{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:50:33Z","timestamp":1791996633282,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573305"],"award-info":[{"award-number":["32573305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072817"],"award-info":[{"award-number":["32072817"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C02004"],"award-info":[{"award-number":["2024C02004"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.intimp.2026.116935","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T15:41:42Z","timestamp":1780155702000},"page":"116935","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cepharanthine inhibits NLRP3 inflammasome-induced pyroptosis through ARIH2-mediated degradation of NLRP3"],"prefix":"10.1016","volume":"184","author":[{"given":"Yumeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi'an","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilv","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fushan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7575","key":"10.1016\/j.intimp.2026.116935_bb0005","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.intimp.2026.116935_bb0010","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: Mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116935_bb0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10787-025-02083-4","article-title":"Targeting gasdermin D-mediated pyroptosis: a precision anti-inflammatory strategy for acute and chronic lung diseases","volume":"34","author":"Samuel","year":"2026","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.intimp.2026.116935_bb0020","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-026-02260-y","article-title":"Non-canonical cell death in neurodegeneration: emerging mechanisms and therapeutic frontiers","volume":"31","author":"Ercin","year":"2026","journal-title":"Apoptosis"},{"issue":"10","key":"10.1016\/j.intimp.2026.116935_bb0025","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/eji.201545772","article-title":"Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux","volume":"45","author":"R\u00fchl","year":"2015","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116935_bb0030","article-title":"Pyroptosis in health and disease: mechanisms, regulation and clinical perspective","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.116935_bb0035","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-024-02183-9","article-title":"Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication","volume":"23","author":"Wang","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2026.116935_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1586364","article-title":"The key players of inflammasomes and pyroptosis in sepsis-induced pathogenesis and organ dysfunction","volume":"16","author":"Zhu","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116935_bb0045","article-title":"Compound Yujie decoction ameliorates LPS-induced acute lung injury by suppressing NLRP3 inflammasome-mediated macrophage pyroptosis","author":"Ma","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2026.116935_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107605","article-title":"Scutellarin inhibits pyroptosis via selective autophagy degradation of p30\/GSDMD and suppression of ASC oligomerization","volume":"212","author":"Li","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"7","key":"10.1016\/j.intimp.2026.116935_bb0055","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1716095115","article-title":"OLT1177, a \u03b2-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation","volume":"115","author":"Marchetti","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.intimp.2026.116935_bb0060","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2026.116935_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152956","article-title":"Cepharanthine: an update of its mode of action, pharmacological properties and medical applications","volume":"62","author":"Bailly","year":"2019","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.intimp.2026.116935_bb0070","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1007\/s00210-023-02537-y","article-title":"Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives","volume":"396","author":"Shi","year":"2023","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116935_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2026.116356","article-title":"Cepharanthine protects against lipopolysaccharide-induced acute lung injury in mice by blocking NLRP3 inflammasome activation","volume":"174","author":"Wang","year":"2026","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116935_bb0080","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-023-01752-z","article-title":"Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway","volume":"9","author":"Lu","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.intimp.2026.116935_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176839","article-title":"Cepharanthine triggers ferroptosis through inhibition of NRF2 for robust ER stress against lung cancer","volume":"979","author":"Bai","year":"2024","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116935_bb0090","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1637\/aviandiseases-D-24-00083","article-title":"Bis-Benzylisoquinoline alkaloids exhibit inhibitory properties against Infectious Bronchitis Virus infection In Vitro and In Ovo","volume":"69","author":"Du","year":"2025","journal-title":"Avian Dis."},{"issue":"1","key":"10.1016\/j.intimp.2026.116935_bb0095","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-025-03561-w","article-title":"NLRP3 inflammasome and hearing loss: from mechanisms to therapies","volume":"22","author":"Murillo-Cuesta","year":"2025","journal-title":"J. Neuroinflammation"},{"issue":"11","key":"10.1016\/j.intimp.2026.116935_bb0100","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1084\/jem.20171419","article-title":"Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders","volume":"214","author":"Jiang","year":"2017","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.116935_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04947-6","article-title":"Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity","volume":"9","author":"He","year":"2018","journal-title":"Nat. Commun."},{"issue":"7761","key":"10.1016\/j.intimp.2026.116935_bb0110","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41586-019-1295-z","article-title":"Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome","volume":"570","author":"Sharif","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2026.116935_bb0115","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13727","article-title":"The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3","volume":"7","author":"Song","year":"2016","journal-title":"Nat. Commun."},{"issue":"7575","key":"10.1016\/j.intimp.2026.116935_bb0120","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.intimp.2026.116935_bb0125","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20182091","article-title":"Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia","volume":"217","author":"Tang","year":"2020","journal-title":"J. Exp. Med."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2026.116935_bb0130","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cell.2014.11.047","article-title":"Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome","volume":"160","author":"Yan","year":"2015","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.intimp.2026.116935_bb0135","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.4049\/jimmunol.1700184","article-title":"ARIH2 ubiquitinates NLRP3 and negatively regulates NLRP3 inflammasome activation in macrophages","volume":"199","author":"Kawashima","year":"2017","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116935_bb0140","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1042\/BJ20140006","article-title":"RBR E3 ubiquitin ligases: new structures, new insights, new questions","volume":"458","author":"Spratt","year":"2014","journal-title":"Biochem. J."},{"issue":"8","key":"10.1016\/j.intimp.2026.116935_bb0145","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.15252\/embr.201642641","article-title":"Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms","volume":"17","author":"Dove","year":"2016","journal-title":"EMBO Rep."},{"issue":"10","key":"10.1016\/j.intimp.2026.116935_bb0150","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/s41589-021-00858-8","article-title":"CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation","volume":"17","author":"Kostrhon","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.intimp.2026.116935_bb0155","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1038\/emboj.2013.209","article-title":"TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes","volume":"32","author":"Kelsall","year":"2013","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.intimp.2026.116935_bb0160","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/s41590-025-02230-7","article-title":"The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets","volume":"26","author":"Weber","year":"2025","journal-title":"Nat. Immunol."},{"issue":"7366","key":"10.1016\/j.intimp.2026.116935_bb0165","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature10394","article-title":"Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity","volume":"477","author":"Kofoed","year":"2011","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.intimp.2026.116935_bb0170","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.celrep.2014.06.028","article-title":"The neutrophil NLRC4 inflammasome selectively promotes IL-1\u03b2 maturation without pyroptosis during acute Salmonella challenge","volume":"8","author":"Chen","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2026.116935_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110151","article-title":"Cepharanthine attenuates cerebral ischemia\/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12\/15-LOX signaling","volume":"127","author":"Zhao","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.intimp.2026.116935_bb0180","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1080\/10717544.2021.2009936","article-title":"Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy","volume":"28","author":"Lu","year":"2021","journal-title":"Drug Deliv."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926007812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926007812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:31:37Z","timestamp":1791995497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926007812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":36,"alternative-id":["S1567576926007812"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116935","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cepharanthine inhibits NLRP3 inflammasome-induced pyroptosis through ARIH2-mediated degradation of NLRP3","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116935","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116935"}}