{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:11:21Z","timestamp":1784232681956,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MH019"],"award-info":[{"award-number":["ZR2023MH019"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071635"],"award-info":[{"award-number":["82071635"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.intimp.2026.117012","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:50:36Z","timestamp":1781542236000},"page":"117012","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Electrical stimulation improves arteriogenic erectile dysfunction by modulating CYLD-mediated macrophage\u2013smooth muscle cell crosstalk"],"prefix":"10.1016","volume":"185","author":[{"given":"Guanbo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjie","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2026.117012_bb0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jsxm.2015.12.019","article-title":"Definitions of sexual dysfunctions in women and men: a consensus statement from the fourth international consultation on sexual medicine 2015","volume":"13","author":"McCabe","year":"2016","journal-title":"J. Sex. Med."},{"issue":"5","key":"10.1016\/j.intimp.2026.117012_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11050283","article-title":"Safety and efficacy of Intracavernosal injections of AbobotulinumtoxinA (Dysport((R))) as add on therapy to Phosphosdiesterase type 5 inhibitors or prostaglandin E1 for erectile dysfunction-case studies","volume":"11","author":"Giuliano","year":"2019","journal-title":"Toxins (Basel)"},{"issue":"1","key":"10.1016\/j.intimp.2026.117012_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001372","article-title":"Erectile dysfunction severity as a risk marker for cardiovascular disease hospitalisation and all-cause mortality: a prospective cohort study","volume":"10","author":"Banks","year":"2013","journal-title":"PLoS Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.117012_bb0020","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1743-6109.2005.20103.x","article-title":"Pathophysiology of erectile dysfunction","volume":"2","author":"Saenz de Tejada","year":"2005","journal-title":"J. Sex. Med."},{"issue":"5","key":"10.1016\/j.intimp.2026.117012_bb0025","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1024\/0301-1526\/a000627","article-title":"Erectile dysfunction - overview from a cardiovascular perspective","volume":"46","author":"Baumann","year":"2017","journal-title":"Vasa"},{"issue":"8","key":"10.1016\/j.intimp.2026.117012_bb0030","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1111\/andr.13283","article-title":"Significance of detailed hematological parameters as markers of arteriogenic erectile dysfunction","volume":"10","author":"Liu","year":"2022","journal-title":"Andrology"},{"issue":"9","key":"10.1016\/j.intimp.2026.117012_bb0035","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/j.1464-410X.2007.07376.x","article-title":"Long-term treatment of erectile dysfunction with a phosphodiesterase-5 inhibitor and dose optimization based on nocturnal penile tumescence","volume":"101","author":"Mathers","year":"2008","journal-title":"BJU Int."},{"issue":"5","key":"10.1016\/j.intimp.2026.117012_bb0040","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.14336\/AD.2019.1028","article-title":"Practical approaches to treat ED in PDE5i nonresponders","volume":"11","author":"Cai","year":"2020","journal-title":"Aging Dis."},{"issue":"5","key":"10.1016\/j.intimp.2026.117012_bb0045","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.juro.2011.12.117","article-title":"Does low intensity extracorporeal shock wave therapy have a physiological effect on erectile function? Short-term results of a randomized, double-blind, sham controlled study","volume":"187","author":"Vardi","year":"2012","journal-title":"J Urol"},{"issue":"9","key":"10.1016\/j.intimp.2026.117012_bb0050","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.29271\/jcpsp.2022.09.1181","article-title":"Effects of low-intensity extracorporeal shockwave therapy on erectile dysfunction: a systematic review and Meta-analysis","volume":"32","author":"Liu","year":"2022","journal-title":"J. Coll. Physicians Surg. Pak."},{"issue":"8","key":"10.1016\/j.intimp.2026.117012_bb0055","first-page":"691","article-title":"Transcutaneous neuromuscular electrical stimulation for the treatment of erectile dysfunction: a clinical observation","volume":"28","author":"Zhang","year":"2022","journal-title":"Zhonghua Nan Ke Xue"},{"issue":"4","key":"10.1016\/j.intimp.2026.117012_bb0060","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.sxmr.2019.05.005","article-title":"Impact of immune system activation and vascular impairment on male and female sexual dysfunction","volume":"7","author":"Calmasini","year":"2019","journal-title":"Sex Med Rev"},{"issue":"2","key":"10.1016\/j.intimp.2026.117012_bb0065","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/sxmrev\/qead055","article-title":"The pathogenic role of the immune system in erectile dysfunction and Peyronie's disease: focusing on immunopathophysiology and potential therapeutic strategies","volume":"12","author":"Giagulli","year":"2024","journal-title":"Sex Med Rev"},{"issue":"2","key":"10.1016\/j.intimp.2026.117012_bb0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jsxm.2016.12.012","article-title":"M1 macrophages are predominantly recruited to the major pelvic ganglion of the rat following cavernous nerve injury","volume":"14","author":"Matsui","year":"2017","journal-title":"J. Sex. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.117012_bb0075","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jsxm.2021.01.180","article-title":"Macrophage-specific toll like receptor 9 (TLR9) causes Corpus cavernosum dysfunction in mice fed a high fat diet","volume":"18","author":"Priviero","year":"2021","journal-title":"J. Sex. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.117012_bb0080","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2174\/1389450115666141024152421","article-title":"CYLD-mediated signaling and diseases","volume":"16","author":"Mathis","year":"2015","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.intimp.2026.117012_bb0085","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.2147\/JIR.S307841","article-title":"Upregulation of neuronal Cylindromatosis expression is essential for electroacupuncture-mediated alleviation of neuroinflammatory injury by regulating microglial polarization in rats subjected to focal cerebral ischemia\/reperfusion","volume":"14","author":"Lin","year":"2021","journal-title":"J. Inflamm. Res."},{"issue":"4","key":"10.1016\/j.intimp.2026.117012_bb0090","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/ATVBAHA.121.316233","article-title":"Crosstalk between macrophages and vascular smooth muscle cells in atherosclerotic plaque stability","volume":"42","author":"Yurdagul","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117012_bb0095","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41420-024-01859-x","article-title":"Galectin-3 is involved in inflammation and fibrosis in arteriogenic erectile dysfunction via the TLR4\/MyD88\/NF-kappaB pathway","volume":"10","author":"Wang","year":"2024","journal-title":"Cell Death Discov."},{"issue":"3","key":"10.1016\/j.intimp.2026.117012_bb0100","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/nau.24896","article-title":"The preventive effects of colony-stimulating factor 1 receptor (CSF-1R) inhibition on bladder outlet obstruction induced remodeling","volume":"41","author":"Wang","year":"2022","journal-title":"Neurourol.Urodyn."},{"issue":"1","key":"10.1016\/j.intimp.2026.117012_bb0105","article-title":"Establishing a thermal imaging technology (IRT) based system for evaluating rat erectile function","volume":"10","author":"Liu","year":"2022","journal-title":"Sex Med"},{"key":"10.1016\/j.intimp.2026.117012_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115449","article-title":"Therapeutic potential of mesenchymal stem cell-derived exosomal miR-296-5p and miR-337-3p in age-related erectile dysfunction via regulating PTEN\/PI3K\/AKT pathway","volume":"167","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2026.117012_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116964","article-title":"miR-200a-3p-enriched MSC-derived extracellular vesicles reverse erectile function in diabetic rats by targeting Keap1","volume":"177","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.intimp.2026.117012_bb0120","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1001\/archinte.166.2.213","article-title":"The prevalence of erectile dysfunction in the primary care setting: importance of risk factors for diabetes and vascular disease","volume":"166","author":"Grover","year":"2006","journal-title":"Arch. Intern. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.117012_bb0125","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5534\/wjmh.190031","article-title":"Molecular and histologic evidence of novel erectile dysfunction rat model as an aging atherosclerosis model: a preliminary study","volume":"38","author":"Kim","year":"2020","journal-title":"World J Mens Health"},{"issue":"1","key":"10.1016\/j.intimp.2026.117012_bb0130","doi-asserted-by":"crossref","DOI":"10.4068\/cmj.2009.45.1.1","article-title":"Oxidative stress and molecular reactions in Arteriogenic erectile dysfunction","volume":"45","author":"Azadzoi","year":"2009","journal-title":"Chonnam Med. J."},{"key":"10.1016\/j.intimp.2026.117012_bb0135","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ijcard.2014.12.072","article-title":"Acute effect of sildenafil on inflammatory markers\/mediators in patients with vasculogenic erectile dysfunction","volume":"182","author":"Vlachopoulos","year":"2015","journal-title":"Int. J. Cardiol."},{"issue":"10","key":"10.1016\/j.intimp.2026.117012_bb0140","first-page":"1033","article-title":"Study on the mechanism of electroacupuncture regulating macrophage polarization to improve ulcerative colitis in rats","volume":"48","author":"Xu","year":"2023","journal-title":"Zhen Ci Yan Jiu"},{"issue":"3","key":"10.1016\/j.intimp.2026.117012_bb0145","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/09645284221118588","article-title":"Electroacupuncture pretreatment protects septic rats from acute lung injury by relieving inflammation and regulating macrophage polarization","volume":"41","author":"Zhou","year":"2023","journal-title":"Acupunct. Med."},{"issue":"5","key":"10.1016\/j.intimp.2026.117012_bb0150","doi-asserted-by":"crossref","first-page":"520","DOI":"10.7150\/ijbs.8879","article-title":"Macrophage polarization in inflammatory diseases","volume":"10","author":"Liu","year":"2014","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117012_bb0155","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12964-022-00993-2","article-title":"How vascular smooth muscle cell phenotype switching contributes to vascular disease","volume":"20","author":"Cao","year":"2022","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.intimp.2026.117012_bb0160","article-title":"ShenLian extract enhances TGF-beta functions in the macrophage-SMC unit and stabilizes atherosclerotic plaques","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117012_bb0165","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/107632703322495529","article-title":"Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices","volume":"9","author":"Falke","year":"2003","journal-title":"Tissue Eng."},{"issue":"3","key":"10.1016\/j.intimp.2026.117012_bb0170","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00441-014-1902-0","article-title":"Phenotypic transition of corpus cavernosum smooth muscle cells subjected to hypoxia","volume":"357","author":"Lv","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.intimp.2026.117012_bb0175","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12950-019-0233-z","article-title":"Corpus cavernosum smooth muscle cell dysfunction and phenotype transformation are related to erectile dysfunction in prostatitis rats with chronic prostatitis\/chronic pelvic pain syndrome","volume":"17","author":"Wang","year":"2020","journal-title":"J Inflamm (Lond)"},{"issue":"9","key":"10.1016\/j.intimp.2026.117012_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25094647","article-title":"Type II Interleukin-4 receptor activation in basal breast Cancer cells promotes tumor progression via metabolic and epigenetic modulation","volume":"25","author":"Williams","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.intimp.2026.117012_bb0185","doi-asserted-by":"crossref","first-page":"5966","DOI":"10.4049\/jimmunol.179.9.5966","article-title":"Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia","volume":"179","author":"Qin","year":"2007","journal-title":"J. Immunol."},{"issue":"46","key":"10.1016\/j.intimp.2026.117012_bb0190","doi-asserted-by":"crossref","first-page":"38495","DOI":"10.1074\/jbc.M112.353649","article-title":"Acetylation of myocardin is required for the activation of cardiac and smooth muscle genes","volume":"287","author":"Cao","year":"2012","journal-title":"J. Biol. Chem."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:39:40Z","timestamp":1784230780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926008581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":38,"alternative-id":["S1567576926008581"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117012","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electrical stimulation improves arteriogenic erectile dysfunction by modulating CYLD-mediated macrophage\u2013smooth muscle cell crosstalk","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117012"}}