{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:03:31Z","timestamp":1790370211636,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015286","name":"Hebei Provincial Key Research Projects","doi-asserted-by":"publisher","award":["2024BCB042"],"award-info":[{"award-number":["2024BCB042"]}],"id":[{"id":"10.13039\/501100015286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015640","name":"Tongji Hospital","doi-asserted-by":"publisher","award":["2023CXZH006"],"award-info":[{"award-number":["2023CXZH006"]}],"id":[{"id":"10.13039\/501100015640","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570050"],"award-info":[{"award-number":["82570050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170036"],"award-info":[{"award-number":["82170036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.intimp.2026.117451","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:17:43Z","timestamp":1790104663000},"page":"117451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["ACOX1 downregulation contributes to macrophage M1 polarization and neutrophilic airway inflammation in asthma"],"prefix":"10.1016","volume":"189","author":[{"given":"Wei","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiru","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10196","key":"10.1016\/j.intimp.2026.117451_bb0005","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(19)31147-X","article-title":"Prevalence, risk factors, and management of asthma in China: a national cross-sectional study","volume":"394","author":"Huang","year":"2019","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.intimp.2026.117451_bb0010","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.jaci.2021.10.001","article-title":"Advances in asthma: new understandings of asthma\u2019s natural history, risk factors, underlying mechanisms, and clinical management","volume":"148","author":"Miller","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2026.117451_bb0015","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s13312-024-3260-7","article-title":"Global initiative for asthma guidelines 2024: An update","volume":"61","author":"Rajvanshi","year":"2024","journal-title":"Indian Pediatr."},{"issue":"1","key":"10.1016\/j.intimp.2026.117451_bb0020","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1440-1843.2006.00784.x","article-title":"Inflammatory subtypes in asthma: assessment and identification using induced sputum","volume":"11","author":"Simpson","year":"2006","journal-title":"Respirology"},{"issue":"10","key":"10.1016\/j.intimp.2026.117451_bb0025","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1136\/thorax.57.10.875","article-title":"Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids","volume":"57","author":"Green","year":"2002","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.intimp.2026.117451_bb0030","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.jaci.2013.10.011","article-title":"Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis","volume":"133","author":"Moore","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117451_bb0035","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1164\/ajrccm.157.2.97-02099","article-title":"Bronchial neutrophilia in patients with noninfectious status asthmaticus","volume":"157","author":"Lamblin","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"13","key":"10.1016\/j.intimp.2026.117451_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310451","article-title":"Macrophages orchestrate airway inflammation, remodeling, and resolution in asthma","volume":"24","author":"Britt","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2026.117451_bb0045","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2026.117451_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173090","article-title":"Macrophage M1\/M2 polarization","volume":"877","author":"Yunna","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2026.117451_bb0055","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00196-2017","article-title":"Macrophage dysfunction in the pathogenesis and treatment of asthma","volume":"50","author":"Fricker","year":"2017","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.intimp.2026.117451_bb0060","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1183\/09031936.00105013","article-title":"Elevated expression of the NLRP3 inflammasome in neutrophilic asthma","volume":"43","author":"Simpson","year":"2014","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.intimp.2026.117451_bb0065","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s10020-023-00702-w","article-title":"Leptin\/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages","volume":"29","author":"Wang","year":"2023","journal-title":"Mol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.117451_bb0070","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ni.3366","article-title":"Fatty acid oxidation in macrophage polarization","volume":"17","author":"Nomura","year":"2016","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2026.117451_bb0075","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.tcb.2020.09.006","article-title":"Lipid metabolism in regulation of macrophage functions","volume":"30","author":"Yan","year":"2020","journal-title":"Trends Cell Biol."},{"issue":"9","key":"10.1016\/j.intimp.2026.117451_bb0080","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ni.2956","article-title":"Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages","volume":"15","author":"Huang","year":"2014","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117451_bb0085","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2006.05.011","article-title":"Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation","volume":"4","author":"Vats","year":"2006","journal-title":"Cell Metab."},{"issue":"12","key":"10.1016\/j.intimp.2026.117451_bb0090","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1172\/JCI58577","article-title":"Hematopoietic AMPK \u03b21 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity","volume":"121","author":"Galic","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.intimp.2026.117451_bb0095","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.immuni.2019.11.009","article-title":"Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate Lyase","volume":"51","author":"Lauterbach","year":"2019","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.intimp.2026.117451_bb0100","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0163-7827(87)90009-9","article-title":"Fatty acid metabolism of isolated mammalian cells","volume":"26","author":"Rosenthal","year":"1987","journal-title":"Prog. Lipid Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.117451_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18061126","article-title":"The peroxisome-mitochondria connection: how and why?","volume":"18","author":"Fransen","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117451_bb0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4168\/aair.2025.17.1.111","article-title":"Peroxisome metabolism pathway and EHHADH expression are downregulated in macrophages in neutrophilic asthma","volume":"17","author":"Chen","year":"2025","journal-title":"Allergy, Asthma Immunol. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.117451_bb0115","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.molcel.2020.05.007","article-title":"Acetyl-CoA derived from hepatic peroxisomal \u03b2-oxidation inhibits autophagy and promotes steatosis via mTORC1 activation","volume":"79","author":"He","year":"2020","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.intimp.2026.117451_bb0120","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cmet.2014.01.002","article-title":"Peroxisomes: a nexus for lipid metabolism and cellular signaling","volume":"19","author":"Lodhi","year":"2014","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.intimp.2026.117451_bb0125","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.neuron.2020.02.021","article-title":"Loss- or gain-of-function mutations in ACOX1 cause axonal loss via different mechanisms","volume":"106","author":"Chung","year":"2020","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.intimp.2026.117451_bb0130","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/humu.20535","article-title":"Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency","volume":"28","author":"Ferdinandusse","year":"2007","journal-title":"Hum. Mutat."},{"issue":"7","key":"10.1016\/j.intimp.2026.117451_bb0135","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S2213-2600(23)00230-8","article-title":"2023 GINA report for asthma","volume":"11","author":"Venkatesan","year":"2023","journal-title":"Lancet Respir. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.117451_bb0140","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/ije\/dyac173","article-title":"Asthma inflammatory phenotypes on four continents: most asthma is non-eosinophilic","volume":"52","author":"Pembrey","year":"2023","journal-title":"Int. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117451_bb0145","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/cea.13959","article-title":"Comparative features of eosinophilic and non-eosinophilic asthma","volume":"52","author":"Xu","year":"2022","journal-title":"Clin. Exp. Allergy"},{"issue":"7","key":"10.1016\/j.intimp.2026.117451_bb0150","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1398-9995.2012.02832.x","article-title":"Untangling asthma phenotypes and endotypes","volume":"67","author":"Agache","year":"2012","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.intimp.2026.117451_bb0155","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1615\/CritRevImmunol.2018026459","article-title":"Airway macrophage and dendritic cell subsets in the resting human lung","volume":"38","author":"Patel","year":"2018","journal-title":"Crit. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2026.117451_bb0160","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1074\/jbc.M116.763532","article-title":"Specific inhibition of acyl-CoA oxidase-1 by an acetylenic acid improves hepatic lipid and reactive oxygen species (ROS) metabolism in rats fed a high fat diet","volume":"292","author":"Zeng","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2026.117451_bb0165","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.ATV.0000251608.09329.9a","article-title":"Role of the toll-like receptor 4\/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages","volume":"27","author":"Suganami","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"8","key":"10.1016\/j.intimp.2026.117451_bb0170","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1161\/01.ATV.20.8.1953","article-title":"Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients","volume":"20","author":"Janabi","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"7","key":"10.1016\/j.intimp.2026.117451_bb0175","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.joca.2004.04.005","article-title":"Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB","volume":"12","author":"Nishimura","year":"2004","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.intimp.2026.117451_bb0180","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1152\/physrev.00009.2014","article-title":"NOD-like receptors: versatile cytosolic sentinels","volume":"95","author":"Motta","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.intimp.2026.117451_bb0185","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-3-030-60204-8_5","article-title":"Fatty acid oxidation in peroxisomes: enzymology, metabolic crosstalk with other organelles and peroxisomal disorders","volume":"1299","author":"Wanders","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"11","key":"10.1016\/j.intimp.2026.117451_bb0190","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1111\/all.70018","article-title":"Myeloid cAMP reduction shifts rhinovirus-induced airway inflammation from neutrophilic to eosinophilic by suppressing M1-interstitial macrophages","volume":"80","author":"Park","year":"2025","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.intimp.2026.117451_bb0195","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ajpath.2011.04.030","article-title":"Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice","volume":"179","author":"Huang","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2026.117451_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107105","article-title":"ACOX1 deficiency-induced lipid metabolic disorder facilitates chronic interstitial fibrosis development in renal allografts","volume":"201","author":"Zhang","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.intimp.2026.117451_bb0205","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.bbalip.2018.10.005","article-title":"A microglial cell model for acyl-CoA oxidase 1 deficiency","volume":"1864","author":"Raas","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.intimp.2026.117451_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108138","article-title":"PPAR\u03b1\/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: An integrated approach","volume":"178","author":"Yang","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.intimp.2026.117451_bb0215","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.3389\/fimmu.2019.02993","article-title":"New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages","volume":"10","author":"Batista-Gonzalez","year":"2019","journal-title":"Front. Immunol."},{"issue":"15","key":"10.1016\/j.intimp.2026.117451_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512032","article-title":"Impact of lipid metabolism on macrophage polarization: implications for inflammation and tumor immunity","volume":"24","author":"Vassiliou","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117451_bb0225","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jhep.2012.02.028","article-title":"Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis","volume":"57","author":"Leroux","year":"2012","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.intimp.2026.117451_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.112168","article-title":"Interaction between lipid metabolism and macrophage polarization in atherosclerosis","volume":"28","author":"Wang","year":"2025","journal-title":"iScience"},{"issue":"3","key":"10.1016\/j.intimp.2026.117451_bb0235","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ni.1990","article-title":"IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses","volume":"12","author":"Krausgruber","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2026.117451_bb0240","doi-asserted-by":"crossref","first-page":"1122586","DOI":"10.3389\/fimmu.2023.1122586","article-title":"The role of NOD-like receptors in innate immunity","volume":"14","author":"Almeida-da-Silva","year":"2023","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117451_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2024.107666","article-title":"Velvet antler polypeptide (VAP) protects against cerebral ischemic injury through NF-\u03baB signaling pathway in vitro","volume":"33","author":"Wu","year":"2024","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"3","key":"10.1016\/j.intimp.2026.117451_bb0250","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s10142-023-01152-7","article-title":"Involvement of IGF1 in endoplasmic reticulum stress contributes to cataract formation through regulating Nrf2\/NF-\u03baB signaling","volume":"23","author":"Peng","year":"2023","journal-title":"Funct. Integr. Genomics"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926012981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926012981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:31:44Z","timestamp":1790368304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926012981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":50,"alternative-id":["S1567576926012981"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117451","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ACOX1 downregulation contributes to macrophage M1 polarization and neutrophilic airway inflammation in asthma","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117451","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117451"}}