{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:47:01Z","timestamp":1793580421390,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015337","name":"Guangdong Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370564"],"award-info":[{"award-number":["82370564"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.intimp.2026.116626","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T13:49:54Z","timestamp":1775656194000},"page":"116626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["ACAT1-mediated lactylation reprogramming governs immune-stromal crosstalk in ulcerative colitis"],"prefix":"10.1016","volume":"179","author":[{"given":"Jiayu","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuosi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianxiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9853","key":"10.1016\/j.intimp.2026.116626_bb0005","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord\u00e1s","year":"2012","journal-title":"Lancet (London, England)"},{"issue":"9573","key":"10.1016\/j.intimp.2026.116626_bb0010","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0140-6736(07)60751-X","article-title":"Inflammatory bowel disease: clinical aspects and established and evolving therapies","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet (London, England)"},{"issue":"10401","key":"10.1016\/j.intimp.2026.116626_bb0015","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet (London, England)"},{"issue":"4","key":"10.1016\/j.intimp.2026.116626_bb0020","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.48.4.526","article-title":"The risk of colorectal cancer in ulcerative colitis: a meta-analysis","volume":"48","author":"Eaden","year":"2001","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.intimp.2026.116626_bb0025","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1053\/j.gastro.2007.08.001","article-title":"Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study","volume":"133","author":"Gupta","year":"2007","journal-title":"Gastroenterology"},{"issue":"10080","key":"10.1016\/j.intimp.2026.116626_bb0030","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet (London, England)"},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0035","article-title":"Mucosal immune systems of pediatric inflammatory bowel disease: a review","volume":"65","author":"Kudo","year":"2023","journal-title":"Pediatrics international\u202f: official journal of the Japan Pediatric Society"},{"issue":"7779","key":"10.1016\/j.intimp.2026.116626_bb0040","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0045","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13059-021-02308-z","article-title":"Histone lactylation drives oncogenesis by facilitating m(6)a reader protein YTHDF2 expression in ocular melanoma","volume":"22","author":"Yu","year":"2021","journal-title":"Genome Biol."},{"issue":"11","key":"10.1016\/j.intimp.2026.116626_bb0050","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/CIRCRESAHA.122.320488","article-title":"Histone lactylation boosts reparative gene activation post-myocardial infarction","volume":"131","author":"Wang","year":"2022","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41418-021-00841-9","article-title":"Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis","volume":"29","author":"Yang","year":"2022","journal-title":"Cell Death Differ."},{"issue":"5","key":"10.1016\/j.intimp.2026.116626_bb0060","doi-asserted-by":"crossref","first-page":"eadc9465","DOI":"10.1126\/sciadv.adc9465","article-title":"Lactate promotes endothelial-to-mesenchymal transition via snail1 lactylation after myocardial infarction","volume":"9","author":"Fan","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.intimp.2026.116626_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103194","article-title":"Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury","volume":"74","author":"Wu","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2026.116626_bb0070","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.freeradbiomed.2024.09.021","article-title":"The effect of tau k677 lactylation on ferritinophagy and ferroptosis in alzheimer\u2019s disease","volume":"224","author":"An","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2026.116626_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120179","article-title":"Lactate-utilizing bacteria ameliorates DSS-induced colitis in mice","volume":"288","author":"Chen","year":"2022","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0080","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12967-024-04955-9","article-title":"A multi-dimensional approach to unravel the intricacies of lactylation related signature for prognostic and therapeutic insight in colorectal cancer","volume":"22","author":"Huang","year":"2024","journal-title":"J. Transl. Med."},{"issue":"7","key":"10.1016\/j.intimp.2026.116626_bb0085","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.intimp.2026.116626_bb0090","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"ClusterProfiler: An r package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics\u202f: a journal of integrative biology"},{"key":"10.1016\/j.intimp.2026.116626_bb0095","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC bioinformatics"},{"key":"10.1016\/j.intimp.2026.116626_bb0100","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: An r package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC bioinformatics"},{"issue":"D1","key":"10.1016\/j.intimp.2026.116626_bb0105","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.intimp.2026.116626_bb0110","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0115","doi-asserted-by":"crossref","first-page":"289","DOI":"10.32614\/RJ-2016-021","article-title":"Mclust 5: clustering, classification and density estimation using Gaussian finite mixture models","volume":"8","author":"Scrucca","year":"2016","journal-title":"R J."},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0120","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13148-019-0730-1","article-title":"Statistical predictions with glmnet","volume":"11","author":"Engebretsen","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.intimp.2026.116626_bb0125","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"PROC: An open-source package for r and s+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC bioinformatics"},{"key":"10.1016\/j.intimp.2026.116626_bb0130","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/1471-2105-14-244","article-title":"RCircos: An r package for circos 2D track plots","volume":"14","author":"Zhang","year":"2013","journal-title":"BMC bioinformatics"},{"issue":"12","key":"10.1016\/j.intimp.2026.116626_bb0135","first-page":"1572","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinf. (Oxf.)"},{"key":"10.1016\/j.intimp.2026.116626_bb0140","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","article-title":"Profiling tumor infiltrating immune cells with CIBERSORT","volume":"1711","author":"Chen","year":"2018","journal-title":"Methods .Mol. Biol. (Clifton, N.J.)"},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0145","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s13046-018-1002-1","article-title":"Classification of triple-negative breast cancers based on immunogenomic profiling","volume":"37","author":"He","year":"2018","journal-title":"Journal of experimental & clinical cancer research\u202f: CR"},{"issue":"5","key":"10.1016\/j.intimp.2026.116626_bb0150","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116626_bb0155","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.intimp.2026.116626_bb0160","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.intimp.2026.116626_bb0165","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1016\/j.csbj.2021.06.043","article-title":"UCell: robust and scalable single-cell gene signature scoring","volume":"19","author":"Andreatta","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.intimp.2026.116626_bb0170","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"Hanzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0175","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/s41467-021-21244-x","article-title":"Dissection of intercellular communication using the transcriptome-based framework ICELLNET","volume":"12","author":"Noel","year":"2021","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.intimp.2026.116626_bb0180","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.intimp.2026.116626_bb0185","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"eLife"},{"issue":"4","key":"10.1016\/j.intimp.2026.116626_bb0190","doi-asserted-by":"crossref","first-page":"260","DOI":"10.15430\/JCP.2015.20.4.260","article-title":"Adequate dextran sodium sulfate-induced colitis model in mice and effective outcome measurement method","volume":"20","author":"Park","year":"2015","journal-title":"Journal of cancer prevention"},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0195","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s13046-022-02477-0","article-title":"PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K\/AKT signaling in tumor cells and phenotypic polarization of macrophages","volume":"41","author":"Wang","year":"2022","journal-title":"Journal of experimental & clinical cancer research : CR"},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0200","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"7","key":"10.1016\/j.intimp.2026.116626_bb0205","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","article-title":"Lactate: the ugly duckling of energy metabolism","volume":"2","author":"Rabinowitz","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.intimp.2026.116626_bb0210","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.freeradbiomed.2022.06.242","article-title":"STAT3-mediated ferroptosis is involved in ulcerative colitis","volume":"188","author":"Huang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.intimp.2026.116626_bb0215","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/BF02148853","article-title":"Butyrate absorption and lactate secretion in ulcerative colitis","volume":"38","author":"Hove","year":"1995","journal-title":"Dis. Colon Rectum"},{"issue":"3","key":"10.1016\/j.intimp.2026.116626_bb0220","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41575-023-00746-7","article-title":"Lactylation and HCC progression","volume":"20","author":"Kotsiliti","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"39","key":"10.1016\/j.intimp.2026.116626_bb0225","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1093\/eurheartj\/ehae379","article-title":"TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone h4 lysine 12 lactylation","volume":"45","author":"Li","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.intimp.2026.116626_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2024.101059","article-title":"Single-cell transcriptome analysis reveals the association between histone lactylation and cisplatin resistance in bladder cancer","volume":"73","author":"Li","year":"2024","journal-title":"Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy"},{"issue":"Database issue","key":"10.1016\/j.intimp.2026.116626_bb0235","first-page":"D991","article-title":"NCBI GEO: archive for functional genomics data sets--update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.intimp.2026.116626_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167300","article-title":"Identification and experimental validation of immune-related gene PPARG is involved in ulcerative colitis","volume":"1870","author":"Li","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.intimp.2026.116626_bb0245","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.859806","article-title":"Adipose-derived mesenchymal stem cells reprogram m1 macrophage metabolism via PHD2\/HIF-1\u03b1 pathway in colitis mice","volume":"13","author":"Yuan","year":"2022","journal-title":"Front. Immunol."},{"issue":"29","key":"10.1016\/j.intimp.2026.116626_bb0250","doi-asserted-by":"crossref","first-page":"eadg2697","DOI":"10.1126\/sciadv.adg2697","article-title":"D-lactate modulates m2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma","volume":"9","author":"Han","year":"2023","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0255","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12916-022-02352-x","article-title":"Ketone body \u03b2-hydroxybutyrate ameliorates colitis by promoting m2 macrophage polarization through the STAT6-dependent signaling pathway","volume":"20","author":"Huang","year":"2022","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.116626_bb0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08830185.2024.2401358","article-title":"The m6A methyltransferase METTL3 modifies kcnk6 promoting on inflammation associated carcinogenesis is essential for colon homeostasis and defense system through histone lactylation dependent YTHDF2 binding","volume":"44","author":"Yuan","year":"2025","journal-title":"Int. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116626_bb0265","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4196\/kjpp.2014.18.4.279","article-title":"A review on chemical-induced inflammatory bowel disease models in rodents","volume":"18","author":"Randhawa","year":"2014","journal-title":"the korean journal of physiology & pharmacology: official journal of the korean physiological society and the korean society of Pharmacology"},{"key":"10.1016\/j.intimp.2026.116626_bb0270","doi-asserted-by":"crossref","first-page":"1149989","DOI":"10.3389\/fimmu.2023.1149989","article-title":"Identification of lactylation related model to predict prognostic, tumor infiltrating immunocytes and response of immunotherapy in gastric cancer","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116626_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116592","article-title":"The recent insights into the function of ACAT1: a possible anti-cancer therapeutic target","volume":"232","author":"Goudarzi","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2026.116626_bb0280","article-title":"Lactate metabolism-associated lncRNA pairs: a prognostic signature to reveal the immunological landscape and mediate therapeutic response in patients with colon adenocarcinoma","volume":"13","author":"Xiao","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116626_bb0285","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.molcel.2016.11.023","article-title":"Drugging ACAT1 for cancer therapy","volume":"64","author":"Garcia-Bermudez","year":"2016","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.intimp.2026.116626_bb0290","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.molcel.2016.10.014","article-title":"Tetrameric acetyl-CoA acetyltransferase 1 is important for tumor growth","volume":"64","author":"Fan","year":"2016","journal-title":"Mol. Cell"},{"issue":"35","key":"10.1016\/j.intimp.2026.116626_bb0295","article-title":"Integrated lactylome characterization reveals the molecular dynamics of protein regulation in gastrointestinal cancers","volume":"11","author":"Duan","year":"2024","journal-title":"Advanced Science (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.intimp.2026.116626_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2020.08.011","article-title":"Acidic extracellular pH promotes accumulation of free cholesterol in human monocyte-derived macrophages via inhibition of ACAT1 activity","volume":"312","author":"Lee-Rueckert","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.intimp.2026.116626_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102643","article-title":"Mitochondrial cholesterol: metabolism and impact on redox biology and disease","volume":"61","author":"Goicoechea","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2026.116626_bb0310","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.freeradbiomed.2023.06.007","article-title":"Mitochondrial remodeling and energy metabolism adaptations in colonic crypts during spontaneous epithelial repair after colitis induction in mice","volume":"205","author":"Lan","year":"2023","journal-title":"Free Radic. Biol. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926004716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926004716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:17:12Z","timestamp":1777130232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926004716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":62,"alternative-id":["S1567576926004716"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116626","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ACAT1-mediated lactylation reprogramming governs immune-stromal crosstalk in ulcerative colitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116626","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116626"}}