{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:08:57Z","timestamp":1784232537000,"version":"3.55.0"},"reference-count":164,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-11-32"],"award-info":[{"award-number":["320.6750.2024-11-32"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601449"],"award-info":[{"award-number":["81601449"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500116"],"award-info":[{"award-number":["81500116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["202311"],"award-info":[{"award-number":["202311"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["2023XZD098"],"award-info":[{"award-number":["2023XZD098"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["20250PSFX6P002Y"],"award-info":[{"award-number":["20250PSFX6P002Y"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.intimp.2026.117027","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:04:07Z","timestamp":1781611447000},"page":"117027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Block, clear, and boost: a novel therapeutic framework for targeting intercellular mitochondrial transfer in Cancer immunotherapy"],"prefix":"10.1016","volume":"185","author":[{"given":"Ruoyan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhening","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuopeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0005","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0010","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri2975","article-title":"Mitochondria in innate immune responses","volume":"11","author":"West","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0015","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic competition in the tumor microenvironment is a driver of Cancer progression","volume":"162","author":"Chang","year":"2015","journal-title":"Cell"},{"issue":"8049","key":"10.1016\/j.intimp.2026.117027_bb0020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41586-024-08439-0","article-title":"Immune evasion through mitochondrial transfer in the tumour microenvironment","volume":"638","author":"Ikeda","year":"2025","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0025","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41392-024-01868-3","article-title":"Targeting cytokine and chemokine signaling pathways for cancer therapy","volume":"9","author":"Yi","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22063245","article-title":"Mitochondrial transfer in Cancer: a comprehensive review","volume":"22","author":"Zampieri","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.intimp.2026.117027_bb0035","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.ccell.2023.09.003","article-title":"Systematic investigation of mitochondrial transfer between cancer cells and T cells at single-cell resolution","volume":"41","author":"Zhang","year":"2023","journal-title":"Cancer Cell"},{"issue":"8075","key":"10.1016\/j.intimp.2026.117027_bb0040","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41586-025-09176-8","article-title":"Nerve-to-cancer transfer of mitochondria during cancer metastasis","volume":"644","author":"Hoover","year":"2025","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0045","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s13046-024-03087-8","article-title":"Mitochondrial transfer from adipose stem cells to breast cancer cells drives multi-drug resistance","volume":"43","author":"Del Vecchio","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"23","key":"10.1016\/j.intimp.2026.117027_bb0050","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1016\/j.cell.2024.08.029","article-title":"Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy","volume":"187","author":"Baldwin","year":"2024","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25031857","article-title":"Endothelial mitochondria transfer to melanoma induces M2-type macrophage polarization and promotes tumor growth by the Nrf2\/HO-1-mediated pathway","volume":"25","author":"Kuo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.intimp.2026.117027_bb0060","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105789","article-title":"Peering into tunneling nanotubes-the path forward","volume":"40","author":"Cordero Cervantes","year":"2021","journal-title":"EMBO J."},{"issue":"5660","key":"10.1016\/j.intimp.2026.117027_bb0065","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1126\/science.1093133","article-title":"Nanotubular highways for intercellular organelle transport","volume":"303","author":"Rustom","year":"2004","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.intimp.2026.117027_bb0070","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41419-023-05835-8","article-title":"Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of \u03b1-Synuclein and mitochondria","volume":"14","author":"Chakraborty","year":"2023","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.intimp.2026.117027_bb0075","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/ncb1990","article-title":"M-sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex","volume":"11","author":"Hase","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0080","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1038\/s41467-023-40680-5","article-title":"Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired","volume":"14","author":"Liang","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0085","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/s41467-021-21984-w","article-title":"Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs","volume":"12","author":"Todkar","year":"2021","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0090","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1177\/0271678X251349304","article-title":"Extracellular vesicle-mediated mitochondria delivery: premise and promise","volume":"46","author":"Manickam","year":"2026","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.intimp.2026.117027_bb0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.mito.2019.02.002","article-title":"Forms of extracellular mitochondria and their impact in health","volume":"48","author":"Miliotis","year":"2019","journal-title":"Mitochondrion"},{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0100","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/tra.12786","article-title":"Transfer of mitochondria and endosomes between cells by gap junction internalization","volume":"22","author":"Norris","year":"2021","journal-title":"Traffic"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0105","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1186\/s13287-024-03932-9","article-title":"Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes","volume":"15","author":"Irwin","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"39","key":"10.1016\/j.intimp.2026.117027_bb0110","doi-asserted-by":"crossref","first-page":"36725","DOI":"10.1074\/jbc.M109797200","article-title":"Gap junctions between cells expressing connexin 43 or 32 show inverse permselectivity to adenosine and ATP","volume":"277","author":"Goldberg","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2026.117027_bb0115","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.82206","article-title":"Connexin 43 hemichannels regulate mitochondrial ATP generation, mobilization, and mitochondrial homeostasis against oxidative stress","volume":"11","author":"Zhang","year":"2022","journal-title":"Elife"},{"issue":"12","key":"10.1016\/j.intimp.2026.117027_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210294","article-title":"Extracellular vesicles and Cx43-gap junction channels are the Main routes for mitochondrial transfer from ultra-purified mesenchymal stem cells, RECs","volume":"24","author":"Yang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.intimp.2026.117027_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114652","article-title":"Beyond mitochondrial transfer, cell fusion rescues metabolic dysfunction and boosts malignancy in adenoid cystic carcinoma","volume":"43","author":"Qiao","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2026.117027_bb0130","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/978-3-031-37936-9_19","article-title":"Mechanisms of cell fusion in Cancer","volume":"71","author":"Noubissi","year":"2024","journal-title":"Results Probl. Cell Differ."},{"issue":"31","key":"10.1016\/j.intimp.2026.117027_bb0135","doi-asserted-by":"crossref","first-page":"51370","DOI":"10.18632\/oncotarget.17986","article-title":"Fusion between M2-macrophages and cancer cells results in a subpopulation of radioresistant cells with enhanced DNA-repair capacity","volume":"8","author":"Lindstr\u00f6m","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0140","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"10","key":"10.1016\/j.intimp.2026.117027_bb0145","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1-Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0150","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202101287","article-title":"Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy","volume":"5","author":"Rusilowicz-Jones","year":"2022","journal-title":"Life Sci Alliance"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0155","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s44342-025-00064-1","article-title":"Mitochondrial transfer in cancer: mechanisms, immune evasion, and therapeutic opportunities","volume":"24","author":"Ka","year":"2026","journal-title":"Genomics Inform"},{"issue":"11","key":"10.1016\/j.intimp.2026.117027_bb0160","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1038\/s41590-024-02008-3","article-title":"How to feed mitochondria to T cells","volume":"25","author":"Bernard","year":"2024","journal-title":"Nat. Immunol."},{"issue":"28","key":"10.1016\/j.intimp.2026.117027_bb0165","doi-asserted-by":"crossref","first-page":"43150","DOI":"10.18632\/oncotarget.9504","article-title":"Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells","volume":"7","author":"Desir","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0170","doi-asserted-by":"crossref","first-page":"7826","DOI":"10.1038\/s41598-019-44346-5","article-title":"Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer","volume":"9","author":"Kretschmer","year":"2019","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.intimp.2026.117027_bb0175","article-title":"Mitochondrial transfer between Cancer and T cells: implications for immune evasion","volume":"14","author":"Chun","year":"2025","journal-title":"Antioxidants (Basel)"},{"issue":"43","key":"10.1016\/j.intimp.2026.117027_bb0180","doi-asserted-by":"crossref","first-page":"E9066","DOI":"10.1073\/pnas.1704862114","article-title":"Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer","volume":"114","author":"Sansone","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12943-021-01376-w","article-title":"The roles of tumor-derived exosomes in altered differentiation, maturation and function of dendritic cells","volume":"20","author":"Hosseini","year":"2021","journal-title":"Mol. Cancer"},{"issue":"10","key":"10.1016\/j.intimp.2026.117027_bb0190","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003217","article-title":"Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment","volume":"9","author":"Ma","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"8","key":"10.1016\/j.intimp.2026.117027_bb0195","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jacc.2020.12.060","article-title":"Mitochondria-rich extracellular vesicles from autologous stem cell-derived cardiomyocytes restore energetics of ischemic myocardium","volume":"77","author":"Ikeda","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"issue":"29","key":"10.1016\/j.intimp.2026.117027_bb0200","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adt1318","article-title":"Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine","volume":"11","author":"Lou","year":"2025","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.intimp.2026.117027_bb0205","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.7150\/thno.113741","article-title":"Nitric oxide-primed engineered extracellular vesicles restore bioenergetics in acute kidney injury via mitochondrial transfer","volume":"15","author":"Peng","year":"2025","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0210","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12943-024-02175-9","article-title":"Targeting mitochondria: restoring the antitumor efficacy of exhausted T cells","volume":"23","author":"Yang","year":"2024","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.intimp.2026.117027_bb0215","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/neuonc\/nox207","article-title":"Targeting different domains of gap junction protein to control malignant glioma","volume":"20","author":"Wang","year":"2018","journal-title":"Neuro-Oncology"},{"issue":"8","key":"10.1016\/j.intimp.2026.117027_bb0220","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.bbamem.2011.10.022","article-title":"Opposing roles of connexin43 in glioma progression","volume":"1818","author":"Sin","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0225","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12964-023-01085-5","article-title":"Intrinsic signalling factors associated with cancer cell-cell fusion","volume":"21","author":"Dittmar","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"9","key":"10.1016\/j.intimp.2026.117027_bb0230","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41419-024-07003-y","article-title":"Extracellular vesicle-associated DNA: ten years since its discovery in human blood","volume":"15","author":"Tsering","year":"2024","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.intimp.2026.117027_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15123225","article-title":"Enhancement of the anticancer ability of natural killer cells through allogeneic mitochondrial transfer","volume":"15","author":"Kim","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0240","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12935-020-01719-5","article-title":"The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment","volume":"21","author":"Emami Nejad","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"9","key":"10.1016\/j.intimp.2026.117027_bb0245","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1182\/blood-2006-07-035972","article-title":"Inhibitory effect of tumor cell-derived lactic acid on human T cells","volume":"109","author":"Fischer","year":"2007","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.intimp.2026.117027_bb0250","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.immuni.2021.05.003","article-title":"Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8(+) T cells in tumors","volume":"54","author":"Xu","year":"2021","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.intimp.2026.117027_bb0255","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s41590-020-0725-2","article-title":"Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen","volume":"21","author":"Vardhana","year":"2020","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0260","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.immuni.2011.12.007","article-title":"Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development","volume":"36","author":"van der Windt","year":"2012","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0265","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1038\/s41467-023-42634-3","article-title":"Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1\u03b1-mediated glycolytic reprogramming","volume":"14","author":"Wu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.117027_bb0270","doi-asserted-by":"crossref","first-page":"1572764","DOI":"10.3389\/fimmu.2025.1572764","article-title":"The impact of the tumor microenvironment on macrophages","volume":"16","author":"Xiao","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.117027_bb0275","doi-asserted-by":"crossref","first-page":"1453886","DOI":"10.3389\/fimmu.2024.1453886","article-title":"Mitochondrial regulation in the tumor microenvironment: targeting mitochondria for immunotherapy","volume":"15","author":"Ahn","year":"2024","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2026.117027_bb0280","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/stem.2372","article-title":"Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in vivo models of ARDS","volume":"34","author":"Jackson","year":"2016","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0285","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1038\/s41467-018-05077-9","article-title":"Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts","volume":"9","author":"Torralba","year":"2018","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.intimp.2026.117027_bb0290","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1158\/2326-6066.CIR-17-0581","article-title":"Exosomes shuttle TREX1-sensitive IFN-stimulatory dsDNA from irradiated Cancer cells to DCs","volume":"6","author":"Diamond","year":"2018","journal-title":"Cancer Immunol. Res."},{"issue":"12","key":"10.1016\/j.intimp.2026.117027_bb0295","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202006049","article-title":"PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness","volume":"220","author":"Rabas","year":"2021","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0300","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1038\/s41467-018-07505-2","article-title":"Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression","volume":"9","author":"Rice","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0305","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40364-025-00731-z","article-title":"Neutrophil extracellular traps in tumor metabolism and microenvironment","volume":"13","author":"Liu","year":"2025","journal-title":"Biomark. Res."},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/cells10020306","article-title":"The release kinetics of eosinophil peroxidase and mitochondrial DNA is different in association with eosinophil extracellular trap formation","volume":"10","author":"Germic","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2026.117027_bb0315","article-title":"USP30: structure, emerging physiological role, and target inhibition","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2026.117027_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101134","article-title":"Proteomic analysis demonstrates the role of the quality control protease LONP1 in mitochondrial protein aggregation","volume":"297","author":"Pollecker","year":"2021","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0325","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.molcel.2023.02.012","article-title":"Determinants and outcomes of mitochondrial dynamics","volume":"83","author":"Quintana-Cabrera","year":"2023","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0330","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202050827","article-title":"OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development","volume":"22","author":"Wu","year":"2021","journal-title":"EMBO Rep."},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0335","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s44318-024-00027-2","article-title":"In situ architecture of Opa1-dependent mitochondrial cristae remodeling","volume":"43","author":"Fry","year":"2024","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2026.117027_bb0340","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fcell.2020.00017","article-title":"T cell dysfunction and exhaustion in Cancer","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"8","key":"10.1016\/j.intimp.2026.117027_bb0345","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1016\/j.ymthe.2025.07.025","article-title":"Neurons fuel cancer metastasis through mitochondrial transfer","volume":"33","author":"Zhang","year":"2025","journal-title":"Mol. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0350","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41388-024-03228-5","article-title":"The influence of endothelial metabolic reprogramming on the tumor microenvironment","volume":"44","author":"Kane","year":"2025","journal-title":"Oncogene"},{"issue":"15","key":"10.1016\/j.intimp.2026.117027_bb0355","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16152769","article-title":"Adipose stem cells and their interplay with Cancer cells and mitochondrial reservoir: a new promising target","volume":"16","author":"Rehman","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"14","key":"10.1016\/j.intimp.2026.117027_bb0360","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.260419","article-title":"Mitochondrial transfer from cancer-associated fibroblasts increases migration in aggressive breast cancer","volume":"136","author":"Goliwas","year":"2023","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0365","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1158\/2767-9764.CRC-23-0144","article-title":"Mitochondria transfer from mesenchymal stem cells confers Chemoresistance to glioblastoma stem cells through metabolic rewiring","volume":"3","author":"Nakhle","year":"2023","journal-title":"Cancer Res Commun"},{"issue":"10","key":"10.1016\/j.intimp.2026.117027_bb0370","first-page":"1714","article-title":"MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation","volume":"6","author":"Cangkrama","year":"2025","journal-title":"Nat. Can."},{"issue":"11","key":"10.1016\/j.intimp.2026.117027_bb0375","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1182\/blood.2024026340","article-title":"The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against multiple myeloma","volume":"146","author":"Perini","year":"2025","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.intimp.2026.117027_bb0380","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2025-012069","article-title":"Mitochondrial pathway signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma","volume":"13","author":"Zhang","year":"2025","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0385","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1533","article-title":"A novel computational tool for tracking cancer energy hijacking from immune cells","volume":"14","author":"Zhang","year":"2024","journal-title":"Clin. Transl. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0390","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41568-024-00782-8","article-title":"Nanotubes power up T cells","volume":"25","author":"Brewer","year":"2025","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0395","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0960-9822(95)00128-X","article-title":"Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells","volume":"5","author":"Rizzuto","year":"1995","journal-title":"Curr. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0400","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.201603039","article-title":"Mito-QC illuminates mitophagy and mitochondrial architecture in vivo","volume":"214","author":"McWilliams","year":"2016","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0405","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s42003-024-05964-6","article-title":"Exploring the limitations of mitochondrial dye as a genuine horizontal mitochondrial transfer surrogate","volume":"7","author":"Chen","year":"2024","journal-title":"Commun Biol"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0410","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s42255-024-01200-x","article-title":"Recommendations for mitochondria transfer and transplantation nomenclature and characterization","volume":"7","author":"Brestoff","year":"2025","journal-title":"Nat. Metab."},{"issue":"8","key":"10.1016\/j.intimp.2026.117027_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104983","article-title":"Gi\/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a g\u03b2\u03b3\/PKC\u03b1\/FARP1\/Cdc42 axis","volume":"299","author":"Cooke","year":"2023","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.intimp.2026.117027_bb0420","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052306","article-title":"Opportunities and challenges in tunneling nanotubes research: how far from clinical application?","volume":"22","author":"Han","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.117027_bb0425","doi-asserted-by":"crossref","first-page":"33548","DOI":"10.1038\/srep33548","article-title":"Distinct roles for the N- and C-terminal regions of M-sec in plasma membrane deformation during tunneling nanotube formation","volume":"6","author":"Kimura","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0430","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4161\/cib.3.3.11242","article-title":"M-sec: emerging secrets of tunneling nanotube formation","volume":"3","author":"Ohno","year":"2010","journal-title":"Commun Integr Biol"},{"issue":"11","key":"10.1016\/j.intimp.2026.117027_bb0435","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1038\/s12276-022-00898-7","article-title":"Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer","volume":"54","author":"Kim","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0440","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12865-022-00514-3","article-title":"Blockade of exosome generation by GW4869 inhibits the education of M2 macrophages in prostate cancer","volume":"23","author":"Peng","year":"2022","journal-title":"BMC Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2026.117027_bb0445","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18138","article-title":"Exosome inhibition improves response to first-line therapy in small cell lung cancer","volume":"28","author":"Irep","year":"2024","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0450","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0455","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12416","article-title":"MISEV2023: An updated guide to EV research and applications","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.intimp.2026.117027_bb0460","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/bs.mie.2020.07.005","article-title":"Quantification of mtDNA in extracellular vesicles","volume":"645","author":"Soltesz","year":"2020","journal-title":"Methods Enzymol."},{"issue":"9","key":"10.1016\/j.intimp.2026.117027_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2022.100273","article-title":"Quantitative proteomics identifies proteins enriched in large and small extracellular vesicles","volume":"21","author":"Lischnig","year":"2022","journal-title":"Mol. Cell. Proteomics"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0470","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13283","article-title":"Mitochondrial DNA in extracellular vesicles declines with age","volume":"20","author":"Lazo","year":"2021","journal-title":"Aging Cell"},{"issue":"8","key":"10.1016\/j.intimp.2026.117027_bb0475","article-title":"Extracellular flux assay (seahorse assay): diverse applications in metabolic research across biological disciplines","volume":"47","author":"Yoo","year":"2024","journal-title":"Mol. Cell"},{"issue":"10","key":"10.1016\/j.intimp.2026.117027_bb0480","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202256380","article-title":"Calculation of ATP production rates using the seahorse XF analyzer","volume":"24","author":"Desousa","year":"2023","journal-title":"EMBO Rep."},{"issue":"5","key":"10.1016\/j.intimp.2026.117027_bb0485","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.immuni.2020.04.014","article-title":"Developmental relationships of four exhausted CD8(+) T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms","volume":"52","author":"Beltra","year":"2020","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.intimp.2026.117027_bb0490","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/s41590-019-0403-4","article-title":"Single-cell RNA-seq reveals TOX as a key regulator of CD8(+) T cell persistence in chronic infection","volume":"20","author":"Yao","year":"2019","journal-title":"Nat. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2026.117027_bb0495","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/s41590-020-0760-z","article-title":"Early precursor T cells establish and propagate T cell exhaustion in chronic infection","volume":"21","author":"Utzschneider","year":"2020","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0500","article-title":"MitoTracker transfers from astrocytes to neurons independently of mitochondria","volume":"6","author":"Hole","year":"2026","journal-title":"Cell Rep. Methods."},{"issue":"11","key":"10.1016\/j.intimp.2026.117027_bb0505","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/s41556-023-01246-1","article-title":"A guide to studying mitochondria transfer","volume":"25","author":"Tiash","year":"2023","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0510","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2417252121","article-title":"Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling","volume":"122","author":"Yardeni","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.intimp.2026.117027_bb0515","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1038\/s41591-025-03699-3","article-title":"Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma","volume":"31","author":"Monson","year":"2025","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.117027_bb0520","first-page":"659","article-title":"Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma","volume":"5","author":"Mahmood","year":"2024","journal-title":"Nat. Can."},{"issue":"10","key":"10.1016\/j.intimp.2026.117027_bb0525","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010008","article-title":"Leveraging mitochondrial-programmed cell death dynamics to enhance prognostic accuracy and immunotherapy efficacy in lung adenocarcinoma","volume":"12","author":"Zhang","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0530","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001882","article-title":"Fast progression in non-small cell lung cancer: results from the randomized phase III OAK study evaluating second-line atezolizumab versus docetaxel","volume":"9","author":"Gandara","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"D1","key":"10.1016\/j.intimp.2026.117027_bb0535","doi-asserted-by":"crossref","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","article-title":"MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations","volume":"49","author":"Rath","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0540","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cmet.2015.11.002","article-title":"Mitochondrial membrane potential identifies cells with enhanced Stemness for cellular therapy","volume":"23","author":"Sukumar","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.intimp.2026.117027_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150738","article-title":"Impaired mitochondrial oxidative phosphorylation induces CD8(+) T cell exhaustion","volume":"734","author":"Liu","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0550","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13578-022-00771-0","article-title":"DNA in extracellular vesicles: from evolution to its current application in health and disease","volume":"12","author":"Ghanam","year":"2022","journal-title":"Cell Biosci."},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0555","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41419-024-06494-z","article-title":"Roles of exosomes in immunotherapy for solid cancers","volume":"15","author":"Lyu","year":"2024","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0560","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.3892\/ol.2020.11831","article-title":"Next generation sequencing-based analysis of mitochondrial DNA characteristics in plasma extracellular vesicles of patients with hepatocellular carcinoma","volume":"20","author":"Li","year":"2020","journal-title":"Oncol. Lett."},{"issue":"7580","key":"10.1016\/j.intimp.2026.117027_bb0565","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature16071","article-title":"Brain tumour cells interconnect to a functional and resistant network","volume":"528","author":"Osswald","year":"2015","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.intimp.2026.117027_bb0570","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/neuonc\/nox070","article-title":"Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas","volume":"19","author":"Weil","year":"2017","journal-title":"Neuro-Oncology"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0575","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12943-021-01490-9","article-title":"Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic melanoma","volume":"21","author":"Serrat\u00ec","year":"2022","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0580","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006522","article-title":"Metabolic reprogramming via an engineered PGC-1\u03b1 improves human chimeric antigen receptor T-cell therapy against solid tumors","volume":"11","author":"Lontos","year":"2023","journal-title":"J. Immunother. Cancer"},{"issue":"4","key":"10.1016\/j.intimp.2026.117027_bb0585","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1084\/jem.20171068","article-title":"4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses","volume":"215","author":"Menk","year":"2018","journal-title":"J. Exp. Med."},{"issue":"625","key":"10.1016\/j.intimp.2026.117027_bb0590","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aay8248","article-title":"4-1BB costimulation promotes CAR T cell survival through noncanonical NF-\u03baB signaling","volume":"13","author":"Philipson","year":"2020","journal-title":"Sci. Signal."},{"issue":"7","key":"10.1016\/j.intimp.2026.117027_bb0595","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/s41423-020-0365-3","article-title":"Enforced PGC-1\u03b1 expression promotes CD8 T cell fitness, memory formation and antitumor immunity","volume":"18","author":"Dumauthioz","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0600","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41591-022-02103-8","article-title":"Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials","volume":"29","author":"Yap","year":"2023","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0605","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/s41416-023-02394-9","article-title":"Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities","volume":"129","author":"Machado","year":"2023","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0610","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1158\/1078-0432.CCR-19-2023","article-title":"Randomized phase 0\/I trial of the mitochondrial inhibitor ME-344 or placebo added to bevacizumab in early HER2-negative breast Cancer","volume":"26","author":"Quintela-Fandino","year":"2020","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0615","first-page":"60","article-title":"A phase 1b study of the OxPhos inhibitor ME-344 with bevacizumab in refractory metastatic colorectal cancer","volume":"43","author":"Boland","year":"2025","journal-title":"Investig. New Drugs"},{"issue":"5","key":"10.1016\/j.intimp.2026.117027_bb0620","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/cam4.112","article-title":"BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I","volume":"2","author":"Ellinghaus","year":"2013","journal-title":"Cancer Med."},{"issue":"7","key":"10.1016\/j.intimp.2026.117027_bb0625","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1158\/1078-0432.CCR-24-3296","article-title":"Mitochondria targeting of oxidative phosphorylation inhibitors to alleviate hypoxia and enhance anticancer treatment efficacy","volume":"31","author":"Beerkens","year":"2025","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0630","doi-asserted-by":"crossref","first-page":"2512109","DOI":"10.1080\/2162402X.2025.2512109","article-title":"Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue","volume":"14","author":"Zhao","year":"2025","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.intimp.2026.117027_bb0635","article-title":"Mitochondria-targeted photothermal-chemodynamic therapy enhances checkpoint blockade immunotherapy on colon cancer","volume":"31","author":"Zheng","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0640","doi-asserted-by":"crossref","first-page":"14556","DOI":"10.1038\/s41598-021-93775-8","article-title":"Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions","volume":"11","author":"Valdebenito","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.117027_bb0645","doi-asserted-by":"crossref","first-page":"2701345","DOI":"10.1155\/2020\/2701345","article-title":"Investigating tunneling nanotubes in Cancer cells: guidelines for structural and functional studies through cell imaging","volume":"2020","author":"Dubois","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.intimp.2026.117027_bb0650","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40170-015-0138-0","article-title":"Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth","volume":"3","author":"Sch\u00f6ckel","year":"2015","journal-title":"Cancer Metab"},{"issue":"12","key":"10.1016\/j.intimp.2026.117027_bb0655","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121487","article-title":"Mechanism-specific pharmacodynamics of a novel complex-I inhibitor quantified by imaging reversal of consumptive hypoxia with [(18)F]FAZA PET in vivo","volume":"8","author":"Gammon","year":"2019","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0660","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cmet.2021.02.010","article-title":"Mitochondrial dysfunction defines T cell exhaustion","volume":"33","author":"Soto-Heredero","year":"2021","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0665","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9020216","article-title":"Mitochondrial oxidative stress and \u201cMito-inflammation\u201d: actors in the diseases","volume":"9","author":"Patergnani","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.intimp.2026.117027_bb0670","doi-asserted-by":"crossref","first-page":"1204363","DOI":"10.3389\/fimmu.2023.1204363","article-title":"Strategies to reinvigorate exhausted CD8(+) T cells in tumor microenvironment","volume":"14","author":"Guan","year":"2023","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117027_bb0675","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201825","article-title":"Segregation of pathways leading to pexophagy","volume":"6","author":"Barone","year":"2023","journal-title":"Life Sci Alliance"},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0680","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1021\/acs.jproteome.4c00618","article-title":"Structural dynamics of the ubiquitin specific protease USP30 in complex with a Cyanopyrrolidine-containing covalent inhibitor","volume":"24","author":"O\u2019Brien","year":"2025","journal-title":"J. Proteome Res."},{"issue":"9","key":"10.1016\/j.intimp.2026.117027_bb0685","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1038\/s41594-025-01534-4","article-title":"Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30","volume":"32","author":"Kazi","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0690","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41389-021-00306-1","article-title":"LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival","volume":"10","author":"Lee","year":"2021","journal-title":"Oncogenesis"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0695","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1186\/s12964-025-02127-w","article-title":"Targeting mitochondrial proteases CLPP and LONP1 via disruption of mitochondrial redox homeostasis induces proteotoxic stress and suppresses tumor progression","volume":"23","author":"Nandha","year":"2025","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0700","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1038\/s41467-018-05655-x","article-title":"The cristae modulator optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function","volume":"9","author":"Quintana-Cabrera","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.117027_bb0705","doi-asserted-by":"crossref","first-page":"626117","DOI":"10.3389\/fcell.2021.626117","article-title":"Mitochondrial OMA1 and OPA1 as gatekeepers of Organellar structure\/function and cellular stress response","volume":"9","author":"Gilkerson","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0710","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbapap.2020.140558","article-title":"OMA1-An integral membrane protease?","volume":"1869","author":"Alavi","year":"2021","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0715","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/embj.201386474","article-title":"Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics","volume":"33","author":"Baker","year":"2014","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.intimp.2026.117027_bb0720","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112332","article-title":"The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage","volume":"42","author":"Rivera-Mej\u00edas","year":"2023","journal-title":"Cell Rep."},{"issue":"10","key":"10.1016\/j.intimp.2026.117027_bb0725","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/14728222.2023.2261631","article-title":"OXPHOS-targeting drugs in oncology: new perspectives","volume":"27","author":"Kalyanaraman","year":"2023","journal-title":"Expert Opin. Ther. Targets"},{"issue":"5","key":"10.1016\/j.intimp.2026.117027_bb0730","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41419-024-06668-9","article-title":"A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity","volume":"15","author":"Al Assi","year":"2024","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.intimp.2026.117027_bb0735","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.it.2024.11.001","article-title":"Nanotube-mediated mitochondrial transfer: power to the T cells!","volume":"45","author":"Baldari","year":"2024","journal-title":"Trends Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2026.117027_bb0740","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1038\/s42255-023-00854-3","article-title":"Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota","volume":"5","author":"Ji","year":"2023","journal-title":"Nat. Metab."},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0745","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1136\/gutjnl-2022-326928","article-title":"Methionine deficiency facilitates antitumour immunity by altering m(6)a methylation of immune checkpoint transcripts","volume":"72","author":"Li","year":"2023","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.intimp.2026.117027_bb0750","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2020.01.006","article-title":"Methionine metabolism shapes T helper cell responses through regulation of epigenetic reprogramming","volume":"31","author":"Roy","year":"2020","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0755","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1158\/0008-5472.CAN-15-1743","article-title":"Neutralization of tumor acidity improves antitumor responses to immunotherapy","volume":"76","author":"Pilon-Thomas","year":"2016","journal-title":"Cancer Res."},{"issue":"277","key":"10.1016\/j.intimp.2026.117027_bb0760","doi-asserted-by":"crossref","first-page":"277ra30","DOI":"10.1126\/scitranslmed.aaa1260","article-title":"Immunological mechanisms of the antitumor effects of supplemental oxygenation","volume":"7","author":"Hatfield","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"11","key":"10.1016\/j.intimp.2026.117027_bb0765","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.1172\/JCI137554","article-title":"Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy","volume":"130","author":"Hatfield","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.intimp.2026.117027_bb0770","first-page":"648","article-title":"Mitochondrial transplantation sensitizes chemotherapy to inhibit tumor development by enhancing anti-tumor immunity","volume":"22","author":"Lin","year":"2025","journal-title":"Cancer Biol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0775","first-page":"34","article-title":"p32\/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer","volume":"56","author":"Yu","year":"2024","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"issue":"Suppl. 10","key":"10.1016\/j.intimp.2026.117027_bb0780","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1186\/s12859-021-04285-3","article-title":"MitoTox: a comprehensive mitochondrial toxicity database","volume":"22","author":"Lin","year":"2021","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0785","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13046-022-02379-1","article-title":"Extracellular vesicle PD-L1 dynamics predict durable response to immune-checkpoint inhibitors and survival in patients with non-small cell lung cancer","volume":"41","author":"de Miguel-Perez","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0790","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1186\/s13063-019-3664-1","article-title":"Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols","volume":"20","author":"Park","year":"2019","journal-title":"Trials"},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0795","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJMoa1513749","article-title":"Adaptive randomization of Veliparib-carboplatin treatment in breast Cancer","volume":"375","author":"Rugo","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.intimp.2026.117027_bb0800","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.molonc.2015.02.011","article-title":"The brave New World of clinical cancer research: adaptive biomarker-driven trials integrating clinical practice with clinical research","volume":"9","author":"Berry","year":"2015","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117027_bb0805","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1056\/NEJMra1510062","article-title":"Master protocols to study multiple therapies, multiple diseases, or both","volume":"377","author":"Woodcock","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0810","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.1016\/S1470-2045(17)30074-8","article-title":"iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics","volume":"18","author":"Seymour","year":"2017","journal-title":"Lancet Oncol."},{"issue":"4","key":"10.1016\/j.intimp.2026.117027_bb0815","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.ccell.2023.03.009","article-title":"Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade","volume":"41","author":"Pai","year":"2023","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.intimp.2026.117027_bb0820","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1152\/physrev.00023.2024","article-title":"Transforming the concept of connectivity: unveiling tunneling nanotube biology and their roles in brain development and neurodegeneration","volume":"105","author":"Palese","year":"2025","journal-title":"Physiol. Rev."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:34:44Z","timestamp":1784230484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926008738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":164,"alternative-id":["S1567576926008738"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117027","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Block, clear, and boost: a novel therapeutic framework for targeting intercellular mitochondrial transfer in Cancer immunotherapy","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117027"}}