{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:38:13Z","timestamp":1793302693856,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["C2023102"],"award-info":[{"award-number":["C2023102"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20261262"],"award-info":[{"award-number":["20261262"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M761350"],"award-info":[{"award-number":["2024M761350"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110121"],"award-info":[{"award-number":["2023A1515110121"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.intimp.2026.116760","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T19:17:59Z","timestamp":1777749479000},"page":"116760","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Electroacupuncture modulates P300-mediated STAT6\/PPAR\u03b3 binding to promote M2 polarization of microglia following cerebral ischemic injury"],"prefix":"10.1016","volume":"181","author":[{"given":"Zengyu","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyi","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhinan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2026.116760_bb0005","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/17474930241308142","article-title":"World Stroke Organization: Global stroke fact sheet 2025","volume":"20","author":"Feigin","year":"2025","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.intimp.2026.116760_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106482","article-title":"Spatiotemporal lipidomics reveals key features of brain lipid dynamic changes after cerebral ischemia and reperfusion therapy","volume":"185","author":"Ma","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2026.116760_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157548","article-title":"Tanshinone IIA attenuates cerebral-ischemia-reperfusion-induced neuroinflammation by inhibiting the TLR4\/NF-\u03baB signaling cascade: A study integrating network pharmacology, bioinformatics, and experimental validation","volume":"149","author":"Zhou","year":"2025","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.intimp.2026.116760_bb0020","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/STROKEAHA.122.036946","article-title":"Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities","volume":"53","author":"Candelario-Jalil","year":"2022","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.intimp.2026.116760_bb0025","doi-asserted-by":"crossref","first-page":"466","DOI":"10.14336\/AD.2020.0701","article-title":"Microglial polarization: Novel therapeutic strategy against ischemic stroke","volume":"12","author":"Xue","year":"2021","journal-title":"Aging Dis."},{"issue":"2","key":"10.1016\/j.intimp.2026.116760_bb0030","first-page":"123","article-title":"Effects of the adjunctive therapy of Sun's abdominal acupuncture on acute ischemic stroke and inflammatory factors: a randomized controlled trial","volume":"44","author":"Zhu","year":"2024","journal-title":"Zhongguo Zhen Jiu."},{"issue":"8","key":"10.1016\/j.intimp.2026.116760_bb0035","first-page":"849","article-title":"Electroacupuncture for acute ischemic stroke and its effect on plasma levels of IL-17 and IL-10","volume":"42","author":"Li","year":"2022","journal-title":"Zhongguo Zhen Jiu."},{"key":"10.1016\/j.intimp.2026.116760_bb0040","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.2147\/NDT.S485884","article-title":"Electroacupuncture protects against cerebral ischemia-reperfusion injury: Reducing inflammatory response and cell pyroptosis by inhibiting P2X7\/NLRP3\/GSDMD pathway","volume":"20","author":"Chen","year":"2024","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"11","key":"10.1016\/j.intimp.2026.116760_bb0045","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1007\/s11064-024-04228-3","article-title":"Pre-electroacupuncture ameliorates cerebral ischemia-reperfusion injury by inhibiting microglial RhoA\/pyrin\/GSDMD signaling pathway","volume":"49","author":"Fang","year":"2024","journal-title":"Neurochem. Res."},{"issue":"12","key":"10.1016\/j.intimp.2026.116760_bb0050","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1111\/cns.13256","article-title":"Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain","volume":"25","author":"Zhang","year":"2019","journal-title":"CNS Neurosci. Ther."},{"issue":"5","key":"10.1016\/j.intimp.2026.116760_bb0055","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.immuni.2010.11.009","article-title":"STAT6 transcription factor is a facilitator of the nuclear receptor PPAR\u03b3-regulated gene expression in macrophages and dendritic cells","volume":"33","author":"Szanto","year":"2010","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.intimp.2026.116760_bb0060","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/cbf.3433","article-title":"Control of expression and activity of peroxisome proliferated-activated receptor \u03b3 by Annexin A1 on microglia during efferocytosis","volume":"37","author":"Da Rocha","year":"2019","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.intimp.2026.116760_bb0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuroscience.2023.09.007","article-title":"Electroacupuncture alleviates neuroinflammation by regulating microglia polarization via STAT6\/PPAR\u03b3 in ischemic stroke rats","volume":"532","author":"Yao","year":"2023","journal-title":"Neuroscience"},{"issue":"21","key":"10.1016\/j.intimp.2026.116760_bb0070","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1016\/j.cell.2022.09.023","article-title":"The JAK-STAT pathway at 30: Much learned, much more to do","volume":"185","author":"Philips","year":"2022","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2026.116760_bb0075","article-title":"Protein tyrosine phosphatases as wardens of STAT signaling","volume":"3","author":"B\u00f6hmer","year":"2014","journal-title":"Jakstat"},{"issue":"21","key":"10.1016\/j.intimp.2026.116760_bb0080","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.4155\/fmc-2020-0224","article-title":"The roles of post-translational modifications and coactivators of STAT6 signaling in tumor growth and progression","volume":"12","author":"Huang","year":"2020","journal-title":"Future Med. Chem."},{"issue":"6274","key":"10.1016\/j.intimp.2026.116760_bb0085","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad5510","article-title":"Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells","volume":"351","author":"Soucie","year":"2016","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.intimp.2026.116760_bb0090","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.immuni.2017.12.010","article-title":"The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages","volume":"48","author":"Czimmerer","year":"2018","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.intimp.2026.116760_bb0095","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.cellsig.2013.05.007","volume":"25","author":"Zhuang","year":"2013","journal-title":"Cell. Signal."},{"issue":"9","key":"10.1016\/j.intimp.2026.116760_bb0100","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1111\/febs.12225","article-title":"Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression","volume":"280","author":"Qiu","year":"2013","journal-title":"FEBS J."},{"issue":"7","key":"10.1016\/j.intimp.2026.116760_bb0105","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.intimp.2026.116760_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4248526","article-title":"17\u03b2-Estradiol regulates microglia activation and polarization in the hippocampus following global cerebral ischemia","volume":"2018","author":"Thakkar","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2026.116760_bb0115","first-page":"776","article-title":"Improvement of a murine model of middle cerebral artery occlusion and reperfusion established by inserting thread","volume":"06","author":"Sun","year":"2005","journal-title":"Journal of Jinan University(Natural Science & Medicine Edition)"},{"issue":"6","key":"10.1016\/j.intimp.2026.116760_bb0120","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-025-04603-8","article-title":"Electroacupuncture alleviates cerebral ischemia-reperfusion injury by downregulating IL-17 A and inhibiting neurotoxic astrocyte activation","volume":"50","author":"Zhao","year":"2025","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.intimp.2026.116760_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.822088","article-title":"Mechanism of electroacupuncture against cerebral ischemia-reperfusion injury: reducing inflammatory response and cell pyroptosis by inhibiting NLRP3 and Caspase-1","volume":"15","author":"Cai","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116760_bb0130","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.intimp.2026.116760_bb0135","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1007\/s10753-025-02287-4","article-title":"Microglial Annexin A3 downregulation alleviates ischemic injury by inhibiting NF-\u03baB\/NLRP3-mediated inflammation","volume":"48","author":"Zhang","year":"2025","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.intimp.2026.116760_bb0140","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1161\/01.STR.29.5.1037","article-title":"Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion","volume":"29","author":"Ashwal","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.intimp.2026.116760_bb0145","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x2023e13140","article-title":"Rectangular method: a modified technique for sampling the ischemic border zone in a rat model of transient middle cerebral artery occlusion","volume":"56","author":"Xu","year":"2023","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"03","key":"10.1016\/j.intimp.2026.116760_bb0150","first-page":"554","article-title":"Analysis of application of electroacupuncture parameters in study of cerebral ischemia mechanism based on data mining","volume":"35","author":"Zhang","year":"2017","journal-title":"Chinese Archives of Traditional Chinese."},{"key":"10.1016\/j.intimp.2026.116760_bb0155","series-title":"Experimental acupuncture","author":"Yu","year":"2014"},{"key":"10.1016\/j.intimp.2026.116760_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2025.1642337","article-title":"Electroacupuncture pretreatment ameliorates anesthesia and surgery-induced cognitive dysfunction in aged rats: insights from gut microbiota modulation","volume":"16","author":"Lei","year":"2025","journal-title":"Front. Microbiol."},{"issue":"47","key":"10.1016\/j.intimp.2026.116760_bb0165","doi-asserted-by":"crossref","first-page":"57568","DOI":"10.1021\/acsomega.5c05266","article-title":"Prior exercise attenuates LPS-induced neuroinflammation, dopaminergic dysfunction, and fatigue-like behavior in mice","volume":"10","author":"Alves","year":"2025","journal-title":"ACS Omega"},{"key":"10.1016\/j.intimp.2026.116760_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156040","article-title":"Praelolide alleviates collagen-induced arthritis through increasing catalase activity and activating Nrf2 pathway","volume":"135","author":"Qi","year":"2024","journal-title":"Phytomedicine"},{"issue":"02","key":"10.1016\/j.intimp.2026.116760_bb0175","first-page":"225","article-title":"Electroacupuncture intervenes with changes of mitogen-activated protein kinase pathway in a rat model of cerebral ischemia\/reperfusion due to middle cerebral artery occlusion","volume":"26","author":"Lai","year":"2022","journal-title":"Zhongguo Zu Zhi Gong Cheng Yan Jiu"},{"key":"10.1016\/j.intimp.2026.116760_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114289","article-title":"Ischemic stroke rehabilitation through optogenetic modulation of parvalbumin neurons in the contralateral motor cortex","volume":"360","author":"Liu","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2026.116760_bb0185","first-page":"159","article-title":"Ischemic penumbra is defined in transient middle cerebral artery occlusion in the rat","volume":"03","author":"Zhang","year":"2000","journal-title":"Zhongguo Lin Chuang Shen Jing Ke Xue"},{"key":"10.1016\/j.intimp.2026.116760_bb0190","first-page":"4271","article-title":"MRI cerebral function imaging following acupuncture at Hegu, Zusanli, Neiguan and Sanyinjiao points","volume":"22","author":"Zhang","year":"2007","journal-title":"Zhongguo Zu Zhi Gong Cheng Yan Jiu"},{"issue":"46","key":"10.1016\/j.intimp.2026.116760_bb0195","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2404203121","article-title":"Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia","volume":"121","author":"Zucha","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.intimp.2026.116760_bb0200","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-025-04647-w","article-title":"Primary human reactive microglia display mitochondrial dysfunction and metabolic imbalance upon lipopolysaccharide exposure","volume":"51","author":"Fontes","year":"2026","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.intimp.2026.116760_bb0205","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01462","article-title":"The metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2026.116760_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20122882","article-title":"Epigenetic alterations induced by photothrombotic stroke in the rat cerebral cortex: deacetylation of histone h3, upregulation of histone deacetylases and histone acetyltransferases","volume":"20","author":"Demyanenko","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2026.116760_bb0215","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrm1368","article-title":"Shaping the nuclear action of NF-kappaB","volume":"5","author":"Chen","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"15","key":"10.1016\/j.intimp.2026.116760_bb0220","doi-asserted-by":"crossref","first-page":"10212","DOI":"10.1074\/jbc.272.15.10212","article-title":"Interleukin-4 suppression of tumor necrosis factor alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB","volume":"272","author":"Bennett","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.intimp.2026.116760_bb0225","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/glia.24501","article-title":"Role of microglia in stroke","volume":"72","author":"Planas","year":"2024","journal-title":"Glia"},{"issue":"20","key":"10.1016\/j.intimp.2026.116760_bb0230","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131355","article-title":"STAT6\/Arg1 promotes microglia\/macrophage efferocytosis and inflammation resolution in stroke mice","volume":"4","author":"Cai","year":"2019","journal-title":"JCI Insight"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926006065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926006065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:24:39Z","timestamp":1783178679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926006065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":46,"alternative-id":["S1567576926006065"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116760","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electroacupuncture modulates P300-mediated STAT6\/PPAR\u03b3 binding to promote M2 polarization of microglia following cerebral ischemic injury","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116760","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116760"}}