{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:07:59Z","timestamp":1784232479159,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2017-JYB-JS-057"],"award-info":[{"award-number":["2017-JYB-JS-057"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.intimp.2026.116986","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:18:01Z","timestamp":1781655481000},"page":"116986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Daphnetin alleviates neuropathic pain in rats by modulating spinal microglial polarization via the Nrf2\/NLRP3 inflammasome pathway"],"prefix":"10.1016","volume":"185","author":[{"given":"Wulin","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiling","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minke","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.116986_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2021.102030","article-title":"Neuropathic pain modeling: focus on synaptic and ion channel mechanisms","volume":"201","author":"Bouali-Benazzouz","year":"2021","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.intimp.2026.116986_b0010","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev-pharmtox-051421-112259","article-title":"Neuropathic pain: mechanisms, sex differences, and potential therapies for a global problem","volume":"63","author":"Ghazisaeidi","year":"2023","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116986_b0015","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pain.2007.12.011","article-title":"Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study","volume":"138","author":"Gordh","year":"2008","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.intimp.2026.116986_b0020","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/GRF.0000000000000412","article-title":"Psychology of chronic pelvic pain: prevalence, neurobiological vulnerabilities, and treatment","volume":"62","author":"Till","year":"2019","journal-title":"Clin. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.intimp.2026.116986_b0025","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrn.2018.2","article-title":"Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential","volume":"19","author":"Inoue","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116986_b0030","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12974-022-02495-x","article-title":"DKK3 ameliorates neuropathic pain via inhibiting ASK-1\/JNK\/p-38-mediated microglia polarization and neuroinflammation","volume":"19","author":"Zhang","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"10.1016\/j.intimp.2026.116986_b0035","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1002\/ptr.7396","article-title":"Kaempferol exerts a neuroprotective effect to reduce neuropathic pain through TLR4\/NF-\u0138B signaling pathway","volume":"36","author":"Chang","year":"2022","journal-title":"Phytother. Res."},{"issue":"23","key":"10.1016\/j.intimp.2026.116986_b0040","doi-asserted-by":"crossref","first-page":"8138","DOI":"10.3390\/molecules27238138","article-title":"Syringaresinol alleviates Oxaliplatin-induced neuropathic pain symptoms by inhibiting the inflammatory responses of spinal microglia","volume":"27","author":"Lee","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.intimp.2026.116986_b0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/13872877241313223","article-title":"Microglial polarization in Alzheimer's disease: mechanisms, implications, and therapeutic opportunities","volume":"104","author":"Yang","year":"2025","journal-title":"J. Alzheimer's disease: JAD."},{"issue":"1","key":"10.1016\/j.intimp.2026.116986_b0050","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12974-021-02178-z","article-title":"Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice","volume":"18","author":"Shao","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.intimp.2026.116986_b0055","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s10787-023-01216-x","article-title":"Microglia polarization in nociplastic pain: mechanisms and perspectives","volume":"31","author":"Atta","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2026.116986_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155594","article-title":"Huangqin decoction attenuates spared nerve injury (SNI)-induced neuropathic pain by modulating microglial M1\/M2 polarization partially mediated by intestinal nicotinamide metabolism","volume":"129","author":"Gao","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.intimp.2026.116986_b0065","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12974-018-1054-3","article-title":"Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats","volume":"15","author":"Wang","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116986_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154725","article-title":"Gastrodin programs an Arg-1(+) microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice","volume":"113","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116986_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113863","article-title":"Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators","volume":"175","author":"Liu","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.116986_b0080","first-page":"149","article-title":"Nrf2 in the field of dentistry with special attention to NLRP3","volume":"11","author":"Schieffer","year":"2022","journal-title":"Antioxidants (Basel, Switzerland)."},{"key":"10.1016\/j.intimp.2026.116986_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153692","article-title":"Magnolol attenuates depressive-like behaviors by polarizing microglia towards the M2 phenotype through the regulation of Nrf2\/HO-1\/NLRP3 signaling pathway","volume":"91","author":"Tao","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116986_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.993562","article-title":"Daphnetin: a bioactive natural coumarin with diverse therapeutic potentials","volume":"13","author":"Javed","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116986_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153241","article-title":"Enhanced Keap1-Nrf2\/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1\/JNK and Txnip\/NLRP3 inflammasome activation","volume":"71","author":"Lv","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.116986_b0100","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.579178","article-title":"Daphnetin attenuated cisplatin-induced acute nephrotoxicity with enhancing antitumor activity of cisplatin by upregulating SIRT1\/SIRT6-Nrf2 pathway","volume":"11","author":"Fan","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.116986_b0105","article-title":"Daphnetin inhibits spinal glial activation via Nrf2\/HO-1\/NF-\u03baB signaling pathway and attenuates CFA-induced inflammatory pain","volume":"98","author":"Y, Y., Q, S., Z, N., L, L., W, Z., G, C., F, Y., L, S., Z, L., J, X., D, W","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2026.116986_b0110","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/jnen\/nlae043","article-title":"Daphnetin protects neurons in an Alzheimer disease mouse model and normal rat neurons by inhibiting BACE1 activity and activating the Nrf2\/HO-1 pathway","volume":"83","author":"Zhang","year":"2024","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"6","key":"10.1016\/j.intimp.2026.116986_b0115","first-page":"503","article-title":"Daphnetin attenuates OGD\/R-induced inflammatory response and apoptosis in hippocampal neurons by inhibiting TXNIP\/NLRP3 signaling pathway","volume":"29","author":"Zhao","year":"2022","journal-title":"Stroke and Nervous Diseases."},{"issue":"6","key":"10.1016\/j.intimp.2026.116986_b0120","article-title":"Daphnetin ameliorates neuropathic pain via regulation of microglial responses and Glycerophospholipid metabolism in the spinal cord","volume":"17","author":"Liang","year":"2024","journal-title":"Pharmaceuticals (Basel, Switzerland)."},{"issue":"2","key":"10.1016\/j.intimp.2026.116986_b0125","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3390\/ph16020243","article-title":"Daphnetin improves neuropathic pain by inhibiting the expression of chemokines and inflammatory factors in the spinal cord and interfering with glial cell polarization","volume":"16","author":"Zhang","year":"2023","journal-title":"Pharmaceuticals (Basel, Switzerland)."},{"issue":"2","key":"10.1016\/j.intimp.2026.116986_b0130","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0165-0270(95)00164-6","article-title":"Lumbar catheterization of the spinal subarachnoid space in the rat","volume":"65","author":"St\u00f8rkson","year":"1996","journal-title":"J. Neurosci. Methods"},{"issue":"2\u20133","key":"10.1016\/j.intimp.2026.116986_b0135","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0304-3959(98)00017-7","article-title":"The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models","volume":"75","author":"Jasmin","year":"1998","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.intimp.2026.116986_b0140","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic pain: from mechanisms to treatment","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.intimp.2026.116986_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105280","article-title":"Neuroinflammation, oxidative stress and their interplay in neuropathic pain: focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies","volume":"162","author":"Teixeira-Santos","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2026.116986_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175901","article-title":"NLR family pyrin domain containing 3 (NLRP3) inflammasomes and peripheral neuropathic pain - emphasis on microRNAs (miRNAs) as important regulators","volume":"955","author":"Basu","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2026.116986_b0155","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11064-021-03459-y","article-title":"Salidroside alleviates chronic constriction injury-induced neuropathic pain and inhibits of TXNIP\/NLRP3 pathway","volume":"47","author":"Hu","year":"2022","journal-title":"Neurochem. Res."},{"issue":"9","key":"10.1016\/j.intimp.2026.116986_b0160","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.3390\/biom11091343","article-title":"Neuropathic pain: biomolecular intervention and imaging via targeting microglia activation","volume":"11","author":"Ji","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.intimp.2026.116986_b0165","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/imr.13317","article-title":"Epigenetic control of microglial immune responses","volume":"323","author":"Scholz","year":"2024","journal-title":"Immunol. Rev."},{"issue":"9","key":"10.1016\/j.intimp.2026.116986_b0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26093964","article-title":"Paeonol relieves chronic neuropathic pain by reducing communication between Schwann cells and macrophages in the dorsal root ganglia after injury","volume":"26","author":"Li","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116986_b0175","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/978-3-031-55529-9_22","article-title":"Microglia in neuropathic pain","volume":"37","author":"Inoue","year":"2024","journal-title":"Adv. Neurobiol."},{"issue":"9","key":"10.1016\/j.intimp.2026.116986_b0180","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1111\/cns.14211","article-title":"Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA\/p38MAPK signaling pathway","volume":"29","author":"Li","year":"2023","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.116986_b0185","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11481-025-10202-9","article-title":"(+)-Catechin alleviates CCI-induced neuropathic pain by modulating microglia M1 and M2 polarization via the TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"20","author":"Jing","year":"2025","journal-title":"J. Neuroimmune Pharmacol. Official J. Society on Neuroimmune Pharmacol."},{"key":"10.1016\/j.intimp.2026.116986_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1182621","article-title":"Regulation of microglia polarization after cerebral ischemia","volume":"17","author":"Wang","year":"2023","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.116986_b0195","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12974-021-02137-8","article-title":"Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke","volume":"18","author":"Xu","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.116986_b0200","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.01016","article-title":"The NLRP3 inflammasome: role and therapeutic potential in pain treatment","volume":"11","author":"Starobova","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.intimp.2026.116986_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104339","article-title":"Pharmacological inhibition of the NLRP3 inflammasome as a potential target for cancer-induced bone pain","volume":"147","author":"Chen","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.116986_b0210","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12974-018-1073-0","article-title":"miRNA-23a\/CXCR4 regulates neuropathic pain via directly targeting TXNIP\/NLRP3 inflammasome axis","volume":"15","author":"Pan","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"24","key":"10.1016\/j.intimp.2026.116986_b0215","doi-asserted-by":"crossref","first-page":"E3441","DOI":"10.1073\/pnas.1602070113","article-title":"Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation","volume":"113","author":"Grace","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.intimp.2026.116986_b0220","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s10787-021-00861-4","article-title":"Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer's disease: flavonoids and phenols","volume":"29","author":"Zhang","year":"2021","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.intimp.2026.116986_b0225","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2174\/1570159X20666220830115018","article-title":"Secondary white matter injury mediated by Neuroinflammation after intracerebral hemorrhage and promising therapeutic strategies of targeting the NLRP3 Inflammasome","volume":"21","author":"Xiao","year":"2023","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.intimp.2026.116986_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155578","article-title":"Aloe-emodin alleviates cerebral ischemia-reperfusion injury by regulating microglial polarization and pyroptosis through inhibition of NLRP3 inflammasome activation","volume":"129","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.intimp.2026.116986_b0235","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.4103\/1673-5374.389302","article-title":"Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway","volume":"19","author":"Li","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"13","key":"10.1016\/j.intimp.2026.116986_b0240","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.3390\/ijms21134777","article-title":"NRF2, a transcription factor for stress response and beyond","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.116986_b0245","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2018.03.007","article-title":"Nrf2 inhibits oxaliplatin-induced peripheral neuropathy via protection of mitochondrial function","volume":"120","author":"Yang","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2026.116986_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105746","article-title":"Nrf2\/HO-1 signaling pathway participated in the protection of hydrogen sulfide on neuropathic pain in rats","volume":"75","author":"Chen","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2026.116986_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107846","article-title":"The therapeutic potential of Nrf2 inducers in chronic pain: evidence from preclinical studies","volume":"225","author":"Zhou","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2026.116986_b0260","first-page":"430","article-title":"The effects of nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) activation in preclinical models of peripheral neuropathic pain","volume":"11","author":"Basu","year":"2022","journal-title":"Antioxidants (Basel, Switzerland)."},{"issue":"5","key":"10.1016\/j.intimp.2026.116986_b0265","first-page":"870","article-title":"NLRP3 Inflammasome and Pyroptosis in liver pathophysiology: the emerging relevance of Nrf2 inducers","volume":"11","author":"Hurtado-Navarro","year":"2022","journal-title":"Antioxidants (Basel, Switzerland)."},{"key":"10.1016\/j.intimp.2026.116986_b0270","article-title":"The Nrf2 pathway in liver diseases","volume":"10","author":"Zhou","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2026.116986_b0275","article-title":"Coumarins as modulators of the Keap1\/Nrf2\/ARE signaling pathway","author":"EHM","year":"2020","journal-title":"Oxid. Med. Cell. Longev. 2020"},{"issue":"6","key":"10.1016\/j.intimp.2026.116986_b0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3724\/abbs.2025002","article-title":"Daphnetin-mediated mitophagy alleviates intervertebral disc degeneration via the Nrf2\/PINK1 pathway","volume":"57","author":"Tu","year":"2025","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"10","key":"10.1016\/j.intimp.2026.116986_b0285","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1016\/j.bmcl.2013.03.013","article-title":"Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction","volume":"23","author":"Hu","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"4","key":"10.1016\/j.intimp.2026.116986_b0290","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.apsb.2015.05.008","article-title":"Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents","volume":"5","author":"Abed","year":"2015","journal-title":"Acta Pharm. Sin. B"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:31:46Z","timestamp":1784230306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926008325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":58,"alternative-id":["S1567576926008325"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116986","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Daphnetin alleviates neuropathic pain in rats by modulating spinal microglial polarization via the Nrf2\/NLRP3 inflammasome pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.116986","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116986"}}