{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:06:07Z","timestamp":1777878367988,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.intimp.2026.116664","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T03:01:08Z","timestamp":1776567668000},"page":"116664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["DS-10 mitigates cerebral ischemia-reperfusion injury in mice through suppressing caspase-1-mediated pyroptosis"],"prefix":"10.1016","volume":"180","author":[{"given":"Zhiqi","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuefan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116664_bb0005","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.amjmed.2021.07.027","article-title":"Ischemic stroke","volume":"134","author":"Feske","year":"2021","journal-title":"Am. J. Med."},{"key":"10.1016\/j.intimp.2026.116664_bb0010","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1001\/jama.2020.26867","article-title":"Diagnosis and management of transient ischemic attack and acute ischemic stroke","volume":"325","author":"Mendelson","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.intimp.2026.116664_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113518","article-title":"Emerging neuroprotective strategies for the treatment of ischemic stroke: an overview of clinical and preclinical studies","volume":"335","author":"Paul","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2026.116664_bb0020","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.7150\/thno.71086","article-title":"Pyroptosis in inflammatory diseases and cancer","volume":"12","author":"Rao","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2026.116664_bb0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.brainresbull.2020.10.009","article-title":"Targeting pyroptosis to regulate ischemic stroke injury: molecular mechanisms and preclinical evidences","volume":"165","author":"Ye","year":"2020","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.intimp.2026.116664_bb0030","article-title":"Targeting pyroptosis with nanoparticles to alleviateneuroinflammatory for preventing secondary damagefollowing traumatic brain injury","volume":"10","author":"Zhang","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.intimp.2026.116664_bb0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12974-021-02137-8","article-title":"Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke","volume":"18","author":"Xu","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116664_bb0040","doi-asserted-by":"crossref","first-page":"e790","DOI":"10.1038\/cddis.2013.326","article-title":"Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke","volume":"4","author":"Yang-Wei Fann","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116664_bb0045","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/cns.13699","article-title":"AIM2 deletion enhances blood-brain barrier integrity in experimental ischemic stroke","volume":"27","author":"Xu","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2026.116664_bb0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: Gasdermin-mediated programmed necrotic cell death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.intimp.2026.116664_bb0055","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1186\/s12916-025-04242-4","article-title":"Vagus nerve stimulation inhibits pyroptosis and improves outcome of cerebral ischemic stroke by upregulating osteopontin (SPP1) to disturb ASC oligomerization","volume":"23","author":"Wen","year":"2025","journal-title":"BMC Med."},{"key":"10.1016\/j.intimp.2026.116664_bb0060","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12974-022-02501-2","article-title":"Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4\/NF\u03baB\/NLRP3 signaling pathway in cerebral ischemic mice","volume":"19","author":"Luo","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116664_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109315","article-title":"Edaravone dexborneol provides neuroprotective benefits by suppressing NLRP3 inflammasome-induced microglial pyroptosis in experimental ischemic stroke","volume":"113","author":"Hu","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116664_bb0070","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1039\/C7FO01328K","article-title":"Oral administration of lyophilized Dunaliella salina, a carotenoid-rich marine alga, reduces tumor progression in mammary cancer induced rats","volume":"8","author":"Srinivasan","year":"2017","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2026.116664_bb0075","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jfda.2016.11.018","article-title":"Dunaliella salina alga extract inhibits the production of interleukin-6, nitric oxide, and reactive oxygen species by regulating nuclear factor-\u03baB\/Janus kinase\/signal transducer and activator of transcription in virus-infected RAW264.7 cells","volume":"25","author":"Lin","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.intimp.2026.116664_bb0080","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.3390\/ijms24043871","article-title":"Dunaliella salina alga protects against myocardial ischemia\/reperfusion injury by attenuating TLR4 signaling","volume":"24","author":"Tsai","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116664_bb0085","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.12349","article-title":"Anti-proliferative, anti-inflammatory and pro-apoptotic effects of Dunaliella salinaon human KB oral carcinoma cells","volume":"41","author":"Chiu","year":"2017","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.intimp.2026.116664_bb0090","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.tifs.2021.08.017","article-title":"Bioactive peptides derived from marine sources: biological and functional properties","volume":"119","author":"Cunha","year":"2022","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.intimp.2026.116664_bb0095","first-page":"1","article-title":"Optimization and identification of antioxidant peptide from underutilized Dunaliella salina protein: extraction, in vitro gastrointestinal digestion, and fractionation","volume":"2019","author":"Xia","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.intimp.2026.116664_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117334","article-title":"Activation of the Nrf2\/HO-1\/GPX4 pathway by cGAMP mitigates oxidative stress and ferroptosis in ischaemic stroke","volume":"242","author":"Li","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116664_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115021","article-title":"Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K\/AKT\/Nrf2 and SLC7A11\/GPX4 signaling pathway after ischemia","volume":"289","author":"Fu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2026.116664_bb0110","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/s41401-023-01177-5","article-title":"Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway","volume":"45","author":"Li","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2026.116664_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155820","article-title":"Elucidating the mechanisms of Buyang Huanwu Decoction in treating chronic cerebral ischemia: A combined approach using network pharmacology, molecular docking, and in vivo validation","volume":"132","author":"Cao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116664_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114798","article-title":"Drug affinity responsive target stability (DARTS) accelerated small molecules target discovery: principles and application","volume":"194","author":"Ren","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116664_bb0125","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41420-023-01440-y","article-title":"Targeting pyroptosis as a preventive and therapeutic approach for stroke","volume":"9","author":"Long","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.intimp.2026.116664_bb0130","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2022.04.003","article-title":"NLRP3 and pyroptosis blockers for treating inflammatory diseases","volume":"43","author":"Coll","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2026.116664_bb0135","doi-asserted-by":"crossref","first-page":"22351","DOI":"10.1038\/s41598-021-01465-2","article-title":"Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma","volume":"11","author":"Koizumi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.116664_bb0140","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0140-6736(20)31179-X","article-title":"Stroke","volume":"396","author":"Campbell","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2026.116664_bb0145","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12974-019-1516-2","article-title":"Neuroinflammation: friend and foe for ischemic stroke","volume":"16","author":"Jayaraj","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116664_bb0150","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41582-021-00605-6","article-title":"Pharmacological brain cytoprotection in acute ischaemic stroke \u2014 renewed hope in the reperfusion era","volume":"18","author":"Fisher","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.intimp.2026.116664_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.714943","article-title":"Janus kinase inhibition ameliorates ischemic stroke injury and neuroinflammation through reducing NLRP3 inflammasome activation via JAK2\/STAT3 pathway inhibition","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116664_bb0160","doi-asserted-by":"crossref","first-page":"12331","DOI":"10.1021\/acs.jmedchem.4c03115","article-title":"Target engagement assays in early drug discovery","volume":"68","author":"St John-Campbell","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.intimp.2026.116664_bb0165","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.116664_bb0170","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/jnr.24385","article-title":"Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro","volume":"97","author":"Zhang","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.intimp.2026.116664_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.856372","article-title":"Caspase-1: a promising target for preserving blood\u2013brain barrier integrity in acute stroke","volume":"15","author":"Ye","year":"2022","journal-title":"Front. Mol. Neurosci."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926005096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926005096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:18:35Z","timestamp":1777591115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926005096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":35,"alternative-id":["S1567576926005096"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116664","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DS-10 mitigates cerebral ischemia-reperfusion injury in mice through suppressing caspase-1-mediated pyroptosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116664","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116664"}}