{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T01:29:08Z","timestamp":1786325348311,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470741"],"award-info":[{"award-number":["82470741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270733"],"award-info":[{"award-number":["82270733"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270752"],"award-info":[{"award-number":["82270752"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["A202303057091"],"award-info":[{"award-number":["A202303057091"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ30042"],"award-info":[{"award-number":["2025JJ30042"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.intimp.2026.117087","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:37:38Z","timestamp":1782877058000},"page":"117087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The mechanism of intestinal IgA class switching regulated by TRIM21 through down-regulation of AID in IgA nephropathy"],"prefix":"10.1016","volume":"186","author":[{"given":"Qian","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanyong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2026.117087_bb0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41581-024-00885-3","article-title":"The pathogenesis of IgA nephropathy and implications for treatment","volume":"21","author":"Cheung","year":"2025","journal-title":"Nat. Rev. Nephrol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117087_bb0010","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1681\/ASN.2018101017","article-title":"Mortality in IgA nephropathy: a Nationwide population-based cohort study","volume":"30","author":"Jarrick","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.intimp.2026.117087_bb0015","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1053\/j.ajkd.2021.01.024","article-title":"IgA nephropathy: Core curriculum 2021","volume":"78","author":"Pattrapornpisut","year":"2021","journal-title":"Am. J. Kidney Dis."},{"issue":"11","key":"10.1016\/j.intimp.2026.117087_bb0020","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/ng.3118","article-title":"Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens","volume":"46","author":"Kiryluk","year":"2014","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.intimp.2026.117087_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103835","article-title":"New thoughts on the intestinal microbiome-B cell-IgA axis and therapies in IgA nephropathy","volume":"24","author":"Dang","year":"2025","journal-title":"Autoimmun. Rev."},{"issue":"10","key":"10.1016\/j.intimp.2026.117087_bb0030","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.ekir.2020.08.009","article-title":"NefIgArd study steering C: Why target the gut to treat IgA nephropathy?","volume":"5","author":"Barratt","year":"2020","journal-title":"Kidney Int. Rep."},{"issue":"6287","key":"10.1016\/j.intimp.2026.117087_bb0035","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf4822","article-title":"IgA production requires B cell interaction with subepithelial dendritic cells in Peyer\u2019s patches","volume":"352","author":"Reboldi","year":"2016","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.intimp.2026.117087_bb0040","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1681\/ASN.2021010133","article-title":"MicroRNA-23b-3p deletion induces an IgA nephropathy-like disease associated with dysregulated mucosal IgA synthesis","volume":"32","author":"Li","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.intimp.2026.117087_bb0045","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrneph.2015.208","article-title":"The mucosa-kidney axis in IgA nephropathy","volume":"12","author":"Floege","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117087_bb0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.immuni.2011.02.002","article-title":"Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction","volume":"34","author":"Tezuka","year":"2011","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.intimp.2026.117087_bb0055","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00011-011-0347-0","article-title":"Expression of IgA class switching gene in tonsillar mononuclear cells in patients with IgA nephropathy","volume":"60","author":"Liu","year":"2011","journal-title":"Inflamm. Res."},{"issue":"2","key":"10.1016\/j.intimp.2026.117087_bb0060","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1073\/pnas.0913790107","article-title":"The RNF8\/RNF168 ubiquitin ligase cascade facilitates class switch recombination","volume":"107","author":"Ramachandran","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.intimp.2026.117087_bb0065","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1080\/15548627.2022.2164427","article-title":"Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules","volume":"19","author":"Yang","year":"2023","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.intimp.2026.117087_bb0070","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.it.2017.07.005","article-title":"TRIM21 and the function of antibodies inside cells","volume":"38","author":"Rhodes","year":"2017","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117087_bb0075","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41467-023-36523-y","article-title":"TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.intimp.2026.117087_bb0080","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41418-021-00867-z","article-title":"TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization","volume":"29","author":"Gao","year":"2022","journal-title":"Cell Death Differ."},{"issue":"7","key":"10.1016\/j.intimp.2026.117087_bb0085","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/s12276-025-01490-5","article-title":"The ubiquitin E3 ligase TRIM21 suppresses type I interferon signaling via STING degradation and ameliorates systemic autoimmunity","volume":"57","author":"Kim","year":"2025","journal-title":"Exp. Mol. Med."},{"issue":"8","key":"10.1016\/j.intimp.2026.117087_bb0090","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1084\/jem.20090585","article-title":"Loss of the lupus autoantigen Ro52\/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway","volume":"206","author":"Espinosa","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2026.117087_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00098","article-title":"TRIM21 dysfunction enhances aberrant B-cell differentiation in autoimmune pathogenesis","volume":"11","author":"Kunishita","year":"2020","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2026.117087_bb0100","doi-asserted-by":"crossref","DOI":"10.1172\/JCI164354","article-title":"The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain of function in cancer","volume":"133","author":"Liu","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.intimp.2026.117087_bb0105","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.molcel.2016.02.007","article-title":"TRIM21 Ubiquitylates SQSTM1\/p62 and suppresses protein sequestration to regulate redox homeostasis","volume":"61","author":"Pan","year":"2016","journal-title":"Mol. Cell"},{"issue":"2","key":"10.1016\/j.intimp.2026.117087_bb0110","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/cmi.2011.58","article-title":"C-type lectin receptor-induced NF-kappaB activation in innate immune and inflammatory responses","volume":"9","author":"Kingeter","year":"2012","journal-title":"Cell. Mol. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2026.117087_bb0115","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41419-018-0881-6","article-title":"TRIM52 plays an oncogenic role in ovarian cancer associated with NF-kB pathway","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.intimp.2026.117087_bb0120","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1073\/pnas.1318227111","article-title":"TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2\/3","volume":"111","author":"Hu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.intimp.2026.117087_bb0125","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1038\/s41423-020-00564-w","article-title":"The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK\/NF-kappaB activation and the innate immune response","volume":"18","author":"Gu","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.intimp.2026.117087_bb0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bone.2018.05.009","article-title":"TRIM38 regulates NF-kappaB activation through TAB2 degradation in osteoclast and osteoblast differentiation","volume":"113","author":"Kim","year":"2018","journal-title":"Bone"},{"issue":"14","key":"10.1016\/j.intimp.2026.117087_bb0135","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1016\/j.molimm.2010.05.004","article-title":"Downregulation of active IKK beta by Ro52-mediated autophagy","volume":"47","author":"Niida","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2026.117087_bb0140","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.10395","article-title":"Comprehensive analysis of circRNA expression profiles and circRNA-associated competing endogenous RNA networks in IgA nephropathy","volume":"8","author":"Liu","year":"2020","journal-title":"PeerJ"},{"issue":"9","key":"10.1016\/j.intimp.2026.117087_bb0145","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"issue":"9","key":"10.1016\/j.intimp.2026.117087_bb0150","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13278","article-title":"Triptolide promotes autophagy to inhibit mesangial cell proliferation in IgA nephropathy via the CARD9\/p38 MAPK pathway","volume":"55","author":"Zhao","year":"2022","journal-title":"Cell Prolif."},{"issue":"13","key":"10.1016\/j.intimp.2026.117087_bb0155","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.7150\/ijbs.61274","article-title":"Downregulation of miR214-3p attenuates mesangial hypercellularity by targeting PTENmediated JNK\/c-Jun signaling in IgA nephropathy","volume":"17","author":"Li","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2026.117087_bb0160","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/imm.13938","article-title":"Unravelling the impact of outer membrane protein, OmpA, from S. Typhimurium on aberrant AID expression and IgM to IgA class switching in human B-cells","volume":"175","author":"Chaudhari","year":"2025","journal-title":"Immunology"},{"issue":"12","key":"10.1016\/j.intimp.2026.117087_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105431","article-title":"Evaluation of potential role of R-loop and G-quadruplex DNA in the fragility of c-MYC during chromosomal translocation associated with Burkitt\u2019s lymphoma","volume":"299","author":"Kumari","year":"2023","journal-title":"J. Biol. Chem."},{"issue":"79","key":"10.1016\/j.intimp.2026.117087_bb0170","article-title":"A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency","volume":"8","author":"Consortium IRFI","year":"2023","journal-title":"Sci. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117087_bb0175","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1038\/s41467-021-22331-9","article-title":"Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes","volume":"12","author":"He","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2026.117087_bb0180","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.7150\/ijbs.122689","article-title":"FBXL8 stabilizes IkappaBalpha and negatively regulated NF-kappaB activation to suppress pancreatic Cancer progression","volume":"22","author":"Li","year":"2026","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117087_bb0185","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13578-023-01056-w","article-title":"TRIM67 alleviates cerebral ischemia\u2013reperfusion injury by protecting neurons and inhibiting neuroinflammation via targeting IkappaBalpha for K63-linked polyubiquitination","volume":"13","author":"Yu","year":"2023","journal-title":"Cell Biosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117087_bb0190","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-026-03766-7","article-title":"Microglial NCAM1 attenuates ischemic brain injury by inhibiting NF-kappaB-driven neuroinflammation through IkappaBalpha stabilization","volume":"23","author":"Yu","year":"2026","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.intimp.2026.117087_bb0195","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00281-021-00871-y","article-title":"The mucosal immune system and IgA nephropathy","volume":"43","author":"Gesualdo","year":"2021","journal-title":"Semin. Immunopathol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117087_bb0200","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00281-021-00879-4","article-title":"The immune landscape of IgA induction in the gut","volume":"43","author":"Seikrit","year":"2021","journal-title":"Semin. Immunopathol."},{"issue":"25","key":"10.1016\/j.intimp.2026.117087_bb0205","doi-asserted-by":"crossref","first-page":"11462","DOI":"10.7150\/thno.49778","article-title":"Perspectives on how mucosal immune responses, infections and gut microbiome shape IgA nephropathy and future therapies","volume":"10","author":"He","year":"2020","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.intimp.2026.117087_bb0210","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/joim.12375","article-title":"Reduced expression of TRIM21\/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease","volume":"278","author":"Brauner","year":"2015","journal-title":"J. Intern. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.117087_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2017.09.038","article-title":"Tripartite motif-containing (TRIM) 21 negatively regulates intestinal mucosal inflammation through inhibiting T(H)1\/T(H)17 cell differentiation in patients with inflammatory bowel diseases","volume":"142","author":"Zhou","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117087_bb0220","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2026.117087_bb0225","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1695818","article-title":"TRIM21 regulation of IRF-mediated type I interferon signaling in systemic autoimmune diseases","volume":"16","author":"Panlu","year":"2025","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2026.117087_bb0230","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1165\/rcmb.2018-0366OC","article-title":"TRIM21 mitigates human lung microvascular endothelial cells\u2019 inflammatory responses to LPS","volume":"61","author":"Li","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.intimp.2026.117087_bb0235","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41467-024-54882-y","article-title":"Phenazine biosynthesis-like domain-containing protein (PBLD) and Cedrelone promote antiviral immune response by activating NF-kB","volume":"16","author":"Hou","year":"2025","journal-title":"Nat. Commun."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926009331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926009331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:48:59Z","timestamp":1786322939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926009331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":47,"alternative-id":["S1567576926009331"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117087","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mechanism of intestinal IgA class switching regulated by TRIM21 through down-regulation of AID in IgA nephropathy","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117087","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117087"}}