{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:06:44Z","timestamp":1789146404956,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402120"],"award-info":[{"award-number":["81402120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504290"],"award-info":[{"award-number":["82504290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2026JJ60577"],"award-info":[{"award-number":["2026JJ60577"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ60549"],"award-info":[{"award-number":["2025JJ60549"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20242035"],"award-info":[{"award-number":["GZC20242035"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["BX20250226"],"award-info":[{"award-number":["BX20250226"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024\\u202FM763721"],"award-info":[{"award-number":["2024\\u202FM763721"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.intimp.2026.117249","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T21:25:23Z","timestamp":1786137923000},"page":"117249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting IMPDH2 by Casticin attenuates psoriatic inflammation by suppressing STAT3 activation in keratinocytes"],"prefix":"10.1016","volume":"187","author":[{"given":"Jia","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoru","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.117249_bb0005","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.intimp.2026.117249_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-025-00630-5","article-title":"Psoriasis","volume":"11","author":"Armstrong","year":"2025","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.intimp.2026.117249_bb0015","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2026.117249_bb0020","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jaci.2017.07.004","article-title":"Psoriasis pathogenesis and the development of novel targeted immune therapies","volume":"140","author":"Hawkes","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2026.117249_bb0025","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.it.2012.11.005","article-title":"The IL-23\/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses","volume":"34","author":"Lowes","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1016\/j.intimp.2026.117249_bb0030","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/bs.acc.2020.06.003","article-title":"Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases","volume":"101","author":"Sarandi","year":"2021","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.intimp.2026.117249_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1201912","article-title":"Psoriasis immunometabolism: Progress on metabolic biomarkers and targeted therapy","volume":"10","author":"Sarandi","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.intimp.2026.117249_bb0040","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/jb\/mvaa085","article-title":"GTP metabolic reprogramming by IMPDH2: unlocking cancer cells\u2019 fuelling mechanism","volume":"168","author":"Kofuji","year":"2020","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.intimp.2026.117249_bb0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1042\/BST20210446","article-title":"IMPDH dysregulation in disease: a mini review","volume":"50","author":"Burrell","year":"2022","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.intimp.2026.117249_bb0050","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/s41598-024-85094-5","article-title":"Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer","volume":"15","author":"da Silva Fernandes","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.117249_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112567","article-title":"IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma","volume":"28","author":"Schnabel","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.intimp.2026.117249_bb0060","doi-asserted-by":"crossref","first-page":"E5986","DOI":"10.1073\/pnas.1706778114","article-title":"Highly selective inhibition of IMPDH2 provides the basis of antineuroinflammation therapy","volume":"114","author":"Liao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.intimp.2026.117249_bb0065","doi-asserted-by":"crossref","unstructured":"Z. Li, Y. Zou, J. Niu, Y. Zhang, A. Yang, W. Lin, J. Guo, S. Wang, R. Liu, IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target, (n.d.). doi:https:\/\/doi.org\/10.1111\/cpr.70031.","DOI":"10.1111\/cpr.70031"},{"key":"10.1016\/j.intimp.2026.117249_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/molecules30061359","article-title":"Combination effects of Aminolevulinic acid and mycophenolic acid on Hacat cell proliferation and inhibition of inosine monophosphate dehydrogenase","volume":"30","author":"Venkatesh","year":"2025","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2026.117249_bb0075","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1038\/s44318-025-00418-z","article-title":"The biochemical mechanism of rho GTPase membrane binding, activation and retention in activity patterning","volume":"44","author":"Armstrong","year":"2025","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2026.117249_bb0080","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/biom15010003","article-title":"The expression regulation and Cancer-promoting roles of RACGAP1","volume":"15","author":"Lin","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.intimp.2026.117249_bb0085","article-title":"Depletion of the rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling","volume":"40","author":"W\u00e5hl\u00e9n","year":"2024","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.intimp.2026.117249_bb0090","article-title":"Role of the STAT3 signaling pathway in cell proliferation and inflammation in psoriasis and approaches for targeted therapies: a review","volume":"32","author":"Li","year":"2026","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.intimp.2026.117249_bb0095","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20230683","article-title":"TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation","volume":"221","author":"Qin","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2026.117249_bb0100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jdermsci.2018.11.007","article-title":"Stat3 activation in epidermal keratinocytes induces Langerhans cell activation to form an essential circuit for psoriasis via IL-23 production","volume":"93","author":"Nakajima","year":"2019","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.intimp.2026.117249_bb0105","article-title":"Epidermal keratinocyte-specific STAT3 deficiency aggravated atopic dermatitis-like skin inflammation in mice through TSLP upregulation","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.117249_bb0110","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1038\/s41467-025-63791-7","article-title":"Keratinocyte-specific H4K12 lactylation drives a non-canonical IL-17-dependent signaling in psoriasis progression in mice","volume":"16","author":"Shen","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.117249_bb0115","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/s42003-024-06700-w","article-title":"p38\u03b1 deficiency ameliorates psoriasis development by downregulating STAT3-mediated keratinocyte proliferation and cytokine production","volume":"7","author":"Zheng","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.intimp.2026.117249_bb0120","article-title":"Vitexicarpin suppresses malignant progression of colorectal cancer through affecting c-Myc ubiquitination by targeting IMPDH2","volume":"132","author":"Ding","year":"2024","journal-title":"Phytomedicine Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.intimp.2026.117249_bb0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41419-022-04523-3","article-title":"Advances in the pathogenesis of psoriasis: from keratinocyte perspective","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2026.117249_bb0130","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41392-023-01655-6","article-title":"Signaling pathways and targeted therapies for psoriasis","volume":"8","author":"Guo","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2026.117249_bb0135","first-page":"249","article-title":"Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through rho GTPase\/STAT3\/VEGFA pathway","volume":"42","author":"Yuan","year":"2023","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"10.1016\/j.intimp.2026.117249_bb0140","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3390\/ijms19010171","article-title":"Psoriasis: a STAT3-centric view","volume":"19","author":"Calautti","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.117249_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjidi.2021.100066","article-title":"Identification of keratinocyte mitogens: implications for hyperproliferation in psoriasis and atopic dermatitis","volume":"2","author":"Niehues","year":"2022","journal-title":"JID Innovations"},{"key":"10.1016\/j.intimp.2026.117249_bb0150","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.molmed.2020.04.004","article-title":"Metabolic pathways that control skin homeostasis and inflammation","volume":"26","author":"Cibrian","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.intimp.2026.117249_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111897","article-title":"Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation","volume":"41","author":"Veras","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2026.117249_bb0160","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/s41556-019-0363-9","article-title":"IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma","volume":"21","author":"Kofuji","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.intimp.2026.117249_bb0165","first-page":"1","article-title":"Dynamic control of nucleotide metabolism in physiology and disease","author":"Kim","year":"2026","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.intimp.2026.117249_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105224","article-title":"Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms","volume":"163","author":"He","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2026.117249_bb0175","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1007\/s10787-025-01639-8","article-title":"Casticin reduces rosacea-related inflammation by inhibiting mast cell activation via mas-related G protein-coupled receptor X2","volume":"33","author":"Jia","year":"2025","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2026.117249_bb0180","doi-asserted-by":"crossref","first-page":"6872","DOI":"10.1038\/s41598-025-91237-z","article-title":"Immunological profile of lactate metabolism-related genes in psoriasis a comprehensive analysis based on bulk and single-cell RNA sequencing data","volume":"15","author":"Liu","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.117249_bb0185","doi-asserted-by":"crossref","unstructured":"I. Subudhi, P. Konieczny, A. Prystupa, R.L. Castillo, E. Sze-Tu, Y. Xing, D. Rosenblum, I. Reznikov, I. Sidhu, C. Loomis, C.P. Lu, N. Anandasabapathy, M. Su\u00e1rez-Fari\u00f1as, J.E. Gudjonsson, A. Tsirigos, J.U. Scher, S. Naik, Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation, Immunity 57 (2024) S1074\u20137613(24)00227\u20139. doi:https:\/\/doi.org\/10.1016\/j.immuni.2024.04.022.","DOI":"10.1016\/j.immuni.2024.04.022"},{"key":"10.1016\/j.intimp.2026.117249_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202417049","article-title":"Reprogramming of fatty acid metabolism via PPAR\u03b1-orchestrated FADS2 in keratinocytes modulates skin inflammation in psoriasis","volume":"12","author":"Cai","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.intimp.2026.117249_bb0195","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202417093","article-title":"Role of SLC16A10 in psoriasis through the regulation of arachidonic acid metabolism in keratinocytes","volume":"12","author":"Yang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.intimp.2026.117249_bb0200","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s10753-023-01961-9","article-title":"Advance in multi-omics research strategies on cholesterol metabolism in psoriasis","volume":"47","author":"Guo","year":"2024","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2026.117249_bb0205","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41392-024-01954-6","article-title":"Metabolic regulation of the immune system in health and diseases: mechanisms and interventions","volume":"9","author":"Hu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2026.117249_bb0210","article-title":"Beyond the dichotomy: understanding the overlap between atopic dermatitis and psoriasis","volume":"16","author":"Li","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.117249_bb0215","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1126\/science.aan4665","article-title":"Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity","volume":"360","author":"Kornberg","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.intimp.2026.117249_bb0220","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.3390\/jcm11164778","article-title":"Efficacy and safety of dimethyl fumarate in patients with moderate-to-severe plaque psoriasis: DIMESKIN-2, a multicentre single-arm phase IIIb study","volume":"11","author":"Pellacani","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2026.117249_bb0225","first-page":"1","article-title":"IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (review)","volume":"57","author":"Zhu","year":"2026","journal-title":"Int. J. Mol. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926010957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926010957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:12:21Z","timestamp":1789143141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926010957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":45,"alternative-id":["S1567576926010957"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117249","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting IMPDH2 by Casticin attenuates psoriatic inflammation by suppressing STAT3 activation in keratinocytes","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117249","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117249"}}