{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:25:27Z","timestamp":1783095927589,"version":"3.54.6"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["20251A011073"],"award-info":[{"award-number":["20251A011073"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["B2023049"],"award-info":[{"award-number":["B2023049"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.intimp.2026.116733","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:17:05Z","timestamp":1777591025000},"page":"116733","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting IRF5 enhances S100A9-mediated granulocytic MDSC accumulation and suppressive function: a novel therapeutic strategy for ulcerative colitis"],"prefix":"10.1016","volume":"181","author":[{"given":"Yi-mei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-wen","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-jie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-na","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-yun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-cong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116733_bb0005","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2026.116733_bb0010","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord\u00e1s","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2026.116733_bb0015","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.3748\/wjg.v29.i29.4481","article-title":"Predictors and optimal management of tumor necrosis factor antagonist nonresponse in inflammatory bowel disease: a literature review","volume":"29","author":"Wang","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2026.116733_bb0020","article-title":"Colombel, loss of response to anti-TNFs: definition, epidemiology, and management, clinical and translational","volume":"7","author":"Roda","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2026.116733_bb0025","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/ibd\/izac200","article-title":"Systematic review and meta-analysis: loss of response and need for dose escalation of infliximab and adalimumab in ulcerative colitis","volume":"29","author":"Savelkoul","year":"2022","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.intimp.2026.116733_bb0030","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.3390\/ijms26073291","article-title":"Unraveling the complexities of myeloid-derived suppressor cells in inflammatory bowel disease","volume":"26","author":"Zhu","year":"2025","journal-title":"IJMS"},{"key":"10.1016\/j.intimp.2026.116733_bb0035","article-title":"The paradoxical role of MDSCs in inflammatory bowel diseases: from bench to bedside","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116733_bb0040","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.116733_bb0045","article-title":"Myeloid-derived suppressor cell accumulation drives intestinal fibrosis through mCCL6\/hCCL15 chemokine-mediated fibroblast activation, advanced","volume":"12","author":"Cheng","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.intimp.2026.116733_bb0050","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ni.1990","article-title":"IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses","volume":"12","author":"Krausgruber","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2026.116733_bb0055","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aax6085","article-title":"IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation","volume":"5","author":"Corbin","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.intimp.2026.116733_bb0060","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/ibd\/izaa200","article-title":"IRF5 acts as a potential therapeutic marker in inflammatory bowel diseases","volume":"27","author":"Yang","year":"2020","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.intimp.2026.116733_bb0065","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1093\/hmg\/ddm259","article-title":"An insertion deletion polymorphism in the interferon regulatory factor 5 (IRF5) gene confers risk of inflammatory bowel diseases","volume":"16","author":"Dideberg","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.intimp.2026.116733_bb0070","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41385-019-0165-1","article-title":"Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens","volume":"12","author":"Pandey","year":"2019","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.intimp.2026.116733_bb0075","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1136\/gutjnl-2021-324855","article-title":"Calprotectin: from biomarker to biological function","volume":"70","author":"Jukic","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2026.116733_bb0080","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2567.2012.03619.x","article-title":"Induction of nuclear factor-\u03baB responses by the S100A9 protein is toll-like receptor-4-dependent","volume":"137","author":"Riva","year":"2012","journal-title":"Immunology"},{"key":"10.1016\/j.intimp.2026.116733_bb0085","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1084\/jem.20080132","article-title":"Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein","volume":"205","author":"Cheng","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2026.116733_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02243","article-title":"S100A9 regulates MDSCs-mediated immune suppression via the RAGE and TLR4 signaling pathways in colorectal carcinoma","volume":"10","author":"Huang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116733_bb0095","doi-asserted-by":"crossref","unstructured":"F. Magro, P. Gionchetti, R. Eliakim, S. Ardizzone, A. Armuzzi, M. Barreiro-de Acosta, J. Burisch, K.B. Gecse, A.L. Hart, P. Hindryckx, C. Langner, J.K. Limdi, G. Pellino, E. Zag\u00f3rowicz, T. Raine, M. Harbord, F. Rieder, Third european evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders, J. Crohn's Colitis 11 (2017) 649\u2013670. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjx008.","DOI":"10.1093\/ecco-jcc\/jjx008"},{"key":"10.1016\/j.intimp.2026.116733_bb0100","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","article-title":"Coated oral 5-Aminosalicylic acid therapy for mildly to moderately active ulcerative colitis","volume":"317","author":"Schroeder","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2026.116733_bb0105","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1369\/jhc.2009.952804","article-title":"Thymidine kinase 1 and thymidine phosphorylase expression in non-small-cell lung carcinoma in relation to angiogenesis and proliferation","volume":"57","author":"Brockenbrough","year":"2009","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.intimp.2026.116733_bb0110","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1177\/0271678X20943823","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"40","author":"Percie du Sert","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.intimp.2026.116733_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100029","article-title":"Analysis of myeloid cells in mouse tissues with flow cytometry","volume":"1","author":"Liu","year":"2020","journal-title":"STAR Protocols."},{"key":"10.1016\/j.intimp.2026.116733_bb0120","doi-asserted-by":"crossref","unstructured":"P.B. Rogers, E.H. Schwartz, Generation of Large Numbers of Myeloid Progenitors and Dendritic Cell Precursors from Murine Bone Marrow Using a Novel Cell Sorting Strategy, JoVE. (2018). https:\/\/doi.org\/10.3791\/57365.","DOI":"10.3791\/57365"},{"key":"10.1016\/j.intimp.2026.116733_bb0125","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73692-2","article-title":"Immunomodulatory effect of dicrocoelium dendriticum ova on DSS-induced experimental colitis in C57BL\/6 mouse","volume":"14","author":"Mighani","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.116733_bb0130","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.2353\/ajpath.2009.080718","article-title":"MicroRNA-196a is a potential marker of progression during barretts metaplasia-dysplasia-invasive adenocarcinoma sequence in esophagus","volume":"174","author":"Maru","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2026.116733_bb0135","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.116733_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107820","article-title":"T cell-intrinsic IRF5 regulates t cell signaling, migration, and differentiation and promotes intestinal inflammation","volume":"31","author":"Yan","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2026.116733_bb0145","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.116733_bb0150","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1172\/JCI60083","article-title":"STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients","volume":"123","author":"Vasquez-Dunddel","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2026.116733_bb0155","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1158\/2326-6066.CIR-18-0108","article-title":"Lnc-C\/EBP\u03b2 negatively regulates the suppressive function of myeloid-derived suppressor cells","volume":"6","author":"Gao","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.intimp.2026.116733_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01661","article-title":"Lnc-C\/EBP\u03b2 modulates differentiation of MDSCs through downregulating IL4i1 with C\/EBP\u03b2 LIP and WDR5","volume":"10","author":"Gao","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116733_bb0165","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1093\/nar\/gky002","article-title":"DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation","volume":"46","author":"Andrilenas","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2026.116733_bb0170","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.4049\/jimmunol.1000482","article-title":"Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression","volume":"185","author":"Feng","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2026.116733_bb0175","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1023\/B:BREA.0000041594.36418.f6","article-title":"Induction of S100A9 gene expression by cytokine oncostatin m in breast cancer cells through the STAT3 signaling cascade","volume":"87","author":"Li","year":"2004","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.intimp.2026.116733_bb0180","article-title":"Interleukin-6 Induces S100A9 Expression in Colonic Epithelial Cells through STAT3 Activation in Experimental Ulcerative Colitis","volume":"7","author":"Lee","year":"2012","journal-title":"PLoS ONE."},{"key":"10.1016\/j.intimp.2026.116733_bb0185","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-018-0512-2","article-title":"HBx-induced S100A9 in NF-\u03baB dependent manner promotes growth and metastasis of hepatocellular carcinoma cells","volume":"9","author":"Duan","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116733_bb0190","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75594","article-title":"C\/EBP\u03b4-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9","volume":"11","author":"Jauch-Speer","year":"2022","journal-title":"ELife"},{"key":"10.1016\/j.intimp.2026.116733_bb0195","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molimm.2019.04.019","article-title":"S100A9 maintains myeloid-derived suppressor cells in chronic sepsis by inducing miR-21 and miR-181b","volume":"112","author":"Alkhateeb","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2026.116733_bb0200","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-023-04652-x","article-title":"Therapeutic S100A8\/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction","volume":"27","author":"Jakobsson","year":"2023","journal-title":"Crit. Care"},{"key":"10.1016\/j.intimp.2026.116733_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/cells11020310","article-title":"Myeloid-derived suppressor cells in solid tumors","volume":"11","author":"Ma","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.116733_bb0210","article-title":"Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion, exp","volume":"13","author":"Lu","year":"2024","journal-title":"Hematol. Oncol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926005795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926005795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:08:28Z","timestamp":1783094908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926005795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":42,"alternative-id":["S1567576926005795"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116733","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting IRF5 enhances S100A9-mediated granulocytic MDSC accumulation and suppressive function: a novel therapeutic strategy for ulcerative colitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116733","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116733"}}