{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:00:51Z","timestamp":1790438451183,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402561"],"award-info":[{"award-number":["82402561"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.intimp.2026.117311","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:43:33Z","timestamp":1787705013000},"page":"117311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Remodeling lipid and mitochondrial homeostasis: a novel mechanism by which polydatin attenuates renal tubular senescence in chronic kidney disease"],"prefix":"10.1016","volume":"188","author":[{"given":"Tingting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunni","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6734","key":"10.1016\/j.intimp.2026.117311_bb0005","article-title":"Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants","volume":"387","author":"Liu","year":"2025","journal-title":"Science (1979)"},{"issue":"1","key":"10.1016\/j.intimp.2026.117311_bb0010","doi-asserted-by":"crossref","first-page":"7814","DOI":"10.1038\/s41467-023-43529-z","article-title":"MicroRNA-mediated attenuation of branched-chain amino acid catabolism promotes ferroptosis in chronic kidney disease","volume":"14","author":"Sone","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.117311_bb0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41581-022-00631-7","article-title":"Cisplatin nephrotoxicity: new insights and therapeutic implications","volume":"19","author":"Tang","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"issue":"10","key":"10.1016\/j.intimp.2026.117311_bb0020","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41581-023-00741-w","article-title":"Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease","volume":"19","author":"Mitrofanova","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.intimp.2026.117311_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107459","article-title":"Lipid-modifying therapy in chronic kidney disease: pathophysiological and clinical considerations","volume":"207","author":"Heine","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.intimp.2026.117311_bb0030","doi-asserted-by":"crossref","first-page":"612","DOI":"10.4093\/dmj.2023.0067","article-title":"Dyslipidemia in patients with chronic kidney disease: an updated overview","volume":"47","author":"Suh","year":"2023","journal-title":"Diabetes Metab. J."},{"issue":"7","key":"10.1016\/j.intimp.2026.117311_bb0035","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1016\/j.cell.2025.01.045","article-title":"Functional diversification of dietary plant small molecules by the gut microbiome","volume":"188","author":"Kuziel","year":"2025","journal-title":"Cell"},{"issue":"50","key":"10.1016\/j.intimp.2026.117311_bb0040","doi-asserted-by":"crossref","first-page":"32123","DOI":"10.1021\/acs.jafc.5c12375","article-title":"Engineering glycosyltransferase by semi-rational design for highly regioselective synthesis of polydatin","volume":"73","author":"Fan","year":"2025","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.intimp.2026.117311_bb0045","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/ptr.7306","article-title":"Old dog, new tricks: polydatin as a multitarget agent for current diseases","volume":"36","author":"Ye","year":"2022","journal-title":"Phytother. Res."},{"issue":"5","key":"10.1016\/j.intimp.2026.117311_bb0050","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1039\/C6FO01561A","article-title":"Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-\u03baB\/NLRP3 inflammasome activation via the AMPK\/SIRT1 pathway","volume":"88","author":"Chen","year":"2017","journal-title":"Food Funct."},{"issue":"10","key":"10.1016\/j.intimp.2026.117311_bb0055","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.3390\/pharmaceutics14102202","article-title":"Polydatin ameliorates high fructose-induced podocyte oxidative stress via suppressing HIF-1\u03b1\/NOX4 pathway","volume":"14","author":"Ding","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.intimp.2026.117311_bb0060","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.freeradbiomed.2017.03.003","article-title":"Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys","volume":"106","author":"Gong","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.intimp.2026.117311_bb0065","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1038\/s41401-020-0475-6","article-title":"Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway","volume":"41","author":"Chen","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2026.117311_bb0070","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s13075-018-1749-y","article-title":"Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation","volume":"20","author":"Liao","year":"2018","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.117311_bb0075","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12967-020-02283-2","article-title":"Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury","volume":"18","author":"Gao","year":"2020","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2026.117311_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115621","article-title":"Polydatin protects against calcium oxalate crystal-induced renal injury through the cytoplasmic\/mitochondrial reactive oxygen species-NLRP3 inflammasome pathway","volume":"167","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2026.117311_bb0085","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9947191","article-title":"Polydatin attenuates cisplatin-induced acute kidney injury by inhibiting ferroptosis","volume":"2022","author":"Zhou","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2026.117311_bb0090","article-title":"Polydatin attenuates cisplatin-induced acute kidney injury via SIRT6-mediated autophagy activation","volume":"2022","author":"Li","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"38","key":"10.1016\/j.intimp.2026.117311_bb0095","doi-asserted-by":"crossref","first-page":"14447","DOI":"10.1073\/pnas.0803790105","article-title":"A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis","volume":"105","author":"Ahn","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2026.117311_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155975","article-title":"Ligustilide alleviates oxidative stress during renal ischemia-reperfusion injury through maintaining Sirt3-dependent mitochondrial homeostasis","volume":"134","author":"Xia","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.intimp.2026.117311_bb0105","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/15548627.2023.2252265","article-title":"Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation","volume":"2020","author":"Deng","year":"2024","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.intimp.2026.117311_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116823","article-title":"NNMT inhibition counteracts tubular senescence and fibrosis in early stages of chronic kidney disease","volume":"45","author":"Chanvillard","year":"2026","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.intimp.2026.117311_bb0115","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.166643","article-title":"Tubular cell senescence promotes maladaptive kidney repair and chronic kidney disease after cisplatin nephrotoxicity","volume":"88","author":"Li","year":"2023","journal-title":"JCI Insight"},{"issue":"44","key":"10.1016\/j.intimp.2026.117311_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202404774","article-title":"Catalytically self-supplied oxygen to alleviate hypoxia for treatment of acute kidney injury","volume":"34","author":"Wang","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"3","key":"10.1016\/j.intimp.2026.117311_bb0125","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1021\/acs.jmedchem.3c01979","article-title":"SIRT3 activation a promise in drug development? New insights into SIRT3 biology and its implications on the drug discovery process","volume":"67","author":"Lambona","year":"2024","journal-title":"J. Med. Chem."},{"issue":"7","key":"10.1016\/j.intimp.2026.117311_bb0130","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/mt.2015.65","article-title":"Barrier function of the repaired skin is disrupted following arrest of dicer in keratinocytes","volume":"23","author":"Ghatak","year":"2015","journal-title":"Mol. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2026.117311_bb0135","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.kint.2022.06.030","article-title":"Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury","volume":"102","author":"Valentijn","year":"2022","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.intimp.2026.117311_bb0140","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.tibs.2025.01.007","article-title":"Decoding ceramide function: how localization shapes cellular fate and how to study it","volume":"50","author":"Chitkara","year":"2025","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.intimp.2026.117311_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2023.111858","article-title":"Lipids and the hallmarks of ageing: from pathology to interventions","volume":"215","author":"Sharma","year":"2023","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.intimp.2026.117311_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156846","article-title":"18\u03b2-glycyrrhetinic acid mitigates lipotoxicity-induced premature senescence of tubular epithelial cells by activating SIRT1-TFEB signaling","volume":"143","author":"Yang","year":"2025","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.intimp.2026.117311_bb0155","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1016\/j.ymthe.2025.05.035","article-title":"Podocyte FFAR4 deficiency aggravated glomerular diseases and aging","volume":"33","author":"Yin","year":"2025","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.117311_bb0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13024-025-00802-7","article-title":"Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD","volume":"20","author":"Wang","year":"2025","journal-title":"Mol. Neurodegener."},{"issue":"5","key":"10.1016\/j.intimp.2026.117311_bb0165","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1111\/brv.12866","article-title":"New insight into dyslipidemia-induced cellular senescence in atherosclerosis","volume":"97","author":"Xiang","year":"2022","journal-title":"Biol. Rev."},{"key":"10.1016\/j.intimp.2026.117311_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2024.111932","article-title":"Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4","volume":"219","author":"Wang","year":"2024","journal-title":"Mech. Ageing Dev."},{"issue":"12","key":"10.1016\/j.intimp.2026.117311_bb0175","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/s43587-021-00151-2","article-title":"Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice","volume":"1","author":"Suda","year":"2021","journal-title":"Nat. Aging"},{"issue":"12","key":"10.1016\/j.intimp.2026.117311_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102216","article-title":"GPNMB promotes abdominal fat deposition in chickens: genetic variation, expressional profile, biological function, and transcriptional regulation","volume":"101","author":"Wang","year":"2022","journal-title":"Poult. Sci."},{"issue":"8110","key":"10.1016\/j.intimp.2026.117311_bb0185","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41586-026-10160-z","article-title":"RYK is a GPNMB receptor that drives MASH","volume":"652","author":"Xi","year":"2026","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.intimp.2026.117311_bb0190","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/ki.2011.28","article-title":"Hematopoietic growth factor inducible neurokinin-1 (Gpnmb\/Osteoactivin) is a biomarker of progressive renal injury across species","volume":"79","author":"Patel-Chamberlin","year":"2011","journal-title":"Kidney Int."},{"issue":"12","key":"10.1016\/j.intimp.2026.117311_bb0195","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.cmet.2022.09.026","article-title":"Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis","volume":"34","author":"Li","year":"2022","journal-title":"Cell Metab."},{"issue":"43","key":"10.1016\/j.intimp.2026.117311_bb0200","article-title":"In vivo expression of VCAM1 precedes nephron loss following kidney tubular necrosis, science advances","volume":"11","author":"Kristensen","year":"2025"},{"issue":"9","key":"10.1016\/j.intimp.2026.117311_bb0205","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.70022","article-title":"Sirt3 rescues Porphyromonas gingivalis-impaired cementogenesis via SOD2 deacetylation","volume":"58","author":"Huang","year":"2025","journal-title":"Cell Prolif."},{"issue":"7","key":"10.1016\/j.intimp.2026.117311_bb0210","doi-asserted-by":"crossref","DOI":"10.1172\/JCI181928","article-title":"Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake","volume":"135","author":"Sun","year":"2025","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.intimp.2026.117311_bb0215","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.13850","article-title":"Reduction in acetylation of superoxide dismutase 2 in skeletal muscle improves exercise capacity in mice with heart failure","volume":"16","author":"Masunaga","year":"2025","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.intimp.2026.117311_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103752","article-title":"SENP1-Sirt3 axis regulates type II alveolar epithelial cell activity to confer resistance against oxidative damage in lung tissue","volume":"85","author":"Zhang","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2026.117311_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107261","article-title":"Sirtuin 3 in renal diseases and aging: from mechanisms to potential therapies","volume":"206","author":"Peng","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"15","key":"10.1016\/j.intimp.2026.117311_bb0230","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1097\/CM9.0000000000004162","article-title":"Incidence, DALYs, and death rates of chronic kidney disease in China, 1990\u20132023: results from the Global Burden of Disease Study 2023","volume":"139","author":"Wang","year":"2026","journal-title":"Chin. Med. J."},{"issue":"1","key":"10.1016\/j.intimp.2026.117311_bb0235","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1186\/s12889-025-21851-z","article-title":"Global, regional, and national burden of chronic kidney disease and its underlying etiologies from 1990 to 2021: a systematic analysis for the global burden of disease study 2021","volume":"25","author":"Deng","year":"2025","journal-title":"BMC Public Health"},{"issue":"7","key":"10.1016\/j.intimp.2026.117311_bb0240","doi-asserted-by":"crossref","DOI":"10.1111\/liv.70747","article-title":"Global prevalence, incidence, and outcomes of coexisting MASLD and chronic kidney disease: a meta-analysis","volume":"46","author":"Kueh","year":"2026","journal-title":"Liver Int."},{"issue":"1","key":"10.1016\/j.intimp.2026.117311_bb0245","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12933-023-01867-8","article-title":"Cardiovascular mortality in patients with advanced chronic kidney disease with and without diabetes: a nationwide cohort study","volume":"22","author":"Kofod","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"issue":"42","key":"10.1016\/j.intimp.2026.117311_bb0250","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1093\/eurheartj\/ehaa498","article-title":"Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial","volume":"41","author":"Tu\u00f1\u00f3n","year":"2020","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.intimp.2026.117311_bb0255","doi-asserted-by":"crossref","first-page":"742","DOI":"10.2215\/CJN.0000000704","article-title":"Obesity and metabolic health in CKD","volume":"20","author":"Kovesdy","year":"2025","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"594","key":"10.1016\/j.intimp.2026.117311_bb0260","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb0203","article-title":"Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair","volume":"13","author":"Mylonas","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.117311_bb0265","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrneph.2016.183","article-title":"Cellular senescence in renal ageing and disease","volume":"13","author":"Sturmlechner","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"issue":"24","key":"10.1016\/j.intimp.2026.117311_bb0270","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202503532R","article-title":"Cellular senescence in kidney diseases: from bench to clinic","volume":"39","author":"Shu","year":"2025","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.intimp.2026.117311_bb0275","first-page":"215","article-title":"Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition","volume":"20","author":"Linghu","year":"2025","journal-title":"Chin. Med. (United Kingdom)"},{"issue":"1","key":"10.1016\/j.intimp.2026.117311_bb0280","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s43587-024-00755-4","article-title":"Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing","volume":"5","author":"Gasek","year":"2025","journal-title":"Nat. Aging"},{"key":"10.1016\/j.intimp.2026.117311_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116373","article-title":"Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway","volume":"226","author":"Liang","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2026.117311_bb0290","doi-asserted-by":"crossref","first-page":"0551","DOI":"10.34133\/research.0551","article-title":"Polydatin-mediated inhibition of HSP90\u03b1 disrupts NLRP3 complexes and alleviates acute pancreatitis","volume":"7","author":"Yang","year":"2024","journal-title":"Research"},{"key":"10.1016\/j.intimp.2026.117311_bb0295","article-title":"Polydatin protects against DSS-induced ulcerative colitis via Nrf2\/Slc7a11\/Gpx4-dependent inhibition of ferroptosis signalling activation","volume":"15","author":"Zheng","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2026.117311_bb0300","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1002\/ptr.70088","article-title":"Polydatin alleviated ischemia\u2013reperfusion induced kidney injury by inhibiting SETD2-mediated ferroptosis","volume":"39","author":"He","year":"2025","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2026.117311_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111784","article-title":"Oxidative stress and inflammation in renal fibrosis: novel molecular mechanisms and therapeutic targets","volume":"421","author":"Liu","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.intimp.2026.117311_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156392","article-title":"Polydatin mitigates thrombosis by inhibiting PHD2-induced proline hydroxylation on collagen, reducing platelet adhesion","volume":"138","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.intimp.2026.117311_bb0315","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1042\/BSR20241307","article-title":"Potential role of polydatin in treating diabetes mellitus and diabetes-related chronic complications","volume":"45","author":"Yasmin","year":"2025","journal-title":"Biosci. Rep."},{"issue":"4","key":"10.1016\/j.intimp.2026.117311_bb0320","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41374-019-0332-8","article-title":"Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation","volume":"100","author":"Wu","year":"2020","journal-title":"Lab. Investig."},{"key":"10.1016\/j.intimp.2026.117311_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111110","article-title":"Polydatin: a potential NAFLD therapeutic drug that regulates mitochondrial autophagy through SIRT3-FOXO3-BNIP3 and PINK1-PRKN mechanisms - a network pharmacology and experimental investigation","volume":"398","author":"He","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.intimp.2026.117311_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156948","article-title":"Phenotypic screening identified polydatin alleviating cartilage degeneration by modulating SIRT3-dependent mitochondrial dysfunction","volume":"144","author":"Mao","year":"2025","journal-title":"Phytomedicine"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926011586?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926011586?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:35:54Z","timestamp":1790436954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926011586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":66,"alternative-id":["S1567576926011586"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117311","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Remodeling lipid and mitochondrial homeostasis: a novel mechanism by which polydatin attenuates renal tubular senescence in chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117311","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117311"}}