{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:08:11Z","timestamp":1789243691786,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["YJS20240036"],"award-info":[{"award-number":["YJS20240036"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072134"],"award-info":[{"award-number":["82072134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.intimp.2026.116841","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:13:02Z","timestamp":1778760782000},"page":"116841","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Albiflorin contributes to Xuebijing-mediated protection against sepsis-associated acute kidney injury by modulating the succinate-PFKFB3 immunometabolic axis"],"prefix":"10.1016","volume":"182","author":[{"given":"Yang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingge","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfeng","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10219","key":"10.1016\/j.intimp.2026.116841_bb0005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.intimp.2026.116841_bb0010","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00134-023-07138-0","article-title":"Sepsis-associated acute kidney injury in the intensive care unit: incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes. A multicenter, observational study","volume":"49","author":"White","year":"2023","journal-title":"Intensive Care Med."},{"issue":"10","key":"10.1016\/j.intimp.2026.116841_bb0015","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41581-018-0052-0","article-title":"Global epidemiology and outcomes of acute kidney injury","volume":"14","author":"Hoste","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116841_bb0020","doi-asserted-by":"crossref","first-page":"311","DOI":"10.5507\/bp.2024.016","article-title":"The renoprotective effect of tibolone in sepsis-induced acute kidney injury","volume":"168","author":"Bora","year":"2024","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub."},{"key":"10.1016\/j.intimp.2026.116841_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155974","article-title":"Metabolic reprogramming in septic acute kidney injury: pathogenesis and therapeutic implications","volume":"158","author":"Liu","year":"2024","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.intimp.2026.116841_bb0030","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/ni.3398","article-title":"Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis","volume":"17","author":"Cheng","year":"2016","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116841_bb0035","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.tem.2024.08.009","article-title":"Metabolic reprogramming of macrophages in cancer therapy","volume":"36","author":"Wang","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.intimp.2026.116841_bb0040","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1097\/CCM.0b013e3181e7c5c9","article-title":"A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis","volume":"38","author":"Rice","year":"2010","journal-title":"Crit. Care Med."},{"issue":"6","key":"10.1016\/j.intimp.2026.116841_bb0045","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1681\/ASN.2014060561","article-title":"The macrophage mediates the renoprotective effects of endotoxin preconditioning","volume":"26","author":"Hato","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116841_bb0050","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","volume":"11","author":"Mart\u00ednez-Reyes","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116841_bb0055","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic Remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.intimp.2026.116841_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01462","article-title":"The metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116841_bb0065","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nrc2468","article-title":"Hypoxia, HIF1 and glucose metabolism in the solid tumour","volume":"8","author":"Denko","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.intimp.2026.116841_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1054176","article-title":"Xuebijing injection inhibited neutrophil extracellular traps to reverse lung injury in sepsis mice via reducing Gasdermin D","volume":"13","author":"Shang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"Pt 1","key":"10.1016\/j.intimp.2026.116841_bb0075","article-title":"XueBiJing injection improves the symptoms of sepsis-induced acute lung injury by mitigating oxidative stress and ferroptosis","volume":"337","author":"Zou","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116841_bb0080","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.apsb.2019.06.003","article-title":"High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care","volume":"9","author":"Li","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"issue":"7","key":"10.1016\/j.intimp.2026.116841_bb0085","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1001\/jamainternmed.2023.0780","article-title":"Effect of an herbal-based injection on 28-day mortality in patients with Sepsis: the EXIT-SEP randomized clinical trial","volume":"183","author":"Liu","year":"2023","journal-title":"JAMA Intern. Med."},{"issue":"5","key":"10.1016\/j.intimp.2026.116841_bb0090","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/s41401-023-01224-1","article-title":"Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation","volume":"45","author":"Cheng","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2026.116841_bb0095","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.toxlet.2023.11.002","article-title":"Formaldehyde promotes tumor-associated macrophage polarizations and functions through induction of HIF-1\u03b1-mediated glycolysis","volume":"390","author":"Shu","year":"2023","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.intimp.2026.116841_bb0100","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-024-02739-9","article-title":"Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis","volume":"25","author":"Huang","year":"2024","journal-title":"Respir. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116841_bb0105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"issue":"7444","key":"10.1016\/j.intimp.2026.116841_bb0110","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.intimp.2026.116841_bb0115","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.jpha.2022.01.001","article-title":"Novel assays for quality evaluation of XueBiJing: quality variability of a Chinese herbal injection for sepsis management","volume":"12","author":"Yu","year":"2022","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.intimp.2026.116841_bb0120","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jpba.2017.01.024","article-title":"Rapid determination of 30 bioactive constituents in XueBiJing injection using ultra high performance liquid chromatography-high resolution hybrid quadrupole-orbitrap mass spectrometry coupled with principal component analysis","volume":"137","author":"Zuo","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.intimp.2026.116841_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112439","article-title":"Albiflorin alleviates neuroinflammation of rats after MCAO via PGK1\/Nrf2\/HO-1 signaling pathway","volume":"137","author":"Ou","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116841_bb0130","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s10753-024-01978-8","article-title":"Albiflorin attenuates neuroinflammation and improves functional recovery after spinal cord injury through regulating LSD1-mediated microglial activation and ferroptosis","volume":"47","author":"Zhang","year":"2024","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.intimp.2026.116841_bb0135","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2174\/1566524023666230309124004","article-title":"Albiflorin alleviates Sepsis-induced acute liver injury through mTOR\/p70S6K pathway","volume":"24","author":"Liu","year":"2024","journal-title":"Curr. Mol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.116841_bb0140","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.cmet.2016.08.012","article-title":"Suppressors of superoxide-H2O2 production at site IQ of mitochondrial complex I protect against stem cell hyperplasia and ischemia-reperfusion injury","volume":"24","author":"Brand","year":"2016","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.intimp.2026.116841_bb0145","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.abb.2009.06.009","article-title":"Inhibition of succinate-linked respiration and complex II activity by hydrogen peroxide","volume":"488","author":"Moser","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.intimp.2026.116841_bb0150","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.redox.2018.10.007","article-title":"TMEM126B deficiency reduces mitochondrial SDH oxidation by LPS, attenuating HIF-1\u03b1 stabilization and IL-1\u03b2 expression","volume":"20","author":"Fuhrmann","year":"2019","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116841_bb0155","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"issue":"7699","key":"10.1016\/j.intimp.2026.116841_bb0160","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.intimp.2026.116841_bb0165","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1084\/jem.20160061","article-title":"GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis","volume":"213","author":"Littlewood-Evans","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2026.116841_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115105","article-title":"Succinate links TCA cycle dysfunction to inflammation by activating HIF-1\u03b1 signaling in acute kidney injury","volume":"161","author":"Xu","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2026.116841_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/md20110660","article-title":"Astaxanthin exerts immunomodulatory effect by regulating SDH-HIF-1\u03b1 Axis and reprogramming mitochondrial metabolism in LPS-stimulated RAW264.7 cells","volume":"20","author":"Sun","year":"2022","journal-title":"Mar. Drugs."},{"issue":"11","key":"10.1016\/j.intimp.2026.116841_bb0180","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1172\/JCI130996","article-title":"Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis","volume":"130","author":"Patoli","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"5516","key":"10.1016\/j.intimp.2026.116841_bb0185","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIF\u03b1 targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.intimp.2026.116841_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115781","article-title":"Iso-seco-tanapartholide from Artemisia argyi inhibits the PFKFB3-mediated glycolytic pathway to attenuate airway inflammation in lipopolysaccharide-induced acute lung injury mice","volume":"301","author":"Kong","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116841_bb0195","article-title":"Interactions between NLRP3 inflammasome and glycolysis in macrophages: new insights into chronic inflammation pathogenesis","volume":"10","author":"Yu","year":"2022","journal-title":"Immunity Inflamm. Dis."},{"issue":"8","key":"10.1016\/j.intimp.2026.116841_bb0200","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.4049\/jimmunol.1901246","article-title":"Zhx2 accelerates Sepsis by promoting macrophage glycolysis via Pfkfb3","volume":"204","author":"Wang","year":"2020","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116841_bb0205","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1038\/s41598-019-40619-1","article-title":"The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1\u03b2-dependent manner in macrophages","volume":"9","author":"Finucane","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116841_bb0210","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1038\/s41467-024-50104-7","article-title":"Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.116841_bb0215","doi-asserted-by":"crossref","first-page":"8624","DOI":"10.1038\/s41467-024-53006-w","article-title":"MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1\u03b1 pathways in mice","volume":"15","author":"Wu","year":"2024","journal-title":"Nat. Commun."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926006879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926006879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:59:40Z","timestamp":1789243180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926006879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":43,"alternative-id":["S1567576926006879"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116841","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Albiflorin contributes to Xuebijing-mediated protection against sepsis-associated acute kidney injury by modulating the succinate-PFKFB3 immunometabolic axis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116841","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116841"}}