{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:52:30Z","timestamp":1791996750305,"version":"4.4.0"},"reference-count":158,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.intimp.2026.116930","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:35:48Z","timestamp":1780090548000},"page":"116930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Curcumin for neurological diseases: from molecular mechanisms to translational strategies"],"prefix":"10.1016","volume":"184","author":[{"given":"Yuchen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Zu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.intimp.2026.116930_bb0005","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s00018-008-7452-4","article-title":"Curcumin: from ancient medicine to current clinical trials","volume":"65","author":"Hatcher","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"issue":"12","key":"10.1016\/j.intimp.2026.116930_bb0010","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1021\/np980269k","article-title":"Cytotoxicity of curcuminoids and some novel compounds from Curcuma zedoaria","volume":"61","author":"Syu","year":"1998","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.intimp.2026.116930_bb0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1749-8546-3-11","article-title":"Recent advances in the investigation of curcuminoids","volume":"3","author":"Itokawa","year":"2008","journal-title":"Chin. Med."},{"issue":"15","key":"10.1016\/j.intimp.2026.116930_bb0020","doi-asserted-by":"crossref","first-page":"4986","DOI":"10.1039\/C5CS00088B","article-title":"Metal complexes of curcumin--synthetic strategies, structures and medicinal applications","volume":"44","author":"Wanninger","year":"2015","journal-title":"Chem. Soc. Rev."},{"issue":"Pt 2","key":"10.1016\/j.intimp.2026.116930_bb0025","article-title":"Celastrol as a neuroprotective drug: current status and challenges","volume":"168","author":"Wang","year":"2026","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2026.116930_bb0030","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1056\/NEJMra2314942","article-title":"Primary central nervous system Vasculitis","volume":"391","author":"Salvarani","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.116930_bb0035","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"23","year":"2024","journal-title":"Lancet Neurol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116930_bb0040","doi-asserted-by":"crossref","first-page":"767","DOI":"10.2174\/1871527317666180720162029","article-title":"Amyotrophic lateral sclerosis and oxidative stress: a double-blind therapeutic trial after curcumin supplementation","volume":"17","author":"Chico","year":"2018","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.intimp.2026.116930_bb0045","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.phrs.2017.08.004","article-title":"Curcumin in Alzheimer\u2019s disease: can we think to new strategies and perspectives for this molecule?","volume":"124","author":"Serafini","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"20","key":"10.1016\/j.intimp.2026.116930_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011248","article-title":"Neuroprotective activities of curcumin in Parkinson\u2019s disease: a review of the literature","volume":"22","author":"Nebrisi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2026.116930_bb0055","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.2174\/1570159X18666200522201123","article-title":"Therapeutic and mechanistic effects of curcumin in Huntington\u2019s disease","volume":"19","author":"Labanca","year":"2021","journal-title":"Curr. Neuropharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0060","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s11671-025-04379-4","article-title":"Curcumin-based biocompatible nanocarriers: a contemporary perspective in functional foods and biomedical applications","volume":"20","author":"Alshammari","year":"2025","journal-title":"Discov. Nano."},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1021\/np060263s","article-title":"NMR study of the solution structure of curcumin","volume":"70","author":"Payton","year":"2007","journal-title":"J. Nat. Prod."},{"issue":"22","key":"10.1016\/j.intimp.2026.116930_bb0070","doi-asserted-by":"crossref","first-page":"11041","DOI":"10.1021\/jf902244g","article-title":"Phenolic and enolic hydroxyl groups in curcumin: which plays the major role in scavenging radicals?","volume":"57","author":"Feng","year":"2009","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.intimp.2026.116930_bb0075","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"issue":"5","key":"10.1016\/j.intimp.2026.116930_bb0080","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.saa.2011.05.002","article-title":"Study binding of Al-curcumin complex to ds-DNA, monitoring by multispectroscopic and voltammetric techniques","volume":"79","author":"Ahmadi","year":"2011","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"issue":"4","key":"10.1016\/j.intimp.2026.116930_bb0085","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2006-957450","article-title":"Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers","volume":"64","author":"Shoba","year":"1998","journal-title":"Planta Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0090","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1600-0773.1978.tb02240.x","article-title":"A study on the fate of curcumin in the rat","volume":"43","author":"Wahlstr\u00f6m","year":"1978","journal-title":"Acta Pharmacol Toxicol (Copenh)."},{"issue":"3","key":"10.1016\/j.intimp.2026.116930_bb0095","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1021\/jf058146a","article-title":"Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver","volume":"54","author":"Hoehle","year":"2006","journal-title":"J. Agric. Food Chem."},{"issue":"3","key":"10.1016\/j.intimp.2026.116930_bb0100","first-page":"1058","article-title":"Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production","volume":"61","author":"Ireson","year":"2001","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.intimp.2026.116930_bb0105","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1093\/carcin\/bgm123","article-title":"Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism","volume":"28","author":"Sandur","year":"2007","journal-title":"Carcinogenesis"},{"issue":"7","key":"10.1016\/j.intimp.2026.116930_bb0110","first-page":"1894","article-title":"Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer","volume":"7","author":"Sharma","year":"2001","journal-title":"Clin. Cancer Res."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2026.116930_bb0115","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jchromb.2007.03.010","article-title":"Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS\/MS","volume":"853","author":"Yang","year":"2007","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"issue":"4","key":"10.1016\/j.intimp.2026.116930_bb0120","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0300-483X(81)90027-5","article-title":"Metabolism of curcumn-studies with [3H]curcumin","volume":"22","author":"Ravindranath","year":"1981","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0125","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s12883-023-03358-5","article-title":"Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review","volume":"23","author":"Qiu","year":"2023","journal-title":"BMC Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0130","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ijpharm.2011.06.030","article-title":"Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration","volume":"416","author":"Tsai","year":"2011","journal-title":"Int. J. Pharm."},{"issue":"17","key":"10.1016\/j.intimp.2026.116930_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/nu17172884","article-title":"The neuroprotective role of curcumin: from molecular pathways to clinical translation-a narrative review","volume":"17","author":"Lehoczki","year":"2025","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.intimp.2026.116930_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027865","article-title":"A novel neurotrophic drug for cognitive enhancement and Alzheimer\u2019s disease","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.intimp.2026.116930_bb0145","doi-asserted-by":"crossref","first-page":"937","DOI":"10.18632\/aging.100838","article-title":"A comprehensive multiomics approach toward understanding the relationship between aging and dementia","volume":"7","author":"Currais","year":"2015","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"10.1016\/j.intimp.2026.116930_bb0150","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1590\/s0102-865020180060000008","article-title":"A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1","volume":"33","author":"Lv","year":"2018","journal-title":"Acta Cir. Bras."},{"issue":"7","key":"10.1016\/j.intimp.2026.116930_bb0160","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1038\/s41418-023-01178-1","article-title":"Curcumin activates a ROS\/KEAP1\/NRF2\/miR-34a\/b\/c cascade to suppress colorectal cancer metastasis","volume":"30","author":"Liu","year":"2023","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2023.05.023","article-title":"Curcumin-QingDai combination for patients with active ulcerative colitis: a randomized, double-blinded, placebo-controlled trial","volume":"22","author":"Ben-Horin","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2026.116930_bb0170","article-title":"Curcumin and Curcuma longa extract in the treatment of 10 types of autoimmune diseases: a systematic review and Meta-analysis of 31 randomized controlled trials","volume":"13","author":"Zeng","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.116930_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111119","article-title":"The role of curcumin in aging and senescence: molecular mechanisms","volume":"134","author":"Zia","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/nu14010231","article-title":"Curcumin supplementation (Meriva\u00ae) modulates inflammation, lipid peroxidation and gut microbiota composition in chronic kidney disease","volume":"14","author":"Pivari","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27010167","article-title":"Nrf2 regulation by curcumin: molecular aspects for therapeutic prospects","volume":"27","author":"Shahcheraghi","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0190","doi-asserted-by":"crossref","first-page":"8430","DOI":"10.1038\/s41598-021-87225-8","article-title":"Curcumin activates Nrf2 through PKC\u03b4-mediated p62 phosphorylation at Ser351","volume":"11","author":"Park","year":"2021","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2026.116930_bb0195","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s12192-020-01079-z","article-title":"Nrf2\/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation","volume":"25","author":"Jiang","year":"2020","journal-title":"Cell Stress Chaperones"},{"issue":"3","key":"10.1016\/j.intimp.2026.116930_bb0200","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","article-title":"The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis","volume":"98","author":"Yamamoto","year":"2018","journal-title":"Physiol. Rev."},{"issue":"6753","key":"10.1016\/j.intimp.2026.116930_bb0205","doi-asserted-by":"crossref","DOI":"10.1126\/science.adx0043","article-title":"Neuroinflammation across neurological diseases","volume":"388","author":"Shi","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.intimp.2026.116930_bb0210","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.2147\/DDDT.S327378","article-title":"Anti-inflammatory effects of curcumin in the inflammatory diseases: status, limitations and countermeasures","volume":"15","author":"Peng","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2026.116930_bb0215","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.01223","article-title":"Curcumin mitigates neuro-inflammation by modulating microglia polarization through inhibiting TLR4 axis signaling pathway following experimental subarachnoid hemorrhage","volume":"13","author":"Gao","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2026.116930_bb0220","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molimm.2019.09.020","article-title":"Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2\/ TLR4\/ NF-\u03baB pathways in BV2 cells","volume":"116","author":"Zhang","year":"2019","journal-title":"Mol. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116930_bb0225","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1002\/jcp.27360","article-title":"Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF-\u03baB signaling pathway","volume":"234","author":"Chowdhury","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2026.116930_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104921","article-title":"Curcumin: an inflammasome silencer","volume":"159","author":"Hasanzadeh","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.intimp.2026.116930_bb0235","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s10787-019-00607-3","article-title":"Curcumin: a modulator of inflammatory signaling pathways in the immune system","volume":"27","author":"Kahkhaie","year":"2019","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.intimp.2026.116930_bb0240","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/ptr.7391","article-title":"Curcumin suppress inflammatory response in traumatic brain injury via p38\/MAPK signaling pathway","volume":"36","author":"Li","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2026.116930_bb0250","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.2147\/DDDT.S215712","article-title":"Inhibition of JNK phosphorylation by curcumin Analog C66 protects LPS-induced acute lung injury","volume":"13","author":"Xiao","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"issue":"13","key":"10.1016\/j.intimp.2026.116930_bb0255","doi-asserted-by":"crossref","first-page":"7244","DOI":"10.1021\/acs.jafc.4c00882","article-title":"Curcumin-piperlongumine hybrid molecule increases cell cycle arrest and apoptosis in lung Cancer through JNK\/c-Jun Signaling pathway","volume":"72","author":"Zhang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2026.116930_bb0260","article-title":"Curcumin derived from medicinal homologous foods: its main signals in immunoregulation of oxidative stress, inflammation, and apoptosis","volume":"14","author":"Hu","year":"2023","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2026.116930_bb0265","first-page":"5567","article-title":"Curcumin combined with glycyrrhetinic acid inhibits the development of hepatocellular carcinoma cells by down-regulating the PTEN\/PI3K\/AKT signalling pathway","volume":"9","author":"Chang","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.116930_bb0270","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1111\/jcmm.14326","article-title":"Curcumin induces apoptosis in JAK2-mutated cells by the inhibition of JAK2\/STAT and mTORC1 pathways","volume":"23","author":"Petiti","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.intimp.2026.116930_bb0275","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.2147\/TCRM.S141738","article-title":"Curcumin inhibits apoptosis by modulating Bax\/Bcl-2 expression and alleviates oxidative stress in testes of streptozotocin-induced diabetic rats","volume":"13","author":"Zhao","year":"2017","journal-title":"Ther. Clin. Risk Manag."},{"issue":"12","key":"10.1016\/j.intimp.2026.116930_bb0280","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.7150\/ijbs.90798","article-title":"Potential roles and mechanisms of curcumin and its derivatives in the regulation of ferroptosis","volume":"20","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.intimp.2026.116930_bb0285","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3469840","article-title":"Transcriptome investigation and in vitro verification of curcumin-induced HO-1 as a feature of ferroptosis in breast cancer cells","volume":"2020","author":"Li","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.intimp.2026.116930_bb0290","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1007\/s12033-024-01166-x","article-title":"Curcumin inhibits the progression of non-small cell lung Cancer by regulating DMRT3\/SLC7A11 Axis","volume":"67","author":"Xu","year":"2025","journal-title":"Mol. Biotechnol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116930_bb0295","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1002\/ptr.8258","article-title":"Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11\/glutathione\/glutathione peroxidase 4 signaling axis","volume":"38","author":"Ming","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2026.116930_bb0300","doi-asserted-by":"crossref","DOI":"10.1177\/2058738419861600","article-title":"Curcumin inhibits the lymphangiogenesis of gastric cancer cells by inhibiton of HMGB1\/VEGF-D signaling","volume":"33","author":"Da","year":"2019","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116930_bb0305","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1002\/ptr.7121","article-title":"Curcumin and cancer biology: focusing regulatory effects in different signalling pathways","volume":"35","author":"Bhatia","year":"2021","journal-title":"Phytother. Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.116930_bb0310","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.3390\/ijms19061716","article-title":"The role of curcumin in prevention and Management of Metastatic Disease","volume":"19","author":"Bachmeier","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116930_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114689","article-title":"Curcumin inhibits the invasion and metastasis of triple negative breast cancer via hedgehog\/gli1 signaling pathway","volume":"283","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2026.116930_bb0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/112_2016_3","article-title":"Curcumin as a MicroRNA regulator in Cancer: a review","volume":"171","author":"Momtazi","year":"2016","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116930_bb0325","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s12272-020-01240-3","article-title":"Curcumin derivatives for type 2 diabetes management and prevention of complications","volume":"43","author":"Oliveira","year":"2020","journal-title":"Arch. Pharm. Res."},{"issue":"5","key":"10.1016\/j.intimp.2026.116930_bb0330","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3390\/ijms20051033","article-title":"A review of curcumin and its derivatives as anticancer agents","volume":"20","author":"Tomeh","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116930_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111631","article-title":"Curcumin analogues and their hybrid molecules as multifunctional drugs","volume":"182","author":"Noureddin","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.intimp.2026.116930_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105489","article-title":"The potency of heterocyclic curcumin analogues: an evidence-based review","volume":"166","author":"Rodrigues","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.intimp.2026.116930_bb0345","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/j.1471-4159.2008.05236.x","article-title":"A broadly neuroprotective derivative of curcumin","volume":"105","author":"Liu","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.intimp.2026.116930_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112648","article-title":"The Alzheimer\u2019s disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK\/ACC1 signaling in the liver","volume":"147","author":"Kepchia","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2026.116930_bb0355","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41514-020-00048-1","article-title":"Targeting of intracellular Ca2+ stores as a therapeutic strategy against age-related neurotoxicities","volume":"6","author":"Goldberg","year":"2020","journal-title":"NPJ Aging Mech Dis."},{"key":"10.1016\/j.intimp.2026.116930_bb0360","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.trsl.2024.08.007","article-title":"J147 treatment protects against traumatic brain injury by inhibiting neuronal endoplasmic reticulum stress potentially via the AMPK\/SREBP-1 pathway","volume":"274","author":"Jin","year":"2024","journal-title":"Transl. Res."},{"key":"10.1016\/j.intimp.2026.116930_bb0365","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3389\/fnins.2020.00701","article-title":"Sub-acute treatment of curcumin derivative J147 ameliorates depression-like behavior through 5-HT1A-mediated cAMP Signaling","volume":"14","author":"Li","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2026.116930_bb0370","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fonc.2018.00614","article-title":"Bioactivities of EF24, a novel curcumin Analog: a review","volume":"8","author":"He","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.intimp.2026.116930_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111202","article-title":"EF24 induces ferroptosis in osteosarcoma cells through HMOX1","volume":"136","author":"Lin","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0380","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12964-025-02583-4","article-title":"EF24 targets METTL3 to reprogram m6A methylation and induce ferroptosis: an epitranscriptomic mechanism with therapeutical potential for glioma","volume":"24","author":"Yang","year":"2025","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0385","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00163-21","article-title":"The curcumin Analog EF24 inhibits proliferation and invasion of triple-negative breast Cancer cells by targeting the Long noncoding RNA HCG11\/Sp1 Axis","volume":"42","author":"Duan","year":"2022","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.intimp.2026.116930_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155882","article-title":"Curcumin analogue EF24 prevents alveolar epithelial cell senescence to ameliorate idiopathic pulmonary fibrosis via activation of PTEN","volume":"133","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0395","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1038\/s41598-020-64207-w","article-title":"The synthetic curcumin analogue GO-Y030 effectively suppresses the development of pressure overload-induced heart failure in mice","volume":"10","author":"Shimizu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.116930_bb0400","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.687669","article-title":"The curcumin Analog GO-Y030 controls the generation and stability of regulatory T cells","volume":"12","author":"MaruYama","year":"2021","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2026.116930_bb0405","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1111\/cas.15136","article-title":"Curcumin analog GO-Y030 boosts the efficacy of anti-PD-1 cancer immunotherapy","volume":"112","author":"MaruYama","year":"2021","journal-title":"Cancer Sci."},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0410","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/HEP.0000000000000937","article-title":"Effect of phospholipid curcumin Meriva on liver histology and kidney disease in nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled trial","volume":"81","author":"Musso","year":"2025","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.intimp.2026.116930_bb0415","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.joim.2018.07.001","article-title":"Bioavailable curcumin formulations: a review of pharmacokinetic studies in healthy volunteers","volume":"16","author":"Jamwal","year":"2018","journal-title":"J. Integr. Med."},{"issue":"5","key":"10.1016\/j.intimp.2026.116930_bb0420","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1177\/0269881114552744","article-title":"Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population","volume":"29","author":"Cox","year":"2015","journal-title":"J. Psychopharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116930_bb0425","doi-asserted-by":"crossref","first-page":"684","DOI":"10.5414\/CP204058","article-title":"Comparative pharmacokinetics of Theracurmin, a highly bioavailable curcumin, in healthy adult subjects","volume":"59","author":"Chung","year":"2021","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0430","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13063-019-3327-2","article-title":"Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study","volume":"20","author":"Shep","year":"2019","journal-title":"Trials"},{"issue":"4","key":"10.1016\/j.intimp.2026.116930_bb0435","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4103\/0250-474X.44591","article-title":"A pilot cross-over study to evaluate human Oral bioavailability of BCM-95CG (Biocurcumax), a novel bioenhanced preparation of curcumin","volume":"70","author":"Antony","year":"2008","journal-title":"Indian J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0440","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/s13046-019-1368-8","article-title":"Curcumin C3 complex\u00ae\/Bioperine\u00ae has antineoplastic activity in mesothelioma: an in vitro and in vivo analysis","volume":"38","author":"Di Meo","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2026.116930_bb0445","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13063-015-0641-1","article-title":"Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial","volume":"16","author":"Irving","year":"2015","journal-title":"Trials"},{"issue":"6","key":"10.1016\/j.intimp.2026.116930_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112575","article-title":"A pharmacokinetic study and critical reappraisal of curcumin formulations enhancing bioavailability","volume":"28","author":"Kroon","year":"2025","journal-title":"iScience"},{"issue":"4","key":"10.1016\/j.intimp.2026.116930_bb0455","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s13318-024-00898-0","article-title":"Comparative pharmacokinetic study of standard astaxanthin and its micellar formulation in healthy male volunteers","volume":"49","author":"Khayyal","year":"2024","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.intimp.2026.116930_bb0460","doi-asserted-by":"crossref","DOI":"10.3389\/frdem.2023.1222708","article-title":"Influence of CurQfen\u00ae-curcumin on cognitive impairment: a randomized, double-blinded, placebo-controlled, 3-arm, 3-sequence comparative study","volume":"2","author":"Das","year":"2023","journal-title":"Front Dement."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0465","doi-asserted-by":"crossref","DOI":"10.1111\/cbdd.14439","article-title":"A highly bioavailable curcumin formulation ameliorates inflammation cytokines and neurotrophic factors in mice with traumatic brain injury","volume":"103","author":"Sakul","year":"2024","journal-title":"Chem. Biol. Drug Des."},{"issue":"7","key":"10.1016\/j.intimp.2026.116930_bb0470","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.3390\/nu11071692","article-title":"Eight weeks of a high dose of curcumin supplementation may attenuate performance decrements following muscle-damaging exercise","volume":"11","author":"J\u00e4ger","year":"2019","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.intimp.2026.116930_bb0475","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1474-4422(23)00120-5","article-title":"Sex, gender, and the cost of neurological disorders","volume":"22","author":"The Lancet Neurology","year":"2023","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0480","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/procel\/pwae026","article-title":"Alzheimer\u2019s disease: insights into pathology, molecular mechanisms, and therapy","volume":"16","author":"Zheng","year":"2025","journal-title":"Protein Cell"},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0485","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: an update on pathobiology and treatment strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0490","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4103\/0972-2327.40220","article-title":"The effect of curcumin (turmeric) on Alzheimer\u2019s disease: an overview","volume":"11","author":"Mishra","year":"2008","journal-title":"Ann. Indian Acad. Neurol."},{"issue":"5","key":"10.1016\/j.intimp.2026.116930_bb0495","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/j.1471-4159.2004.02800.x","article-title":"Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor","volume":"91","author":"Giri","year":"2004","journal-title":"J. Neurochem."},{"issue":"7","key":"10.1016\/j.intimp.2026.116930_bb0500","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1074\/jbc.M404751200","article-title":"Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo","volume":"280","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0505","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/hmg\/ddae154","article-title":"The regulation of miRNAs using curcumin and other polyphenols during the prevention and treatment of Alzheimer\u2019s disease","volume":"34","author":"Wang","year":"2025","journal-title":"Hum. Mol. Genet."},{"issue":"10","key":"10.1016\/j.intimp.2026.116930_bb0510","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.3390\/ijms25105123","article-title":"Curcumin improves neurogenesis in Alzheimer\u2019s disease mice via the upregulation of Wnt\/\u03b2-catenin and BDNF","volume":"25","author":"Lou","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"50","key":"10.1016\/j.intimp.2026.116930_bb0515","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202405781","article-title":"Intranasal delivery of pure nanodrug loaded liposomes for Alzheimer\u2019s disease treatment by efficiently regulating microglial polarization","volume":"20","author":"Feng","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.intimp.2026.116930_bb0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.115129","article-title":"Nanocurcumin prevents memory impairment, hippocampal apoptosis, Akt and CaMKII-\u03b1 signaling disruption in the central STZ model of Alzheimer\u2019s disease in rat","volume":"471","author":"Moosavi","year":"2024","journal-title":"Behav. Brain Res."},{"issue":"45","key":"10.1016\/j.intimp.2026.116930_bb0525","article-title":"A photolabile curcumin-diazirine analogue enables phototherapy with physically and molecularly produced light for Alzheimer\u2019s disease treatment","volume":"62","author":"Kuang","year":"2023","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.intimp.2026.116930_bb0530","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jconrel.2023.12.030","article-title":"Erythrocyte membrane-coated nanocarriers modified by TGN for Alzheimer\u2019s disease","volume":"366","author":"Gu","year":"2024","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.intimp.2026.116930_bb0535","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jphys.2021.06.004","article-title":"Physiotherapy management of Parkinson\u2019s disease","volume":"67","author":"Pang","year":"2021","journal-title":"J. Physiother."},{"key":"10.1016\/j.intimp.2026.116930_bb0540","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1593191","article-title":"Curcumin as a potential therapeutic agent for Parkinson\u2019s disease: a systematic review","volume":"16","author":"Chang","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0545","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1874609814666210526115740","article-title":"Parkinsonism-like disease induced by rotenone in rats: treatment role of curcumin, dopamine agonist and adenosine A2A receptor antagonist","volume":"15","author":"Naser","year":"2022","journal-title":"Curr. Aging Sci."},{"key":"10.1016\/j.intimp.2026.116930_bb0550","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.887407","article-title":"Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson\u2019s disease","volume":"12","author":"Cui","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2026.116930_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2022.105297","article-title":"Neuroprotective effects of curcumin via autophagy induction in 6-hydroxydopamine Parkinson\u2019s models","volume":"155","author":"He","year":"2022","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.intimp.2026.116930_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106543","article-title":"Design, synthesis and evaluation of monoketene compounds as novel potential Parkinson\u2019s disease agents by suppressing ER stress via AKT","volume":"136","author":"Chen","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.intimp.2026.116930_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107587","article-title":"Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson\u2019s disease","volume":"150","author":"de Freitas Silva","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"17","key":"10.1016\/j.intimp.2026.116930_bb0570","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1021\/acschemneuro.0c00363","article-title":"Novel curcumin-diethyl fumarate hybrid as a dualistic GSK-3\u03b2 inhibitor\/Nrf2 inducer for the treatment of Parkinson\u2019s disease","volume":"11","author":"Di Martino","year":"2020","journal-title":"ACS Chem. Neurosci."},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0575","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1021\/acsnano.9b06453","article-title":"A self-assembled \u03b1-synuclein Nanoscavenger for Parkinson\u2019s disease","volume":"14","author":"Liu","year":"2020","journal-title":"ACS Nano"},{"issue":"50","key":"10.1016\/j.intimp.2026.116930_bb0580","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba3967","article-title":"Targeted exosome coating gene-chem nanocomplex as \u201cnanoscavenger\u201d for clearing \u03b1-synuclein and immune activation of Parkinson\u2019s disease","volume":"6","author":"Liu","year":"2020","journal-title":"Sci. Adv."},{"issue":"22","key":"10.1016\/j.intimp.2026.116930_bb0585","article-title":"Ameliorating mitochondrial dysfunction of neurons by biomimetic targeting nanoparticles mediated mitochondrial biogenesis to boost the therapy of Parkinson\u2019s disease","volume":"10","author":"Zheng","year":"2023","journal-title":"Adv. Sci. (Weinh)."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0590","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1021\/acsnano.1c08473","article-title":"Intranasal Administration of Self-Oriented Nanocarriers Based on therapeutic exosomes for synergistic treatment of Parkinson\u2019s disease","volume":"16","author":"Peng","year":"2022","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.intimp.2026.116930_bb0595","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1172\/JCI135530","article-title":"Immune responses to stroke: mechanisms, modulation, and therapeutic potential","volume":"130","author":"Iadecola","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"10446","key":"10.1016\/j.intimp.2026.116930_bb0600","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/S0140-6736(24)00642-1","article-title":"Stroke","volume":"403","author":"Hilkens","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2026.116930_bb0605","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.nutres.2023.02.009","article-title":"Curcumin protects against cerebral ischemia-reperfusion injury in rats by attenuating oxidative stress and inflammation: a meta-analysis and mechanism exploration","volume":"113","author":"Yang","year":"2023","journal-title":"Nutr. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0610","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1517\/13543784.2011.542410","article-title":"Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective","volume":"20","author":"Lapchak","year":"2011","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0615","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12937-023-00905-1","article-title":"The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial","volume":"22","author":"Boshagh","year":"2023","journal-title":"Nutr. J."},{"issue":"5\u20136","key":"10.1016\/j.intimp.2026.116930_bb0620","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1080\/15384101.2021.1889188","article-title":"The protective effects of curcumin in cerebral ischemia and reperfusion injury through PKC-\u03b8 signaling","volume":"20","author":"Mo","year":"2021","journal-title":"Cell Cycle"},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0625","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.921","article-title":"Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke","volume":"8","author":"Xie","year":"2018","journal-title":"Brain Behav."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0630","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12974-023-02738-5","article-title":"Human umbilical cord-derived mesenchymal stem cell transplantation supplemented with curcumin improves the outcomes of ischemic stroke via AKT\/GSK-3\u03b2\/\u03b2-TrCP\/Nrf2 axis","volume":"20","author":"Li","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.intimp.2026.116930_bb0635","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1139\/bcb-2021-0423","article-title":"Curcumin attenuates intracerebral hemorrhage-induced neuronal apoptosis and neuroinflammation by suppressing JAK1\/STAT1 pathway","volume":"100","author":"Wang","year":"2022","journal-title":"Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0640","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41598-024-82571-9","article-title":"Curcumin reverses cognitive deficits through promoting neurogenesis and synapse plasticity via the upregulation of PSD95 and BDNF in mice","volume":"15","author":"Li","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0645","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12872-018-0768-6","article-title":"Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function","volume":"18","author":"Lan","year":"2018","journal-title":"BMC Cardiovasc. Disord."},{"issue":"12","key":"10.1016\/j.intimp.2026.116930_bb0650","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.2217\/nnm-2024-0008","article-title":"Curcumin nanogel and its efficacy against oxidative stress and inflammation in rat models of ischemic stroke","volume":"19","author":"Khuwaja","year":"2024","journal-title":"Nanomedicine (London)"},{"issue":"6","key":"10.1016\/j.intimp.2026.116930_bb0655","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00709-013-0516-9","article-title":"A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin, and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke","volume":"250","author":"Ahmad","year":"2013","journal-title":"Protoplasma"},{"issue":"12","key":"10.1016\/j.intimp.2026.116930_bb0660","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202400304","article-title":"Intranasal delivery of curcumin nanoparticles improves neuroinflammation and neurological deficits in mice with intracerebral hemorrhage","volume":"8","author":"Duan","year":"2024","journal-title":"Small Methods"},{"issue":"10422","key":"10.1016\/j.intimp.2026.116930_bb0665","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(23)01473-3","article-title":"Multiple sclerosis","volume":"403","author":"Jakimovski","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2026.116930_bb0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2024.103091","article-title":"Beyond the spice: the multifaceted role of curcumin in multiple sclerosis management","volume":"86","author":"Sahebkar","year":"2024","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/j.intimp.2026.116930_bb0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.103274","article-title":"ProspeCtive study to evaluate efficacy, safety and tOlerability of dietary supplemeNT of curcumin (BCM95) in subjects with active relapsing multiple sclerosis treated with subcutaNeous interferon beta 1a 44 mcg TIW (CONTAIN): a randomized, controlled trial","volume":"56","author":"Petracca","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.intimp.2026.116930_bb0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136821","article-title":"Curcumin regulates anti-inflammatory responses by AXL\/JAK2\/STAT3 signaling pathway in experimental autoimmune encephalomyelitis","volume":"787","author":"Sun","year":"2022","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2026.116930_bb0685","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.772962","article-title":"Curcumin \u03b2-D-glucuronide modulates an autoimmune model of multiple sclerosis with altered gut microbiota in the ileum and Feces","volume":"11","author":"Khadka","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2026.116930_bb0690","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jconrel.2022.05.046","article-title":"Curcumin-based nanotechnology approaches and therapeutics in restoration of autoimmune diseases","volume":"348","author":"Rahiman","year":"2022","journal-title":"J. Control. Release"},{"issue":"22","key":"10.1016\/j.intimp.2026.116930_bb0695","first-page":"2151","article-title":"Nanocarrier-mediated curcumin delivery: an adjuvant strategy for CNS disease treatment","volume":"248","author":"Godse","year":"2023","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.intimp.2026.116930_bb0700","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neuropharm.2015.07.013","article-title":"Polymerized nano-curcumin attenuates neurological symptoms in EAE model of multiple sclerosis through down regulation of inflammatory and oxidative processes and enhancing neuroprotection and myelin repair","volume":"99","author":"Mohajeri","year":"2015","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0705","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-023-01477-6","article-title":"Spinal cord injury: molecular mechanisms and therapeutic interventions","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2026.116930_bb0710","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1080\/1028415X.2022.2070703","article-title":"The potential of curcumin for treating spinal cord injury: a meta-analysis study","volume":"26","author":"Kahuripour","year":"2023","journal-title":"Nutr. Neurosci."},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0715","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jss.2009.07.001","article-title":"Curcumin provides neuroprotection after spinal cord injury","volume":"166","author":"Lin","year":"2011","journal-title":"J. Surg. Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.116930_bb0720","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jcyt.2020.03.002","article-title":"Transplantation of activated olfactory ensheathing cells by curcumin strengthens regeneration and recovery of function after spinal cord injury in rats","volume":"22","author":"Guo","year":"2020","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0725","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12964-024-01539-4","article-title":"Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia\/macrophage in OEC anti-inflammatory activity for functional repair of spinal cord injury","volume":"22","author":"Guo","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"3","key":"10.1016\/j.intimp.2026.116930_bb0730","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s11481-023-10081-y","article-title":"Curcumin-activated olfactory ensheathing cells improve functional recovery after spinal cord injury by modulating microglia polarization through APOE\/TREM2\/NF-\u03baB Signaling pathway","volume":"18","author":"Jiang","year":"2023","journal-title":"J. NeuroImmune Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0735","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/10790268.2019.1616147","article-title":"Curcumin promotes functional recovery and inhibits neuronal apoptosis after spinal cord injury through the modulation of autophagy","volume":"44","author":"Li","year":"2021","journal-title":"J. Spinal Cord Med."},{"issue":"27","key":"10.1016\/j.intimp.2026.116930_bb0740","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado9120","article-title":"Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays","volume":"10","author":"Tan","year":"2024","journal-title":"Sci. Adv."},{"issue":"50","key":"10.1016\/j.intimp.2026.116930_bb0745","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202307624","article-title":"Microenvironment self-adaptive nanomedicine promotes spinal cord repair by suppressing inflammation cascade and neural apoptosis","volume":"36","author":"Qian","year":"2024","journal-title":"Adv. Mater."},{"issue":"10","key":"10.1016\/j.intimp.2026.116930_bb0750","doi-asserted-by":"crossref","first-page":"7346","DOI":"10.1021\/acsnano.3c08662","article-title":"In situ reaction-generated aldehyde-scavenging polypeptides-curcumin conjugate nanoassemblies for combined treatment of spinal cord injury","volume":"18","author":"Liu","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.intimp.2026.116930_bb0755","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biomaterials.2016.10.032","article-title":"Combined polymer-curcumin conjugate and ependymal progenitor\/stem cell treatment enhances spinal cord injury functional recovery","volume":"113","author":"Requejo-Aguilar","year":"2017","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0760","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s13311-018-0606-7","article-title":"Safety and efficacy of nanocurcumin as add-on therapy to Riluzole in patients with amyotrophic lateral sclerosis: a pilot randomized clinical trial","volume":"15","author":"Ahmadi","year":"2018","journal-title":"Neurotherapeutics"},{"issue":"5","key":"10.1016\/j.intimp.2026.116930_bb0765","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bbapap.2015.01.014","article-title":"Curcumin binds to the pre-fibrillar aggregates of Cu\/Zn superoxide dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity","volume":"1854","author":"Bhatia","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"7\u20138","key":"10.1016\/j.intimp.2026.116930_bb0770","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/21678421.2021.2012699","article-title":"Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis","volume":"23","author":"Kato","year":"2022","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"issue":"23","key":"10.1016\/j.intimp.2026.116930_bb0775","first-page":"4012","article-title":"Curcumin dietary supplementation ameliorates disease phenotype in an animal model of Huntington\u2019s disease","volume":"28","author":"Elifani","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.intimp.2026.116930_bb0780","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1326-7-12","article-title":"Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington\u2019s disease","volume":"7","author":"Hickey","year":"2012","journal-title":"Mol. Neurodegener."},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0785","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/15353702211046927","article-title":"Management of altered metabolic activity in Drosophila model of Huntington\u2019s disease by curcumin","volume":"247","author":"Aditi","year":"2022","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"4","key":"10.1016\/j.intimp.2026.116930_bb0790","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3233\/JHD-230595","article-title":"Amendment of altered immune response by curcumin in Drosophila model of Huntington\u2019s disease","volume":"12","author":"Dhankhar","year":"2023","journal-title":"J Huntingtons Dis."},{"issue":"1","key":"10.1016\/j.intimp.2026.116930_bb0795","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/07420528.2020.1842752","article-title":"Melatonin and curcumin reestablish disturbed circadian gene expressions and restore locomotion ability and eclosion behavior in Drosophila model of Huntington\u2019s disease","volume":"38","author":"Khyati","year":"2021","journal-title":"Chronobiol. Int."},{"issue":"2","key":"10.1016\/j.intimp.2026.116930_bb0800","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1177\/13872877251344188","article-title":"Curcumin\u2019s multi-target mechanisms in the treatment of Alzheimer\u2019s disease and creative modification techniques","volume":"106","author":"Meng","year":"2025","journal-title":"J. Alzheimer\u2019s Dis"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926007769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926007769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:30:58Z","timestamp":1791995458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926007769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":158,"alternative-id":["S1567576926007769"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116930","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin for neurological diseases: from molecular mechanisms to translational strategies","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116930","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116930"}}