{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:52:06Z","timestamp":1776167526343,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007924","name":"Bengbu Medical University","doi-asserted-by":"publisher","award":["2023byzd027"],"award-info":[{"award-number":["2023byzd027"]}],"id":[{"id":"10.13039\/501100007924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2024AH051240"],"award-info":[{"award-number":["2024AH051240"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.intimp.2026.116551","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T15:54:27Z","timestamp":1774194867000},"page":"116551","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ophiopogonin D reprograms the polarization of macrophages through modulating PPM1K-mediated branched-chain amino acids catabolism to delay atherogenesis"],"prefix":"10.1016","volume":"177","author":[{"given":"Shangmin","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.intimp.2026.116551_bb0005","first-page":"2141","article-title":"Immunotherapy for atherosclerosis","volume":"105","author":"Monaco","year":"2025","journal-title":"Physiol. Rev."},{"issue":"8033","key":"10.1016\/j.intimp.2026.116551_bb0010","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41586-024-07993-x","article-title":"Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis","volume":"634","author":"Takaoka","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2026.116551_bb0015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4244\/EIJ-D-23-00606","article-title":"Targeting inflammation in atherosclerosis: overview, strategy and directions","volume":"20","author":"Waksman","year":"2024","journal-title":"EuroIntervention"},{"issue":"10","key":"10.1016\/j.intimp.2026.116551_bb0020","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41419-023-06206-z","article-title":"Macrophage polarization and metabolism in atherosclerosis","volume":"14","author":"Hou","year":"2023","journal-title":"Cell Death Dis."},{"issue":"47","key":"10.1016\/j.intimp.2026.116551_bb0025","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.1093\/eurheartj\/ehab660","article-title":"Macrophage NFAT c3 prevents foam cell formation and atherosclerosis: evidence and mechanisms","volume":"42","author":"Liu","year":"2021","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.intimp.2026.116551_bb0030","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00395-023-01023-z","article-title":"Macrophage profiling in atherosclerosis: understanding the unstable plaque","volume":"119","author":"Gianopoulos","year":"2024","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.intimp.2026.116551_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101993","article-title":"Immunometabolism and immune response regulate macrophage function in atherosclerosis","volume":"90","author":"Xue","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"11","key":"10.1016\/j.intimp.2026.116551_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e32073","article-title":"Macrophage polarisation and inflammatory mechanisms in atherosclerosis: implications for prevention and treatment","volume":"10","author":"Yang","year":"2024","journal-title":"Heliyon"},{"issue":"12","key":"10.1016\/j.intimp.2026.116551_bb0045","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrendo.2014.171","article-title":"Branched-chain amino acids in metabolic signalling and insulin resistance","volume":"10","author":"Lynch","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116551_bb0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/molecules30010056","article-title":"Primary roles of branched chain amino acids (BCAAs) and their metabolism in physiology and metabolic disorders","volume":"30","author":"Bo","year":"2025","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.intimp.2026.116551_bb0055","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41569-022-00760-3","article-title":"Branched-chain amino acids in cardiovascular disease","volume":"20","author":"McGarrah","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.intimp.2026.116551_bb0060","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.nutres.2018.06.008","article-title":"Watermelon and l-arginine consumption improve serum lipid profile and reduce inflammation and oxidative stress by altering gene expression in rats fed an atherogenic diet","volume":"58","author":"Hong","year":"2018","journal-title":"Nutr. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116551_bb0065","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/CIRCULATIONAHA.119.043581","article-title":"Branched-chain amino acid catabolism promotes thrombosis risk by enhancing Tropomodulin-3 Propionylation in platelets","volume":"142","author":"Xu","year":"2020","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.intimp.2026.116551_bb0070","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1111\/jcmm.13759","article-title":"Branched-chain amino acids promote endothelial dysfunction through increased reactive oxygen species generation and inflammation","volume":"22","author":"Zhenyukh","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.intimp.2026.116551_bb0075","doi-asserted-by":"crossref","first-page":"1469163","DOI":"10.3389\/fimmu.2024.1469163","article-title":"Branched-chain amino acid catabolism promotes M2 macrophage polarization","volume":"15","author":"Lu","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116551_bb0080","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s10020-024-00894-9","article-title":"Branched-chain amino acids supplementation induces insulin resistance and pro-inflammatory macrophage polarization via INFGR1\/JAK1\/STAT1 signal pathway","volume":"30","author":"Huang","year":"2024","journal-title":"Mol. Med."},{"issue":"20","key":"10.1016\/j.intimp.2026.116551_bb0085","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1111\/bph.17309","article-title":"Off-target effects of statins: molecular mechanisms, side effects and the emerging role of kinases","volume":"181","author":"Lagunas-Rangel","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116551_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134165","article-title":"Structural elucidation of a novel polysaccharide from Ophiopogonis Radix and its self-assembly mechanism in aqueous solution","volume":"402","author":"Wang","year":"2023","journal-title":"Food Chem."},{"issue":"9","key":"10.1016\/j.intimp.2026.116551_bb0095","doi-asserted-by":"crossref","first-page":"5432","DOI":"10.1021\/jf9044588","article-title":"Effects of storage condition factors on fungal invasion of Radix Ophiopogonis","volume":"58","author":"Wang","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2026.116551_bb0100","article-title":"Ophiopogonin D: review of pharmacological activity","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116551_bb0105","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.phymed.2018.01.002","article-title":"Ophiopogonin D modulates multiple oncogenic signaling pathways, leading to suppression of proliferation and chemosensitization of human lung cancer cells","volume":"40","author":"Lee","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116551_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155482","article-title":"Ophiopogonin D alleviates acute lung injury by regulating inflammation via the STAT3\/A20\/ASK1 axis","volume":"130","author":"Shen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116551_bb0115","doi-asserted-by":"crossref","first-page":"1586937","DOI":"10.3389\/fphar.2025.1586937","article-title":"Ophiopogonin D mitigates doxorubicin-induced cardiomyocyte ferroptosis through the \u03b2-catenin\/GPX4 pathway","volume":"16","author":"Lei","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116551_bb0120","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1142\/S0192415X21500683","article-title":"The role of ophiopogonin D in atherosclerosis: impact on lipid metabolism and gut microbiota","volume":"49","author":"Zhang","year":"2021","journal-title":"Am. J. Chin. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.116551_bb0125","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12979-023-00403-2","article-title":"An aging-related immune landscape in the hematopoietic immune system","volume":"21","author":"Lv","year":"2024","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.intimp.2026.116551_bb0130","doi-asserted-by":"crossref","first-page":"1345099","DOI":"10.3389\/fphar.2024.1345099","article-title":"Amino acid metabolomics and machine learning for assessment of post-hepatectomy liver regeneration","volume":"15","author":"Yan","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116551_bb0135","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1210\/jc.2016-1053","article-title":"Serum amino acid profiles in childhood predict triglyceride level in adulthood: a 7-year longitudinal study in girls","volume":"101","author":"Wiklund","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.intimp.2026.116551_bb0140","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/aps.2015.88","article-title":"Leucine supplementation via drinking water reduces atherosclerotic lesions in apoE null mice","volume":"37","author":"Zhao","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.intimp.2026.116551_bb0145","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1373\/clinchem.2015.251710","article-title":"Plasma branched-chain amino acids and incident cardiovascular disease in the PREDIMED trial","volume":"62","author":"Ruiz-Canela","year":"2016","journal-title":"Clin. Chem."},{"issue":"4","key":"10.1016\/j.intimp.2026.116551_bb0150","article-title":"Circulating branched-chain amino acids and incident cardiovascular disease in a prospective cohort of US women","volume":"11","author":"Tobias","year":"2018","journal-title":"Circulation: Genomic Precision Med."},{"issue":"11","key":"10.1016\/j.intimp.2026.116551_bb0155","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/bph.13624","article-title":"Branched-chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view","volume":"174","author":"Bifari","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"7612","key":"10.1016\/j.intimp.2026.116551_bb0160","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.intimp.2026.116551_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/nu12102982","article-title":"Gut microbiota in hypertension and atherosclerosis: a review","volume":"12","author":"Verhaar","year":"2020","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.intimp.2026.116551_bb0170","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage function","volume":"213","author":"O\u2019Neill","year":"2015","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.intimp.2026.116551_bb0175","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nri2634","article-title":"Transcriptional control of the inflammatory response","volume":"9","author":"Medzhitov","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116551_bb0180","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1074\/jbc.M115.676817","article-title":"Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of Itaconate and to enable cytokine expression*","volume":"291","author":"Meiser","year":"2016","journal-title":"J. Biol. Chem."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926003966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926003966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:58:25Z","timestamp":1776164305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926003966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":36,"alternative-id":["S1567576926003966"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116551","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ophiopogonin D reprograms the polarization of macrophages through modulating PPM1K-mediated branched-chain amino acids catabolism to delay atherogenesis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116551","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116551"}}