{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:08:47Z","timestamp":1784232527310,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472477"],"award-info":[{"award-number":["82472477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A6008"],"award-info":[{"award-number":["U23A6008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.intimp.2026.117031","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:32:05Z","timestamp":1781764325000},"page":"117031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["FKBP10 mitigates osteoporosis by restraining the HSPA5-coupled ERS-pyroptosis axis to enhance osteogenic differentiation in BMSCs"],"prefix":"10.1016","volume":"185","author":[{"given":"Da","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingchao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hepeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei G.","family":"Kalinichenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga V.","family":"Shevchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Palkovics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10514","key":"10.1016\/j.intimp.2026.117031_bb0005","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/S0140-6736(25)01385-6","article-title":"Osteoporosis","volume":"406","author":"Ye","year":"2025","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.intimp.2026.117031_bb0010","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1007\/s00198-022-06454-3","article-title":"Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis","volume":"33","author":"Xiao","year":"2022","journal-title":"Osteoporos. Int."},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0015","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41514-025-00269-2","article-title":"Global epidemiology and burden of osteoporosis among postmenopausal women: insights from the global burden of disease study 2021","volume":"11","author":"Liang","year":"2025","journal-title":"NPJ Aging"},{"issue":"8","key":"10.1016\/j.intimp.2026.117031_bb0020","article-title":"Regulation of bone homeostasis: signaling pathways and therapeutic targets","volume":"5","author":"Wu","year":"2024","journal-title":"MedComm (2020)"},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0025","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s43556-025-00349-5","article-title":"Osteoporosis: molecular pathogenesis and therapeutic interventions","volume":"6","author":"Zhang","year":"2025","journal-title":"Mol Biomed"},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0030","doi-asserted-by":"crossref","DOI":"10.1186\/s10020-024-00957-x","article-title":"Wnt\/\u03b2-catenin signaling pathway: proteins\u2019 roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis","volume":"30","author":"Wang","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.intimp.2026.117031_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2025.1625806","article-title":"Mechanisms and therapeutic strategies linking mesenchymal stem cells senescence to osteoporosis","volume":"16","author":"Tong","year":"2025","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12956","article-title":"Advances in mesenchymal stem cell transplantation for the treatment of osteoporosis","volume":"54","author":"Jiang","year":"2020","journal-title":"Cell Prolif."},{"issue":"46","key":"10.1016\/j.intimp.2026.117031_bb0045","doi-asserted-by":"crossref","first-page":"31584","DOI":"10.1074\/jbc.M802535200","article-title":"The rough endoplasmic reticulum-resident FK506-binding protein FKBP65 is a molecular chaperone that interacts with collagens","volume":"283","author":"Ishikawa","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.intimp.2026.117031_bb0050","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1093\/hmg\/ddu608","article-title":"HSP47 and FKBP65 cooperate in the synthesis of type I procollagen","volume":"24","author":"Duran","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"10028","key":"10.1016\/j.intimp.2026.117031_bb0055","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0140-6736(15)00728-X","article-title":"Osteogenesis imperfecta","volume":"387","author":"Forlino","year":"2015","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0060","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jbmr\/zjae185","article-title":"Bmpr1aa modulates the severity of the skeletal phenotype in an fkbp10-deficient Bruck syndrome zebrafish model","volume":"40","author":"Jarayseh","year":"2024","journal-title":"J. Bone Miner. Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.117031_bb0065","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.3892\/mmr.2017.6544","article-title":"Identification of novel genes associated with fracture healing in osteoporosis induced by Krm2 overexpression or Lrp5 deficiency","volume":"15","author":"Gao","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0070","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-024-01958-2","article-title":"Pyroptosis in health and disease: mechanisms, regulation and clinical perspective","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2026.117031_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120847","article-title":"Targeting chronic inflammation as a potential adjuvant therapy for osteoporosis","volume":"306","author":"Livshits","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2026.117031_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155516","article-title":"Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling","volume":"128","author":"Chai","year":"2024","journal-title":"Phytomedicine"},{"issue":"Pt B","key":"10.1016\/j.intimp.2026.117031_bb0085","article-title":"Inhibition of Caspase-1-mediated pyroptosis promotes osteogenic differentiation, offering a therapeutic target for osteoporosis","volume":"124","author":"Ruan","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2026.117031_bb0090","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202006194","article-title":"The NLRP3-inflammasome as a sensor of organelle dysfunction","volume":"219","author":"Seoane","year":"2020","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117031_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1247","article-title":"The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders","volume":"10","author":"Chong","year":"2021","journal-title":"Clin. Transl. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2026.117031_bb0100","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"31","key":"10.1016\/j.intimp.2026.117031_bb0105","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2303448120","article-title":"ER chaperone GRP78\/BiP translocates to the nucleus under stress and acts as a transcriptional regulator","volume":"120","author":"Liu","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0110","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: molecular mechanism and therapeutic targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"40","key":"10.1016\/j.intimp.2026.117031_bb0115","doi-asserted-by":"crossref","first-page":"27551","DOI":"10.1074\/jbc.M113.528174","article-title":"Endoplasmic reticulum stress is chronically activated in chronic pancreatitis","volume":"289","author":"Sah","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.intimp.2026.117031_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8111793","article-title":"The circulating GRP78\/BiP is a marker of metabolic diseases and atherosclerosis: bringing endoplasmic reticulum stress into the clinical scenario","volume":"8","author":"Girona","year":"2019","journal-title":"J. Clin. Med."},{"issue":"9","key":"10.1016\/j.intimp.2026.117031_bb0125","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.metabol.2016.06.004","article-title":"Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone","volume":"65","author":"Khadir","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.intimp.2026.117031_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112815","article-title":"Grp78 regulates NLRP3 inflammasome and participates in Sjogren\u2019s syndrome","volume":"140","author":"He","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.intimp.2026.117031_bb0135","doi-asserted-by":"crossref","DOI":"10.1093\/stcltm\/szac049","article-title":"METTL14 regulates osteogenesis of bone marrow mesenchymal stem cells via inducing autophagy through m6A\/IGF2BPs\/Beclin-1 signal Axis","volume":"11","author":"He","year":"2022","journal-title":"Stem Cells Transl. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0140","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1038\/s41467-019-10809-6","article-title":"Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis","volume":"10","author":"Yang","year":"2019","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.intimp.2026.117031_bb0145","article-title":"GTSE1-expressed osteoblastic cells facilitate formation of pro-metastatic tumor microenvironment in osteosarcoma","volume":"12","author":"Wang","year":"2025","journal-title":"Genes Dis."},{"key":"10.1016\/j.intimp.2026.117031_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157066","article-title":"Antitumor effects of cannabidiol (CBD) on osteosarcoma by targeting TNF-\u03b1\/NF-\u03baB\/CCL5 signaling axis","volume":"145","author":"Yang","year":"2025","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.intimp.2026.117031_bb0155","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s11914-018-0427-y","article-title":"Good, bad, or ugly: the biological roles of bone marrow fat","volume":"16","author":"Singh","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"issue":"30","key":"10.1016\/j.intimp.2026.117031_bb0160","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2412246122","article-title":"Stress-induced translocation of the endoplasmic reticulum chaperone GRP78\/BiP and its impact on human disease and therapy","volume":"122","author":"Lee","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0165","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s10020-024-00808-9","article-title":"Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer","volume":"30","author":"Yuan","year":"2024","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0170","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s13238-016-0312-3","article-title":"Dual role for the unfolded protein response in the ovary: adaption and apoptosis","volume":"8","author":"Huang","year":"2016","journal-title":"Protein Cell"},{"issue":"3","key":"10.1016\/j.intimp.2026.117031_bb0175","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a013169","article-title":"Endoplasmic reticulum stress sensing in the unfolded protein response","volume":"5","author":"Gardner","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117031_bb0180","article-title":"The unfolded protein response: An overview","volume":"10","author":"Read","year":"2021","journal-title":"Biology (Basel)"},{"issue":"3","key":"10.1016\/j.intimp.2026.117031_bb0185","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/jbmr.250","article-title":"Mutations in FKBP10 cause recessive osteogenesis imperfecta and Bruck syndrome","volume":"26","author":"Kelley","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.intimp.2026.117031_bb0190","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ajhg.2010.02.022","article-title":"Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta","volume":"86","author":"Alanay","year":"2010","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0195","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12929-023-00920-8","article-title":"Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss","volume":"30","author":"Yoon","year":"2023","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0200","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41413-023-00296-3","article-title":"Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1\/\u03b2-catenin signaling","volume":"11","author":"Liu","year":"2023","journal-title":"Bone Res"},{"key":"10.1016\/j.intimp.2026.117031_bb0205","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.jare.2025.03.012","article-title":"BMP9 alleviates iron accumulation-induced osteoporosis via the USP10\/FOXO1\/GPX4 axis","volume":"79","author":"Huang","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.intimp.2026.117031_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.752546","article-title":"NLRP3 Inflammasome: a new target for prevention and control of osteoporosis?","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.intimp.2026.117031_bb0215","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jot.2025.09.004","article-title":"Naringin inhibits the osteoblast-osteoclast pyroptosis cascade reaction mediated by accumulated bone marrow adipose tissue in the treatment of postmenopausal osteoporosis","volume":"55","author":"Li","year":"2025","journal-title":"J Orthop Translat"},{"issue":"10","key":"10.1016\/j.intimp.2026.117031_bb0220","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.7150\/thno.95423","article-title":"Osteoblast-specific down-regulation of NLRP3 inflammasome by aptamer-functionalized liposome nanoparticles improves bone quality in postmenopausal osteoporosis rats","volume":"14","author":"Xu","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2026.117031_bb0225","article-title":"Study on the mechanism of NLRP3 effect on the skeleton of de-ovalized mice","volume":"35","author":"Yang","year":"2023","journal-title":"Biochem. Biophys. Rep."},{"issue":"6511","key":"10.1016\/j.intimp.2026.117031_bb0230","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1126\/science.abb9818","article-title":"Succination inactivates gasdermin D and blocks pyroptosis","volume":"369","author":"Humphries","year":"2020","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.intimp.2026.117031_bb0235","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1074\/jbc.REV118.002804","article-title":"The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: getting by with a little help from ERdj friends","volume":"294","author":"Pobre","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.intimp.2026.117031_bb0240","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/onc.2015.214","article-title":"Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer","volume":"35","author":"Chang","year":"2015","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.intimp.2026.117031_bb0245","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/ncb3177","article-title":"Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding","volume":"17","author":"Cha-Molstad","year":"2015","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0250","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13018-025-05541-5","article-title":"Association of serum and local GRP78 and CHOP expressions with disease progression in patients with non-traumatic osteonecrosis of femoral head","volume":"20","author":"Zhang","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"issue":"11","key":"10.1016\/j.intimp.2026.117031_bb0255","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/s41594-019-0324-9","article-title":"UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor","volume":"26","author":"Kopp","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.intimp.2026.117031_bb0260","doi-asserted-by":"crossref","unstructured":"C.A.d. Costa, W.E. Manaa, E. Duplan, F. Checler, The endoplasmic reticulum stress\/unfolded protein response and their contributions to Parkinson's disease physiopathology, Cells 9(11) (2020), doi:https:\/\/doi.org\/10.3390\/cells9112495.","DOI":"10.3390\/cells9112495"},{"issue":"11","key":"10.1016\/j.intimp.2026.117031_bb0265","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.4103\/1673-5374.393105","article-title":"The physiological role of the unfolded protein response in the nervous system","volume":"19","author":"Wu","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0270","article-title":"Endoplasmic reticulum stress in disease pathogenesis: its implications for therapy","volume":"11","author":"Wei","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"#cr-split#-10.1016\/j.intimp.2026.117031_bb0275.1","doi-asserted-by":"crossref","unstructured":"Y. Liu, C. Xu, R. Gu, R. Han, Z. Li, X. Xu, Endoplasmic reticulum stress in diseases, MedComm (2020) 5","DOI":"10.1002\/mco2.701"},{"key":"#cr-split#-10.1016\/j.intimp.2026.117031_bb0275.2","doi-asserted-by":"crossref","unstructured":"(9) (2024) e701, doi:https:\/\/doi.org\/10.1002\/mco2.701.","DOI":"10.1002\/mco2.701"},{"issue":"4","key":"10.1016\/j.intimp.2026.117031_bb0280","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s10753-024-01989-5","article-title":"Inhibition of endoplasmic reticulum stress improves chronic ischemic hippocampal damage associated with suppression of IRE1\u03b1\/TRAF2\/ASK1\/JNK-dependent apoptosis","volume":"47","author":"Kang","year":"2024","journal-title":"Inflammation"},{"issue":"10","key":"10.1016\/j.intimp.2026.117031_bb0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045078","article-title":"ER stress activates NF-\u03baB by integrating functions of basal IKK activity, IRE1 and PERK","volume":"7","author":"Tam","year":"2012","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0290","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s12931-024-03044-1","article-title":"Inhibition of IRE1\u03b1\/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP\/NLRP3 inflammasome activation and ERK\/p65 signaling pathway","volume":"25","author":"Wang","year":"2024","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.intimp.2026.117031_bb0295","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1021\/acs.jafc.2c06134","article-title":"Ginsenoside compound K ameliorates osteoarthritis by inhibiting the chondrocyte endoplasmic reticulum stress-mediated IRE1\u03b1-TXNIP-NLRP3 Axis and Pyroptosis","volume":"71","author":"Tian","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2026.117031_bb0300","article-title":"Stage-dependent endoplasmic reticulum homeostasis in osteogenic differentiation","volume":"14","author":"Wang","year":"2026","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117031_bb0305","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-025-00457-6","article-title":"The role of the unfolded protein response pathway in bone homeostasis and potential therapeutic target in cancer-associated bone disease","volume":"13","author":"Muehlebach","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.intimp.2026.117031_bb0310","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.actbio.2017.03.018","article-title":"Role of the unfolded protein response in topography-induced osteogenic differentiation in rat bone marrow mesenchymal stem cells","volume":"54","author":"Shi","year":"2017","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.intimp.2026.117031_bb0315","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1074\/jbc.M111.253187","article-title":"BMP2 protein regulates osteocalcin expression via Runx2-mediated Atf6 gene transcription","volume":"287","author":"Jang","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"22","key":"10.1016\/j.intimp.2026.117031_bb0320","doi-asserted-by":"crossref","first-page":"10454","DOI":"10.1111\/jcmm.16974","article-title":"GPX7 facilitates BMSCs Osteoblastogenesis via ER stress and mTOR pathway","volume":"25","author":"Hu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.117031_bb0325","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1159\/000354476","article-title":"ER stress activating ATF4\/CHOP-TNF-\u03b1 signaling pathway contributes to alcohol-induced disruption of osteogenic lineage of multipotential mesenchymal stem cell","volume":"32","author":"Chen","year":"2013","journal-title":"Cell. Physiol. Biochem."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926008775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:36:39Z","timestamp":1784230599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926008775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":66,"alternative-id":["S1567576926008775"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117031","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FKBP10 mitigates osteoporosis by restraining the HSPA5-coupled ERS-pyroptosis axis to enhance osteogenic differentiation in BMSCs","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117031"}}