{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:00:12Z","timestamp":1790438412505,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20240813150436048"],"award-info":[{"award-number":["JCYJ20240813150436048"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["ZSQYRSFPD0100"],"award-info":[{"award-number":["ZSQYRSFPD0100"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270873"],"award-info":[{"award-number":["82270873"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.intimp.2026.117314","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T09:33:59Z","timestamp":1787132039000},"page":"117314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Faecalibacterium prausnitzii attenuates diabetes-associated affective disorders by suppressing neuroinflammation through the SCFAs\/FFAR3\/NF-\u03baB\/NLRP3 pathway"],"prefix":"10.1016","volume":"188","author":[{"given":"Yangyang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiahong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.117314_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pcd.2021.11.001","article-title":"A systematic review and meta-analysis to compare the prevalence of depression between people with and without type 1 and type 2 diabetes","volume":"16","author":"Farooqi","year":"2022","journal-title":"Prim. Care Diabetes"},{"key":"10.1016\/j.intimp.2026.117314_bb0010","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.comppsych.2012.03.011","article-title":"Prevalence of psychiatric disorders in patients with diabetes types 1 and 2","volume":"53","author":"de Ornelas Maia","year":"2012","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.intimp.2026.117314_bb0015","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/s42255-025-01281-2","article-title":"Neuronal CCL2 responds to hyperglycaemia and contributes to anxiety disorders in the context of diabetes","volume":"7","author":"Pan","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.intimp.2026.117314_bb0020","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S2213-8587(25)00397-3","article-title":"Diabetes and mental health","volume":"14","author":"Pouwer","year":"2026","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.intimp.2026.117314_bb0025","doi-asserted-by":"crossref","DOI":"10.1186\/s13098-023-01149-z","article-title":"Antidepressants and type 2 diabetes: highways to knowns and unknowns","volume":"15","author":"Alruwaili","year":"2023","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.intimp.2026.117314_bb0030","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/j.cell.2021.03.022","article-title":"SnapShot: the microbiota-gut-brain axis","volume":"184","author":"Agirman","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2026.117314_bb0035","article-title":"Implication of the gut microbiome composition of type 2 diabetic patients from northern China","volume":"10","author":"Li","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.117314_bb0040","doi-asserted-by":"crossref","first-page":"7929","DOI":"10.1080\/10408398.2021.1920884","article-title":"Short-chain fatty acids-producing probiotics: a novel source of psychobiotics","volume":"62","author":"Cheng","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.intimp.2026.117314_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-67904-0","article-title":"Neuropeptide SP protects against colitis and linked anxiety-like behavior through the putative roles of gut microbiota and metabolite inositol","volume":"17","author":"Lan","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.117314_bb0050","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature12198","article-title":"Gut metagenome in European women with normal, impaired and diabetic glucose control","volume":"498","author":"Karlsson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2026.117314_bb0055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2026.117314_bb0060","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-32015-7","article-title":"Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota","volume":"13","author":"Hosomi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.117314_bb0065","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1038\/s41591-024-03067-7","article-title":"Strain-specific gut microbial signatures in type 2 diabetes identified in a cross-cohort analysis of 8,117 metagenomes","volume":"30","author":"Mei","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2026.117314_bb0070","doi-asserted-by":"crossref","DOI":"10.1186\/s12888-025-06871-8","article-title":"Gut microbiota variations in depression and anxiety: a systematic review","volume":"25","author":"Cao","year":"2025","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.intimp.2026.117314_bb0075","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered fecal microbiota composition in patients with major depressive disorder","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2026.117314_bb0080","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41586-023-06378-w","article-title":"Synergy and oxygen adaptation for development of next-generation probiotics","volume":"620","author":"Khan","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2026.117314_bb0085","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.mib.2013.06.003","article-title":"Faecalibacterium prausnitzii and human intestinal health","volume":"16","author":"Miquel","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.intimp.2026.117314_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2009.01514.x","article-title":"Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine","volume":"294","author":"Louis","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.intimp.2026.117314_bb0095","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuint.2016.06.011","article-title":"The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis?","volume":"99","author":"Stilling","year":"2016","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.intimp.2026.117314_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/bjbs.2023.10794","article-title":"Faecalibacterium prausnitzii improves lipid metabolism disorder and insulin resistance in type 2 diabetic mice","volume":"80","author":"Xuan","year":"2023","journal-title":"Br. J. Biomed. Sci."},{"key":"10.1016\/j.intimp.2026.117314_bb0105","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-024-01961-3","article-title":"F. Prausnitzii potentially modulates the association between citrus intake and depression","volume":"12","author":"Samuthpongtorn","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.intimp.2026.117314_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104527","article-title":"Gut microbiota and its metabolites in depression: from pathogenesis to treatment","volume":"90","author":"Liu","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.intimp.2026.117314_bb0115","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41575-023-00890-0","article-title":"Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota-gut-brain axis","volume":"21","author":"Aburto","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2026.117314_bb0120","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbrc.2021.12.037","article-title":"Neuroinflammatory transcriptional signatures in the entorhinal cortex based on lipopolysaccharide-induced depression model in mice","volume":"590","author":"Tian","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2026.117314_bb0125","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-immunol-090222-102035","article-title":"Microbial metabolites and gut immunology","volume":"42","author":"Takeuchi","year":"2024","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.117314_bb0130","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2026.117314_bb0135","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2026.117314_bb0140","doi-asserted-by":"crossref","first-page":"16731","DOI":"10.1073\/pnas.0804812105","article-title":"Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients","volume":"105","author":"Sokol","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2026.117314_bb0145","doi-asserted-by":"crossref","first-page":"D734","DOI":"10.1093\/nar\/gkaf1190","article-title":"GMrepo v3: a curated human gut microbiome database with expanded disease coverage and enhanced cross-dataset biomarker analysis","volume":"54","author":"Liu","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2026.117314_bb0150","doi-asserted-by":"crossref","DOI":"10.1007\/s11481-024-10142-w","article-title":"Semaglutide attenuates anxious and depressive-like behaviors and reverses the cognitive impairment in a type 2 diabetes mellitus mouse model via the microbiota-gut-brain Axis","volume":"19","author":"de Paiva","year":"2024","journal-title":"J. NeuroImmune Pharmacol."},{"key":"10.1016\/j.intimp.2026.117314_bb0155","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-024-03160-1","article-title":"Intermittent hypoxia exacerbates anxiety in high-fat diet-induced diabetic mice by inhibiting TREM2-regulated IFNAR1 signaling","volume":"21","author":"Ni","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.117314_bb0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2026.117314_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2024\/8322844","article-title":"Pharmacological manipulation of Corticotropin-releasing factor receptors in the anterior and posterior subregions of the insular cortex differently affects anxiety-like behaviors in the elevated plus maze in rats","volume":"2024","author":"Lopes","year":"2024","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.intimp.2026.117314_bb0170","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.conb.2019.12.003","article-title":"The microbiota and the hypothalamus-pituitary-adrenocortical (HPA) axis, implications for anxiety and stress disorders","volume":"62","author":"Frankiensztajn","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.intimp.2026.117314_bb0175","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.psyneuen.2018.12.010","article-title":"Role of corticosterone in altered neurobehavioral responses to acute stress in a model of compromised hypothalamic-pituitary-adrenal axis function","volume":"102","author":"Kinlein","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.intimp.2026.117314_bb0180","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2337\/dc20-1059","article-title":"Emotional regulation and diabetes distress in adults with type 1 and type 2 diabetes","volume":"44","author":"Coccaro","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.intimp.2026.117314_bb0185","article-title":"Interventions for depression and anxiety among people with diabetes mellitus: review of systematic reviews","volume":"18","author":"Lau","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2026.117314_bb0190","doi-asserted-by":"crossref","first-page":"6290","DOI":"10.7150\/thno.109513","article-title":"KLK8\/HGF\/met signaling pathway mediates diabetes-associated hippocampal neuroinflammation in male mice","volume":"15","author":"Xu","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2026.117314_bb0195","article-title":"Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome","volume":"6","author":"Block","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2026.117314_bb0200","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota-gut-brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.intimp.2026.117314_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911245","article-title":"The microbiota-gut-brain Axis in psychiatric disorders","volume":"23","author":"G\u00f3ralczyk-Bi\u0144kowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.117314_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105840","article-title":"The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders","volume":"172","author":"Soca\u0142a","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2026.117314_bb0215","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-024-01752-w","article-title":"Effect of a multi-strain probiotic mixture consumption on anxiety and depression symptoms induced in adult mice by postnatal maternal separation","volume":"12","author":"De Santa","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.intimp.2026.117314_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpr.2020.101943","article-title":"The gut microbiota in anxiety and depression \u2013 a systematic review","volume":"83","author":"Simpson","year":"2021","journal-title":"Clin. Psychol. Rev."},{"key":"10.1016\/j.intimp.2026.117314_bb0225","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.psyneuen.2019.02.025","article-title":"Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats","volume":"104","author":"Hao","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.intimp.2026.117314_bb0230","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nm.4345","article-title":"Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug","volume":"23","author":"Wu","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2026.117314_bb0235","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4611","article-title":"The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism","volume":"5","author":"Frost","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.117314_bb0240","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jpsychires.2016.07.019","article-title":"Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat","volume":"82","author":"Kelly","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.intimp.2026.117314_bb0245","article-title":"Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene","volume":"18","author":"Wei","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.intimp.2026.117314_bb0250","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/ismej.2016.176","article-title":"Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics","volume":"11","author":"Lopez-Siles","year":"2017","journal-title":"ISME J."},{"key":"10.1016\/j.intimp.2026.117314_bb0255","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00300-15","article-title":"Identification of metabolic signatures linked to anti-inflammatory effects of Faecalibacterium prausnitzii","volume":"6","author":"Miquel","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.intimp.2026.117314_bb0260","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.aao5774","article-title":"Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes","volume":"359","author":"Zhao","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.intimp.2026.117314_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122527","article-title":"A novel antidepressant homogeneous polysaccharide YLP-1 from Millettia pulchra ameliorates tryptophan metabolism and SCFAs through modulating gut microbiota","volume":"344","author":"Yu","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.intimp.2026.117314_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10122507","article-title":"Dietary fiber intake and gut microbiota in human health","volume":"10","author":"Fu","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.intimp.2026.117314_bb0275","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2014.07.050","article-title":"Interactions of innate and adaptive immunity in brain development and function","volume":"1617","author":"Filiano","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.intimp.2026.117314_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107938","article-title":"Akkermansia muciniphila-derived SCFAs improve the depression-like behaviors of mice by inhibiting neuroinflammation","volume":"220","author":"Wang","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2026.117314_bb0285","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2420765","article-title":"How important are fatty acids in human health and can they be used in treating diseases?","volume":"16","author":"Dicks","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.intimp.2026.117314_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010305","article-title":"Associations between melatonin, neuroinflammation, and brain alterations in depression","volume":"23","author":"Won","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.117314_bb0295","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.euroneuro.2021.09.006","article-title":"Depression and inflammation: correlation between changes in inflammatory markers with antidepressant response and long-term prognosis","volume":"54","author":"Kofod","year":"2022","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.intimp.2026.117314_bb0300","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.diabet.2011.11.006","article-title":"Inflammation and type 2 diabetes","volume":"38","author":"Calle","year":"2012","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.intimp.2026.117314_bb0305","article-title":"Immunoregulatory role of the gut microbiota in inflammatory depression","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.117314_bb0310","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2024.2417179","article-title":"Limosilactobacillus-related 3-OMDP as a potential therapeutic target for depression","volume":"56","author":"Zhong","year":"2024","journal-title":"Ann. Med."},{"key":"10.1016\/j.intimp.2026.117314_bb0315","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/j.cell.2025.03.005","article-title":"Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety","volume":"188","author":"Lee","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2026.117314_bb0320","article-title":"Targeting microglial \u03b1-Synuclein\/TLRs\/NF-kappaB\/NLRP3 Inflammasome Axis in Parkinson\u2019s disease","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2026.117314_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106625","article-title":"The NLRP3 inflammasome in depression: potential mechanisms and therapies","volume":"187","author":"Xia","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2026.117314_bb0330","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2009.05.058","article-title":"Mood and gut feelings","volume":"24","author":"Forsythe","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2026.117314_bb0335","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/hup.609","article-title":"Cytokines: abnormalities in major depression and implications for pharmacological treatment","volume":"19","author":"O\u2019Brien","year":"2004","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"10.1016\/j.intimp.2026.117314_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2026.120936","article-title":"Neurochemical biomarkers in major depressive disorder","volume":"586","author":"Khatami","year":"2026","journal-title":"Clin. Chim. Acta"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926011616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926011616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:29:07Z","timestamp":1790436547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926011616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":68,"alternative-id":["S1567576926011616"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117314","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Faecalibacterium prausnitzii attenuates diabetes-associated affective disorders by suppressing neuroinflammation through the SCFAs\/FFAR3\/NF-\u03baB\/NLRP3 pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117314","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117314"}}