{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:42:11Z","timestamp":1790876531296,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.intimp.2026.116684","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:47:22Z","timestamp":1777056442000},"page":"116684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Loss of cGAS facilitates angiogenesis in diabetic foot ulcer healing by suppressing the STING\/ferroptosis pathway"],"prefix":"10.1016","volume":"180","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116684_bb0005","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2023.10578","article-title":"Diabetic foot ulcers: a review","volume":"330","author":"Armstrong","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.intimp.2026.116684_bb0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2337\/dci22-0043","article-title":"Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers","volume":"46","author":"McDermott","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.intimp.2026.116684_bb0015","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1111\/dme.14045","article-title":"Diabetic foot ulcer incidence and survival with improved diabetic foot services: An 18-year study","volume":"36","author":"Paisey","year":"2019","journal-title":"Diabet. Med."},{"key":"10.1016\/j.intimp.2026.116684_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9093009","article-title":"Mortality in patients with diabetic foot ulcers: causes, risk factors, and their association with evolution and severity of ulcer","volume":"9","author":"Rubio","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2026.116684_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102405","article-title":"Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors","volume":"99","author":"Barbieri","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2026.116684_bb0030","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/acs.accounts.0c00864","article-title":"Strategy for treatment of infected diabetic foot ulcers","volume":"54","author":"Chang","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.intimp.2026.116684_bb0035","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/SLA.0000000000006398","article-title":"Local management for diabetic foot ulcers: a systematic review and network meta-analysis of randomized controlled trials","volume":"281","author":"Qian","year":"2024","journal-title":"Ann. Surg."},{"key":"10.1016\/j.intimp.2026.116684_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.14465","article-title":"Identification of potential immunologic resilience in the healing process of diabetic foot ulcers","volume":"21","author":"Cheng","year":"2024","journal-title":"Int. Wound J."},{"key":"10.1016\/j.intimp.2026.116684_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.106858","article-title":"Proteomic analysis of foot ulcer tissue reveals novel potential therapeutic targets of wound healing in diabetic foot ulcers","volume":"159","author":"Wang","year":"2023","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.intimp.2026.116684_bb0050","article-title":"Key extracellular proteins and TF-miRNA co-regulatory network in diabetic foot ulcer: bioinformatics and experimental insights","volume":"19","author":"Lin","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2026.116684_bb0055","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"CGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2026.116684_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114987","article-title":"The interplay between STING and metabolic reprogramming: from mechanisms to therapeutic strategies","volume":"161","author":"Zhou","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116684_bb0065","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s41401-024-01369-7","article-title":"Cyclic GMP-AMP synthase recognizes the physical features of DNA","volume":"46","author":"Dong","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2026.116684_bb0070","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cGAS-STING signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.intimp.2026.116684_bb0075","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1146\/annurev-immunol-101721-032910","article-title":"Regulation of the cGAS-STING pathway","volume":"43","author":"Zhang","year":"2025","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.116684_bb0080","article-title":"The role of cGAS-STING pathway ubiquitination in innate immunity and multiple diseases","volume":"16","author":"Deng","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116684_bb0085","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41581-022-00589-6","article-title":"Role of the cGAS-STING pathway in systemic and organ-specific diseases","volume":"18","author":"Skopelja-Gardner","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.intimp.2026.116684_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117632","article-title":"STING inhibitors and degraders: potential therapeutic agents in inflammatory diseases","volume":"291","author":"Wu","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.intimp.2026.116684_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102691","article-title":"CGAS-STING targeting offers novel therapeutic opportunities in neurological diseases","volume":"105","author":"Wang","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2026.116684_bb0100","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41392-022-01252-z","article-title":"Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2026.116684_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114902","article-title":"CGAS-STING and neurodegenerative diseases: a molecular crosstalk and therapeutic perspective","volume":"159","author":"Dhapola","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116684_bb0110","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbrc.2023.05.081","article-title":"High glucose-induced endothelial STING activation inhibits diabetic wound healing through impairment of angiogenesis","volume":"668","author":"Luo","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2026.116684_bb0115","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbrc.2022.04.085","article-title":"STING activation promotes inflammatory response and delays skin wound healing in diabetic mice","volume":"611","author":"Feng","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2026.116684_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-023-01425-x","article-title":"High glucose-induced STING activation inhibits diabetic wound healing through promoting m1 polarization of macrophages","volume":"9","author":"Geng","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.intimp.2026.116684_bb0125","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401299RR","article-title":"Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis","volume":"38","author":"Wang","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2026.116684_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123470","article-title":"Cardiomyocyte-specific deletion of STING improves cardiac function, glucose homeostasis, and wound healing in diabetic mice","volume":"366-367","author":"Li","year":"2025","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2026.116684_bb0135","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00403-024-03065-2","article-title":"Adipose stem cell-derived exosomes promote high glucose-induced wound healing by regulating the TRIM32\/STING axis","volume":"316","author":"He","year":"2024","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.intimp.2026.116684_bb0140","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","article-title":"Cell death","volume":"187","author":"Newton","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2026.116684_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115647","article-title":"Ferroptosis as a precise target for tumor-associated neutrophils: from molecular insights to targeted therapies","volume":"167","author":"Zhao","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116684_bb0150","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.intimp.2026.116684_bb0155","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2026.116684_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114745","article-title":"Disrupting the immune homeostasis: the emerging role of macrophage ferroptosis in autoimmune diseases","volume":"157","author":"Liu","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116684_bb0165","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2026.116684_bb0170","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2026.116684_bb0175","article-title":"The role of programmed cell death in diabetic foot ulcers","volume":"21","author":"Li","year":"2023","journal-title":"Int. Wound J."},{"key":"10.1016\/j.intimp.2026.116684_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155715","article-title":"Pathological insights into cell death pathways in diabetic wound healing","volume":"264","author":"Harithpriya","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.intimp.2026.116684_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167797","article-title":"The IGF2BP2-circ-DAPK1 axis promotes high-glucose-induced ferroptosis of HUVECs by decreasing NQO1 expression","volume":"1871","author":"Qiu","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.intimp.2026.116684_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70221","article-title":"Sodium pump subunit NKAalpha1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy-lysosome degradation of ACSL4","volume":"15","author":"Zhu","year":"2025","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.intimp.2026.116684_bb0195","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9999612","article-title":"Mechanism of ferroptosis and its role in type 2 diabetes mellitus","volume":"2021","author":"Sha","year":"2021","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.intimp.2026.116684_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.142313","article-title":"Supermolecular poly-N-acryloyl glycinamide\/polyglutamic acid\/Fe(3+) hydrogel incorporated with bioactive small extracellular vesicles promote diabetic wound healing by suppressing ferroptosis","volume":"308","author":"Liu","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.intimp.2026.116684_bb0205","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jcjd.2025.03.002","article-title":"Loss of MAF bZIP transcription factor g restores ATG7\/BECN1-mediated autophagy to inhibit ferroptosis and improve angiogenesis in diabetic foot ulcer wound healing","volume":"49","author":"Huang","year":"2025","journal-title":"Can. J. Diabetes"},{"key":"10.1016\/j.intimp.2026.116684_bb0210","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/0115733998352547250107065356","article-title":"Deciphering the iron metabolism and ferroptosis in diabetic wound healing","volume":"22","author":"Feng","year":"2026","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.intimp.2026.116684_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.898657","article-title":"Oxidative stress and lipid peroxidation: prospective associations between ferroptosis and delayed wound healing in diabetic ulcers","volume":"10","author":"Feng","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2026.116684_bb0220","doi-asserted-by":"crossref","first-page":"E509","DOI":"10.1152\/ajpendo.00042.2021","article-title":"Diabetic ferroptosis plays an important role in triggering on inflammation in diabetic wound","volume":"321","author":"Li","year":"2021","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2026.116684_bb0225","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/iid3.492","article-title":"The infection characteristics and autophagy defect of dermal macrophages in STZ-induced diabetic rats skin wound staphylococcus aureus infection model","volume":"9","author":"Xie","year":"2021","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.intimp.2026.116684_bb0230","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1007\/s10753-025-02297-2","article-title":"SIRT6 overexpression enhances diabetic foot ulcer healing via nrf2 pathway activation","volume":"48","author":"Wei","year":"2025","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2026.116684_bb0235","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1582-4934.2008.00324.x","article-title":"Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats","volume":"13","author":"Aliev","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.intimp.2026.116684_bb0240","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkad050","article-title":"The cGAS-STING pathway: a therapeutic target in diabetes and its complications","volume":"12","author":"He","year":"2024","journal-title":"Burns & Trauma"},{"key":"10.1016\/j.intimp.2026.116684_bb0245","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.4239\/wjd.v15.i10.2041","article-title":"Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications","volume":"15","author":"Fan","year":"2024","journal-title":"world J. Diabetes"},{"key":"10.1016\/j.intimp.2026.116684_bb0250","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jare.2022.10.014","article-title":"Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS\/STING signaling dependent on LKB1\/AMPK\/ULK1-mediated autophagy","volume":"51","author":"Lu","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.intimp.2026.116684_bb0255","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41419-023-06111-5","article-title":"TGR5 supresses cGAS\/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116684_bb0260","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/s12964-023-01393-w","article-title":"Hyperglycemia-induced STING signaling activation leads to aortic endothelial injury in diabetes","volume":"21","author":"An","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.intimp.2026.116684_bb0265","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10753-024-02058-7","article-title":"BRG1 deficiency promotes cardiomyocyte inflammation and apoptosis by activating the cGAS-STING signaling in diabetic cardiomyopathy","volume":"48","author":"Chen","year":"2025","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2026.116684_bb0270","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.tem.2024.11.004","article-title":"Intracellular endothelial cell metabolism in vascular function and dysfunction","volume":"36","author":"Citrin","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2026.116684_bb0275","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.186504","article-title":"Endothelial FOXM1 and dab2 promote diabetic wound healing","volume":"10","author":"Bhattacharjee","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.intimp.2026.116684_bb0280","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1016\/j.apsb.2024.03.011","article-title":"Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling","volume":"14","author":"He","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.intimp.2026.116684_bb0285","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202350386","article-title":"CGAS-STING signaling in cell death: mechanisms of action and implications in pathologies","volume":"53","author":"Xu","year":"2023","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.intimp.2026.116684_bb0290","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jare.2024.12.028","article-title":"The role of cGAS-STING signaling pathway in ferroptosis","volume":"76","author":"Ding","year":"2025","journal-title":"J Adv Res"},{"key":"10.1016\/j.intimp.2026.116684_bb0295","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12974-022-02602-y","article-title":"Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis","volume":"19","author":"Hu","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116684_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2026.116458","article-title":"Danggui sini decoction attenuates intervertebral disc degeneration by regulating ferroptosis in nucleus pulposus cells via the GJA1\/cGAS\/STING signaling axis","volume":"176","author":"Chen","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116684_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2026.116364","article-title":"Neuronal TLR4 upregulation activates the cGAS-STING pathway to induce ferroptosis in EAE mice","volume":"174","author":"Qin","year":"2026","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116684_bb0310","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.freeradbiomed.2023.08.025","article-title":"STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury","volume":"208","author":"Jin","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2026.116684_bb0315","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41419-022-05115-x","article-title":"The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages","volume":"13","author":"Wu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116684_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116102","article-title":"STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease","volume":"222","author":"Zhao","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116684_bb0325","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1016\/j.cell.2024.05.031","article-title":"STING orchestrates the neuronal inflammatory stress response in multiple sclerosis","volume":"187","author":"Woo","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2026.116684_bb0330","article-title":"STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation","volume":"10","author":"Wang","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2026.116684_bb0335","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1016\/j.ymthe.2023.07.026","article-title":"STING\/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease","volume":"31","author":"Gao","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.intimp.2026.116684_bb0340","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1007\/s00210-024-03400-4","article-title":"Study on the mechanism of activating SIRT1\/Nrf2\/p62 pathway to mediate autophagy-dependent ferroptosis to promote healing of diabetic foot ulcers","volume":"398","author":"Han","year":"2025","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116684_bb0345","doi-asserted-by":"crossref","DOI":"10.1111\/dme.15031","article-title":"Bone marrow stromal cell-derived exosomal circular RNA improves diabetic foot ulcer wound healing by activating the nuclear factor erythroid 2-related factor 2 pathway and inhibiting ferroptosis","volume":"40","author":"Chen","year":"2023","journal-title":"Diabet. Med."},{"key":"10.1016\/j.intimp.2026.116684_bb0350","doi-asserted-by":"crossref","first-page":"12492","DOI":"10.1038\/s41598-025-97831-5","article-title":"Mechanism of dracorhodin in accelerating diabetic foot ulcer healing via the nrf2 pathway, a network pharmacology, molecular docking and experimental validation","volume":"15","author":"Tang","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.116684_bb0355","first-page":"51","article-title":"Mesenchymal stromal cell therapy alone does not lead to complete restoration of skin parameters in diabetic foot patients within a 3-year follow-up period","volume":"12","author":"Maksimova","year":"2022","journal-title":"Bioimpacts"},{"key":"10.1016\/j.intimp.2026.116684_bb0360","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.3390\/ijms22126341","article-title":"Endothelial cell participation in inflammatory reaction","volume":"22","author":"Wautier","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116684_bb0365","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1111\/iwj.14102","article-title":"Research progress and insights on the role of ferroptosis in wound healing","volume":"20","author":"Bi","year":"2023","journal-title":"Int. Wound J."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926005308?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926005308?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:19:53Z","timestamp":1777591193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926005308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":73,"alternative-id":["S1567576926005308"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116684","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of cGAS facilitates angiogenesis in diabetic foot ulcer healing by suppressing the STING\/ferroptosis pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116684","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116684"}}