{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:41:32Z","timestamp":1790808092854,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018608","name":"High-end Foreign Experts Recruitment Plan of China","doi-asserted-by":"publisher","award":["H20250747"],"award-info":[{"award-number":["H20250747"]}],"id":[{"id":"10.13039\/501100018608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["LZU-GXJJ-2025-003"],"award-info":[{"award-number":["LZU-GXJJ-2025-003"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160111"],"award-info":[{"award-number":["82160111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.intimp.2026.116975","type":"journal-article","created":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T14:57:56Z","timestamp":1780844276000},"page":"116975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Swertiamarin promotes barrier function to alleviate ulcerative colitis by inducing autophagy via the PI3K\/AKT\/mTOR-signaling pathway"],"prefix":"10.1016","volume":"185","author":[{"given":"Yaohui","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhu","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2026.116975_bb0005","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/PAS.0000000000001594","article-title":"Clinicopathologic features of chronic intestinal schistosomiasis and its distinction from Crohn disease","volume":"45","author":"Cai","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.intimp.2026.116975_bb0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12937-015-0014-3","article-title":"Evaluation of diet pattern related to the symptoms of mexican patients with ulcerative colitis (UC): through the validity of a questionnaire","volume":"14","author":"Bueno-Hern\u00e1ndez","year":"2015","journal-title":"Nutr. J."},{"key":"10.1016\/j.intimp.2026.116975_bb0015","article-title":"Inflammatory bowel disease, such as ulcerative colitis, is a risk factor for recurrent thromboembolic events: a case report","volume":"2","author":"O\u2019Connor","year":"2009","journal-title":"Cases J."},{"issue":"6","key":"10.1016\/j.intimp.2026.116975_bb0020","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1134\/S0026893323060043","article-title":"Role of mitochondria in intestinal epithelial barrier dysfunction in inflammatory bowel disease","volume":"57","author":"Chernyavskij","year":"2023","journal-title":"Mol. Biol. (Mosk)"},{"issue":"4","key":"10.1016\/j.intimp.2026.116975_bb0025","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/ecco-jcc\/jjv223","article-title":"Mucosal barrier depletion and loss of bacterial diversity are primary abnormalities in paediatric ulcerative colitis","volume":"10","author":"Alipour","year":"2016","journal-title":"J. Crohns Colitis"},{"issue":"20","key":"10.1016\/j.intimp.2026.116975_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205026","article-title":"Probiotics can cure Oral aphthous-like ulcers in inflammatory bowel disease patients: a review of the literature and a working hypothesis","volume":"20","author":"Cappello","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"Pt A","key":"10.1016\/j.intimp.2026.116975_bb0035","article-title":"Traditional Chinese medicine: a promising strategy to regulate the imbalance of bacterial flora, impaired intestinal barrier and immune function attributed to ulcerative colitis through intestinal microecology","volume":"318","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116975_bb0040","first-page":"181","article-title":"Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis","volume":"15","author":"Yang","year":"2023","journal-title":"Chin. Herb. Med."},{"issue":"28","key":"10.1016\/j.intimp.2026.116975_bb0045","doi-asserted-by":"crossref","first-page":"9468","DOI":"10.3748\/wjg.v20.i28.9468","article-title":"Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier","volume":"20","author":"Chen","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2026.116975_bb0050","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.2147\/JIR.S470520","article-title":"Restore intestinal barrier integrity: an approach for inflammatory bowel disease therapy","volume":"17","author":"Kong","year":"2024","journal-title":"J. Inflamm. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116975_bb0055","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10620-021-06834-5","article-title":"Serum globulin is associated with endoscopic findings and mucosal healing in Japanese patients with ulcerative colitis","volume":"67","author":"Shiraishi","year":"2022","journal-title":"Dig. Dis. Sci."},{"issue":"22","key":"10.1016\/j.intimp.2026.116975_bb0060","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","article-title":"Autophagy: process and function","volume":"21","author":"Mizushima","year":"2007","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.intimp.2026.116975_bb0065","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.aninu.2015.08.014","article-title":"Autophagy and tight junction proteins in the intestine and intestinal diseases","volume":"1","author":"Hu","year":"2015","journal-title":"Anim. Nutr."},{"issue":"5","key":"10.1016\/j.intimp.2026.116975_bb0070","first-page":"C753","article-title":"Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6\/beclin 1","volume":"316","author":"Wong","year":"2019","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.intimp.2026.116975_bb0075","article-title":"Curcumin alleviates experimental colitis in mice by suppressing necroptosis of intestinal epithelial cells","volume":"14","author":"Zhong","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116975_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.697360","article-title":"Regulation of endoplasmic reticulum stress-autophagy: a potential therapeutic target for ulcerative colitis","volume":"12","author":"Qiao","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116975_bb0085","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12035-024-04269-3","article-title":"The current potential pathogenesis of amyotrophic lateral sclerosis","volume":"62","author":"Jiang","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116975_bb0090","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1007\/s12035-020-01945-y","article-title":"Mitochondrial dysfunction: a potential therapeutic target to treat Alzheimer\u2019s disease","volume":"57","author":"Rai","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116975_bb0095","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cmet.2008.08.009","article-title":"Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet","volume":"8","author":"Ebato","year":"2008","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.intimp.2026.116975_bb0100","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1111\/cas.14646","article-title":"Autophagy involvement in oncogenesis","volume":"111","author":"Torii","year":"2020","journal-title":"Cancer Sci."},{"issue":"7","key":"10.1016\/j.intimp.2026.116975_bb0105","article-title":"From intestinal epithelial homeostasis to colorectal cancer: autophagy regulation in cellular stress","volume":"11","author":"Liu","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2026.116975_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155383","article-title":"Osthole impairs mitochondrial metabolism and the autophagic flux in colorectal cancer","volume":"125","author":"Song","year":"2024","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.intimp.2026.116975_bb0115","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.celrep.2017.07.019","article-title":"Intrinsic autophagy is required for the maintenance of intestinal stem cells and for irradiation-induced intestinal regeneration","volume":"20","author":"Asano","year":"2017","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116975_bb0120","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1038\/s41598-018-23065-3","article-title":"Autophagy maintains stem cells and intestinal homeostasis in Drosophila","volume":"8","author":"Nagy","year":"2018","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.intimp.2026.116975_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225066","article-title":"Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation","volume":"14","author":"Kubota","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2026.116975_bb0130","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.freeradbiomed.2015.09.012","article-title":"Autophagy protects intestinal epithelial cells against deoxynivalenol toxicity by alleviating oxidative stress via IKK signaling pathway","volume":"89","author":"Tang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2026.116975_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115164","article-title":"Swertiamarin, an active iridoid glycoside from Swertia pseudochinensis H. Hara, protects against alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and bile acid excretion pathway","volume":"291","author":"Shi","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"2\u20133","key":"10.1016\/j.intimp.2026.116975_bb0140","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.phymed.2008.09.010","article-title":"Antinociceptive activity of swertiamarin isolated from Enicostemma axillare","volume":"16","author":"Jaishree","year":"2009","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116975_bb0145","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.biopha.2016.10.044","article-title":"A systematic review of the protective role of swertiamarin in cardiac and metabolic diseases","volume":"84","author":"Leong","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2026.116975_bb0150","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.biopha.2016.07.028","article-title":"Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis","volume":"83","author":"Patel","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2026.116975_bb0155","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejps.2014.02.005","article-title":"Swertiamarin attenuates inflammation mediators via modulating NF-\u03baB\/I\u03baB and JAK2\/STAT3 transcription factors in adjuvant induced arthritis","volume":"56","author":"Saravanan","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"issue":"8","key":"10.1016\/j.intimp.2026.116975_bb0160","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/ptr.3708","article-title":"Beneficial effects of swertiamarin on dyslipidaemia in streptozotocin-induced type 2 diabetic rats","volume":"26","author":"Vaidya","year":"2012","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.intimp.2026.116975_bb0165","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11418-009-0350-8","article-title":"Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats","volume":"63","author":"Vaidya","year":"2009","journal-title":"J. Nat. Med."},{"issue":"8","key":"10.1016\/j.intimp.2026.116975_bb0170","doi-asserted-by":"crossref","first-page":"10597","DOI":"10.1007\/s00210-025-03944-z","article-title":"Network pharmacology analysis and animal experiment validation of inflammation inhibition by Swertiamarin in treating ulcerative colitis","volume":"398","author":"Jiafeng","year":"2025","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116975_bb0175","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad120","article-title":"Machine learning for synergistic network pharmacology: a comprehensive overview","volume":"24","author":"Noor","year":"2023","journal-title":"Brief. Bioinform."},{"issue":"5","key":"10.1016\/j.intimp.2026.116975_bb0180","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1007\/s00210-024-03625-3","article-title":"Harnessing network pharmacology in drug discovery: an integrated approach","volume":"398","author":"Joshi","year":"2025","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116975_bb0185","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1053\/j.gastro.2020.06.049","article-title":"Intestinal epithelial expression of MHCII determines severity of chemical, T-cell-induced, and infectious colitis in mice","volume":"159","author":"Jamwal","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2026.116975_bb0190","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.redox.2018.02.003","article-title":"Hydrogen peroxide production by lactobacilli promotes epithelial restitution during colitis","volume":"16","author":"Singh","year":"2018","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116975_bb0195","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00470-17","article-title":"Gut microbiota mediates the protective effects of dietary capsaicin against chronic low-grade inflammation and associated obesity induced by high-fat diet","volume":"8","author":"Kang","year":"2017","journal-title":"mBio"},{"issue":"7","key":"10.1016\/j.intimp.2026.116975_bb0200","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/bph.13712","article-title":"Inhibition of matrix metalloproteinase-9 by a barbiturate-nitrate hybrid ameliorates dextran sulphate sodium-induced colitis: effect on inflammation-related genes","volume":"174","author":"O\u2019Sullivan","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116975_bb0205","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"10","key":"10.1016\/j.intimp.2026.116975_bb0210","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1021\/ci200227u","article-title":"LigPlot+: multiple ligand-protein interaction diagrams for drug discovery","volume":"51","author":"Laskowski","year":"2011","journal-title":"J. Chem. Inf. Model."},{"issue":"16","key":"10.1016\/j.intimp.2026.116975_bb0215","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.intimp.2026.116975_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106553","article-title":"Biological impact and therapeutic perspective of targeting PI3K\/Akt signaling in hepatocellular carcinoma: promises and challenges","volume":"187","author":"Paskeh","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2026.116975_bb0225","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.2147\/DDDT.S299753","article-title":"Chemistry, pharmacology and therapeutic potential of swertiamarin - a promising natural lead for new drug discovery and development","volume":"15","author":"Muhamad Fadzil","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2026.116975_bb0230","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10787-016-0290-3","article-title":"Amelioration of oxidative and inflammatory changes by Swertia chirayita leaves in experimental arthritis","volume":"24","author":"Lad","year":"2016","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2026.116975_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2018.12.005","article-title":"Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice","volume":"59","author":"Yang","year":"2019","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.intimp.2026.116975_bb0240","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1159\/000475639","article-title":"Antioxidant and hepatoprotective effect of Swertiamarin on carbon tetrachloride-induced hepatotoxicity via the Nrf2\/HO-1 pathway","volume":"41","author":"Wu","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.intimp.2026.116975_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156190","article-title":"Swertiamarin ameliorates type 2 diabetes by activating ADRB3\/UCP1 thermogenic signals in adipose tissue","volume":"135","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.intimp.2026.116975_bb0250","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/21623945.2021.1906510","article-title":"Swertiamarin supplementation prevents obesity-related chronic inflammation and insulin resistance in mice fed a high-fat diet","volume":"10","author":"Xu","year":"2021","journal-title":"Adipocyte"},{"issue":"1","key":"10.1016\/j.intimp.2026.116975_bb0255","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1186\/s12906-023-04171-w","article-title":"Identification and validation of targets of swertiamarin on idiopathic pulmonary fibrosis through bioinformatics and molecular docking-based approach","volume":"23","author":"Chang","year":"2023","journal-title":"BMC Complement. Med. Ther."},{"issue":"22","key":"10.1016\/j.intimp.2026.116975_bb0260","doi-asserted-by":"crossref","first-page":"10409","DOI":"10.18632\/aging.102467","article-title":"The anti-inflammation, anti-oxidative and anti-fibrosis properties of swertiamarin in cigarette smoke exposure-induced prostate dysfunction in rats","volume":"11","author":"Chen","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"9","key":"10.1016\/j.intimp.2026.116975_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26092748","article-title":"Protective effects of Swertiamarin against methylglyoxal-induced epithelial-mesenchymal transition by improving oxidative stress in rat kidney epithelial (NRK-52E) cells","volume":"26","author":"Parwani","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.intimp.2026.116975_bb0270","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1038\/s41467-022-32505-8","article-title":"Mannose ameliorates experimental colitis by protecting intestinal barrier integrity","volume":"13","author":"Dong","year":"2022","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.intimp.2026.116975_bb0275","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2018.08.067","article-title":"Structural Remodeling of the human colonic mesenchyme in inflammatory bowel disease","volume":"175","author":"Kinchen","year":"2018","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.intimp.2026.116975_bb0280","doi-asserted-by":"crossref","first-page":"1131s","DOI":"10.1093\/ajcn\/73.6.1131S","article-title":"Microbial modulation of innate defense: goblet cells and the intestinal mucus layer","volume":"73","author":"Deplancke","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"issue":"3","key":"10.1016\/j.intimp.2026.116975_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.103017","article-title":"The influence of cytokines on the complex pathology of ulcerative colitis","volume":"21","author":"Nakase","year":"2022","journal-title":"Autoimmun. Rev."},{"issue":"5","key":"10.1016\/j.intimp.2026.116975_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052719","article-title":"The role of tumor necrosis factor alpha (TNF-\u03b1) in autoimmune disease and current TNF-\u03b1 inhibitors in therapeutics","volume":"22","author":"Jang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116975_bb0295","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.1038\/s41467-020-20164-6","article-title":"D-mannose suppresses macrophage IL-1\u03b2 production","volume":"11","author":"Torretta","year":"2020","journal-title":"Nat. Commun."},{"issue":"13","key":"10.1016\/j.intimp.2026.116975_bb0300","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.7150\/ijbs.74304","article-title":"P2RY13 exacerbates intestinal inflammation by damaging the intestinal mucosal barrier via activating IL-6\/STAT3 pathway","volume":"18","author":"Wu","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2026.116975_bb0305","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/bjd\/ljae272","article-title":"Network pharmacology as a platform for drug discovery for hypertrophic scars","volume":"191","author":"Wang","year":"2024","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.intimp.2026.116975_bb0310","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.semcancer.2024.08.004","article-title":"Unveiling the role of PIK3R1 in cancer: a comprehensive review of regulatory signaling and therapeutic implications","volume":"106-107","author":"Gupta","year":"2024","journal-title":"Semin. Cancer Biol."},{"issue":"7","key":"10.1016\/j.intimp.2026.116975_bb0315","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.3168\/jds.2023-24007","article-title":"The HSP90AA1 gene is involved in heat stress responses and its functional genetic polymorphisms are associated with heat tolerance in Holstein cows","volume":"107","author":"Hu","year":"2024","journal-title":"J. Dairy Sci."},{"issue":"7","key":"10.1016\/j.intimp.2026.116975_bb0320","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1080\/15548627.2024.2323259","article-title":"The HSP90 chaperone code regulates the crosstalk between proteostasis and autophagy","volume":"20","author":"Backe","year":"2024","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.intimp.2026.116975_bb0325","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s42003-021-02564-6","article-title":"The multiple mechanisms of MCL1 in the regulation of cell fate","volume":"4","author":"Widden","year":"2021","journal-title":"Commun Biol"},{"issue":"12","key":"10.1016\/j.intimp.2026.116975_bb0330","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1084\/jem.20170558","article-title":"Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium","volume":"214","author":"Matsuzawa-Ishimoto","year":"2017","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.116975_bb0335","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.chom.2017.12.017","article-title":"Intestinal epithelial cell autophagy is required to protect against TNF-induced apoptosis during chronic colitis in mice","volume":"23","author":"Pott","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.intimp.2026.116975_bb0340","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.chom.2018.01.015","article-title":"Autophagy: suicide prevention hotline for the gut epithelium","volume":"23","author":"Grizotte-Lake","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"17","key":"10.1016\/j.intimp.2026.116975_bb0345","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1158\/0008-5472.CAN-17-3835","article-title":"Flightless-I blocks p62-mediated recognition of LC3 to impede selective autophagy and promote breast Cancer progression","volume":"78","author":"He","year":"2018","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.intimp.2026.116975_bb0350","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1002\/jcp.27262","article-title":"PI3k\/AKT signaling pathway: erythropoiesis and beyond","volume":"234","author":"Jafari","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116975_bb0355","doi-asserted-by":"crossref","first-page":"7930","DOI":"10.1007\/s12035-024-04039-1","article-title":"Targeting PI3K\/Akt in cerebral ischemia reperfusion injury alleviation: from Signaling networks to targeted therapy","volume":"61","author":"Zheng","year":"2024","journal-title":"Mol. Neurobiol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:35:31Z","timestamp":1784230531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926008210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":71,"alternative-id":["S1567576926008210"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116975","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Swertiamarin promotes barrier function to alleviate ulcerative colitis by inducing autophagy via the PI3K\/AKT\/mTOR-signaling pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116975"}}