year":"2024","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-36484-2","article-title":"Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts","volume":"14","author":"Ng","year":"2023","journal-title":"Nat. Commun."},{"issue":"17","key":"10.1016\/j.intimp.2026.116487_bb0095","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.191688","article-title":"Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength","volume":"10","author":"James","year":"2025","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-023-01331-2","article-title":"Resveratrol protects osteocytes against oxidative stress in ovariectomized rats through AMPK\/JNK1-dependent pathway leading to promotion of autophagy and inhibition of apoptosis","volume":"9","author":"Wei","year":"2023","journal-title":"Cell Death Discov."},{"issue":"15","key":"10.1016\/j.intimp.2026.116487_bb0105","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/j.scib.2024.03.055","article-title":"Excitatory amino acid transporter supports inflammatory macrophage responses","volume":"69","author":"Gan","year":"2024","journal-title":"Sci. Bull. (Beijing)"},{"issue":"4","key":"10.1016\/j.intimp.2026.116487_bb0110","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-002137","article-title":"Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity","volume":"9","author":"Zhang","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54344-5","article-title":"The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB\/TFE3-dependent mitochondrial fitness","volume":"15","author":"Zhu","year":"2024","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202400154","article-title":"Hematopoietic stem cell metabolism within the bone marrow niche - insights and opportunities","volume":"47","author":"Kemna","year":"2025","journal-title":"Bioessays"},{"issue":"13","key":"10.1016\/j.intimp.2026.116487_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136857","article-title":"The role of hypoxic bone marrow microenvironment in acute myeloid leukemia and future therapeutic opportunities","volume":"22","author":"Bruno","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0130","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-025-04304-7","article-title":"Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities","volume":"16","author":"Liao","year":"2025","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0135","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-023-00249-w","article-title":"The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies","volume":"11","author":"Zhang","year":"2023","journal-title":"Bone Res."},{"issue":"7","key":"10.1016\/j.intimp.2026.116487_bb0140","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.stem.2024.04.020","article-title":"Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells","volume":"31","author":"Dellorusso","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.intimp.2026.116487_bb0145","doi-asserted-by":"crossref","unstructured":"He L, Cho S, Blenis J. mTORC1, the maestro of cell metabolism and growth. Genes Dev. 2025;39(1\u20132):109\u2013131. Published 2025 Jan 7. doi:https:\/\/doi.org\/10.1101\/gad.352084.124.","DOI":"10.1101\/gad.352084.124"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0150","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-32515-6","article-title":"Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly","volume":"13","author":"Ratto","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0155","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-025-07870-x","article-title":"Investigation of dynamic regulation of TFEB nuclear shuttling by microfluidics and quantitative modelling","volume":"8","author":"Ruolo","year":"2025","journal-title":"Commun. Biol."},{"issue":"11","key":"10.1016\/j.intimp.2026.116487_bb0160","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1007\/s11999-011-1865-3","article-title":"Human early fracture hematoma is characterized by inflammation and hypoxia","volume":"469","author":"Kolar","year":"2011","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"12","key":"10.1016\/j.intimp.2026.116487_bb0165","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1038\/s41416-021-01329-6","article-title":"Bone marrow niches in the regulation of bone metastasis","volume":"124","author":"Chen","year":"2021","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0170","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-025-05883-7","article-title":"Lysosome heterogeneity and diversity mapped through its distinct cellular functions","volume":"82","author":"Chavan","year":"2025","journal-title":"Cell Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.intimp.2026.116487_bb0175","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202305007","article-title":"Not just protons: chloride also activates lysosomal acidic hydrolases","volume":"222","author":"Feng","year":"2023","journal-title":"J. Cell Biol."},{"issue":"11","key":"10.1016\/j.intimp.2026.116487_bb0180","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1038\/s12276-025-01579-x","article-title":"Failure of lysosomal acidification and endomembrane network in neurodegeneration","volume":"57","author":"Kim","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2026.116487_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113500","article-title":"Impaired V-ATPase leads to increased lysosomal pH, results in disrupted lysosomal degradation and autophagic flux blockage, contributes to fluoride-induced developmental neurotoxicity","volume":"236","author":"Han","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0190","article-title":"V-ATPase-dependent induction of selective autophagy","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"issue":"6056","key":"10.1016\/j.intimp.2026.116487_bb0195","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1207056","article-title":"mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase","volume":"334","author":"Zoncu","year":"2011","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.intimp.2026.116487_bb0200","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nri3818","article-title":"The ins and outs of MHC class II-mediated antigen processing and presentation","volume":"15","author":"Roche","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"24","key":"10.1016\/j.intimp.2026.116487_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/cells14241960","article-title":"CD74 and proteases: impact of location on immune and cellular functions","volume":"14","author":"Dolenc","year":"2025","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.intimp.2026.116487_bb0210","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1074\/jbc.RA119.010645","article-title":"HLA-DM catalytically enhances peptide dissociation by sensing peptide-MHC class II interactions throughout the peptide-binding cleft","volume":"295","author":"Reyes-Vargas","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2026.116487_bb0215","doi-asserted-by":"crossref","unstructured":"Westman J, Grinstein S. Determinants of phagosomal pH during host-pathogen interactions. Front. Cell Dev. Biol. 2021;8:624958. Published 2021 Jan 11. doi:https:\/\/doi.org\/10.3389\/fcell.2020.624958.","DOI":"10.3389\/fcell.2020.624958"},{"issue":"19","key":"10.1016\/j.intimp.2026.116487_bb0220","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.7150\/thno.28391","article-title":"V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis","volume":"8","author":"Duan","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2026.116487_bb0225","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.678532","article-title":"Acid-induced inflammatory cytokines in osteoblasts: a guided path to osteolysis in bone metastasis","volume":"9","author":"Di Pompo","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0230","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.celrep.2012.06.005","article-title":"Age-related oxidative stress compromises endosomal proteostasis","volume":"2","author":"Cannizzo","year":"2012","journal-title":"Cell Rep."},{"issue":"19","key":"10.1016\/j.intimp.2026.116487_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/cells11193153","article-title":"TFEB; beyond its role as an autophagy and lysosomes regulator","volume":"11","author":"Franco-Ju\u00e1rez","year":"2022","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.intimp.2026.116487_bb0240","doi-asserted-by":"crossref","DOI":"10.1111\/acel.70083","article-title":"TFEB orchestrates stress recovery and paves the way for senescence induction in human dermal fibroblasts","volume":"24","author":"Guerrero-Navarro","year":"2025","journal-title":"Aging Cell"},{"issue":"7\u20139","key":"10.1016\/j.intimp.2026.116487_bb0245","article-title":"FGF signaling promotes lysosome biogenesis in chondrocytes via the mannose phosphate receptor pathway","volume":"26","author":"Cinque","year":"2025","journal-title":"Traffic"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0250","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-024-01850-6","article-title":"From the regulatory mechanism of TFEB to its therapeutic implications","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov."},{"issue":"35","key":"10.1016\/j.intimp.2026.116487_bb0255","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2322755121","article-title":"Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway","volume":"121","author":"Valenstein","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7948","key":"10.1016\/j.intimp.2026.116487_bb0260","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/s41586-022-05652-7","article-title":"Structure of the lysosomal mTORC1-TFEB-rag-Ragulator megacomplex","volume":"614","author":"Cui","year":"2023","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0265","article-title":"Induction of lysosomal exocytosis and biogenesis via TRPML1 activation for the treatment of uranium-induced nephrotoxicity","volume":"14","author":"Zhong","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0270","article-title":"Lysosomal Ca2+-mediated TFEB activation modulates mitophagy and functional adaptation of pancreatic \u03b2-cells to metabolic stress","volume":"13","author":"Park","year":"2022","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb0275","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1038\/s12276-023-01055-4","article-title":"Pancreatic \u03b2-cell mitophagy as an adaptive response to metabolic stress and the underlying mechanism that involves lysosomal Ca2+ release","volume":"55","author":"Oh","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.116487_bb0280","doi-asserted-by":"crossref","DOI":"10.1093\/lifemedi\/lnaf015","article-title":"Function of hematopoiesis and bone marrow niche in inflammation and non-hematopoietic diseases","volume":"4","author":"Wang","year":"2025","journal-title":"Life Med."},{"key":"10.1016\/j.intimp.2026.116487_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2021.101506","article-title":"Dimensions of neutrophil life and fate","volume":"57","author":"Hidalgo","year":"2021","journal-title":"Semin. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb0290","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/s41423-023-01058-1","article-title":"Neutrophil diversity and plasticity: implications for organ transplantation","volume":"20","author":"Qu","year":"2023","journal-title":"Cell Mol. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116487_bb0295","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-05931-9","article-title":"Efferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling","volume":"14","author":"Quarato","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116487_bb0300","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev-pharmtox-032723-110507","article-title":"Targeting Efferocytosis in Inflammaging","volume":"64","author":"Poon","year":"2024","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"12","key":"10.1016\/j.intimp.2026.116487_bb0305","article-title":"Efferocytosis in health and disease","volume":"6","author":"Li","year":"2025","journal-title":"MedComm (2020)"},{"key":"10.1016\/j.intimp.2026.116487_bb0310","article-title":"Efferocytosis: the resolution of inflammation in cardiovascular and cerebrovascular disease","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116487_bb0315","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-025-08334-0","article-title":"Lysosomal exocytosis by macrophages as a druggable mechanism for anti-inflammatory clearance of dead adipocytes in adipose tissue","author":"Wehr","year":"2025","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.intimp.2026.116487_bb0320","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/s42255-022-00605-w","article-title":"TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages","volume":"4","author":"Schuster","year":"2022","journal-title":"Nat. Metab."},{"issue":"15","key":"10.1016\/j.intimp.2026.116487_bb0325","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1016\/j.molcel.2022.05.009","article-title":"Itaconate is a lysosomal inducer that promotes antibacterial innate immunity","volume":"82","author":"Zhang","year":"2022","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/cells13090724","article-title":"Bone marrow adipose tissue","volume":"13","author":"Marinelli Busilacchi","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.116487_bb0335","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.853765","article-title":"The implications of bone marrow adipose tissue on inflammaging","volume":"13","author":"Aaron","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0340","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-36906-1","article-title":"Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis","volume":"14","author":"Zioni","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0345","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-56403-x","article-title":"Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel","volume":"16","author":"Xing","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0350","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41423-022-00959-x","article-title":"RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts","volume":"20","author":"Bae","year":"2023","journal-title":"Cell Mol. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116487_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105191","article-title":"Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages","volume":"299","author":"Noda","year":"2023","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.intimp.2026.116487_bb0360","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030366","article-title":"The role of the lysosomal Cl-\/H+ antiporter ClC-7 in osteopetrosis and neurodegeneration","volume":"11","author":"Zifarelli","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.116487_bb0365","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1431566","article-title":"Lysosomal biogenesis and function in osteoclasts: a comprehensive review","volume":"12","author":"Jiang","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0370","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-024-00326-8","article-title":"RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts","volume":"12","author":"Kim","year":"2024","journal-title":"Bone Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0375","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-12397-w","article-title":"The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts","volume":"12","author":"Matsumoto","year":"2022","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb0380","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1042\/BST20180445","article-title":"Membrane trafficking in osteoclasts and implications for osteoporosis","volume":"47","author":"Ng","year":"2019","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.intimp.2026.116487_bb0385","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev-pathmechdis-031521-040919","article-title":"Osteoclasts, master sculptors of bone","volume":"18","author":"Veis","year":"2023","journal-title":"Annu. Rev. Pathol."},{"issue":"21","key":"10.1016\/j.intimp.2026.116487_bb0390","doi-asserted-by":"crossref","DOI":"10.3390\/cells13211766","article-title":"Autophagy regulator Rufy 4 promotes osteoclastic bone resorption by orchestrating cytoskeletal organization via its RUN domain","volume":"13","author":"Sakai","year":"2024","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.intimp.2026.116487_bb0395","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202102001","article-title":"Lysosome biogenesis: regulation and functions","volume":"220","author":"Yang","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.intimp.2026.116487_bb0400","doi-asserted-by":"crossref","unstructured":"Ke PY. Molecular mechanism of autophagosome\u2013lysosome fusion in mammalian cells. Cells 2024;13(6):500. Published 2024 Mar 13. doi:https:\/\/doi.org\/10.3390\/cells13060500.","DOI":"10.3390\/cells13060500"},{"issue":"5","key":"10.1016\/j.intimp.2026.116487_bb0405","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1080\/15548627.2022.2128019","article-title":"Autophagic lysosome reformation in health and disease","volume":"19","author":"Nanayakkara","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.intimp.2026.116487_bb0410","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ceb.2022.01.001","article-title":"Plasmalemmal interface for calcium signaling in osteoclast differentiation","volume":"74","author":"Okada","year":"2022","journal-title":"Curr. Opin. Cell Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb0415","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021647","article-title":"TRPML1-induced lysosomal Ca2+ signals activate AQP2 translocation and water flux in renal collecting duct cells","volume":"24","author":"Scorza","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb0420","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/jbmr.2986","article-title":"Lysosomal Ca2+ signaling is essential for Osteoclastogenesis and bone remodeling","volume":"32","author":"Erkhembaatar","year":"2017","journal-title":"J. Bone Miner. Res."},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb0425","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s12276-024-01157-7","article-title":"Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases","volume":"56","author":"Takegahara","year":"2024","journal-title":"Exp. Mol. Med."},{"issue":"32","key":"10.1016\/j.intimp.2026.116487_bb0430","doi-asserted-by":"crossref","first-page":"19266","DOI":"10.1073\/pnas.2003236117","article-title":"Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1","volume":"117","author":"Peng","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"25","key":"10.1016\/j.intimp.2026.116487_bb0435","doi-asserted-by":"crossref","first-page":"8643","DOI":"10.1073\/pnas.0800642105","article-title":"Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis [published correction appears in proc Natl Acad Sci U S a. 2008 Aug 19;105(33):12093]","volume":"105","author":"Kuroda","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2026.116487_bb0440","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fchem.2018.00122","article-title":"The Physiopathological role of the exchangers belonging to the SLC37 family","volume":"6","author":"Cappello","year":"2018","journal-title":"Front. Chem."},{"issue":"20","key":"10.1016\/j.intimp.2026.116487_bb0445","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1016\/j.devcel.2022.09.013","article-title":"Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption","volume":"57","author":"Li","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.intimp.2026.116487_bb0450","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.675385","article-title":"The role of osteoclast energy metabolism in the occurrence and development of osteoporosis","volume":"12","author":"Da","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.intimp.2026.116487_bb0455","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73539","article-title":"Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton","volume":"11","author":"Das","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.intimp.2026.116487_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102164","article-title":"Mitochondrial iron-sulfur clusters: structure, function, and an emerging role in vascular biology","volume":"47","author":"Read","year":"2021","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116487_bb0465","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/jbmr\/zjaf040","article-title":"Heme metabolism mediates RANKL-induced osteoclastogenesis via mitochondrial oxidative phosphorylation","volume":"40","author":"Qiu","year":"2025","journal-title":"J. Bone Miner. Res."},{"issue":"12","key":"10.1016\/j.intimp.2026.116487_bb0470","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.tibs.2021.07.003","article-title":"The lysosome as a master regulator of iron metabolism","volume":"46","author":"Rizzollo","year":"2021","journal-title":"Trends Biochem. Sci."},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb0475","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1158\/2159-8290.CD-22-0043","article-title":"NCOA4-mediated Ferritinophagy is a pancreatic Cancer dependency via maintenance of Iron bioavailability for Iron-sulfur cluster proteins","volume":"12","author":"Santana-Codina","year":"2022","journal-title":"Cancer Discov."},{"issue":"21","key":"10.1016\/j.intimp.2026.116487_bb0480","doi-asserted-by":"crossref","DOI":"10.3390\/cells11213464","article-title":"Mitoferrin, cellular and mitochondrial iron homeostasis","volume":"11","author":"Ali","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.116487_bb0485","article-title":"Ferrochelatase: mapping the intersection of Iron and porphyrin metabolism in the mitochondria. Front cell","volume":"10","author":"Obi","year":"2022","journal-title":"Dev. Biol."},{"key":"10.1016\/j.intimp.2026.116487_bb0490","article-title":"Regulation of Heme synthesis by mitochondrial homeostasis proteins. Front cell","volume":"10","author":"Yien","year":"2022","journal-title":"Dev. Biol."},{"key":"10.1016\/j.intimp.2026.116487_bb0495","article-title":"Lysosome-iron-mitochondria axis in osteoclasts: iron as a central player","volume":"8","author":"Qin","year":"2025","journal-title":"Research (Washington, D.C.)"},{"issue":"22","key":"10.1016\/j.intimp.2026.116487_bb0500","article-title":"Examining the role of a functional deficiency of iron in lysosomal storage disorders with translational relevance to Alzheimer's disease","volume":"12","author":"SM","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.116487_bb0505","doi-asserted-by":"crossref","unstructured":"Dharmasivam M, Kaya B. Lysosome as a chemical reactor. Int. J. Mol. Sci. 2025;26(23):11581. Published 2025 Nov 29. doi:https:\/\/doi.org\/10.3390\/ijms262311581.","DOI":"10.3390\/ijms262311581"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0510","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-024-00689-6","article-title":"Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell Discov."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0515","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-025-04288-4","article-title":"The bone microenvironment: new insights into the role of stem cells and cell communication in bone regeneration","volume":"16","author":"Dalle Carbonare","year":"2025","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0520","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-025-00457-6","article-title":"The role of the unfolded protein response pathway in bone homeostasis and potential therapeutic target in cancer-associated bone disease","volume":"13","author":"Muehlebach","year":"2025","journal-title":"Bone Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0525","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-023-00297-2","article-title":"Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status","volume":"11","author":"Nandy","year":"2023","journal-title":"Bone Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0530","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Aging and aging-related diseases: from molecular mechanisms to interventions and treatments","volume":"7","author":"Guo","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"11","key":"10.1016\/j.intimp.2026.116487_bb0535","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202357265","article-title":"Lysosomes in senescence and aging","volume":"24","author":"Tan","year":"2023","journal-title":"EMBO Rep."},{"key":"10.1016\/j.intimp.2026.116487_bb0540","doi-asserted-by":"crossref","unstructured":"Li X, Li C, Zhang W, Wang Y, Qian P, Huang H. Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct. Target. Ther. 2023;8(1):239. Published 2023 Jun 8. doi:https:\/\/doi.org\/10.1038\/s41392-023-01502-8.","DOI":"10.1038\/s41392-023-01502-8"},{"key":"10.1016\/j.intimp.2026.116487_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115134","article-title":"Advances in the interaction between endoplasmic reticulum stress and osteoporosis","volume":"165","author":"Zhong","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0550","article-title":"Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.intimp.2026.116487_bb0555","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/s12276-023-01041-w","article-title":"Nicotinamide enhances osteoblast differentiation through activation of the mitochondrial antioxidant defense system","volume":"55","author":"Yoon","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0560","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"11","key":"10.1016\/j.intimp.2026.116487_bb0565","article-title":"TMEM175 plays a crucial role in osteoblast differentiation by regulating lysosomal function and autophagy","volume":"47","author":"Lee","year":"2024","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.intimp.2026.116487_bb0570","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/s12276-025-01480-7","article-title":"Hallmarks of cellular senescence: biology, mechanisms, regulations","volume":"57","author":"Ajoolabady","year":"2025","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.116487_bb0575","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10488","article-title":"Bone aging, cellular senescence, and osteoporosis","volume":"5","author":"Pignolo","year":"2021","journal-title":"JBMR Plus"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0580","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-021-02843-2","article-title":"Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence","volume":"4","author":"Pan","year":"2021","journal-title":"Commun. Biol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.110551","article-title":"Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells","volume":"301","author":"Ali","year":"2025","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb0590","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1080\/15548627.2024.2353548","article-title":"ROS-mediated lysosomal membrane permeabilization and autophagy inhibition regulate bleomycin-induced cellular senescence","volume":"20","author":"Qi","year":"2024","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.intimp.2026.116487_bb0595","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/s41418-022-01028-6","article-title":"Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease","volume":"29","author":"Tan","year":"2022","journal-title":"Cell Death Differ."},{"issue":"12","key":"10.1016\/j.intimp.2026.116487_bb0600","article-title":"Mechanistic study of hypoxia-mediated regulation of osteoblast senescence via ATP6V1A-dependent modulation of metabolic remodeling","volume":"14","author":"Xiao","year":"2025","journal-title":"Biology (Basel)"},{"issue":"7","key":"10.1016\/j.intimp.2026.116487_bb0605","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax0672","article-title":"Osteoblastic lysosome plays a central role in mineralization","volume":"5","author":"Iwayama","year":"2019","journal-title":"Sci. Adv."},{"issue":"12","key":"10.1016\/j.intimp.2026.116487_bb0610","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1038\/s12276-024-01362-4","article-title":"TIGAR coordinates senescence-associated secretory phenotype via lysosome repositioning and \u03b1-tubulin deacetylation","volume":"56","author":"Nam","year":"2024","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0615","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1152\/physrev.00043.2020","article-title":"The osteocyte as a signaling cell","volume":"102","author":"Delgado-Calle","year":"2022","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0620","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-65636-9","article-title":"Piezo1-mediated mechanotransduction controls osteocyte maturation and dendrite development via a YAP-CCN-Src signaling axis","volume":"16","author":"Hu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.116487_bb0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2023.109634","article-title":"Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading","volume":"742","author":"Gao","year":"2023","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.intimp.2026.116487_bb0630","article-title":"Osteocytes enhance osteogenesis by autophagy-mediated FGF23 secretion under mechanical tension. Front cell","volume":"9","author":"Xu","year":"2022","journal-title":"Dev. Biol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb0635","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1080\/15548627.2023.2186112","article-title":"The role of autophagy in bone metabolism and clinical significance","volume":"19","author":"Wang","year":"2023","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.intimp.2026.116487_bb0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114363","article-title":"Connexin hemichannels drive lactation-induced osteocyte acidification and perilacunar-canalicular remodeling","volume":"43","author":"Hua","year":"2024","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.intimp.2026.116487_bb0645","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11914-019-00514-0","article-title":"Investigating Osteocytic Perilacunar\/Canalicular remodeling","volume":"17","author":"Yee","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"issue":"8","key":"10.1016\/j.intimp.2026.116487_bb0650","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/jbmr.4023","article-title":"TGF\u03b2 regulation of Perilacunar\/Canalicular remodeling is sexually dimorphic","volume":"35","author":"Dole","year":"2020","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0655","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-023-00303-7","article-title":"Aging impairs the osteocytic regulation of collagen integrity and bone quality","volume":"12","author":"Schurman","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.intimp.2026.116487_bb0660","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.64393","article-title":"Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein","volume":"10","author":"Gould","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.intimp.2026.116487_bb0665","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150315","article-title":"Nitric oxide contributes to rapid sclerostin protein loss following mechanical load","volume":"727","author":"Buck","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2026.116487_bb0670","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jot.2022.11.003","article-title":"PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes","volume":"38","author":"Yuan","year":"2022","journal-title":"J. Orthop. Translat."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0675","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-024-02139-4","article-title":"Premature senescence is regulated by crosstalk among TFEB, the autophagy lysosomal pathway and ROS derived from damaged mitochondria in NaAsO2-exposed auditory cells","volume":"10","author":"Suzuki","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.intimp.2026.116487_bb0680","article-title":"O-Vanillin enhances bone health and fracture healing by inhibiting cellular senescence in aging mice","author":"Ouyang","year":"2025","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.intimp.2026.116487_bb0685","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e25538","article-title":"Recent advances in senescence-associated secretory phenotype and osteoporosis","volume":"10","author":"Fan","year":"2024","journal-title":"Heliyon"},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb0690","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/toxsci\/kfaf140","article-title":"Contribution of particle-induced lysosome membrane permeabilization to NLRP3 inflammasome activation and mitochondrial ROS production","volume":"208","author":"Albright","year":"2025","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.intimp.2026.116487_bb0695","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1083743","article-title":"IL-1 and senescence: friends and foe of EGFR neutralization and immunotherapy","volume":"10","author":"Romaniello","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2026.116487_bb0700","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81480","article-title":"Osteocytes regulate senescence of bone and bone marrow","volume":"11","author":"Ding","year":"2022","journal-title":"Elife"},{"issue":"19","key":"10.1016\/j.intimp.2026.116487_bb0705","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.138815","article-title":"Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence","volume":"5","author":"Kim","year":"2020","journal-title":"JCI Insight"},{"issue":"14","key":"10.1016\/j.intimp.2026.116487_bb0710","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159838","article-title":"Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation","volume":"8","author":"Miyagawa","year":"2023","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.intimp.2026.116487_bb0715","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202209084","article-title":"Inhibition of endolysosome fusion increases exosome secretion","volume":"222","author":"Shelke","year":"2023","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0720","article-title":"Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.116487_bb0725","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.778078","article-title":"Macrophage-osteoclast associations: origin, polarization, and subgroups","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0730","doi-asserted-by":"crossref","DOI":"10.3390\/jfb14010018","article-title":"Strategies of macrophages to maintain bone homeostasis and promote bone repair: a narrative review","volume":"14","author":"Hu","year":"2022","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.intimp.2026.116487_bb0735","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1683872","article-title":"Macrophages and osteoclasts: similarity and divergence between bone phagocytes","volume":"16","author":"Halper","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116487_bb0740","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1639430","article-title":"Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis","volume":"13","author":"Yin","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2026.116487_bb0745","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.664871","article-title":"The macrophage-osteoclast Axis in Osteoimmunity and Osteo-related diseases","volume":"12","author":"Yao","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0750","article-title":"The alterations of molecular repertoire of the RANKL-induced osteoclastogenesis in the M1 macrophage-derived inflammatory milieu","volume":"15","author":"Wu","year":"2025","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2026.116487_bb0755","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s11914-023-00825-3","article-title":"Novel insights into osteoclast energy metabolism","volume":"21","author":"Ledesma-Colunga","year":"2023","journal-title":"Curr. Osteoporos. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0760","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-77590-5","article-title":"Zuogui wan modulates macrophage polarization and promotes osteogenic differentiation through regulation of CD51-positive bone marrow mesenchymal stem cells","volume":"14","author":"Shen","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0765","article-title":"Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice","volume":"16","author":"Lu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.116487_bb0770","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.2147\/JIR.S423819","article-title":"Macrophage polarization and the regulation of bone immunity in bone homeostasis","volume":"16","author":"Hu","year":"2023","journal-title":"J. Inflamm. Res."},{"issue":"10","key":"10.1016\/j.intimp.2026.116487_bb0775","first-page":"3150","article-title":"T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg\/Th17 balance","volume":"6","author":"Yang","year":"2021","journal-title":"Bioact. Mater."},{"issue":"15","key":"10.1016\/j.intimp.2026.116487_bb0780","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1042\/CS20190672","article-title":"Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition","volume":"133","author":"Yuan","year":"2019","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.intimp.2026.116487_bb0785","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2024.156768","article-title":"Contribution of macrophage polarization in bone metabolism: a literature review","volume":"184","author":"Yan","year":"2024","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.intimp.2026.116487_bb0790","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156303","article-title":"Sphingosine-1-phosphate receptor 2 regulates proinflammatory cytokine production and osteoclastogenesis","volume":"11","author":"Yu","year":"2016","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0795","doi-asserted-by":"crossref","DOI":"10.3390\/cells8010017","article-title":"Sphingosine-1-phosphate receptor 2 controls podosome components induced by RANKL affecting osteoclastogenesis and bone resorption","volume":"8","author":"Hsu","year":"2019","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb0800","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ni.2956","article-title":"Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages","volume":"15","author":"Huang","year":"2014","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116487_bb0805","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ncb2718","article-title":"TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop [published correction appears in Nat cell biol. 2013 Aug;15(8):1016]","volume":"15","author":"Settembre","year":"2013","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0810","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-021-00363-1","article-title":"Targeting macrophage TFEB-14-3-3 epsilon interface by naringenin inhibits abdominal aortic aneurysm","volume":"8","author":"Jia","year":"2022","journal-title":"Cell Discov."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0815","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-000543","article-title":"TFEB is a master regulator of tumor-associated macrophages in breast cancer","volume":"8","author":"Li","year":"2020","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0820","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-03357-1","article-title":"Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT\/mTOR pathway","volume":"12","author":"Fang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116487_bb0825","article-title":"Palladium-based nanocomposites remodel osteoporotic microenvironment by bone-targeted hydrogen enrichment and zincum repletion","volume":"7","author":"Liu","year":"2024","journal-title":"Research (Washington, D.C.)"},{"issue":"4","key":"10.1016\/j.intimp.2026.116487_bb0830","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4196\/kjpp.24.248","article-title":"Colla Carapacis et Plastri ameliorates postmenopausal osteoporosis and macrophage immunity by modulating the RANK\/RANKL\/OPG signaling pathway in ovariectomized rats","volume":"29","author":"Wan","year":"2025","journal-title":"Korean J. Physiol. Pharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116487_bb0835","article-title":"Doxorubicin induces bone loss by increasing autophagy through a mitochondrial ROS\/TRPML1\/TFEB axis in osteoclasts","volume":"11","author":"Park","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"11","key":"10.1016\/j.intimp.2026.116487_bb0840","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1038\/s12276-023-01105-x","article-title":"CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential","volume":"55","author":"Koh","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2026.116487_bb0845","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1698283","article-title":"Functional roles of immune cells in osteoporosis","volume":"16","author":"Qi","year":"2025","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116487_bb0850","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-05937-3","article-title":"Effects of altered glycolysis levels on CD8+ T cell activation and function","volume":"14","author":"Cao","year":"2023","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.intimp.2026.116487_bb0855","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41577-021-00537-8","article-title":"CD8+ T cell metabolism in infection and cancer","volume":"21","author":"Reina-Campos","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.116487_bb0860","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2030818","article-title":"Wheel-running exercise protects ovariectomized mice from bone loss via IFN-\u03b3-mediated suppression of the NF-\u03baB and MAPK pathways","volume":"2022","author":"Shen","year":"2022","journal-title":"Oxidative Med. Cell Longev."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0865","doi-asserted-by":"crossref","DOI":"10.1007\/s00223-025-01402-9","article-title":"CD8a+GZMK+T cells inhibit osteoclastogenesis in postmenopausal osteoporosis via the p38-MAPK pathway","volume":"116","author":"He","year":"2025","journal-title":"Calcif. Tissue Int."},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb0870","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/s41423-025-01321-7","article-title":"Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy","volume":"22","author":"Zou","year":"2025","journal-title":"Cell Mol. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0875","article-title":"Molecular mechanisms of T helper cell differentiation and functional specialization","volume":"23","author":"Lee","year":"2023","journal-title":"Immune Netw."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0880","article-title":"T cells in health and disease","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0885","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-95640-0","article-title":"Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women","volume":"11","author":"Bhadricha","year":"2021","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.intimp.2026.116487_bb0890","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143137","article-title":"Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells","volume":"131","author":"Yu","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"20","key":"10.1016\/j.intimp.2026.116487_bb0895","doi-asserted-by":"crossref","first-page":"20753","DOI":"10.18632\/aging.104008","article-title":"Substance P blocks ovariectomy-induced bone loss by modulating inflammation and potentiating stem cell function","volume":"12","author":"Piao","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb0900","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cellimm.2008.08.007","article-title":"Relationship between CD107a expression and cytotoxic activity","volume":"254","author":"Aktas","year":"2009","journal-title":"Cell Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116487_bb0905","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/s41590-025-02182-y","article-title":"Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells","volume":"26","author":"Petrozziello","year":"2025","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2026.116487_bb0910","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/s41556-024-01503-x","article-title":"Ammonia-induced lysosomal and mitochondrial damage causes cell death of effector CD8+ T cells","volume":"26","author":"Zhang","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb0915","first-page":"105","article-title":"Ammonia-induced lysosomal and mitochondrial damage: a novel perspective on T cell-based cancer immunotherapy","volume":"5","author":"Shentu","year":"2025","journal-title":"J. Natl. Cancer Cent."},{"key":"10.1016\/j.intimp.2026.116487_bb0920","article-title":"Inhibiting glutaminase exerts opposite effects on ovariectomy-induced and age-related reductions in murine bone mass","author":"Guo","year":"2024","journal-title":"Aging Dis."},{"issue":"10","key":"10.1016\/j.intimp.2026.116487_bb0925","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1038\/s44319-024-00255-x","article-title":"Glutaminolysis provides nucleotides and amino acids to regulate osteoclast differentiation in mice","volume":"25","author":"Hu","year":"2024","journal-title":"EMBO Rep."},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb0930","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-06475-2","article-title":"IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism","volume":"15","author":"Peng","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116487_bb0935","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2021.809539","article-title":"Lysosomes in T cell immunity and aging","volume":"2","author":"Jin","year":"2021","journal-title":"Front. Aging"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0940","article-title":"Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes","volume":"13","author":"Chang","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0945","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2023-003926","article-title":"Patients with ankylosing spondylitis present a distinct CD8 T cell subset with osteogenic and cytotoxic potential","volume":"10","author":"Martini","year":"2024","journal-title":"RMD Open"},{"issue":"649","key":"10.1016\/j.intimp.2026.116487_bb0950","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo0686","article-title":"Granzyme K+ CD8 T cells form a core population in inflamed human tissue","volume":"14","author":"Jonsson","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.116487_bb0955","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221839","article-title":"Nutrients: signal 4 in T cell immunity","volume":"221","author":"Raynor","year":"2024","journal-title":"J. Exp. Med."},{"issue":"8089","key":"10.1016\/j.intimp.2026.116487_bb0960","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41586-025-09545-3","article-title":"Structural basis for mTORC1 activation on the lysosomal membrane","volume":"647","author":"Cui","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2026.116487_bb0965","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112217","article-title":"mTOR promotes an inflammatory response through the HIF1 signaling pathway in ulcerative colitis","volume":"134","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116487_bb0970","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41423-025-01284-9","article-title":"Updated insights into the molecular networks for NLRP3 inflammasome activation","volume":"22","author":"Paik","year":"2025","journal-title":"Cell Mol. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb0975","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1038\/s12276-025-01535-9","article-title":"Th17 cell pathogenicity in autoimmune disease","volume":"57","author":"Park","year":"2025","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb0980","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-025-02403-1","article-title":"Metabolic reprogram and T cell differentiation in inflammation: current evidence and future perspectives","volume":"11","author":"Shi","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.intimp.2026.116487_bb0985","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.653605","article-title":"Control of T cell metabolism by cytokines and hormones","volume":"12","author":"Bishop","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116487_bb0990","article-title":"The alterations in and the role of the Th17\/Treg balance in metabolic diseases","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2026.116487_bb0995","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110943","article-title":"Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation","volume":"39","author":"Xiang","year":"2022","journal-title":"Cell Rep."},{"issue":"31","key":"10.1016\/j.intimp.2026.116487_bb1000","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2205469119","article-title":"Transcription factor EB coordinates environmental cues to regulate T regulatory cells\u2019 mitochondrial fitness and function","volume":"119","author":"Xia","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb1005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0281845","article-title":"IL-17A regulates autophagy and promotes osteoclast differentiation through the ERK\/mTOR\/Beclin1 pathway","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.intimp.2026.116487_bb1010","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00109-024-02422-y","article-title":"NLRC3 attenuates osteoclastogenesis by limiting TNF\u03b1+ Th17 cell response in osteoporosis","volume":"102","author":"Ren","year":"2024","journal-title":"J. Mol. Med. (Berlin)"},{"issue":"5","key":"10.1016\/j.intimp.2026.116487_bb1015","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2023.12237","article-title":"Trehalose delays postmenopausal osteoporosis by enhancing AKT\/TFEB pathway-dependent autophagy flow in rats","volume":"26","author":"Wang","year":"2023","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1020","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mucimm.2023.10.005","article-title":"B cell-mediated CD4 T-cell costimulation via CD86 exacerbates pro-inflammatory cytokine production during autoimmune intestinal inflammation","volume":"17","author":"Gadjalova","year":"2024","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.intimp.2026.116487_bb1025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.954936","article-title":"Role of B cells as antigen presenting cells","volume":"13","author":"Rastogi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116487_bb1030","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.691081","article-title":"Regulatory B cells (Bregs) inhibit osteoclastogenesis and play a potential role in ameliorating ovariectomy-induced bone loss","volume":"12","author":"Sapra","year":"2021","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116487_bb1035","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI200317215","article-title":"Role of RANK ligand in mediating increased bone resorption in early postmenopausal women","volume":"111","author":"Eghbali-Fatourechi","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2026.116487_bb1040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.561294","article-title":"Anti-CD20-mediated B cell depletion is associated with bone preservation in lymphoma patients and bone mass increase in mice","volume":"11","author":"Kolomansky","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1045","article-title":"Mechanistic study on the alleviation of postmenopausal osteoporosis by Lactobacillus acidophilus through butyrate-mediated inhibition of osteoclast activity","volume":"14","author":"Dong","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1050","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-42541-7","article-title":"Antigen presentation by B cells enables epitope spreading across an MHC barrier","volume":"14","author":"Fahlquist-Hagert","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.116487_bb1055","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.611795","article-title":"Immunosuppressive mechanisms of regulatory B cells","volume":"12","author":"Catal\u00e1n","year":"2021","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb1060","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10670","article-title":"Reduction of mature B cells and immunoglobulins results in increased trabecular bone","volume":"6","author":"Lagerquist","year":"2022","journal-title":"JBMR Plus"},{"issue":"3","key":"10.1016\/j.intimp.2026.116487_bb1065","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202307047","article-title":"Endolysosomal vesicles at the center of B cell activation","volume":"223","author":"H\u00e4m\u00e4list\u00f6","year":"2024","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1070","doi-asserted-by":"crossref","DOI":"10.1186\/s40364-024-00711-9","article-title":"The multifaceted roles of cathepsins in immune and inflammatory responses: implications for cancer therapy, autoimmune diseases, and infectious diseases","volume":"12","author":"Zhao","year":"2024","journal-title":"Biomark. Res."},{"issue":"24","key":"10.1016\/j.intimp.2026.116487_bb1075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415983","article-title":"The mammalian cysteine protease legumain in health and disease","volume":"23","author":"Solberg","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116487_bb1080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.878271","article-title":"Molecular determinants regulating the plasticity of the MHC class II Immunopeptidome","volume":"13","author":"Santambrogio","year":"2022","journal-title":"Front. Immunol."},{"issue":"36","key":"10.1016\/j.intimp.2026.116487_bb1085","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2205629119","article-title":"LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway","volume":"119","author":"Wang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"18","key":"10.1016\/j.intimp.2026.116487_bb1090","doi-asserted-by":"crossref","first-page":"10405","DOI":"10.1073\/pnas.1533207100","article-title":"Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator","volume":"100","author":"Cenci","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.intimp.2026.116487_bb1095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052688","article-title":"Osteoimmunology: the crosstalk between T cells, B cells, and osteoclasts in rheumatoid arthritis","volume":"25","author":"Yang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116487_bb1100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.semcancer.2021.06.012","article-title":"The HECT family of E3 ubiquitin ligases and PTEN","volume":"85","author":"Song","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1105","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/imr.13070","article-title":"Role of inhibitory signaling in peripheral B cell tolerance","volume":"307","author":"Getahun","year":"2022","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1110","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-31783-6","article-title":"Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation","volume":"13","author":"Jiang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.116487_bb1115","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13075-016-0957-6","article-title":"Generation mechanism of RANKL(+) effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis","volume":"18","author":"Ota","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2026.116487_bb1120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117021","article-title":"Is there a role for N1-N2 neutrophil phenotypes in bone regeneration? A systematic review","volume":"181","author":"Lu","year":"2024","journal-title":"Bone"},{"key":"10.1016\/j.intimp.2026.116487_bb1125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2025.117574","article-title":"Cathepsin D and G expression correlates with human fracture healing phases and specific neutrophil N1 and N2 phenotypes","author":"Lu","year":"2025","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.intimp.2026.116487_bb1130","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1080\/15548627.2020.1761219","article-title":"Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective","volume":"17","author":"Hossain","year":"2021","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb1135","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1199","article-title":"Mature dendritic cells enriched in immunoregulatory molecules (mregDCs): a novel population in the tumour microenvironment and immunotherapy target","volume":"13","author":"Li","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb1140","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.108896","article-title":"Single-cell transcriptomics reveals the role of antigen presentation in liver metastatic breast cancer","volume":"27","author":"Wang","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.intimp.2026.116487_bb1145","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1148061","article-title":"Promising immunotherapeutic targets in lung cancer based on single-cell RNA sequencing","volume":"14","author":"Xue","year":"2023","journal-title":"Front. Immunol."},{"issue":"13","key":"10.1016\/j.intimp.2026.116487_bb1150","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000037555","article-title":"Single-cell transcriptomics reveals comprehensive microenvironment and highlights the dysfuntional state of NK cells in endometrioid carcinoma","volume":"103","author":"Shi","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.intimp.2026.116487_bb1155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139498","article-title":"Multifaceted roles of IL-17 in bone and tendon health","volume":"294","author":"Shen","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1160","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1365-2567.2008.02822.x","article-title":"TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells","volume":"125","author":"Catalfamo","year":"2008","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb1165","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.chembiol.2023.01.001","article-title":"Investigation of osteoclast cathepsin K activity in osteoclastogenesis and bone loss using a set of chemical reagents","volume":"30","author":"Janiszewski","year":"2023","journal-title":"Cell Chem. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1170","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00198-013-2398-2","article-title":"Effect of the cathepsin K inhibitor odanacatib administered once weekly on bone mineral density in Japanese patients with osteoporosis--a double-blind, randomized, dose-finding study","volume":"25","author":"Nakamura","year":"2014","journal-title":"Osteoporos. Int."},{"issue":"12","key":"10.1016\/j.intimp.2026.116487_bb1175","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S2213-8587(19)30346-8","article-title":"Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT extension study","volume":"7","author":"McClung","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116487_bb1180","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1210\/er.2015-1114","article-title":"Cathepsin K inhibitors for osteoporosis: biology, potential clinical utility, and lessons learned","volume":"38","author":"Drake","year":"2017","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.intimp.2026.116487_bb1185","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00433","article-title":"Cathepsin K: the action in and beyond bone","volume":"8","author":"Dai","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1190","article-title":"Targeting strategies for bone diseases: signaling pathways and clinical studies","volume":"8","author":"Xu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2026.116487_bb1195","doi-asserted-by":"crossref","first-page":"86","DOI":"10.7326\/M19-0675","article-title":"Disease-modifying effects of a novel Cathepsin K inhibitor in osteoarthritis: a randomized controlled trial","volume":"172","author":"Conaghan","year":"2020","journal-title":"Ann. Intern. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.116487_bb1200","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/jbmr.2080","article-title":"The effect of the cathepsin K inhibitor ONO-5334 on trabecular and cortical bone in postmenopausal osteoporosis: the OCEAN study","volume":"29","author":"Engelke","year":"2014","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.116487_bb1205","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/jcb.25442","article-title":"Bafilomycin A1 attenuates osteoclast acidification and formation, accompanied by increased levels of SQSTM1\/p62 protein","volume":"117","author":"Zhu","year":"2016","journal-title":"J. Cell Biochem."},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb1210","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.biocel.2012.05.014","article-title":"V-ATPases in osteoclasts: structure, function and potential inhibitors of bone resorption","volume":"44","author":"Qin","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"14","key":"10.1016\/j.intimp.2026.116487_bb1215","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.devcel.2021.06.011","article-title":"Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells","volume":"56","author":"Gong","year":"2021","journal-title":"Dev. Cell"},{"issue":"10","key":"10.1016\/j.intimp.2026.116487_bb1220","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1080\/15548627.2021.2017587","article-title":"Degradation of the NOTCH intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis","volume":"18","author":"Yoshida","year":"2022","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1225","article-title":"Silencing of Vangl2 attenuates the inflammation promoted by Wnt5a via MAPK and NF-\u03baB pathway in chondrocytes","volume":"16","author":"Zhang","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"issue":"10","key":"10.1016\/j.intimp.2026.116487_bb1230","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13101572","article-title":"Porous nanomaterials targeting autophagy in bone regeneration","volume":"13","author":"Zhang","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.intimp.2026.116487_bb1235","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.101984.3","article-title":"The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence","volume":"13","author":"Zhang","year":"2025","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1240","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-024-00351-7","article-title":"Rejuvenation of BMSCs senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates aged-related bone loss and extends lifespan in middle aged mice","volume":"12","author":"Luo","year":"2024","journal-title":"Bone Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1245","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.gendis.2021.06.008","article-title":"Liquiritigenin promotes osteogenic differentiation and prevents bone loss via inducing auto-lysosomal degradation and inhibiting apoptosis","volume":"10","author":"Qiu","year":"2021","journal-title":"Genes Dis."},{"key":"10.1016\/j.intimp.2026.116487_bb1250","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.2147\/IJWH.S315184","article-title":"Clinical utility of Romosozumab in the management of osteoporosis: focus on patient selection and perspectives","volume":"14","author":"Lim","year":"2022","journal-title":"Int. J. Women\u2019s Health"},{"issue":"47","key":"10.1016\/j.intimp.2026.116487_bb1255","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2304492120","article-title":"Osteoblast-lineage calcium\/calmodulin-dependent kinase 2 delta and gamma regulates bone mass and quality","volume":"120","author":"Leser","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.intimp.2026.116487_bb1260","article-title":"Reactive oxygen species (ROS) drive osteocyte dysfunction in diabetic osteoporosis by impairing autophagy and triggering apoptosis","volume":"14","author":"Han","year":"2025","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1275","article-title":"Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts","volume":"19","author":"Moon","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2026.116487_bb1285","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2022.116538","article-title":"The origins and formation of bone-resorbing osteoclasts","volume":"164","author":"Elson","year":"2022","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1290","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s10753-019-01111-0","article-title":"Chloroquine and 3-Methyladenine attenuates periodontal inflammation and bone loss in experimental periodontitis","volume":"43","author":"He","year":"2020","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1315","article-title":"Bone homeostasis regulation by in vivo generation of osteoclast-derived apoptotic bodies using targeted self-assembly","volume":"17","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.intimp.2026.116487_bb1295","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25115890","article-title":"Copper chelation therapy attenuates periodontitis inflammation through the cuproptosis\/autophagy\/lysosome axis","volume":"25","author":"Zhang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1300","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-024-00352-6","article-title":"Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects","volume":"12","author":"Yao","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.intimp.2026.116487_bb1305","article-title":"Citric acid-modified pH-sensitive bone-targeted delivery of estrogen for the treatment of postmenopausal osteoporosis","volume":"22","author":"Chen","year":"2023","journal-title":"Mater. Today Bio"},{"issue":"12","key":"10.1016\/j.intimp.2026.116487_bb1310","first-page":"4697","article-title":"Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis","volume":"6","author":"Dou","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.intimp.2026.116487_bb1320","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1623990","article-title":"Pharmacological mechanism of natural products to treat osteoporosis: a focus on the autophagy","volume":"16","author":"Xin","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116487_bb1335","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12102224","article-title":"Trehalose rescues postmenopausal osteoporosis induced by ovariectomy through alleviating osteoblast pyroptosis via promoting autophagy","volume":"12","author":"Hu","year":"2024","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1325","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-024-05320-8","article-title":"Asperuloside alleviates osteoporosis by promoting autophagy and regulating Nrf2 activation","volume":"19","author":"Huang","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.intimp.2026.116487_bb1340","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157456","article-title":"Kaempferol ameliorates BMSCs senescence in postmenopausal osteoporosis by targeting Sp1 to activate FUNDC1-mediated mitophagy","volume":"148","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1345","article-title":"Curcumin liposomes alleviate senescence of bone marrow mesenchymal stem cells by activating mitophagy","volume":"14","author":"Li","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1330","article-title":"Restrained Mitf-associated autophagy by Mulberroside a ameliorates osteoclastogenesis and counteracts OVX-induced osteoporosis in mice","volume":"10","author":"Xue","year":"2024","journal-title":"Cell Death Discov."},{"issue":"23","key":"10.1016\/j.intimp.2026.116487_bb1350","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1177\/15353702231211977","article-title":"Quercetin suppresses ovariectomy-induced osteoporosis in rat mandibles by regulating autophagy and the NLRP3 pathway","volume":"248","author":"Xiong","year":"2023","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.intimp.2026.116487_bb1355","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.875611","article-title":"Gut metabolite Urolithin A inhibits Osteoclastogenesis and senile osteoporosis by enhancing the autophagy capacity of bone marrow macrophages","volume":"13","author":"Tao","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1360","article-title":"Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway","volume":"47","author":"Ke","year":"2024","journal-title":"Biom. J."},{"key":"10.1016\/j.intimp.2026.116487_bb1365","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116575","article-title":"Advances in autophagy modulation of natural products in cervical cancer","volume":"314","author":"Tao","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116487_bb1380","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1039\/D3CS00344B","article-title":"Targeted protein degradation directly engaging lysosomes or proteasomes","volume":"53","author":"Kim","year":"2024","journal-title":"Chem. Soc. Rev."},{"issue":"9","key":"10.1016\/j.intimp.2026.116487_bb1265","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/jbmr\/zjaf083","article-title":"Pro-inflammatory immune microenvironment and Thrombospondin-1-positive monocytes as drivers of osteoclastogenesis in postmenopausal osteoporosis","volume":"40","author":"Li","year":"2025","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.intimp.2026.116487_bb1270","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41569-024-01072-4","article-title":"Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis","volume":"22","author":"Bonacina","year":"2025","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1280","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-022-00966-5","article-title":"Metformin alleviates bone loss in ovariectomized mice through inhibition of autophagy of osteoclast precursors mediated by E2F1","volume":"20","author":"Xie","year":"2022","journal-title":"Cell Commun. Signal"},{"issue":"6","key":"10.1016\/j.intimp.2026.116487_bb1370","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1002\/med.22047","article-title":"Targeting lysosomal quality control as a therapeutic strategy against aging and diseases","volume":"44","author":"He","year":"2024","journal-title":"Med. Res. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1375","doi-asserted-by":"crossref","DOI":"10.1186\/s40824-023-00413-7","article-title":"Emerging nano-scale delivery systems for the treatment of osteoporosis","volume":"27","author":"Dayanandan","year":"2023","journal-title":"Biomater. Res."},{"key":"10.1016\/j.intimp.2026.116487_bb1385","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1621648","article-title":"Tcirg1 deficiency delays osteoarthritis progression by impairing lysosome acidification and peripheral accumulation in osteoclasts","volume":"13","author":"Sun","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1395","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-023-00298-1","article-title":"Spatial transcriptomic interrogation of the murine bone marrow signaling landscape","volume":"11","author":"Xiao","year":"2023","journal-title":"Bone Res."},{"issue":"10","key":"10.1016\/j.intimp.2026.116487_bb1400","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41556-023-01240-7","article-title":"Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis","volume":"25","author":"Iga","year":"2023","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1405","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41556-019-0439-6","article-title":"Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization","volume":"22","author":"Baccin","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.intimp.2026.116487_bb1410","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1211498","article-title":"Annexin A7 mediates lysosome repair independently of ESCRT-III","volume":"11","author":"Ebstrup","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116487_bb1415","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41422-025-01193-6","article-title":"Repair of damaged lysosomes by TECPR1-mediated membrane tubulation during energy crisis","volume":"36","author":"Chen","year":"2026","journal-title":"Cell Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926003310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926003310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:09:48Z","timestamp":1790838588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926003310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":282,"alternative-id":["S1567576926003310"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116487","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysosomal functions in the osteoimmune microenvironment: a novel perspective in osteoporosis research","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116487"}}