{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:05:17Z","timestamp":1789247117601,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007935","name":"Hainan Medical University","doi-asserted-by":"publisher","award":["XSTS2025172"],"award-info":[{"award-number":["XSTS2025172"]}],"id":[{"id":"10.13039\/501100007935","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["825RC881"],"award-info":[{"award-number":["825RC881"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.intimp.2026.116795","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:03:44Z","timestamp":1778241824000},"page":"116795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Yakuchinone A alleviates hepatic ischemia-reperfusion injury in aging livers via the SESN2\/AKT1\/NRF2 pathway"],"prefix":"10.1016","volume":"182","author":[{"given":"Bo","family":"Ran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.intimp.2026.116795_bb0005","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jcmgh.2023.03.003","article-title":"Mechanistic insight and clinical implications of ischemia\/reperfusion injury post liver transplantation","volume":"15","author":"Liu","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116795_bb0010","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/lt.24136","article-title":"Projections in donor organs available for liver transplantation in the United States: 2014-2025","volume":"21","author":"Parikh","year":"2015","journal-title":"Liver Transpl."},{"issue":"20","key":"10.1016\/j.intimp.2026.116795_bb0015","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401404R","article-title":"Sestrin2 serves as a scaffold protein to maintain cardiac energy and metabolic homeostasis during pathological stress","volume":"38","author":"Seale","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2026.116795_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101865","article-title":"Sestrin2 maintains hepatic immune homeostasis and redox balance partially via inhibiting RIPK3-mediated necroptosis in metabolic dysfunction-associated steatohepatitis","volume":"80","author":"Zhang","year":"2024","journal-title":"Mol. Metab"},{"key":"10.1016\/j.intimp.2026.116795_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2026.116795_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106563","article-title":"Nrf2 and its dependent autophagy activation cooperatively counteract ferroptosis to alleviate acute liver injury","volume":"187","author":"Liu","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"16","key":"10.1016\/j.intimp.2026.116795_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/cells11162614","article-title":"Targeting on Nrf2\/Sesn2 Signaling to rescue cardiac dysfunction during high-fat diet-induced obesity","volume":"11","author":"Krause-Hauch","year":"2022","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.intimp.2026.116795_bb0040","article-title":"Identification of chemical constituents from leaves and stems of Alpinia oxyphylla: potential antioxidant and tyrosinase inhibitory properties","volume":"13","author":"Chen","year":"2024","journal-title":"Antioxidants (Basel)"},{"issue":"Pt A","key":"10.1016\/j.intimp.2026.116795_bb0045","article-title":"Alpinetin prevents inflammatory responses in OVA-induced allergic asthma through modulating PI3K\/AKT\/NF-kappaB and HO-1 signaling pathways in mice","volume":"89","author":"Wu","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2026.116795_bb0050","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1111\/aor.14640","article-title":"End-ischemic hypothermic oxygenated machine perfusion does not improve renal outcome following liver transplantation from aged donors: a single-center retrospective report","volume":"47","author":"Noren","year":"2023","journal-title":"Artif. Organs"},{"issue":"7","key":"10.1016\/j.intimp.2026.116795_bb0055","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s12276-023-01040-x","article-title":"Enhancement of the SESN2-SHP cascade by melatonin ameliorates hepatic gluconeogenesis by inhibiting the CRBN-BTG2-CREBH signaling pathway","volume":"55","author":"An","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.116795_bb0060","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1600-6143.2006.01242.x","article-title":"Characteristics associated with liver graft failure: the concept of a donor risk index","volume":"6","author":"Feng","year":"2006","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.intimp.2026.116795_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114299","article-title":"Liver ischemia reperfusion injury: mechanisms, cellular pathways, and therapeutic approaches","volume":"150","author":"de Oliveira","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116795_bb0070","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41419-023-05669-4","article-title":"Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases","volume":"14","author":"Lu","year":"2023","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.intimp.2026.116795_bb0075","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1111\/jcmm.16540","article-title":"Sestrin2 as a gatekeeper of cellular homeostasis: physiological effects for the regulation of hypoxia-related diseases","volume":"25","author":"Pan","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.116795_bb0080","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1007\/s11064-022-03791-x","article-title":"POU domain class 2 transcription factor 2 inhibits ferroptosis in cerebral ischemia reperfusion injury by activating Sestrin2","volume":"48","author":"Yang","year":"2022","journal-title":"Neurochem. Res."},{"issue":"9","key":"10.1016\/j.intimp.2026.116795_bb0085","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41419-021-04122-8","article-title":"Sestrin2 protects dendrite cells against ferroptosis induced by sepsis","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.116795_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156982","article-title":"Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury","volume":"145","author":"Pu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116795_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2024.106650","article-title":"Microtubules and cardiovascular diseases: insights into pathology and therapeutic strategies","volume":"175","author":"Wu","year":"2024","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"43","key":"10.1016\/j.intimp.2026.116795_bb0100","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000039996","article-title":"The effect of unhealthy lifestyle on the pathogenesis of sick sinus syndrome: a life-guiding review","volume":"103","author":"Chang","year":"2024","journal-title":"Medicine (Baltimore)"},{"issue":"11","key":"10.1016\/j.intimp.2026.116795_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101034","article-title":"Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury","volume":"14","author":"Yang","year":"2024","journal-title":"J Pharm Anal"},{"issue":"8","key":"10.1016\/j.intimp.2026.116795_bb0110","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1002\/ptr.70008","article-title":"Potential candidates of natural antioxidants from herbs for treating lung disorders: focus on redox balance and natural products","volume":"39","author":"Chang","year":"2025","journal-title":"Phytother. Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.116795_bb0115","article-title":"The role of Nrf2 in the regulation of mitochondrial function and ferroptosis in pancreatic Cancer","volume":"13","author":"Baiskhanova","year":"2024","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"10.1016\/j.intimp.2026.116795_bb0120","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41573-025-01145-0","article-title":"Thirty years of NRF2: advances and therapeutic challenges","volume":"24","author":"Zhang","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.intimp.2026.116795_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154729","article-title":"Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice","volume":"113","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.intimp.2026.116795_bb0130","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1038\/s41401-024-01336-2","article-title":"The regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy","volume":"45","author":"Jiang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.intimp.2026.116795_bb0135","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB Signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2026.116795_bb0140","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41368-024-00300-4","article-title":"Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3beta-Nrf2 pathways in Alzheimer\u2019s disease","volume":"16","author":"Xiong","year":"2024","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.intimp.2026.116795_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114881","article-title":"Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3beta inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT\/GSK-3beta\/Nrf2 pathway","volume":"380","author":"Zhao","year":"2024","journal-title":"Exp. Neurol."},{"issue":"11","key":"10.1016\/j.intimp.2026.116795_bb0150","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.7150\/ijbs.95853","article-title":"Nuclear receptor subfamily 4 group a member 1 promotes myocardial ischemia\/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy","volume":"20","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2026.116795_bb0155","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10456-024-09938-4","article-title":"Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction","volume":"27","author":"Pang","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.intimp.2026.116795_bb0160","doi-asserted-by":"crossref","first-page":"1422686","DOI":"10.3389\/fphar.2024.1422686","article-title":"Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality","volume":"15","author":"Pang","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116795_bb0165","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s12951-025-03420-z","article-title":"Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance","volume":"23","author":"Wang","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.intimp.2026.116795_bb0170","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jare.2024.10.030","article-title":"Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy","volume":"75","author":"Wang","year":"2024","journal-title":"J. Adv. Res."},{"issue":"14","key":"10.1016\/j.intimp.2026.116795_bb0175","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.7150\/ijbs.102424","article-title":"Targeting mitochondria by lipid-selenium conjugate drug results in malate\/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression","volume":"20","author":"Chang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"16","key":"10.1016\/j.intimp.2026.116795_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29163905","article-title":"Recent research Progress on the chemical constituents, pharmacology, and pharmacokinetics of Alpinae oxyphyllae fructus","volume":"29","author":"Liao","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2026.116795_bb0185","article-title":"Anti-inflammatory and anti-nociceptive activities of Alpinia Oxyphylla Miquel extracts in animal models","volume":"260","author":"Yu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2026.116795_bb0190","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.biopha.2017.04.131","article-title":"Ethanol extract and its dichloromethane fraction of Alpinia oxyphylla Miquel exhibited hepatoprotective effects against CCl(4)-induced oxidative damage in vitro and in vivo with the involvement of Nrf2","volume":"91","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.intimp.2026.116795_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073992","article-title":"Microbial transformation of YakA and cytotoxicity evaluation of its metabolites","volume":"23","author":"Huo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116795_bb0200","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/TP.0000000000005176","article-title":"Exercise preconditioning of the donor liver decreases cold ischemia\/reperfusion injury in a mouse model","volume":"109","author":"Yazdani","year":"2024","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.intimp.2026.116795_bb0205","article-title":"The ferroptosis-mitochondrial axis in depression: unraveling the feedforward loop of oxidative stress, metabolic homeostasis dysregulation, and neuroinflammation","volume":"14","author":"Liu","year":"2025","journal-title":"Antioxidants (Basel)"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926006417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926006417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:06:36Z","timestamp":1789243596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926006417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":41,"alternative-id":["S1567576926006417"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116795","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Yakuchinone A alleviates hepatic ischemia-reperfusion injury in aging livers via the SESN2\/AKT1\/NRF2 pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116795","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116795"}}