{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:08:01Z","timestamp":1784232481864,"version":"3.55.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010104","name":"Tianjin Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173818"],"award-info":[{"award-number":["82173818"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.intimp.2026.116978","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T20:52:03Z","timestamp":1780779123000},"page":"116978","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ursodeoxycholic acid attenuates sepsis-associated platelet dysfunction through TREM2-linked signaling"],"prefix":"10.1016","volume":"185","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongren","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.intimp.2026.116978_bb0005","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1097\/CCM.0b013e31827c09f8","article-title":"Benchmarking the incidence and mortality of severe sepsis in the United States","volume":"41","author":"Gaieski","year":"2013","journal-title":"Crit. Care Med."},{"issue":"10219","key":"10.1016\/j.intimp.2026.116978_bb0010","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.intimp.2026.116978_bb0015","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s13054-020-02950-2","article-title":"Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019- results from a systematic review and meta-analysis","volume":"24","author":"Bauer","year":"2020","journal-title":"Crit. Care"},{"issue":"24","key":"10.1016\/j.intimp.2026.116978_bb0020","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1182\/blood-2015-11-680744","article-title":"Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients","volume":"127","author":"Claushuis","year":"2016","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.intimp.2026.116978_bb0025","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1182\/blood-2014-05-573915","article-title":"Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice","volume":"124","author":"de Stoppelaar","year":"2014","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.intimp.2026.116978_bb0030","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1182\/blood.2024024901","article-title":"Aging platelets shift their hemostatic properties to inflammatory functions","volume":"145","author":"Anjum","year":"2025","journal-title":"Blood"},{"issue":"Pt 3","key":"10.1016\/j.intimp.2026.116978_bb0035","article-title":"Tyrphostin AG538 inhibits platelet activation and thrombosis via TREM2 agonism","volume":"242","author":"Liu","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116978_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114330","article-title":"TREM2 improves coagulopathy and lung inflammation in sepsis through the AKT-mTOR pathway","volume":"150","author":"Zhou","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116978_bb0045","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13024-022-00542-y","article-title":"TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target","volume":"17","author":"Li","year":"2022","journal-title":"Mol. Neurodegener."},{"issue":"9","key":"10.1016\/j.intimp.2026.116978_bb0050","doi-asserted-by":"crossref","first-page":"e20200785","DOI":"10.1084\/jem.20200785","article-title":"Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer\u2019s disease model","volume":"217","author":"Wang","year":"2020","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.116978_bb0055","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4103\/mgr.MEDGASRES-D-24-00096","article-title":"Hyperbaric oxygen therapy as an adjunt treatment for glioma and brain metastasis: a literature review","volume":"15","author":"Cai","year":"2025","journal-title":"Med Gas Res."},{"issue":"4","key":"10.1016\/j.intimp.2026.116978_bb0060","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/2045-9912.385939","article-title":"The effects of nitric oxide in Alzheimer\u2019s disease","volume":"14","author":"Wang","year":"2024","journal-title":"Med Gas Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116978_bb0065","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/mgr.MEDGASRES-D-24-00005","article-title":"Ozone: complicated effects in central nervous system diseases","volume":"15","author":"Zhang","year":"2025","journal-title":"Med Gas Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.116978_bb0070","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.7150\/ijbs.91519","article-title":"TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-\u03baB\/CXCL3 axis","volume":"20","author":"Fang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"22","key":"10.1016\/j.intimp.2026.116978_bb0075","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1016\/j.cell.2022.09.033","article-title":"TREM2 drives microglia response to amyloid-\u03b2 via SYK-dependent and -independent pathways","volume":"185","author":"Wang","year":"2022","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.intimp.2026.116978_bb0080","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jhep.2022.05.044","article-title":"TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation","volume":"77","author":"Labiano","year":"2022","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.intimp.2026.116978_bb0085","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jhep.2022.05.044","article-title":"TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation","volume":"77","author":"Labiano","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2026.116978_bb0090","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.bbi.2023.11.021","article-title":"Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO","volume":"115","author":"Zhang","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"15","key":"10.1016\/j.intimp.2026.116978_bb0095","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3390\/cells14151137","article-title":"The effect of Ursodeoxycholic acid (UDCA) on serum expression of miR-34a and miR-506 in patients with chronic cholestatic liver diseases","volume":"14","author":"Cielica","year":"2025","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2026.116978_bb0100","doi-asserted-by":"crossref","first-page":"24285","DOI":"10.1038\/s41598-024-75516-9","article-title":"UDCA ameliorates inflammation driven EMT by inducing TGR5 dependent SOCS1 expression in mouse macrophages","volume":"14","author":"Fathima","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.116978_bb0105","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1161\/CIRCULATIONAHA.120.046290","article-title":"PCSK9 (proprotein convertase subtilisin\/Kexin 9) enhances platelet activation, thrombosis, and myocardial infarct expansion by binding to platelet CD36","volume":"143","author":"Qi","year":"2021","journal-title":"Circulation"},{"issue":"13","key":"10.1016\/j.intimp.2026.116978_bb0110","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/CIRCULATIONAHA.114.013743","article-title":"Nucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis","volume":"131","author":"Zhang","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2026.116978_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114315","article-title":"GSK669, a NOD2 receptor antagonist, inhibits thrombosis and oxidative stress via targeting platelet GPVI","volume":"183","author":"Pan","year":"2021","journal-title":"Biochem. Pharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2026.116978_bb0120","doi-asserted-by":"crossref","first-page":"851","DOI":"10.14348\/molcells.2015.0094","article-title":"Ursodeoxycholic acid (UDCA) exerts anti-atherogenic effects by inhibiting endoplasmic reticulum (ER) stress induced by disturbed flow","volume":"38","author":"Chung","year":"2015","journal-title":"Mol. Cell"},{"issue":"9","key":"10.1016\/j.intimp.2026.116978_bb0125","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1136\/gutjnl-2017-315259","article-title":"The British Society of Gastroenterology\/UK-PBC primary biliary cholangitis treatment and management guidelines","volume":"67","author":"Hirschfield","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2026.116978_bb0130","article-title":"Lactobacillus acidophilus and its metabolite ursodeoxycholic acid ameliorate ulcerative colitis by promoting Treg differentiation and inhibiting M1 macrophage polarization","volume":"15","author":"Deng","year":"2024","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116978_bb0135","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/jcp.30619","article-title":"Taurolithocholic acid but not tauroursodeoxycholic acid rescues phagocytosis activity of bone marrow-derived macrophages under inflammatory stress","volume":"237","author":"Wu","year":"2022","journal-title":"J. Cell. Physiol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:31:55Z","timestamp":1784230315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926008246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"alternative-id":["S1567576926008246"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116978","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ursodeoxycholic acid attenuates sepsis-associated platelet dysfunction through TREM2-linked signaling","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116978","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116978"}}