{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:07:45Z","timestamp":1789243665054,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82502643"],"award-info":[{"award-number":["82502643"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["202018782"],"award-info":[{"award-number":["202018782"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Department of Science and Technology of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010909","name":"Excellent Young Scientists Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009330","name":"Medical Science and Technology Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["B2025331"],"award-info":[{"award-number":["B2025331"]}],"id":[{"id":"10.13039\/501100009330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.intimp.2026.116777","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:32:51Z","timestamp":1778286771000},"page":"116777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Celastrol alleviates LPS-induced acute lung injury by suppressing neutrophilic inflammation burst through targeting AKT"],"prefix":"10.1016","volume":"182","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riken","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.intimp.2026.116777_bb0005","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries","volume":"315","author":"Bellani","year":"2016","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.intimp.2026.116777_bb0010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-019-0069-0","article-title":"Acute respiratory distress syndrome","volume":"5","author":"Matthay","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"10358","key":"10.1016\/j.intimp.2026.116777_bb0015","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/S0140-6736(22)01439-8","article-title":"Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management","volume":"400","author":"Gorman","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2026.116777_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116773","article-title":"Exploring immune-related pathogenesis in lung injury: providing new insights into ALI\/ARDS","volume":"175","author":"Zheng","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.intimp.2026.116777_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25031464","article-title":"A narrative review: the role of NETs in acute respiratory distress syndrome\/acute lung injury","volume":"25","author":"Zhou","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.intimp.2026.116777_bb0030","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20100239","article-title":"PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps","volume":"207","author":"Li","year":"2010","journal-title":"J. Exp. Med."},{"issue":"5663","key":"10.1016\/j.intimp.2026.116777_bb0035","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science (New York, N.Y.)"},{"issue":"2","key":"10.1016\/j.intimp.2026.116777_bb0040","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116777_bb0045","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0278-5846(01)00192-0","article-title":"Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer\u2019s disease","volume":"25","author":"Allison","year":"2001","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.intimp.2026.116777_bb0050","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.cell.2007.08.021","article-title":"Molecular understanding and modern application of traditional medicines: triumphs and trials","volume":"130","author":"Corson","year":"2007","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.intimp.2026.116777_bb0055","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.autrev.2012.02.022","article-title":"Effective treatment of rat adjuvant-induced arthritis by celastrol","volume":"11","author":"Casc\u00e3o","year":"2012","journal-title":"Autoimmun. Rev."},{"issue":"22","key":"10.1016\/j.intimp.2026.116777_bb0060","doi-asserted-by":"crossref","first-page":"10290","DOI":"10.7150\/thno.46728","article-title":"Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.intimp.2026.116777_bb0065","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.05.011","article-title":"Treatment of obesity with celastrol","volume":"161","author":"Liu","year":"2015","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.intimp.2026.116777_bb0070","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41591-019-0358-x","article-title":"IL1R1 is required for celastrol\u2019s leptin-sensitization and antiobesity effects","volume":"25","author":"Feng","year":"2019","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.116777_bb0075","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1186\/s12951-024-02725-9","article-title":"Enzyme\/ROS dual-sensitive nanoplatform with on-demand Celastrol release capacity for enhanced ulcerative colitis therapy by ROS scavenging, microbiota rebalancing, inflammation alleviating","volume":"22","author":"Shi","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.intimp.2026.116777_bb0080","doi-asserted-by":"crossref","first-page":"1360177","DOI":"10.3389\/fphar.2024.1360177","article-title":"Celastrol alleviates diabetic vascular injury via Keap1\/Nrf2-mediated anti-inflammation","volume":"15","author":"An","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116777_bb0085","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.freeradbiomed.2024.12.017","article-title":"Celastrol ameliorates lipopolysaccharide (LPS)-induced acute lung injury by improving mitochondrial function through AMPK\/PGC-1alpha\/Nrf1-dependent mechanism","volume":"227","author":"Deng","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.116777_bb0090","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/08958378.2024.2351098","article-title":"Celastrol reduces lung inflammation induced by multiwalled carbon nanotubes in mice via NF-kappab-signaling pathway","volume":"36","author":"Qing","year":"2024","journal-title":"Inhal. Toxicol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116777_bb0095","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116777_bb0100","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41590-019-0571-2","article-title":"Programmed \u2018disarming\u2019 of the neutrophil proteome reduces the magnitude of inflammation","volume":"21","author":"Adrover","year":"2020","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116777_bb0105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/imm.12123","article-title":"Kinase AKT controls innate immune cell development and function","volume":"140","author":"Zhang","year":"2013","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.intimp.2026.116777_bb0110","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2026.116777_bb0115","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1038\/s41467-022-35492-y","article-title":"Locally organised and activated Fth1(hi) neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2026.116777_bb0120","first-page":"L217","article-title":"The mercurial nature of neutrophils: still an enigma in ARDS?","volume":"306","author":"Williams","year":"2014","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"key":"10.1016\/j.intimp.2026.116777_bb0125","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.freeradbiomed.2017.03.002","article-title":"6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury","volume":"106","author":"Tsai","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2026.116777_bb0130","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.ebiom.2019.01.043","article-title":"Targeting allosteric site of AKT by 5,7-dimethoxy-1,4-phenanthrenequinone suppresses neutrophilic inflammation","volume":"40","author":"Chen","year":"2019","journal-title":"EBioMedicine"},{"issue":"9","key":"10.1016\/j.intimp.2026.116777_bb0135","article-title":"Lonicerae Japonicae Flos attenuates neutrophilic inflammation by inhibiting oxidative stress","volume":"11","author":"Lai","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"4","key":"10.1016\/j.intimp.2026.116777_bb0140","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1159\/000350282","article-title":"Regulation of circulating neutrophil numbers under homeostasis and in disease","volume":"5","author":"Strydom","year":"2013","journal-title":"J. Innate Immun."},{"issue":"4","key":"10.1016\/j.intimp.2026.116777_bb0145","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nri.2017.10","article-title":"Neutrophils as protagonists and targets in chronic inflammation","volume":"17","author":"Soehnlein","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.116777_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105572","article-title":"Celastrol in metabolic diseases: Progress and application prospects","volume":"167","author":"Xu","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.intimp.2026.116777_bb0155","doi-asserted-by":"crossref","first-page":"7728","DOI":"10.1021\/acs.nanolett.0c03279","article-title":"Inflammation-targeted Celastrol Nanodrug attenuates collagen-induced arthritis through NF-kappaB and Notch1 pathways","volume":"20","author":"An","year":"2020","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.intimp.2026.116777_bb0160","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/1547691X.2017.1394933","article-title":"Celastrol attenuates impairments associated with lipopolysaccharide-induced acute respiratory distress syndrome (ARDS) in rats","volume":"14","author":"Wei","year":"2017","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.intimp.2026.116777_bb0165","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.intimp.2018.03.033","article-title":"Protective effect of pristimerin against LPS-induced acute lung injury in mice","volume":"59","author":"Shaaban","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116777_bb0170","first-page":"541","article-title":"Celastrol alleviates sepsis-induced acute lung injury in rats by inhibiting the toll-like receptor 4\/nuclear factor-kappaB inflammatory pathway","volume":"33","author":"He","year":"2021","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"issue":"9","key":"10.1016\/j.intimp.2026.116777_bb0175","first-page":"9302","article-title":"Celastrol attenuates ventilator induced lung injury in mouse through inhibition of MAPK pathway","volume":"10","author":"Ren","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116777_bb0180","first-page":"576","article-title":"Protective effect of celastrol for burn-induced acute lung injury in rats","volume":"12","author":"Liu","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.intimp.2026.116777_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2024.114511","article-title":"Intratracheal delivery of macrophage targeted Celastrol-loaded PLGA nanoparticles for enhanced anti-inflammatory efficacy in acute lung injury mice","volume":"204","author":"Yao","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.intimp.2026.116777_bb0190","first-page":"22","article-title":"Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect","volume":"9","author":"Luo","year":"2022","journal-title":"Mil. Med. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116777_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/biom16010062","article-title":"Celastrol activates HSF1 to enhance regulatory T cells function and ameliorate intestinal inflammation","volume":"16","author":"Alula","year":"2025","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.intimp.2026.116777_bb0200","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/ars.2016.6769","article-title":"Dual inhibition of PI3K\/Akt and mTOR by the dietary antioxidant, Delphinidin, ameliorates psoriatic features in vitro and in an Imiquimod-induced psoriasis-like disease in mice","volume":"26","author":"Chamcheu","year":"2017","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.intimp.2026.116777_bb0205","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3324\/haematol.2016.151159","article-title":"ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease","volume":"102","author":"Kim","year":"2017","journal-title":"Haematologica"},{"issue":"9","key":"10.1016\/j.intimp.2026.116777_bb0210","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1073\/pnas.1031526100","article-title":"Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase","volume":"100","author":"Hoyal","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.intimp.2026.116777_bb0215","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3858\/emm.2009.41.4.058","article-title":"p47phox, the phagocyte NADPH oxidase\/NOX2 organizer: structure, phosphorylation and implication in diseases","volume":"41","author":"El-Benna","year":"2009","journal-title":"Exp. Mol. Med."},{"issue":"21","key":"10.1016\/j.intimp.2026.116777_bb0220","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1182\/blood-2009-11-255323","article-title":"Akt isoforms differentially regulate neutrophil functions","volume":"115","author":"Chen","year":"2010","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.intimp.2026.116777_bb0225","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1084\/jem.20131706","article-title":"The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation","volume":"211","author":"Kumar","year":"2014","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.intimp.2026.116777_bb0230","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1182\/blood-2002-09-2936","article-title":"Novel pathways of F-actin polymerization in the human neutrophil","volume":"102","author":"Chodniewicz","year":"2003","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.intimp.2026.116777_bb0235","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4049\/jimmunol.178.1.416","article-title":"Regulation of leukocyte degranulation by cGMP-dependent protein kinase and phosphoinositide 3-kinase: potential roles in phosphorylation of target membrane SNARE complex proteins in rat mast cells","volume":"178","author":"Nanamori","year":"2007","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2026.116777_bb0240","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1136\/thoraxjnl-2015-207604","article-title":"Hypoxia upregulates neutrophil degranulation and potential for tissue injury","volume":"71","author":"Hoenderdos","year":"2016","journal-title":"Thorax"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926006235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926006235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:00:54Z","timestamp":1789243254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926006235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":48,"alternative-id":["S1567576926006235"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116777","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Celastrol alleviates LPS-induced acute lung injury by suppressing neutrophilic inflammation burst through targeting AKT","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116777","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116777"}}