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Chem."},{"key":"10.1016\/j.intimp.2026.117239_bb0495","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.intimp.2026.117239_bb0500","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/biomet\/52.3-4.591","article-title":"An analysis of variance test for normality (complete samples)","volume":"52","author":"Shapiro","year":"1965","journal-title":"Biometrika"},{"key":"10.1016\/j.intimp.2026.117239_bb0505","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1365-2230.2006.02206.x","article-title":"Preliminary testing for normality: some statistical aspects of a common concept","volume":"31","author":"Schoder","year":"2006","journal-title":"Clin. Exp. 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Sci."},{"key":"10.1016\/j.intimp.2026.117239_bb0635","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/path.5212","article-title":"Extracellular traps derived from macrophages, mast cells, eosinophils and neutrophils are generated in a time-dependent manner during atherothrombosis","volume":"247","author":"Pertiwi","year":"2019","journal-title":"J. Pathol."},{"key":"10.1016\/j.intimp.2026.117239_bb0640","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s40064-015-0932-8","article-title":"Prolonged exposure to neutrophil extracellular traps can induce mitochondrial damage in macrophages and dendritic cells","volume":"4","author":"Donis-Maturano","year":"2015","journal-title":"Springerplus"},{"key":"10.1016\/j.intimp.2026.117239_bb0645","article-title":"Ionizing radiation induces extracellular trap release from macrophages","volume":"27","author":"Lee","year":"2026","journal-title":"Int. J. Mol. 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