{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:45:40Z","timestamp":1790948740216,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574088"],"award-info":[{"award-number":["82574088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2026JJ82356"],"award-info":[{"award-number":["2026JJ82356"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ50654"],"award-info":[{"award-number":["2025JJ50654"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.intimp.2026.116632","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T21:44:03Z","timestamp":1775684643000},"page":"116632","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Curcumol alleviates acute pancreatitis by inhibiting RIPK1\/RIPK3\/MLKL pathway-mediated necroptosis: integrated bioinformatics, network pharmacology, molecular docking and dynamics simulations, and experimental validation"],"prefix":"10.1016","volume":"179","author":[{"given":"Xiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengling","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.intimp.2026.116632_bb0005","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: a review","volume":"325","author":"Mederos","year":"2021","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.intimp.2026.116632_bb0010","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1503\/cjs.015015","article-title":"Clinical practice guideline: management of acute pancreatitis","volume":"59","author":"Greenberg","year":"2016","journal-title":"Can. J. Surg."},{"issue":"1","key":"10.1016\/j.intimp.2026.116632_bb0015","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.gastro.2021.09.043","article-title":"Global incidence of acute pancreatitis is increasing over time: a systematic review and Meta-analysis","volume":"162","author":"Iannuzzi","year":"2022","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.intimp.2026.116632_bb0020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ueg2.12743","article-title":"Acute pancreatitis: an update of evidence-based management and recent trends in treatment strategies","volume":"13","author":"Beij","year":"2025","journal-title":"united european Gastroenterol. J."},{"issue":"9","key":"10.1016\/j.intimp.2026.116632_bb0025","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1007\/s10620-024-08530-6","article-title":"Circulating markers of necroptosis in acute pancreatitis","volume":"69","author":"Belfrage","year":"2024","journal-title":"Dig. Dis. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2026.116632_bb0030","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41419-021-03847-w","article-title":"Necroptosis protects against exacerbation of acute pancreatitis","volume":"12","author":"Boonchan","year":"2021","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.intimp.2026.116632_bb0035","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1080\/15548627.2017.1386359","article-title":"Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance","volume":"14","author":"Lin","year":"2018","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.intimp.2026.116632_bb0040","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tcb.2015.01.001","article-title":"RIPK1 and RIPK3: critical regulators of inflammation and cell death","volume":"25","author":"Newton","year":"2015","journal-title":"Trends Cell Biol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116632_bb0045","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.7150\/ijbs.34716","article-title":"Curcumol: from plant roots to cancer roots","volume":"15","author":"Wei","year":"2019","journal-title":"Int. J. Biol. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2026.116632_bb0050","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200933RR","article-title":"Curcumol alleviates liver fibrosis through inducing autophagy and ferroptosis in hepatic stellate cells","volume":"36","author":"Zheng","year":"2022","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.intimp.2026.116632_bb0055","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41420-024-02067-3","article-title":"Curcumol ameliorates neuroinflammation after cerebral ischemia-reperfusion injury via affecting microglial polarization and Treg\/Th17 balance through Nrf2\/HO-1 and NF-kappaB signaling","volume":"10","author":"Liu","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.intimp.2026.116632_bb0060","doi-asserted-by":"crossref","unstructured":"M. Safran, I. Dalah, J. Alexander, N. Rosen, T. Iny Stein, M. Shmoish, N. Nativ, I. Bahir, T. Doniger, H. Krug, A. Sirota-Madi, T. Olender, Y. Golan, G. Stelzer, A. Harel, D. Lancet, GeneCards version 3: the human gene integrator, Database (Oxford) 2010 (2010) baq020.","DOI":"10.1093\/database\/baq020"},{"issue":"D1","key":"10.1016\/j.intimp.2026.116632_bb0065","doi-asserted-by":"crossref","first-page":"D1257","DOI":"10.1093\/nar\/gkac833","article-title":"Comparative toxicogenomics database (CTD): update 2023","volume":"51","author":"Davis","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2026.116632_bb0070","doi-asserted-by":"crossref","unstructured":"D. Grissa, A. Junge, T.I. Oprea, L.J. Jensen, Diseases 2.0: a weekly updated database of disease-gene associations from text mining and data integration, Database (Oxford) 2022 (2022).","DOI":"10.1093\/database\/baac019"},{"issue":"D1","key":"10.1016\/j.intimp.2026.116632_bb0075","doi-asserted-by":"crossref","first-page":"D730","DOI":"10.1093\/nar\/gkae1113","article-title":"The STRING database in 2025: protein networks with directionality of regulation","volume":"53","author":"Szklarczyk","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2026.116632_bb0080","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baaf058","article-title":"A review on gene ontology evaluations","volume":"2025","author":"Pitarch","year":"2025","journal-title":"Database (Oxford)"},{"issue":"1","key":"10.1016\/j.intimp.2026.116632_bb0085","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.intimp.2026.116632_bb0090","doi-asserted-by":"crossref","first-page":"D138","DOI":"10.1093\/nar\/gkad965","article-title":"NCBI GEO: archive for gene expression and epigenomics data sets: 23-year update","volume":"52","author":"Clough","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.intimp.2026.116632_bb0095","doi-asserted-by":"crossref","first-page":"W415","DOI":"10.1093\/nar\/gkae456","article-title":"WebGestalt 2024: faster gene set analysis and new support for metabolomics and multi-omics","volume":"52","author":"Elizarraras","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.intimp.2026.116632_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PloS One"},{"key":"10.1016\/j.intimp.2026.116632_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118506","article-title":"Overview of panax ginseng and its active ingredients protective mechanism on cardiovascular diseases","volume":"334","author":"Zhou","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116632_bb0110","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad518","article-title":"Network pharmacology: towards the artificial intelligence-based precision traditional chinese medicine","volume":"25","author":"Zhang","year":"2023","journal-title":"Brief. Bioinform."},{"issue":"D1","key":"10.1016\/j.intimp.2026.116632_bb0115","doi-asserted-by":"crossref","first-page":"D1404","DOI":"10.1093\/nar\/gkae1037","article-title":"HERB 2.0: an updated database integrating clinical and experimental evidence for traditional chinese medicine","volume":"53","author":"Gao","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.intimp.2026.116632_bb0120","doi-asserted-by":"crossref","first-page":"D1238","DOI":"10.1093\/nar\/gkab1011","article-title":"HIT 2.0: an enhanced platform for herbal ingredients\u2019 targets","volume":"50","author":"Yan","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.intimp.2026.116632_bb0125","doi-asserted-by":"crossref","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","article-title":"PubChem in 2021: new data content and improved web interfaces","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.intimp.2026.116632_bb0130","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.intimp.2026.116632_bb0135","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"5","key":"10.1016\/j.intimp.2026.116632_bb0140","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","article-title":"Ligand docking and binding site analysis with PyMOL and Autodock\/Vina","volume":"24","author":"Seeliger","year":"2010","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"1","key":"10.1016\/j.intimp.2026.116632_bb0145","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/pro.3934","article-title":"The AutoDock suite at 30","volume":"30","author":"Goodsell","year":"2021","journal-title":"Protein Sci."},{"issue":"16","key":"10.1016\/j.intimp.2026.116632_bb0150","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.intimp.2026.116632_bb0155","doi-asserted-by":"crossref","unstructured":"S. Tenner, J. Baillie, J. DeWitt, S.S. Vege, G. American College of, American College of Gastroenterology guideline: management of acute pancreatitis, Am. J. Gastroenterol. 108(9) (2013) 1400\u201315; 1416.","DOI":"10.1038\/ajg.2013.218"},{"key":"10.1016\/j.intimp.2026.116632_bb0160","doi-asserted-by":"crossref","unstructured":"E. de-Madaria, J.L. Buxbaum, P. Maisonneuve, A. Garcia Garcia de Paredes, P. Zapater, L. Guilabert, A. Vaillo-Rocamora, M.A. Rodriguez-Gandia, J. Donate-Ortega, E.E. Lozada-Hernandez, A.J.R. Collazo Moreno, A. lira-Aguilar, L.P. Llovet, R. Mehta, R. Tandel, P. Navarro, A.M. Sanchez-Pardo, C. Sanchez-Marin, M. Cobreros, I. Fernandez-Cabrera, F. Casals-Seoane, D. Casas Deza, E. Lauret-Brana, E. Marti-Marques, L.M. Camacho-Montano, V. Ubieto, M. Ganuza, F. Bolado, E. Consortium, Aggressive or moderate fluid resuscitation in acute pancreatitis, N. Engl. J. Med. 387(11) (2022) 989\u20131000.","DOI":"10.1056\/NEJMoa2202884"},{"key":"10.1016\/j.intimp.2026.116632_bb0165","article-title":"Pain management in acute pancreatitis: a systematic review and Meta-analysis of randomised controlled trials","volume":"8","author":"Cai","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"issue":"2","key":"10.1016\/j.intimp.2026.116632_bb0170","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.clnu.2023.12.019","article-title":"ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis","volume":"43","author":"Arvanitakis","year":"2024","journal-title":"Clin. Nutr."},{"issue":"4","key":"10.1016\/j.intimp.2026.116632_bb0175","first-page":"CD011384","article-title":"Pharmacological interventions for acute pancreatitis","volume":"4","author":"Moggia","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2026.116632_bb0180","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1080\/10717544.2020.1840665","article-title":"Drug discovery and formulation development for acute pancreatitis","volume":"27","author":"Jiang","year":"2020","journal-title":"Drug Deliv."},{"issue":"7","key":"10.1016\/j.intimp.2026.116632_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e18036","article-title":"New insights into regulatory cell death and acute pancreatitis","volume":"9","author":"Li","year":"2023","journal-title":"Heliyon"},{"issue":"2","key":"10.1016\/j.intimp.2026.116632_bb0190","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10495-015-1192-3","article-title":"Necroptosis: a potential, promising target and switch in acute pancreatitis","volume":"21","author":"Wang","year":"2016","journal-title":"Apoptosis"},{"issue":"5","key":"10.1016\/j.intimp.2026.116632_bb0195","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116632_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.167378","article-title":"Apoptosis, pyroptosis, and necroptosis-oh my! The many ways a cell can die","volume":"434","author":"Ketelut-Carneiro","year":"2022","journal-title":"J. Mol. Biol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116632_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/biom12060828","article-title":"Understanding necroptosis in pancreatic diseases","volume":"12","author":"He","year":"2022","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.intimp.2026.116632_bb0210","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41580-023-00689-6","article-title":"A guide to cell death pathways","volume":"25","author":"Yuan","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116632_bb0215","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tips.2016.12.005","article-title":"Complex pathologic roles of RIPK1 and RIPK3: moving beyond necroptosis","volume":"38","author":"Wegner","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2026.116632_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210108","article-title":"The many faces of MLKL, the executor of necroptosis","volume":"24","author":"Martinez-Osorio","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116632_bb0225","doi-asserted-by":"crossref","first-page":"1480027","DOI":"10.3389\/fimmu.2025.1480027","article-title":"RIPK1 in necroptosis and recent progress in related pharmaceutics","volume":"16","author":"Yao","year":"2025","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116632_bb0230","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s10787-024-01447-6","article-title":"Curcumol: a review of its pharmacology, pharmacokinetics, drug delivery systems, structure-activity relationships, and potential applications","volume":"32","author":"Zhai","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2026.116632_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2024.109807","article-title":"Curcumol ameliorates alcohol and high-fat diet-induced fatty liver disease via modulation of the ceruloplasmin\/iron overload\/mtDNA signaling pathway","volume":"136","author":"Ding","year":"2025","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.intimp.2026.116632_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178360","article-title":"Curcumol ameliorates alcoholic liver disease through regulation of SIRT1 signaling pathway","volume":"1008","author":"Qi","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"18","key":"10.1016\/j.intimp.2026.116632_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17183000","article-title":"Curcumol targets the VHL\/HIF-1alpha axis to suppress glycolysis-driven progression in colorectal cancer","volume":"17","author":"Wang","year":"2025","journal-title":"Cancers (Basel)"},{"issue":"3","key":"10.1016\/j.intimp.2026.116632_bb0250","first-page":"203","article-title":"Curcumol inhibits the progression of hepatocellular carcinoma by regulating the expression of hsa_circ_0028861","volume":"39","author":"Wu","year":"2024","journal-title":"Cancer Biother. Radiopharm."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926004777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926004777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:10:29Z","timestamp":1777129829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926004777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":50,"alternative-id":["S1567576926004777"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116632","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumol alleviates acute pancreatitis by inhibiting RIPK1\/RIPK3\/MLKL pathway-mediated necroptosis: integrated bioinformatics, network pharmacology, molecular docking and dynamics simulations, and experimental validation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116632","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116632"}}