{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:16:11Z","timestamp":1783113371444,"version":"3.54.6"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82405141"],"award-info":[{"award-number":["82405141"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.intimp.2026.116776","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T15:22:45Z","timestamp":1777735365000},"page":"116776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Knockdown of histone deacetylase 9 ameliorates immunoglobulin a nephropathy by modulating immune response"],"prefix":"10.1016","volume":"181","author":[{"given":"Sijia","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baisong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoudong","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.intimp.2026.116776_bb0005","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1093\/ndt\/gfad146","article-title":"IgA nephropathy in adults-treatment standard","volume":"38","author":"Gleeson","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"issue":"6","key":"10.1016\/j.intimp.2026.116776_bb0010","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/ndt\/gfae252","article-title":"Long-term outcomes of IgA nephropathy in China","volume":"40","author":"Shen","year":"2025","journal-title":"Nephrol. Dial. Transplant."},{"issue":"6","key":"10.1016\/j.intimp.2026.116776_bb0015","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s40620-025-02261-1","article-title":"Prevalence and trend of biopsy-proven IgA nephropathy in China: a systematic review","volume":"38","author":"Xu","year":"2025","journal-title":"J. Nephrol."},{"key":"10.1016\/j.intimp.2026.116776_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1165394","article-title":"Current understanding of IgA antibodies in the pathogenesis of IgA nephropathy","volume":"14","author":"Nihei","year":"2023","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116776_bb0025","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00281-021-00871-y","article-title":"The mucosal immune system and IgA nephropathy","volume":"43","author":"Gesualdo","year":"2021","journal-title":"Semin. Immunopathol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116776_bb0030","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s13402-021-00626-9","article-title":"Histone deacetylase (HDAC) 9: versatile biological functions and emerging roles in human cancer","volume":"44","author":"Yang","year":"2021","journal-title":"Cell. Oncol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116776_bb0035","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41419-021-03769-7","article-title":"IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation","volume":"12","author":"Cui","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2026.116776_bb0040","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-000529","article-title":"HDAC9 deficiency promotes tumor progression by decreasing the CD8+ dendritic cell infiltration of the tumor microenvironment","volume":"8","author":"Ning","year":"2020","journal-title":"J. Immunother. Cancer"},{"issue":"6","key":"10.1016\/j.intimp.2026.116776_bb0045","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1007\/s10157-024-02620-5","article-title":"HDAC9-mediated deacetylation of CALML6 promotes excessive proliferation of glomerular mesangial cells in IgA nephropathy","volume":"29","author":"Zhuang","year":"2025","journal-title":"Clin. Exp. Nephrol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116776_bb0050","doi-asserted-by":"crossref","first-page":"F809","DOI":"10.1152\/ajprenal.00037.2020","article-title":"RNA-Seq profiling of microdissected glomeruli identifies potential biomarkers for human IgA nephropathy","volume":"319","author":"Park","year":"2020","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.intimp.2026.116776_bb0055","doi-asserted-by":"crossref","unstructured":"Zhuang X, Liu T, Zheng W, Wei L, Gao J. Kidney transcriptomic and proteomic analyses provide new insight into the pathogenesis of IgA nephropathy in mice. Biochem. Genet. 2025. doi:https:\/\/doi.org\/10.1007\/s10528-025-11146-8.","DOI":"10.1007\/s10528-025-11146-8"},{"key":"10.1016\/j.intimp.2026.116776_bb0060","doi-asserted-by":"crossref","unstructured":"Ding WY, Kuzmuk V, Hunter S, et al. Adeno-associated virus gene therapy prevents progression of kidney disease in genetic models of nephrotic syndrome. Sci. Transl. Med. 2023;15(708):eabc8226. doi:https:\/\/doi.org\/10.1126\/scitranslmed.abc8226.","DOI":"10.1126\/scitranslmed.abc8226"},{"key":"10.1016\/j.intimp.2026.116776_bb0065","article-title":"Discovering biomarkers associated with infiltration of CD8+ T cells and tumor-associated fibrosis in colon adenocarcinoma using single-cell RNA sequencing and gene co-expression network","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116776_bb0070","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"issue":"7","key":"10.1016\/j.intimp.2026.116776_bb0075","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/ckj\/sfad025","article-title":"Immune abnormalities in IgA nephropathy","volume":"16","author":"Gentile","year":"2023","journal-title":"Clin. Kidney J."},{"issue":"5","key":"10.1016\/j.intimp.2026.116776_bb0080","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/MNH.0000000000000902","article-title":"Novel agents for treating IgA nephropathy","volume":"32","author":"Kunter","year":"2023","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"6","key":"10.1016\/j.intimp.2026.116776_bb0085","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.kint.2024.03.012","article-title":"A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy","volume":"105","author":"Lafayette","year":"2024","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.intimp.2026.116776_bb0090","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1007\/s00467-024-06620-1","article-title":"The beneficial effect of adding belimumab in severe and refractory IgA nephropathy: a case report","volume":"40","author":"Mao","year":"2025","journal-title":"Pediatr. Nephrol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116776_bb0095","article-title":"HDAC9-mediated epithelial cell cycle arrest in G2\/M contributes to kidney fibrosis in male mice","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.116776_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.107009","article-title":"Histone deacetylase 9 exacerbates podocyte injury in hyperhomocysteinemia through epigenetic repression of klotho","volume":"198","author":"Liu","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.intimp.2026.116776_bb0105","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2422435","article-title":"Histone deacetylase 9 promotes osteogenic trans-differentiation of vascular smooth muscle cells via ferroptosis in chronic kidney disease vascular calcification","volume":"46","author":"Xiong","year":"2024","journal-title":"Ren. Fail."},{"issue":"1","key":"10.1016\/j.intimp.2026.116776_bb0110","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41581-024-00885-3","article-title":"The pathogenesis of IgA nephropathy and implications for treatment","volume":"21","author":"Cheung","year":"2025","journal-title":"Nat. Rev. Nephrol."},{"issue":"Suppl. 2","key":"10.1016\/j.intimp.2026.116776_bb0115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/nep.14367","article-title":"B cell targeting in IgA nephropathy","volume":"29","author":"Suzuki","year":"2024","journal-title":"Nephrology (Carlton)"},{"issue":"3","key":"10.1016\/j.intimp.2026.116776_bb0120","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/jleuko\/qiae103","article-title":"T cell responses in immune-mediated IgA nephropathy","volume":"116","author":"Xie","year":"2024","journal-title":"J. Leukoc. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116776_bb0125","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/08830185.2024.2321901","article-title":"Th17 cells: a new target in kidney disease research","volume":"43","author":"Zhang","year":"2024","journal-title":"Int. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116776_bb0130","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s40620-021-01196-7","article-title":"Oxidative stress and macrophage infiltration in IgA nephropathy","volume":"35","author":"Caliskan","year":"2022","journal-title":"J. Nephrol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116776_bb0135","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00018-022-04137-0","article-title":"Twist1 regulates macrophage plasticity to promote renal fibrosis through galectin-3","volume":"79","author":"Wu","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"4","key":"10.1016\/j.intimp.2026.116776_bb0140","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10456-017-9561-x","article-title":"CXCL10 suppression of hem- and lymph-angiogenesis in inflamed corneas through MMP13","volume":"20","author":"Gao","year":"2017","journal-title":"Angiogenesis"},{"issue":"6","key":"10.1016\/j.intimp.2026.116776_bb0145","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1182\/blood.V97.6.1809","article-title":"B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function","volume":"97","author":"Tamura","year":"2001","journal-title":"Blood"},{"issue":"7607","key":"10.1016\/j.intimp.2026.116776_bb0150","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature18294","article-title":"Aberrant PD-L1 expression through 3\u2019-UTR disruption in multiple cancers","volume":"534","author":"Kataoka","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2026.116776_bb0155","doi-asserted-by":"crossref","unstructured":"Zhu S, Bradfield CJ, Maminska A, et al. Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection. Science 2024;383(6686):eabm9903. doi:https:\/\/doi.org\/10.1126\/science.abm9903.","DOI":"10.1126\/science.abm9903"},{"issue":"12","key":"10.1016\/j.intimp.2026.116776_bb0160","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.3390\/ijms26125477","article-title":"Multifaceted roles of guanylate-binding proteins in Cancer","volume":"26","author":"Ahmetoglu","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2026.116776_bb0165","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1007\/s10753-014-9825-1","article-title":"Mycobacterium leprae upregulates IRGM expression in monocytes and monocyte-derived macrophages","volume":"37","author":"Yang","year":"2014","journal-title":"Inflammation"},{"issue":"19","key":"10.1016\/j.intimp.2026.116776_bb0170","doi-asserted-by":"crossref","first-page":"9358","DOI":"10.7150\/thno.62797","article-title":"IRGM\/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1+\/\u2212 mice display increases atherosclerotic plaque stability","volume":"11","author":"Fang","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.intimp.2026.116776_bb0175","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1186\/s12967-022-03585-3","article-title":"Probiotics ameliorate IgA nephropathy by improving gut dysbiosis and blunting NLRP3 signaling","volume":"20","author":"Tan","year":"2022","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.intimp.2026.116776_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19061599","article-title":"Effects of periostracum cicadae on cytokines and apoptosis regulatory proteins in an IgA nephropathy rat model","volume":"19","author":"Yang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116776_bb0185","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s42003-022-03897-6","article-title":"Interference and co-existence of staphylococci and Cutibacterium acnes within the healthy human skin microbiome","volume":"5","author":"Ahle","year":"2022","journal-title":"Commun Biol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116776_bb0190","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.7150\/thno.72404","article-title":"Exosomal EPHA2 derived from highly metastatic breast cancer cells promotes angiogenesis by activating the AMPK signaling pathway through ephrin A1-EPHA2 forward signaling","volume":"12","author":"Han","year":"2022","journal-title":"Theranostics"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926006223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926006223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:22:30Z","timestamp":1783110150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926006223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":38,"alternative-id":["S1567576926006223"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116776","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knockdown of histone deacetylase 9 ameliorates immunoglobulin a nephropathy by modulating immune response","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116776","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116776"}}