{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:59:12Z","timestamp":1790276352316,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20212ACB206017"],"award-info":[{"award-number":["20212ACB206017"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260131"],"award-info":[{"award-number":["82260131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460128"],"award-info":[{"award-number":["82460128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.intimp.2026.117348","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:59:18Z","timestamp":1788951558000},"page":"117348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["NEDD4L-mediated ALYREF ubiquitination degradation suppresses RUBCNL expression to impair autophagy and promote lipogenesis in alcoholic hepatic fibrosis"],"prefix":"10.1016","volume":"189","author":[{"given":"Xianliang","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qipeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2026.117348_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1432480","article-title":"Alcohol-related liver disease (ALD): current perspectives on pathogenesis, therapeutic strategies, and animal models","volume":"15","author":"Hong","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2026.117348_bb0010","doi-asserted-by":"crossref","first-page":"goaf088","DOI":"10.1093\/gastro\/goaf088","article-title":"Alcohol-related liver disease","volume":"13","author":"Herms","year":"2025","journal-title":"Gastroenterol. Rep. (Oxf)"},{"issue":"11","key":"10.1016\/j.intimp.2026.117348_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22115717","article-title":"Pathophysiological aspects of alcohol metabolism in the liver","volume":"22","author":"Hyun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117348_bb0020","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jhep.2013.03.007","article-title":"Global burden of alcoholic liver diseases","volume":"59","author":"Rehm","year":"2013","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117348_bb0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.14309\/ajg.0000000000002572","article-title":"ACG clinical guideline: alcohol-associated liver disease","volume":"119","author":"Jophlin","year":"2024","journal-title":"Am. J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.intimp.2026.117348_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113875","article-title":"Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice","volume":"43","author":"Wang","year":"2024","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.intimp.2026.117348_bb0035","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1053\/j.gastro.2019.07.036","article-title":"ECM1 prevents activation of transforming growth factor \u03b2, hepatic stellate cells, and fibrogenesis in mice","volume":"157","author":"Fan","year":"2019","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.intimp.2026.117348_bb0040","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00018-022-04319-w","article-title":"Macrophages evoke autophagy of hepatic stellate cells to promote liver fibrosis in NAFLD mice via the PGE2\/EP4 pathway","volume":"79","author":"Cao","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"12","key":"10.1016\/j.intimp.2026.117348_bb0045","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.14463","article-title":"Resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the SIRT1 and JNK signaling pathways","volume":"46","author":"Zhang","year":"2022","journal-title":"J. Food Biochem."},{"issue":"5","key":"10.1016\/j.intimp.2026.117348_bb0050","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12417","article-title":"miR221 regulates TGF-\u03b21-induced HSC activation through inhibiting autophagy by directly targeting LAMP2","volume":"24","author":"Cheng","year":"2021","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.117348_bb0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2026.117348_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.792414","article-title":"Resolvin D1 attenuates CCl4 induced liver fibrosis by inhibiting autophagy-mediated HSC activation via AKT\/mTOR pathway","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117348_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29020417","article-title":"Phomopsterone B alleviates liver fibrosis through mTOR-mediated autophagy and apoptosis pathway","volume":"29","author":"Peng","year":"2024","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.intimp.2026.117348_bb0070","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/15548627.2023.2254191","article-title":"Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease","volume":"20","author":"Ren","year":"2024","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.intimp.2026.117348_bb0075","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1080\/15548627.2019.1596500","article-title":"RUBCNL\/Pacer and RUBCN\/Rubicon in regulation of autolysosome formation and lipid metabolism","volume":"15","author":"Cheng","year":"2019","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.intimp.2026.117348_bb0080","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/cr.2017.55","article-title":"5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.intimp.2026.117348_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122372","article-title":"ALYREF (Aly\/REF export factor): a potential biomarker for predicting cancer occurrence and therapeutic efficacy","volume":"338","author":"Zhao","year":"2024","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117348_bb0090","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41698-024-00737-0","article-title":"ALYREF recruits ELAVL1 to promote colorectal tumorigenesis via facilitating RNA m5C recognition and nuclear export","volume":"8","author":"Zhong","year":"2024","journal-title":"npj Precis. Oncol."},{"issue":"15","key":"10.1016\/j.intimp.2026.117348_bb0095","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.7150\/ijbs.101337","article-title":"The quiet Giant: identification, effectors, molecular mechanism, physiological and pathological function in mRNA 5-methylcytosine modification","volume":"20","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117348_bb0100","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s40001-025-02812-z","article-title":"m5C RNA methylation in cancer: from biological mechanism to clinical perspectives","volume":"30","author":"Yuan","year":"2025","journal-title":"Eur. J. Med. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.117348_bb0105","doi-asserted-by":"crossref","first-page":"331","DOI":"10.7150\/ijbs.82316","article-title":"ALYREF-mediated RNA 5-Methylcytosine modification promotes hepatocellular carcinoma progression via stabilizing EGFR mRNA and pSTAT3 activation","volume":"20","author":"Nulali","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2026.117348_bb0110","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/10985549.2025.2490031","article-title":"ALYREF promotes progression of intrahepatic cholangiocarcinoma through increasing the level of Isocitrate dehydrogenase 1 in an m5C-dependent manner","volume":"45","author":"Hao","year":"2025","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117348_bb0115","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13062-024-00477-y","article-title":"NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate dox-induced liver injury","volume":"19","author":"Huang","year":"2024","journal-title":"Biol. Direct"},{"issue":"3","key":"10.1016\/j.intimp.2026.117348_bb0120","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000641","article-title":"Silencing FAF2 mitigates alcohol-induced hepatic steatosis by modulating lipolysis and PCSK9 pathway","volume":"9","author":"Huda","year":"2025","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.intimp.2026.117348_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157589","article-title":"MARCH5-mediated MIEF2 ubiquitination and degradation contribute to gigantol to against hepatic steatosis and mitochondrial fission in alcoholic liver disease","volume":"150","author":"Wu","year":"2026","journal-title":"Phytomedicine"},{"issue":"26","key":"10.1016\/j.intimp.2026.117348_bb0130","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adt6195","article-title":"Hepatic NMNAT1 is required to defend against alcohol-associated fatty liver disease","volume":"11","author":"Ding","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.intimp.2026.117348_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2022.10.002","article-title":"Nedd4L suppression in lung fibroblasts facilitates pathogenesis of lung fibrosis","volume":"253","author":"Li","year":"2023","journal-title":"Transl. Res."},{"issue":"7","key":"10.1016\/j.intimp.2026.117348_bb0140","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.7150\/thno.81192","article-title":"A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis","volume":"13","author":"Guo","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2026.117348_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.157830","article-title":"Qing Hua Yu Du formula ameliorates alcoholic hepatic fibrosis by regulating MAPK\/TLR4-MyD88 inflammatory pathways, restoring hepatic metabolism and modulating gut microbiota","volume":"152","author":"Ding","year":"2026","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.intimp.2026.117348_bb0150","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/15548627.2023.2249762","article-title":"Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer","volume":"20","author":"Li","year":"2024","journal-title":"Autophagy"},{"issue":"11","key":"10.1016\/j.intimp.2026.117348_bb0155","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1080\/15548627.2024.2367923","article-title":"The autophagy protein RUBCNL\/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis","volume":"20","author":"Rojas-Rivera","year":"2024","journal-title":"Autophagy"},{"issue":"11","key":"10.1016\/j.intimp.2026.117348_bb0160","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1080\/15548627.2024.2367907","article-title":"TBC1D4 antagonizes RAB2A-mediated autophagic and endocytic pathways","volume":"20","author":"Tian","year":"2024","journal-title":"Autophagy"},{"issue":"12","key":"10.1016\/j.intimp.2026.117348_bb0165","doi-asserted-by":"crossref","first-page":"42","DOI":"10.14715\/cmb\/2022.68.12.9","article-title":"MYC-activated CERS6-AS1 sponges miR-6838-5p and regulates the expression of RUBCNL in colorectal cancer","volume":"68","author":"Chen","year":"2022","journal-title":"Cell. Mol. Biol. (Noisy-le-Grand)"},{"key":"10.1016\/j.intimp.2026.117348_bb0170","doi-asserted-by":"crossref","first-page":"1534948","DOI":"10.3389\/fonc.2025.1534948","article-title":"Biological functions of 5-methylcytosine RNA-binding proteins and their potential mechanisms in human cancers","volume":"15","author":"Zhao","year":"2025","journal-title":"Front. Oncol."},{"issue":"7","key":"10.1016\/j.intimp.2026.117348_bb0175","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/cac2.12158","article-title":"The role of the HIF-1\u03b1\/ALYREF\/PKM2 axis in glycolysis and tumorigenesis of bladder cancer","volume":"41","author":"Wang","year":"2021","journal-title":"Cancer Commun. (Lond.)"},{"issue":"1","key":"10.1016\/j.intimp.2026.117348_bb0180","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12943-024-02055-2","article-title":"NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer","volume":"23","author":"Yu","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2026.117348_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217059","article-title":"NSUN4 mediated RNA 5-methylcytosine promotes the malignant progression of glioma through improving the CDC42 mRNA stabilization","volume":"597","author":"Zhao","year":"2024","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.intimp.2026.117348_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/biom14050577","article-title":"NEDD4 and NEDD4L: ubiquitin ligases closely related to digestive diseases","volume":"14","author":"Xu","year":"2024","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.intimp.2026.117348_bb0195","doi-asserted-by":"crossref","DOI":"10.1111\/apha.70163","article-title":"Activation of TGR5 alleviates renal fibrosis by promoting NEDD4L-mediated p-Smad2\/3 ubiquitination","volume":"242","author":"Li","year":"2026","journal-title":"Acta Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117348_bb0200","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1038\/s41467-025-58317-0","article-title":"SIRT7 facilitates endometrial cancer progression by regulating PTEN stability in an estrogen-dependent manner","volume":"16","author":"Hu","year":"2025","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2026.117348_bb0205","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jhep.2024.05.014","article-title":"Angiocrine signaling in sinusoidal homeostasis and liver diseases","volume":"81","author":"Gao","year":"2024","journal-title":"J. Hepatol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926011951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926011951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:03:19Z","timestamp":1790272999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926011951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":41,"alternative-id":["S1567576926011951"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117348","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NEDD4L-mediated ALYREF ubiquitination degradation suppresses RUBCNL expression to impair autophagy and promote lipogenesis in alcoholic hepatic fibrosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117348"}}