{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:01:15Z","timestamp":1790438475201,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274585"],"award-info":[{"award-number":["82274585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.intimp.2026.117324","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T23:46:05Z","timestamp":1788133565000},"page":"117324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Benzyl isothiocyanate alleviates endotoxin-induced uveitis in association with LOX-1 downregulation to modulate JAK2-STAT3 signaling, endoplasmic reticulum stress and apoptosis"],"prefix":"10.1016","volume":"188","author":[{"given":"Wendan","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.intimp.2026.117324_bb0005","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.ophtha.2022.03.014","article-title":"Genetic and clinical features of Blau syndrome among Chinese patients with uveitis","volume":"129","author":"Zhong","year":"2022","journal-title":"Ophthalmology"},{"key":"10.1016\/j.intimp.2026.117324_bb0010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ajo.2025.03.032","article-title":"Incidence and prevalence of uveitis and associated ocular complications in the United States TriNetX database","volume":"276","author":"Kirupaharan","year":"2025","journal-title":"Am. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117324_bb0015","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12974-024-03308-z","article-title":"Ketogenic diet modulates immune cell transcriptional landscape and ameliorates experimental autoimmune uveitis in mice","volume":"21","author":"Duan","year":"2024","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.intimp.2026.117324_bb0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3892\/ijmm.2024.5369","article-title":"Role of microglia\/macrophage polarisation in intraocular diseases (review)","volume":"53","author":"Li","year":"2024","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2026.117324_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2025.103417","article-title":"Preventing the antigen-presenting function of retinal microglia blocks autoimmune neuroinflammation by dendritic cell-primed CD4+ T cells","volume":"153","author":"Shirahama","year":"2025","journal-title":"J. Autoimmun."},{"issue":"10","key":"10.1016\/j.intimp.2026.117324_bb0030","first-page":"CD013818","article-title":"Tumor necrosis factor (TNF) inhibitors for juvenile idiopathic arthritis-associated uveitis","volume":"10","author":"Renton","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"issue":"20","key":"10.1016\/j.intimp.2026.117324_bb0035","doi-asserted-by":"crossref","DOI":"10.1172\/JCI180904","article-title":"Retinal perivascular macrophages regulate immune cell infiltration during neuroinflammation in mouse models of ocular disease","volume":"134","author":"Sterling","year":"2024","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.intimp.2026.117324_bb0040","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/glia.24303","article-title":"Brain injury triggers cell-type-specific and time-dependent endoplasmic reticulum stress responses","volume":"71","author":"Fan","year":"2023","journal-title":"Glia"},{"key":"10.1016\/j.intimp.2026.117324_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116972","article-title":"Rotenone-induced cell apoptosis via endoplasmic reticulum stress and PERK-eIF2\u03b1-CHOP signalling pathways in TM3 cells","volume":"284","author":"Tian","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"4","key":"10.1016\/j.intimp.2026.117324_bb0050","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s10753-024-01989-5","article-title":"Inhibition of endoplasmic reticulum stress improves chronic ischemic hippocampal damage associated with suppression of IRE1\u03b1\/TRAF2\/ASK1\/JNK-dependent apoptosis","volume":"47","author":"Kang","year":"2024","journal-title":"Inflammation"},{"issue":"20","key":"10.1016\/j.intimp.2026.117324_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015186","article-title":"Endoplasmic reticulum stress promotes the expression of TNF-\u03b1 in THP-1 cells by mechanisms involving ROS\/CHOP\/HIF-1\u03b1 and MAPK\/NF-\u03baB pathways","volume":"24","author":"Akhter","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2026.117324_bb0060","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/hep.32562","article-title":"Endoplasmic reticulum stress in liver diseases","volume":"77","author":"Ajoolabady","year":"2023","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.intimp.2026.117324_bb0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41581-025-00938-1","article-title":"Endoplasmic reticulum stress as a driver and therapeutic target for kidney disease","volume":"21","author":"Byun","year":"2025","journal-title":"Nat. Rev. Nephrol."},{"issue":"9","key":"10.1016\/j.intimp.2026.117324_bb0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1167\/iovs.66.9.43","article-title":"6-Shogaol alleviates endotoxin-induced uveitis via activation of HIF-1\u03b1 to regulate inflammatory responses and endoplasmic reticulum stress","volume":"66","author":"Yi","year":"2025","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2026.117324_bb0075","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1084\/jem.20171438","article-title":"Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis","volume":"216","author":"Mentrup","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2026.117324_bb0080","article-title":"The role of C-type lectin receptor signaling in the intestinal microbiota-inflammation-cancer axis","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117324_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/cells14050385","article-title":"Selective azapeptide CD36 ligand MPE-298 regulates oxLDL-LOX-1-mediated inflammation and mitochondrial oxidative stress in macrophages","volume":"14","author":"Mulumba","year":"2025","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.intimp.2026.117324_bb0090","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1073\/pnas.0337528100","article-title":"Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation","volume":"100","author":"Honjo","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"19","key":"10.1016\/j.intimp.2026.117324_bb0095","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/eurheartj\/ehac233","article-title":"New therapeutic targets to reduce inflammation-associated cardiovascular risk: the CCL2-CCR2 axis, LOX-1, and IRF5","volume":"43","author":"Crea","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.intimp.2026.117324_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106190","article-title":"Inhibition of LOX-1 prevents inflammation and photoreceptor cell death in retinal degeneration","volume":"80","author":"Gao","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117324_bb0105","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s10020-024-00887-8","article-title":"Dysregulated lipid metabolism and intervertebral disc degeneration: the important role of ox-LDL\/LOX-1 in endplate chondrocyte senescence and calcification","volume":"30","author":"Bing","year":"2024","journal-title":"Mol. Med."},{"issue":"12","key":"10.1016\/j.intimp.2026.117324_bb0110","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00109-009-0532-6","article-title":"Benzyl isothiocyanate exhibits anti-inflammatory effects in murine macrophages and in mouse skin","volume":"87","author":"Lee","year":"2009","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.intimp.2026.117324_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.117026","article-title":"Gastrointestinal dynamics and glycemic modulation of benzyl isothiocyanate-loaded fish skin gelatin-pectin emulsions: a comprehensive in vitro and in vivo analysis","volume":"220","author":"Liu","year":"2025","journal-title":"Food Res. Int."},{"issue":"13","key":"10.1016\/j.intimp.2026.117324_bb0120","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.3390\/foods13132078","article-title":"Benzyl Isothiocyanate and resveratrol synergistically alleviate dextran sulfate sodium-induced colitis in mice","volume":"13","author":"Liu","year":"2024","journal-title":"Foods"},{"issue":"13","key":"10.1016\/j.intimp.2026.117324_bb0125","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1039\/D1FO00645B","article-title":"Benzyl isothiocyanates modulate inflammation, oxidative stress, and apoptosis via Nrf2\/HO-1 and NF-\u03baB signaling pathways on indomethacin-induced gastric injury in rats","volume":"12","author":"El Badawy","year":"2021","journal-title":"Food Funct."},{"issue":"3","key":"10.1016\/j.intimp.2026.117324_bb0130","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3892\/ijmm.2016.2667","article-title":"Benzyl isothiocyanate inhibits inflammasome activation in E. Coli LPS-stimulated BV2 cells","volume":"38","author":"Lee","year":"2016","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.117324_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031228","article-title":"Benzyl isothiocyanate attenuates inflammasome activation in Pseudomonas aeruginosa LPS-stimulated THP-1 cells and exerts regulation through the MAPKs\/NF-\u03baB pathway","volume":"23","author":"Park","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2026.117324_bb0140","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jcmgh.2022.10.002","article-title":"Ethanol and its nonoxidative metabolites promote acute liver injury by inducing ER stress, adipocyte death, and lipolysis","volume":"15","author":"Park","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117324_bb0145","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12272-024-01496-z","article-title":"Potential of natural products in inflammation: biological activities, structure-activity relationships, and mechanistic targets","volume":"47","author":"Guo","year":"2024","journal-title":"Arch. Pharm. Res."},{"issue":"20","key":"10.1016\/j.intimp.2026.117324_bb0150","doi-asserted-by":"crossref","first-page":"9989","DOI":"10.1073\/pnas.1820387116","article-title":"Retinal microglia initiate neuroinflammation in ocular autoimmunity","volume":"116","author":"Okunuki","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2026.117324_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.860070","article-title":"Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy","volume":"13","author":"Au","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117324_bb0160","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12974-019-1505-5","article-title":"Reactive microglia and IL1\u03b2\/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina","volume":"16","author":"Todd","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.intimp.2026.117324_bb0165","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13046-023-02609-0","article-title":"HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway","volume":"42","author":"Liu","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.intimp.2026.117324_bb0170","article-title":"MicroRNA-204-5p deficiency within the vmPFC region contributes to Neuroinflammation and behavioral disorders via the JAK2\/STAT3 signaling pathway in rats","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci. (Weinh)."},{"issue":"11","key":"10.1016\/j.intimp.2026.117324_bb0175","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1073\/pnas.1904532117","article-title":"Signaling mechanisms of growth hormone-releasing hormone receptor in LPS-induced acute ocular inflammation","volume":"117","author":"Liang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2026.117324_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114517","article-title":"Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis","volume":"251","author":"Jia","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"12","key":"10.1016\/j.intimp.2026.117324_bb0185","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nchembio.467","article-title":"Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins","volume":"6","author":"Hoffstrom","year":"2010","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117324_bb0190","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12933-023-02078-x","article-title":"Melatonin attenuates diabetic cardiomyopathy by increasing autophagy of cardiomyocytes via regulation of VEGF-B\/GRP78\/PERK signaling pathway","volume":"23","author":"Zhang","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117324_bb0195","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jcb.30466","article-title":"Novel mutation in EFEMP1 identified from two Chinese POAG families differentially activated endoplasmic reticulum stress markers and induced glaucoma in mouse","volume":"125","author":"Xiao","year":"2024","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.intimp.2026.117324_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2023.101231","article-title":"The endoplasmic reticulum: homeostasis and crosstalk in retinal health and disease","volume":"98","author":"Zhang","year":"2024","journal-title":"Prog. Retin. Eye Res."},{"issue":"3","key":"10.1016\/j.intimp.2026.117324_bb0205","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/all.15024","article-title":"IRE1 and PERK signaling regulates inflammatory responses in a murine model of contact hypersensitivity","volume":"77","author":"Gendrisch","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2026.117324_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116038","article-title":"CCT020312 exerts anti-prostate cancer effect by inducing G1 cell cycle arrest, apoptosis and autophagy through activation of PERK\/eIF2\u03b1\/ATF4\/CHOP signaling","volume":"221","author":"Zhou","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117324_bb0215","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s13075-024-03461-z","article-title":"KLF2 controls the apoptosis of neutrophils and is associated with disease activity of systemic lupus erythematosus","volume":"26","author":"Zhao","year":"2024","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.117324_bb0220","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1385\/CRIAI:25:1:49","article-title":"Systemic lupus erythematosus and apoptosis: a question of balance","volume":"25","author":"Mevorach","year":"2003","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2026.117324_bb0225","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/cvr\/cvu114","article-title":"LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis","volume":"103","author":"Ding","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.117324_bb0230","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.3892\/ijmm.2013.1513","article-title":"Ox-LDL downregulates eNOS activity via LOX-1-mediated endoplasmic reticulum stress","volume":"32","author":"Zhou","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2026.117324_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108481","article-title":"N-3 PUFAs inhibited hepatic ER stress induced by feeding of a high-saturated fat diet accompanied by the expression LOX-1","volume":"88","author":"Zhang","year":"2021","journal-title":"J. Nutr. Biochem."},{"issue":"12","key":"10.1016\/j.intimp.2026.117324_bb0240","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1080\/02713683.2021.1948063","article-title":"LOX-1 regulates neutrophil apoptosis and fungal load in A. fumigatus keratitis","volume":"46","author":"Li","year":"2021","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.intimp.2026.117324_bb0245","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.freeradbiomed.2024.09.050","article-title":"The neo-potential therapeutic strategy in preeclampsia: downregulated miR-26a-2-3p motivates endothelial cell injury by targeting 15-LOX-1","volume":"225","author":"Chen","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2026.117324_bb0250","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jare.2021.06.023","article-title":"Activation of Nrf2\/HO-1 signaling: an important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress","volume":"34","author":"Zhang","year":"2021","journal-title":"J. Adv. Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926011719?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926011719?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:45:14Z","timestamp":1790437514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926011719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":50,"alternative-id":["S1567576926011719"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117324","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benzyl isothiocyanate alleviates endotoxin-induced uveitis in association with LOX-1 downregulation to modulate JAK2-STAT3 signaling, endoplasmic reticulum stress and apoptosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117324","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117324"}}