{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:48:19Z","timestamp":1789984099252,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32503117"],"award-info":[{"award-number":["32503117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302915"],"award-info":[{"award-number":["32302915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202870"],"award-info":[{"award-number":["32202870"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008867","name":"Department of Education of Zhejiang Province","doi-asserted-by":"publisher","award":["Y202455697"],"award-info":[{"award-number":["Y202455697"]}],"id":[{"id":"10.13039\/501100008867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.intimp.2026.116833","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:13:02Z","timestamp":1778760782000},"page":"116833","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["(2R,6R)-HNK improved LPS-induced depression-like behavior by inhibiting Vcam1\/Caspase-1\/IL-1\u03b2 pathway"],"prefix":"10.1016","volume":"182","author":[{"given":"Jinghua","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YuQiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houhui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10161","key":"10.1016\/j.intimp.2026.116833_bb0005","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.intimp.2026.116833_bb0010","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neuron.2020.06.002","article-title":"The bidirectional relationship of depression and inflammation: double trouble","volume":"107","author":"Beurel","year":"2020","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.intimp.2026.116833_bb0015","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12974-022-02492-0","article-title":"Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116833_bb0020","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6871089","article-title":"The role of neural plasticity in depression: from hippocampus to prefrontal cortex","volume":"2017","author":"Liu","year":"2017","journal-title":"Neural Plast."},{"issue":"3","key":"10.1016\/j.intimp.2026.116833_bb0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116833_bb0030","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/ejn.14720","article-title":"Neuroinflammation and depression: a review","volume":"53","author":"Troubat","year":"2021","journal-title":"Eur. J. Neurosci."},{"issue":"8","key":"10.1016\/j.intimp.2026.116833_bb0035","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.4103\/1673-5374.389361","article-title":"Crosstalk among mitophagy, pyroptosis, ferroptosis, and necroptosis in central nervous system injuries","volume":"19","author":"Zhang","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"9","key":"10.1016\/j.intimp.2026.116833_bb0040","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"7610","key":"10.1016\/j.intimp.2026.116833_bb0045","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.intimp.2026.116833_bb0050","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.15252\/embj.201694696","article-title":"GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death","volume":"35","author":"Sborgi","year":"2016","journal-title":"EMBO J."},{"issue":"8","key":"10.1016\/j.intimp.2026.116833_bb0055","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1177\/02698811211026426","article-title":"Ketamine's effect on inflammation and kynurenine pathway in depression: a systematic review","volume":"35","author":"Kopra","year":"2021","journal-title":"J. Psychopharmacol."},{"issue":"7984","key":"10.1016\/j.intimp.2026.116833_bb0060","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41586-023-06624-1","article-title":"Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb","volume":"622","author":"Ma","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2026.116833_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropharm.2018.06.033","article-title":"(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray","volume":"139","author":"Chou","year":"2018","journal-title":"Neuropharmacology"},{"issue":"7604","key":"10.1016\/j.intimp.2026.116833_bb0070","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature17998","article-title":"NMDAR inhibition-independent antidepressant actions of ketamine metabolites","volume":"533","author":"Zanos","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2026.116833_bb0075","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1073\/pnas.1814709116","article-title":"Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine","volume":"116","author":"Fukumoto","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.intimp.2026.116833_bb0080","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/0092-8674(89)90775-7","article-title":"Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes","volume":"59","author":"Osborn","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2026.116833_bb0085","doi-asserted-by":"crossref","first-page":"6564585","DOI":"10.1155\/2021\/6564585","article-title":"Blood-brain barrier overview: structural and functional correlation","volume":"2021","author":"Alahmari","year":"2021","journal-title":"Neural Plast."},{"issue":"6","key":"10.1016\/j.intimp.2026.116833_bb0090","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/s41591-019-0440-4","article-title":"Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1","volume":"25","author":"Yousef","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2026.116833_bb0095","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jad.2023.12.001","article-title":"Elevated VCAM-1 levels in peripheral blood are associated with brain structural and functional alterations in major depressive disorder","volume":"347","author":"Zhou","year":"2024","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.intimp.2026.116833_bb0100","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.physbeh.2016.04.034","article-title":"Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression","volume":"161","author":"Tang","year":"2016","journal-title":"Physiol. Behav."},{"issue":"7","key":"10.1016\/j.intimp.2026.116833_bb0105","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/jcbfm.2014.75","article-title":"Repeated mild traumatic brain injury causes chronic neuroinflammation, changes in hippocampal synaptic plasticity, and associated cognitive deficits","volume":"34","author":"Aungst","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"Pt B","key":"10.1016\/j.intimp.2026.116833_bb0110","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuropharm.2016.03.024","article-title":"Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases","volume":"112","author":"Lovelace","year":"2017","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1016\/j.intimp.2026.116833_bb0115","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2174\/1570159X14666160119094646","article-title":"Brain-derived neurotrophic factor (BDNF)-TrkB signaling in inflammation-related depression and potential therapeutic targets","volume":"14","author":"Zhang","year":"2016","journal-title":"Curr. Neuropharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116833_bb0120","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.imbio.2016.07.001","article-title":"The role of macrophages in anti-inflammatory activity of antidepressant drugs","volume":"222","author":"Nazimek","year":"2017","journal-title":"Immunobiology"},{"issue":"9","key":"10.1016\/j.intimp.2026.116833_bb0125","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.4103\/1673-5374.390964","article-title":"Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression","volume":"19","author":"Han","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116833_bb0130","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-065X.2011.01043.x","article-title":"Sensing damage by the NLRP3 inflammasome","volume":"243","author":"Leemans","year":"2011","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2026.116833_bb0135","first-page":"29","article-title":"Antidepressants and anti-inflammatory drugs differentially reduce the release of NGF and BDNF from rat platelets","volume":"46","author":"Hochstrasser","year":"2013","journal-title":"Pharmacopsychiatry"},{"issue":"6","key":"10.1016\/j.intimp.2026.116833_bb0140","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1089\/ars.2010.3522","article-title":"Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants","volume":"15","author":"Cook-Mills","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"9","key":"10.1016\/j.intimp.2026.116833_bb0145","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1182\/bloodadvances.2023012282","article-title":"Interactions between integrin \u03b19\u03b21 and VCAM-1 promote neutrophil hyperactivation and mediate poststroke DVT","volume":"8","author":"Pandey","year":"2024","journal-title":"Blood Adv."},{"issue":"10","key":"10.1016\/j.intimp.2026.116833_bb0150","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1021\/acschemneuro.4c00039","article-title":"Increased expression of VCAM1 on brain endothelial cells drives blood-brain barrier impairment following chronic cerebral hypoperfusion","volume":"15","author":"Zhang","year":"2024","journal-title":"ACS Chem. Nerosci."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692600679X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692600679X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:03:00Z","timestamp":1789243380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692600679X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":30,"alternative-id":["S156757692600679X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116833","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"(2R,6R)-HNK improved LPS-induced depression-like behavior by inhibiting Vcam1\/Caspase-1\/IL-1\u03b2 pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116833","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116833"}}