{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:40:31Z","timestamp":1790718031843,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ80965"],"award-info":[{"award-number":["2025JJ80965"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ80936"],"award-info":[{"award-number":["2025JJ80936"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012830","name":"Development and Reform Commission of Hunan Province","doi-asserted-by":"publisher","award":["201930"],"award-info":[{"award-number":["201930"]}],"id":[{"id":"10.13039\/100012830","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104793"],"award-info":[{"award-number":["82104793"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.intimp.2026.116693","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:17:05Z","timestamp":1777591025000},"page":"116693","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Abnormal FKN-CX3CR1-NR signal triggers hippocampal synaptic dysfunction in rheumatoid arthritis-related depression"],"prefix":"10.1016","volume":"181","author":[{"given":"Shu-Xia","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-Yang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-An","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7987","key":"10.1016\/j.intimp.2026.116693_bb0005","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41586-023-06708-y","article-title":"Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes","volume":"623","author":"Zhang","year":"2023","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.intimp.2026.116693_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112857","article-title":"Management of rheumatoid arthritis: an overview","volume":"10","author":"Radu","year":"2021","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.intimp.2026.116693_bb0015","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.6567","article-title":"Comparative risk of alzheimer disease and related dementia among medicare beneficiaries with rheumatoid arthritis treated with targeted disease-modifying antirheumatic agents","volume":"5","author":"Desai","year":"2022","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.intimp.2026.116693_bb0020","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1186\/s12891-022-05520-5","article-title":"Smartphone-based behavioral monitoring and patient-reported outcomes in adults with rheumatic and musculoskeletal disease","volume":"23","author":"Mollard","year":"2022","journal-title":"BMC Musculoskelet. Disord."},{"issue":"5","key":"10.1016\/j.intimp.2026.116693_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2021.105200","article-title":"Rheumatoid arthritis and depression","volume":"88","author":"Fakra","year":"2021","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.intimp.2026.116693_bb0030","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jad.2022.05.108","article-title":"Elucidating a bidirectional association between rheumatoid arthritis and depression: a systematic review and meta-analysis","volume":"311","author":"Ng","year":"2022","journal-title":"J. Affect. Disord."},{"issue":"12","key":"10.1016\/j.intimp.2026.116693_bb0035","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/s41584-023-01037-w","article-title":"Immune mechanisms of depression in rheumatoid arthritis","volume":"19","author":"Brock","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116693_bb0040","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/BOR.0000000000000597","article-title":"Depression and the risk of rheumatoid arthritis","volume":"31","author":"Vallerand","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116693_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092283","article-title":"The role of chemokines in the pathophysiology of major depressive disorder","volume":"20","author":"Milenkovic","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116693_bb0050","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jad.2022.05.003","article-title":"Chemokine receptor 4 expression on blood t lymphocytes predicts severity of major depressive disorder","volume":"310","author":"Freff","year":"2022","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.intimp.2026.116693_bb0055","article-title":"The complex role of the chemokine CX3CL1\/Fractalkine in major depressive disorder: a narrative review of preclinical and clinical studies","volume":"38","author":"Bridge","year":"2024","journal-title":"Brain Behav Immun Health."},{"key":"10.1016\/j.intimp.2026.116693_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105926","article-title":"Blood brain barrier and inflammation in depression","volume":"175","author":"Medina-Rodriguez","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.intimp.2026.116693_bb0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s41232-016-0017-2","article-title":"Therapeutic intervention of inflammatory\/immune diseases by inhibition of the fractalkine (CX3CL1)-CX3CR1 pathway","volume":"36","author":"Imai","year":"2016","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.intimp.2026.116693_bb0070","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2147\/ITT.S277991","article-title":"Emerging role of fractalkine in the treatment of rheumatic diseases","volume":"9","author":"Tanaka","year":"2020","journal-title":"Immunotargets Ther."},{"issue":"12","key":"10.1016\/j.intimp.2026.116693_bb0075","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1177\/02698811251389532","article-title":"Role of chemokines in depression: highlights on CX3CL1\/CX3CR1 signaling","volume":"39","author":"Yin","year":"2025","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.intimp.2026.116693_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112371","article-title":"Involvement of CX3CL1\/CX3CR1 in depression and cognitive impairment induced by chronic unpredictable stress and relevant underlying mechanism","volume":"381","author":"Liu","year":"2020","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.intimp.2026.116693_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.dcmed.2020.06.003","article-title":"Compound Chai Jin Jie Yu tablets, acts as an antidepressant by promoting synaptic function in the hippocampal neurons","volume":"3","author":"Zi-Rong","year":"2020","journal-title":"Digital Chin. Med."},{"issue":"07","key":"10.1016\/j.intimp.2026.116693_bb0090","first-page":"23","article-title":"Effects of Zhuanggu analgesia and depression relief formula on RAD model rat behavior and FKN\/CX3CR1 signaling pathway","volume":"38","author":"Lin","year":"2021","journal-title":"Trad. Chin. Med. Inf."},{"issue":"01","key":"10.1016\/j.intimp.2026.116693_bb0095","first-page":"96","article-title":"Research on the mechanism of action of strong bone analgesia and depression relief formula based on FKN\/CX3CR1 signaling pathway against rheumatoid arthritis with depression","volume":"30","author":"Liu","year":"2023","journal-title":"China J. Tradit. Chin. Med. Inf."},{"issue":"56","key":"10.1016\/j.intimp.2026.116693_bb0100","article-title":"Brain-bone axis dysregulation: biological code underlying the bidirectional association between depression and musculoskeletal disorders","volume":"22","author":"Li","year":"2026","journal-title":"J. Orthop. Translat."},{"issue":"15","key":"10.1016\/j.intimp.2026.116693_bb0105","doi-asserted-by":"crossref","first-page":"7342","DOI":"10.1111\/jcmm.16763","article-title":"The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression","volume":"25","author":"Liu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.intimp.2026.116693_bb0110","article-title":"Activation of hippocampal IR\/IRS-1 signaling contributes to the treatment with Zuogui Jiangtang Jieyu decoction on the diabetes-related depression","volume":"2021","author":"Yang","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.116693_bb0115","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4103\/1673-5374.244794","article-title":"Structural and functional damage to the hippocampal neurovascular unit in diabetes-related depression","volume":"14","author":"Liu","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2026.116693_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.trim.2023.101797","article-title":"The effects of encapsulation on NK cell differentiation potency of C-kit+ hematopoietic stem cells via identifying cytokine profiles","volume":"77","author":"Farahzadi","year":"2023","journal-title":"Transpl. Immunol."},{"issue":"26","key":"10.1016\/j.intimp.2026.116693_bb0125","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.reth.2024.08.008","article-title":"Cytokines secreted from bone marrow-derived mesenchymal stem cells promote apoptosis of CD34+ leukemic stem cells as anti-cancer therapy","volume":"28","author":"Farahzadi","year":"2024","journal-title":"Regen Ther."},{"key":"10.1016\/j.intimp.2026.116693_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.647259","article-title":"Corrigendum: inflammation-associated synaptic alterations as shared threads in depression and multiple sclerosis","volume":"14","author":"Bruno","year":"2021","journal-title":"Front. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.intimp.2026.116693_bb0145","first-page":"123","article-title":"Central and peripheral inflammation link metabolic syndrome and major depressive disorder","volume":"34","author":"Chan","year":"2019","journal-title":"Physiology (Bethesda)"},{"issue":"11","key":"10.1016\/j.intimp.2026.116693_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2019.07.078","article-title":"Microglia-triggered plasticity of intrinsic excitability modulates psychomotor behaviors in acute cerebellar inflammation","volume":"28","author":"Yamamoto","year":"2019","journal-title":"Cell Rep."},{"issue":"2","key":"10.1016\/j.intimp.2026.116693_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2020.12.016","article-title":"Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons","volume":"54","author":"Klawonn","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2026.116693_bb0160","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbi.2020.11.007","article-title":"Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala","volume":"91","author":"Zheng","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116693_bb0165","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116693_bb0170","doi-asserted-by":"crossref","first-page":"765","DOI":"10.31083\/j.jin2003081","article-title":"Comparing underlying mechanisms of depression in multiple sclerosis and rheumatoid arthritis","volume":"20","author":"Wenger","year":"2021","journal-title":"J. Integr. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116693_bb0175","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41398-022-01993-z","article-title":"Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal t cells activation","volume":"12","author":"Pu","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"7639","key":"10.1016\/j.intimp.2026.116693_bb0180","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature20810","article-title":"Pathologically expanded peripheral t helper cell subset drives b cells in rheumatoid arthritis","volume":"542","author":"Rao","year":"2017","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.intimp.2026.116693_bb0185","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s12264-021-00765-x","article-title":"Dlg1 knockout inhibits microglial activation and alleviates lipopolysaccharide-induced depression-like behavior in mice","volume":"37","author":"Peng","year":"2021","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.intimp.2026.116693_bb0190","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bbi.2022.09.008","article-title":"Dorsal root ganglia CX3CR1 expressing monocytes\/macrophages contribute to arthritis pain","volume":"106","author":"Oggero","year":"2022","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116693_bb0195","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/glia.24464","article-title":"Chronic psychosocial stress triggers microglial\u2212\/macrophage-induced inflammatory responses leading to neuronal dysfunction and depressive-related behavior","volume":"72","author":"Kokkosis","year":"2024","journal-title":"Glia"},{"issue":"11","key":"10.1016\/j.intimp.2026.116693_bb0200","doi-asserted-by":"crossref","first-page":"7590","DOI":"10.4049\/jimmunol.180.11.7590","article-title":"Activity of adenosine receptors type 1 is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons","volume":"180","author":"Lauro","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2026.116693_bb0205","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/4637073","article-title":"Fractalkine\/CX3CR1-dependent modulation of synaptic and network plasticity in health and disease","author":"Camacho-Hern\u00e1ndez","year":"2023","journal-title":"Neural Plast."},{"key":"10.1016\/j.intimp.2026.116693_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173861","article-title":"GR\/NF-\u03baB signaling pathway regulates hippocampal inflammatory responses in diabetic rats with chronic unpredictable mild stress","volume":"895","author":"Li","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116693_bb0215","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1007\/s11064-017-2270-4","article-title":"Microglia loss contributes to the development of major depression induced by different types of chronic stresses","volume":"42","author":"Tong","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.intimp.2026.116693_bb0220","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bbi.2021.10.018","article-title":"Stress-induced depressive-like behavior in male rats is associated with microglial activation and inflammation dysregulation in the hippocampus in adulthood","volume":"99","author":"Br\u00e1s","year":"2022","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116693_bb0225","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/ejn.14720","article-title":"Neuroinflammation and depression: a review","volume":"53","author":"Troubat","year":"2021","journal-title":"Eur. J. Neurosci."},{"issue":"8","key":"10.1016\/j.intimp.2026.116693_bb0230","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1111\/febs.16065","article-title":"Long-term plasticity in the hippocampus: maintaining within and \u2018tagging\u2019 between synapses","volume":"289","author":"Bin Ibrahim","year":"2022","journal-title":"FEBS J."},{"issue":"8","key":"10.1016\/j.intimp.2026.116693_bb0235","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1073\/pnas.0830996100","article-title":"Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice","volume":"100","author":"Fukaya","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.intimp.2026.116693_bb0240","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1523\/JNEUROSCI.4485-14.2015","article-title":"Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation","volume":"35","author":"Riazi","year":"2015","journal-title":"J. Neurosci."},{"issue":"13","key":"10.1016\/j.intimp.2026.116693_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2019.05.087","article-title":"Microglia are indispensable for synaptic plasticity in the spinal dorsal horn and chronic pain","volume":"27","author":"Zhou","year":"2019","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116693_bb0250","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/glia.24090","article-title":"Microglia modulate hippocampal synaptic transmission and sleep duration along the light\/dark cycle","volume":"70","author":"Corsi","year":"2022","journal-title":"Glia"},{"issue":"5","key":"10.1016\/j.intimp.2026.116693_bb0255","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1111\/ejn.14969","article-title":"The effects of microglia- and astrocyte-derived factors on neurogenesis in health and disease","volume":"54","author":"Araki","year":"2021","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.intimp.2026.116693_bb0260","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s12035-020-02144-5","article-title":"Antidepressant effect of Paeoniflorin is through inhibiting pyroptosis CASP-11\/GSDMD pathway","volume":"58","author":"Tian","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116693_bb0265","doi-asserted-by":"crossref","DOI":"10.1186\/s12868-022-00710-2","article-title":"Synaptic loss in a mouse model of euthyroid Hashimoto's thyroiditis: possible involvement of the microglia","volume":"23","author":"Wang","year":"2022","journal-title":"BMC Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116693_bb0270","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12974-018-1141-5","article-title":"Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice","volume":"15","author":"Liu","year":"2018","journal-title":"J. Neuroinflammation"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926005394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926005394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:42:04Z","timestamp":1783039324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926005394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":52,"alternative-id":["S1567576926005394"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116693","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abnormal FKN-CX3CR1-NR signal triggers hippocampal synaptic dysfunction in rheumatoid arthritis-related depression","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116693","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116693"}}