{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:14:05Z","timestamp":1778822045232,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019065","name":"Tianjin Municipal Science and Technology Program","doi-asserted-by":"publisher","award":["24ZXGZSY00180"],"award-info":[{"award-number":["24ZXGZSY00180"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371205"],"award-info":[{"award-number":["82371205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.intimp.2026.116526","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T16:30:47Z","timestamp":1774110647000},"page":"116526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tetrahydrocoptisine alleviates postoperative delirium with sleep disturbances by modulating the TH\/NLRP3 Inflammasome pathway"],"prefix":"10.1016","volume":"177","author":[{"given":"Xing","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingshu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2026.116526_bb0005","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S1474-4422(18)30450-2","article-title":"Implications of sleep disturbance and inflammation for Alzheimer\u2019s disease dementia","volume":"18","author":"Irwin","year":"2019","journal-title":"The Lancet Neurology."},{"issue":"10","key":"10.1016\/j.intimp.2026.116526_bb0010","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S1474-4422(14)70172-3","article-title":"Connections between sleep and cognition in older adults","volume":"13","author":"Yaffe","year":"2014","journal-title":"The Lancet Neurology."},{"issue":"4","key":"10.1016\/j.intimp.2026.116526_bb0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s44254-023-00027-1","article-title":"Efficacy of sleep interventions on postoperative delirium: a systematic review and meta-analysis of randomized controlled trials","volume":"1","author":"Tang","year":"2023","journal-title":"Anesthesiology and Perioperative Science."},{"issue":"3","key":"10.1016\/j.intimp.2026.116526_bb0020","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s44254-024-00066-2","article-title":"Sleep disturbance and cognition in the elderly: a narrative review","volume":"2","author":"Ni","year":"2024","journal-title":"Anesthesiology and Perioperative Science."},{"issue":"12","key":"10.1016\/j.intimp.2026.116526_bb0025","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrneurol.2014.206","article-title":"\u2018The clocks that time us\u2019--circadian rhythms in neurodegenerative disorders","volume":"10","author":"Videnovic","year":"2014","journal-title":"Nat. Rev. Neurol."},{"issue":"22","key":"10.1016\/j.intimp.2026.116526_bb0030","article-title":"Activation of the lateral habenula-ventral tegmental area neural circuit contributes to postoperative cognitive dysfunction in mice","volume":"9","author":"Xin","year":"2022","journal-title":"Adv. Sci. (Weinh., Baden-W\u00fcrttemb., Ger.)."},{"key":"10.1016\/j.intimp.2026.116526_bb0035","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.2147\/NSS.S320745","article-title":"The role of perioperative sleep disturbance in postoperative neurocognitive disorders","volume":"13","author":"Wang","year":"2021","journal-title":"Nat. Sci. Sleep"},{"issue":"10","key":"10.1016\/j.intimp.2026.116526_bb0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11910-018-0873-z","article-title":"Does Dexmedetomidine ameliorate postoperative cognitive dysfunction? A brief review of the recent literature","volume":"18","author":"Carr","year":"2018","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116526_bb0045","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13020-024-00900-6","article-title":"A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer\u2019s disease based on the neuroinflammatory","volume":"19","author":"Chen","year":"2024","journal-title":"Chin. Med."},{"issue":"19","key":"10.1016\/j.intimp.2026.116526_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197337","article-title":"Neuroprotective effects of chronic resveratrol treatment and exercise training in the 3xTg-AD mouse model of Alzheimer\u2019s disease","volume":"21","author":"Broderick","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116526_bb0055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbr.2017.08.014","article-title":"Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of Alzheimer\u2019s type","volume":"335","author":"Bassani","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.intimp.2026.116526_bb0060","doi-asserted-by":"crossref","unstructured":"Sarawi WS, Alhusaini AM, Fadda LM, et al. Curcumin and nano-curcumin mitigate copper neurotoxicity by modulating oxidative stress, inflammation, and Akt\/GSK-3\u03b2 signaling. Molecules 2021;vol. 26(18).","DOI":"10.3390\/molecules26185591"},{"key":"10.1016\/j.intimp.2026.116526_bb0065","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ijbiomac.2022.07.024","article-title":"Prediction and verification of potential lead analgesic and antiarrhythmic components in Corydalis yanhusuo W. T. Wang based on voltage-gated sodium channel proteins","volume":"216","author":"Sun","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"Pt 2","key":"10.1016\/j.intimp.2026.116526_bb0070","article-title":"The analgesic effect and mechanism of the active components screening from Corydalis yanhusuo by P2X3 receptors","volume":"337","author":"Luo","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2026.116526_bb0075","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jep.2016.07.025","article-title":"Chinese herbal medicines promote hippocampal neuroproliferation, reduce stress hormone levels, inhibit apoptosis, and improve behavior in chronically stressed mice","volume":"193","author":"Sun","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116526_bb0080","doi-asserted-by":"crossref","first-page":"10047","DOI":"10.3390\/molecules200610047","article-title":"A 1H-NMR-based Metabonomic study on the anti-depressive effect of the Total alkaloid of Corydalis Rhizoma","volume":"20","author":"Wu","year":"2015","journal-title":"Molecules (Basel, Switzerland)."},{"issue":"5","key":"10.1016\/j.intimp.2026.116526_bb0085","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0278-5846(03)00108-8","article-title":"Anxiolytic-like action of orally administered dl-tetrahydropalmatine in elevated plus-maze","volume":"27","author":"Leung","year":"2003","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.intimp.2026.116526_bb0090","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/13880209.2020.1741651","article-title":"Advances in phytochemical and modern pharmacological research of Rhizoma Corydalis","volume":"58","author":"Tian","year":"2020","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.intimp.2026.116526_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.665935","article-title":"Integrative analysis of lncRNA and mRNA and profiles in postoperative delirium patients","volume":"13","author":"Song","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.intimp.2026.116526_bb0100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbi.2022.08.004","article-title":"Sleep disturbance and activation of cellular and transcriptional mechanisms of inflammation in older adults","volume":"106","author":"Piber","year":"2022","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116526_bb0105","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12864-018-4664-3","article-title":"Exploring gene expression biomarker candidates for neurobehavioral impairment from total sleep deprivation","volume":"19","author":"Uyhelji","year":"2018","journal-title":"BMC Genomics"},{"issue":"3","key":"10.1016\/j.intimp.2026.116526_bb0110","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.apsb.2014.04.003","article-title":"Alkaloid profiling of the traditional Chinese medicine Rhizoma corydalis using high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry","volume":"4","author":"Sun","year":"2014","journal-title":"Acta Pharm. Sin. B"},{"issue":"Pt 1","key":"10.1016\/j.intimp.2026.116526_bb0115","article-title":"Based on spinal central sensitization creating analgesic screening approach to excavate anti-neuropathic pain ingredients of Corydalis yanhusuo W.T.Wang","volume":"319","author":"Zhou","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2026.116526_bb0120","doi-asserted-by":"crossref","unstructured":"Wang Z, Yang C, Wang X, et al. Knockdown of RUVBL2 improves hnRNPA2\/B1-stress granules dynamics to inhibit perioperative neurocognitive disorders in aged mild cognitive impairment rats. Aging Cell 2025;24(3):e14418.","DOI":"10.1111\/acel.14418"},{"issue":"6","key":"10.1016\/j.intimp.2026.116526_bb0125","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/ALN.0000000000004046","article-title":"Sleep, pain, and cognition: modifiable targets for optimal perioperative brain health","volume":"135","author":"O\u2019Gara","year":"2021","journal-title":"Anesthesiology"},{"key":"10.1016\/j.intimp.2026.116526_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103578","article-title":"Choline alleviates cognitive impairment in sleep-deprived young mice via reducing neuroinflammation and altering phospholipidomic profile","volume":"81","author":"Huang","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2026.116526_bb0135","doi-asserted-by":"crossref","unstructured":"Kuhn M, Wolf E, Maier JG, et al. Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex. Nat. Commun. 2016;7:12455.","DOI":"10.1038\/ncomms12455"},{"issue":"11","key":"10.1016\/j.intimp.2026.116526_bb0140","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S1474-4422(18)30318-1","article-title":"The glymphatic pathway in neurological disorders","volume":"17","author":"Rasmussen","year":"2018","journal-title":"The Lancet Neurology."},{"key":"10.1016\/j.intimp.2026.116526_bb0145","doi-asserted-by":"crossref","unstructured":"Xu J, Li C, Fan R, et al. BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K\/Akt\/GSK-3\u03b2 pathway activation. Cell Commun. Signal. 2025;23(1):7.","DOI":"10.1186\/s12964-024-02019-5"},{"issue":"2","key":"10.1016\/j.intimp.2026.116526_bb0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/EJA.0000000000001876","article-title":"Update of the European Society of Anaesthesiology and Intensive Care Medicine evidence-based and consensus-based guideline on postoperative delirium in adult patients","volume":"41","author":"Aldecoa","year":"2024","journal-title":"Eur. J. Anaesthesiol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116526_bb0155","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/ptr.1875","article-title":"Corydalis yanhusuo rhizoma extract reduces infarct size and improves heart function during myocardial ischemia\/reperfusion by inhibiting apoptosis in rats","volume":"20","author":"Ling","year":"2006","journal-title":"Phytotherapy research\u202f: PTR."},{"issue":"6","key":"10.1016\/j.intimp.2026.116526_bb0160","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1007\/s10753-014-9945-7","article-title":"Tetrahydrocoptisine protects rats from LPS-induced acute lung injury","volume":"37","author":"Li","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2026.116526_bb0165","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neuroscience.2024.12.006","article-title":"In-silico and in-vivo characterization of anti-neuro inflammatory potential of Tetrahydrocoptisine by using LPS-induced model in mice","volume":"565","author":"Khatun","year":"2025","journal-title":"Neuroscience"},{"issue":"1\u20133","key":"10.1016\/j.intimp.2026.116526_bb0170","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejphar.2013.06.017","article-title":"Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-\u03b1, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-\u03baB activation and MAPK pathway","volume":"715","author":"Li","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116526_bb0175","doi-asserted-by":"crossref","unstructured":"Jin M, Matsumoto S, Ayaki T, et al. DOPAnization of tyrosine in \u03b1-synuclein by tyrosine hydroxylase leads to the formation of oligomers. Nat. Commun. 2022;13(1):6880.","DOI":"10.1038\/s41467-022-34555-4"},{"issue":"2","key":"10.1016\/j.intimp.2026.116526_bb0180","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.162771","article-title":"Neuronal deletion of the circadian clock gene Bmal1 induces cell-autonomous dopaminergic neurodegeneration","volume":"9","author":"Kanan","year":"2024","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.intimp.2026.116526_bb0185","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.molmed.2024.04.011","article-title":"Human dopaminergic system in the exercise-cognition link","volume":"30","author":"Hou","year":"2024","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.intimp.2026.116526_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2021.02.005","article-title":"Dopaminergic modulation of working memory and cognitive flexibility in a zebrafish model of aging-related cognitive decline","volume":"102","author":"Cleal","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.intimp.2026.116526_bb0195","doi-asserted-by":"crossref","unstructured":"Wu M, Zhang X, Feng S, et al. Dopamine pathways mediating affective state transitions after sleep loss. Neuron 2024;112(1):141\u2013154.e148.","DOI":"10.1016\/j.neuron.2023.10.002"},{"issue":"12","key":"10.1016\/j.intimp.2026.116526_bb0200","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1038\/npp.2013.142","article-title":"Interactions between the lateral habenula and the hippocampus: implication for spatial memory processes","volume":"38","author":"Goutagny","year":"2013","journal-title":"Neuropsychopharmacology\u202f: official publication of the American College of Neuropsychopharmacology."},{"issue":"7762","key":"10.1016\/j.intimp.2026.116526_bb0205","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41586-019-1261-9","article-title":"Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons","volume":"570","author":"Engelhard","year":"2019","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.intimp.2026.116526_bb0210","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.neubiorev.2007.01.004","article-title":"A conductor hidden in the orchestra? Role of the habenular complex in monoamine transmission and cognition","volume":"31","author":"Lecourtier","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6584","key":"10.1016\/j.intimp.2026.116526_bb0215","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.abl6618","article-title":"Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice","volume":"375","author":"Hasegawa","year":"2022","journal-title":"Science (New York, N.Y.)"},{"issue":"3","key":"10.1016\/j.intimp.2026.116526_bb0220","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF00181955","article-title":"Biphasic effects of dopamine D-2 receptor agonists on sleep and wakefulness in the rat","volume":"95","author":"Monti","year":"1988","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.intimp.2026.116526_bb0225","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41573-023-00822-2","article-title":"Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets","volume":"23","author":"Vande Walle","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7","key":"10.1016\/j.intimp.2026.116526_bb0230","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41577-024-00995-w","article-title":"Mechanistic insights from inflammasome structures","volume":"24","author":"Fu","year":"2024","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116526_bb0235","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-022-02565-0","article-title":"Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer's disease","volume":"19","author":"Singh","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"8006","key":"10.1016\/j.intimp.2026.116526_bb0240","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41586-024-07167-9","article-title":"Mitochondrial complex I activity in microglia sustains neuroinflammation","volume":"628","author":"Peruzzotti-Jametti","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2026.116526_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2025.106044","article-title":"Circadian rhythm, microglia-mediated neuroinflammation, and Alzheimer\u2019s disease","volume":"170","author":"Geng","year":"2025","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2026.116526_bb0250","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12974-024-03216-2","article-title":"Microglia mediate memory dysfunction via excitatory synaptic elimination in a fracture surgery mouse model","volume":"21","author":"Li","year":"2024","journal-title":"J. Neuroinflammation"},{"issue":"721","key":"10.1016\/j.intimp.2026.116526_bb0255","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adi7828","article-title":"Neuroinflammation: an astrocyte perspective","volume":"15","author":"Lee","year":"2023","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.116526_bb0260","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41593-018-0325-8","article-title":"Astrocyte function from information processing to cognition and cognitive impairment","volume":"22","author":"Santello","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2026.116526_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102223","article-title":"Unveiling the role of astrocytes in postoperative cognitive dysfunction","volume":"95","author":"He","year":"2024","journal-title":"Ageing Res. Rev."}],"updated-by":[{"DOI":"10.1016\/j.intimp.2026.116587","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000}},{"DOI":"10.1016\/j.intimp.2026.116587","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000}}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926003711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926003711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:55:40Z","timestamp":1778820940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926003711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":53,"alternative-id":["S1567576926003711"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116526","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tetrahydrocoptisine alleviates postoperative delirium with sleep disturbances by modulating the TH\/NLRP3 Inflammasome pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116526"}}