{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:35:37Z","timestamp":1781807737076,"version":"3.54.5"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2208085Y32"],"award-info":[{"award-number":["2208085Y32"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010816","name":"Anhui Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010816","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Province Department of Education","doi-asserted-by":"publisher","award":["2022AH020076"],"award-info":[{"award-number":["2022AH020076"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.intimp.2026.116562","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T22:03:14Z","timestamp":1774648994000},"page":"116562","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Artesunate protects against ischemic stroke through THBS2\/CD36\/TLR4 pathway"],"prefix":"10.1016","volume":"178","author":[{"given":"Shanshan","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoliang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116562_bb0005","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/S0140-6736(24)00642-1","article-title":"Stroke","volume":"403","author":"Hilkens","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2026.116562_bb0010","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2026.116562_bb0320","doi-asserted-by":"crossref","first-page":"105494","DOI":"10.1016\/j.ebiom.2024.105494","article-title":"Accelerated biological aging increases the risk of short- and long-term stroke prognosis in patients with ischemic stroke or TIA","volume":"111","author":"Wang","year":"2025","journal-title":"EBioMedicine"},{"key":"10.1016\/j.intimp.2026.116562_bb0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s43856-025-00939-y","article-title":"Epidemiology and future trend predictions of ischemic stroke based on the global burden of disease study 1990-2021","volume":"5","author":"Liu","year":"2025","journal-title":"Commun. Med. (Lond.)"},{"key":"10.1016\/j.intimp.2026.116562_bb0020","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1056\/NEJMoa1713973","article-title":"Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging","volume":"378","author":"Albers","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2026.116562_bb0025","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0140-6736(10)60491-6","article-title":"Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials","volume":"375","author":"Lees","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2026.116562_bb0030","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1161\/STROKEAHA.119.027708","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke","volume":"50","author":"Warner","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.intimp.2026.116562_bb0035","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1161\/STROKEAHA.120.030173","article-title":"Symptomatic intracranial Hemorrhage after mechanical thrombectomy in Chinese ischemic stroke patients: the ASIAN score","volume":"51","author":"Zhang","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.intimp.2026.116562_bib326","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s43657-024-00209-2","article-title":"Characteristic \u2018Pattern of Autofluorescence\u2019 of the Fingernails and Certain Skin\u2019s Positions is a Novel Diagnostic Biomarker for Acute Ischemic Stroke: A Preliminary Study","volume":"5","author":"Wu","year":"2025","journal-title":"Phenomics"},{"key":"10.1016\/j.intimp.2026.116562_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107658","article-title":"The birth of artemisinin","volume":"216","author":"Ma","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2026.116562_bb0045","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/nm.2471","article-title":"The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine","volume":"17","author":"Tu","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2026.116562_bb0050","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1002\/med.21837","article-title":"Recent pharmacological advances in the repurposing of artemisinin drugs","volume":"41","author":"Meng","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.intimp.2026.116562_bb0055","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1515\/tnsci-2020-0136","article-title":"Artesunate attenuates traumatic brain injury-induced impairments in rats","volume":"11","author":"Zhou","year":"2020","journal-title":"Transl Neurosci"},{"key":"10.1016\/j.intimp.2026.116562_bb0060","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13024-023-00597-5","article-title":"Anti-malaria drug artesunate prevents development of amyloid-\u03b2 pathology in mice by upregulating PICALM at the blood-brain barrier","volume":"18","author":"Kisler","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.intimp.2026.116562_bb0065","doi-asserted-by":"crossref","DOI":"10.1177\/03000605211053549","article-title":"Artesunate attenuates inflammatory injury and inhibits the NF-\u03baB pathway in a mouse model of cerebral ischemia","volume":"49","author":"Liu","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.intimp.2026.116562_bb0070","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/bcpt.13848","article-title":"Artesunate alleviates intracerebral haemorrhage secondary injury by inducing ferroptosis in M1-polarized microglia and suppressing inflammation through AMPK\/mTORC1\/GPX4 pathway","volume":"132","author":"Xie","year":"2023","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.intimp.2026.116562_bb0075","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.4103\/1673-5374.390966","article-title":"Cav3.2 channel regulates cerebral ischemia\/reperfusion injury: a promising target for intervention","volume":"19","author":"Dai","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2026.116562_bb0080","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.intimp.2026.116562_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113364","article-title":"Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins","volume":"331","author":"Beker","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2026.116562_bb0090","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/cns.12589","article-title":"Lentivirus-mediated overexpression of MicroRNA-210 improves long-term outcomes after focal cerebral Ischemia in mice","volume":"22","author":"Zeng","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2026.116562_bb0095","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6621296","article-title":"Interleukin-22 plays a protective role by regulating the JAK2-STAT3 pathway to improve inflammation, oxidative stress, and neuronal apoptosis following cerebral ischemia-reperfusion injury","volume":"2021","author":"Dong","year":"2021","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.intimp.2026.116562_bb0100","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12974-022-02511-0","article-title":"Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis","volume":"19","author":"Ding","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116562_bb0105","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12974-024-03086-8","article-title":"STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke","volume":"21","author":"Wu","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116562_bb0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12974-019-1693-z","article-title":"Dectin-1\/Syk signaling triggers neuroinflammation after ischemic stroke in mice","volume":"17","author":"Ye","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116562_bb0115","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s44254-025-00135-0","article-title":"Induction of mitochondrial biogenesis enhances neurogenesis and cognitive recovery following ischaemic stroke","volume":"3","author":"Bai","year":"2025","journal-title":"Anesthesiology and Perioperative Science"},{"key":"10.1016\/j.intimp.2026.116562_bb0120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12974-024-03026-6","article-title":"SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury","volume":"21","author":"Qian","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116562_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2025.111407","article-title":"Artesunate alleviates cerebral ischemia\/reperfusion injury by suppressing FUNDC1-mediated excessive mitophagy","volume":"228","author":"Wang","year":"2025","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.intimp.2026.116562_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1192659","article-title":"Antimalarial and antioxidant activities of novel artesunate-ellagic acid hybrid compound in vitro and in vivo","volume":"15","author":"Ishola","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116562_bb0135","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.21037\/atm-21-4939","article-title":"Anti-inflammatory effects of artesunate on atherosclerosis via miR-16-5p and TXNIP regulation of the NLRP3 inflammasome","volume":"9","author":"Li","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.intimp.2026.116562_bb0140","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1039\/D1MO00491C","article-title":"RNA-seq-based transcriptome analysis of the anti-inflammatory effect of artesunate in the early treatment of the mouse cerebral malaria model","volume":"18","author":"Wang","year":"2022","journal-title":"Mol. Omics"},{"key":"10.1016\/j.intimp.2026.116562_bb0145","article-title":"Artesunate exerts organ- and tissue-protective effects by regulating oxidative stress, inflammation, autophagy, apoptosis, and fibrosis: a review of evidence and mechanisms","volume":"13","author":"Zhu","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2026.116562_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173408","article-title":"Artesunate inhibits atherosclerosis by upregulating vascular smooth muscle cells-derived LPL expression via the KLF2\/NRF2\/TCF7L2 pathway","volume":"884","author":"He","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116562_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116255","article-title":"Artesunate inhibits macrophage-like phenotype switching of vascular smooth muscle cells and attenuates vascular inflammatory injury in atherosclerosis via NLRP3","volume":"172","author":"Liu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2026.116562_bb0160","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1016\/j.cell.2024.09.034","article-title":"Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target","volume":"187","author":"Zhang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2026.116562_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110426","article-title":"Artesunate demonstrates neuroprotective effect through activation of lysosomal function and inhibition of cGAS-STING pathway","volume":"272","author":"Wei","year":"2025","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.intimp.2026.116562_bb0170","doi-asserted-by":"crossref","first-page":"8029","DOI":"10.18632\/aging.103121","article-title":"Artesunate promotes the proliferation of neural stem\/progenitor cells and alleviates Ischemia-reperfusion injury through PI3K\/Akt\/FOXO-3a\/p27(kip1) signaling pathway","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.intimp.2026.116562_bb0175","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.1007\/s12035-021-02710-5","article-title":"Neurogenesis and proliferation of neural stem\/progenitor cells conferred by artesunate via FOXO3a\/p27Kip1 axis in mouse stroke model","volume":"59","author":"Zhang","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2026.116562_bb0180","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11910-023-01282-2","article-title":"Neuroinflammation in acute ischemic and hemorrhagic stroke","volume":"23","author":"Alsbrook","year":"2023","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.intimp.2026.116562_bb0185","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12974-019-1516-2","article-title":"Neuroinflammation: friend and foe for ischemic stroke","volume":"16","author":"Jayaraj","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116562_bb0325","doi-asserted-by":"crossref","first-page":"105843","DOI":"10.1016\/j.ebiom.2025.105843","article-title":"The vascular-immune-neural network: a new pathophysiological paradigm and the dawn of cytoprotection in stroke","volume":"118","author":"Fang","year":"2025","journal-title":"EBioMedicine"},{"key":"10.1016\/j.intimp.2026.116562_bb0190","doi-asserted-by":"crossref","DOI":"10.4103\/NRR.NRR-D-24-00837","article-title":"Elucidation of the mechanism by which manganese-ferric Prussian blue nanozymes alleviate ischemic stroke damage in a mouse model","author":"Li","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2026.116562_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114923","article-title":"Integrated natural enzyme and nanozyme nanoreactor for managing cerebral ischemia-reperfusion injury by regulating neuroimmune microenvironment","volume":"255","author":"Wang","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.intimp.2026.116562_bb0200","doi-asserted-by":"crossref","first-page":"C135","DOI":"10.1152\/ajpcell.00136.2018","article-title":"Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke","volume":"316","author":"Yang","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.intimp.2026.116562_bb0205","series-title":"Cerebral Ischemia","article-title":"Neuroinflammation in post-ischemic brain","author":"\u017divan\u010devi\u0107","year":"2021"},{"key":"10.1016\/j.intimp.2026.116562_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.160664","article-title":"Brain-targeted delivery of Acetyl-11-keto-\u03b2-Boswellic acid with enhanced anti-inflammatory efficacy via blood-brain barrier peptide shuttle PepH3","volume":"509","author":"Cui","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.intimp.2026.116562_bb0215","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jatmed.2025.12.005","article-title":"MANF improves cognitive function and attenuates neuroinflammation in APP\/PS1 transgenic mice through the TLR4\/MYD88\/NF-\u03baB signaling pathway","volume":"4","author":"Tang","year":"2025","journal-title":"Journal of Anesthesia and Translational Medicine"},{"key":"10.1016\/j.intimp.2026.116562_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154540","article-title":"Frankincense-myrrh treatment alleviates neuropathic pain via the inhibition of neuroglia activation mediated by the TLR4\/MyD88 pathway and TRPV1 signaling","volume":"108","author":"Liao","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116562_bb0225","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1248\/bpb.b20-00604","article-title":"Artesunate provides neuroprotection against cerebral ischemia-reperfusion injury via the TLR-4\/NF-\u03baB pathway in rats","volume":"44","author":"Chen","year":"2021","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.intimp.2026.116562_bb0230","first-page":"6639","article-title":"Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS-dependent p38 MAPK and protects against cerebral ischemia-reperfusion injury","volume":"17","author":"Lu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2026.116562_bb0235","doi-asserted-by":"crossref","DOI":"10.21926\/obm.neurobiol.2403239","article-title":"Oxidative stress in cerebral ischemia\/reperfusion injury","volume":"08","author":"Anaya-Fern\u00e1ndez","year":"2024","journal-title":"OBM Neurobiol."},{"key":"10.1016\/j.intimp.2026.116562_bb0240","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.tips.2016.06.007","article-title":"Targeting oxidative stress in central nervous system disorders","volume":"37","author":"Patel","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2026.116562_bb0245","article-title":"Cerebral ischemia-reperfusion injury: mechanisms and promising therapies","volume":"16","author":"Yang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116562_bb0255","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a009712","article-title":"The thrombospondins","volume":"3","author":"Adams","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.intimp.2026.116562_bb0260","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1083\/jcb.201802057","article-title":"Thrombospondin receptor \u03b12\u03b4-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1","volume":"217","author":"Risher","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.intimp.2026.116562_bb0265","first-page":"1275","article-title":"Role of thrombospondin-1 and thrombospondin-2 in cardiovascular diseases (review)","volume":"45","author":"Zhang","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2026.116562_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115455","article-title":"Molecular mechanisms of Thrombospondin-2 modulates tumor vasculogenic mimicry by PI3K\/AKT\/mTOR signaling pathway","volume":"167","author":"Huang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2026.116562_bb0275","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12935-022-02622-x","article-title":"Thrombospondin-2 acts as a bridge between tumor extracellular matrix and immune infiltration in pancreatic and stomach adenocarcinomas: an integrative pan-cancer analysis","volume":"22","author":"Liao","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.intimp.2026.116562_bb0280","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.matbio.2012.01.004","article-title":"Thrombospondins as key regulators of synaptogenesis in the central nervous system","volume":"31","author":"Risher","year":"2012","journal-title":"Matrix Biol."},{"key":"10.1016\/j.intimp.2026.116562_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11051198","article-title":"Platelet-derived drug targets and biomarkers of ischemic stroke-the first dynamic human LC-MS proteomic study","volume":"11","author":"Gawry\u015b","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2026.116562_bb0290","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13148-024-01690-2","article-title":"DNA methylation and stroke prognosis: an epigenome-wide association study","volume":"16","author":"Jim\u00e9nez-Balado","year":"2024","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.intimp.2026.116562_bb0295","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/cvr\/cvaa319","article-title":"The role of CD36 in cardiovascular disease","volume":"118","author":"Shu","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.intimp.2026.116562_bb0300","doi-asserted-by":"crossref","first-page":"re3","DOI":"10.1126\/scisignal.272re3","article-title":"CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior","volume":"2","author":"Silverstein","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.intimp.2026.116562_bb0305","doi-asserted-by":"crossref","first-page":"14783","DOI":"10.1523\/JNEUROSCI.2980-15.2015","article-title":"Endothelial CD36 contributes to postischemic brain injury by promoting neutrophil activation via CSF3","volume":"35","author":"Garcia-Bonilla","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2026.116562_bb0310","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12974-022-02388-z","article-title":"Scavenger receptor CD36 governs recruitment of myeloid cells to the blood-CSF barrier after stroke in neonatal mice","volume":"19","author":"Rayasam","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116562_bb0315","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/ni.1836","article-title":"CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer","volume":"11","author":"Stewart","year":"2010","journal-title":"Nat. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926004078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926004078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:13:57Z","timestamp":1776194037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926004078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":65,"alternative-id":["S1567576926004078"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116562","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Artesunate protects against ischemic stroke through THBS2\/CD36\/TLR4 pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116562","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116562"}}