{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:01:17Z","timestamp":1791468077377,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2025A03J4133"],"award-info":[{"award-number":["2025A03J4133"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2026M794246"],"award-info":[{"award-number":["2026M794246"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.intimp.2026.117485","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:46:47Z","timestamp":1790815607000},"page":"117485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Reserpine enhances dendritic cell cross-presentation and strengthens CD8+ T cell-mediated antitumor immunity"],"prefix":"10.1016","volume":"190","author":[{"given":"Yuling","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiji","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-song","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieying","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxiu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.intimp.2026.117485_bb0005","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1056\/NEJMoa1910836","article-title":"Five-year survival with combined nivolumab and ipilimumab in advanced melanoma","volume":"381","author":"Larkin","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"21","key":"10.1016\/j.intimp.2026.117485_bb0010","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1200\/JCO.21.00174","article-title":"Five-year outcomes with pembrolizumab versus chemotherapy for metastatic non\u2013small-cell lung cancer with PD-L1 tumor proportion score\u2265 50%","volume":"39","author":"Reck","year":"2021","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.intimp.2026.117485_bb0015","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2017.01.017","article-title":"Primary, adaptive, and acquired resistance to cancer immunotherapy","volume":"168","author":"Sharma","year":"2017","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2026.117485_bb0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.immuni.2019.12.011","article-title":"Top 10 challenges in cancer immunotherapy","volume":"52","author":"Hegde","year":"2020","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2026.117485_bb0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41577-019-0210-z","article-title":"Dendritic cells in cancer immunology and immunotherapy","volume":"20","author":"Wculek","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2026.117485_bb0030","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/j.immuni.2023.09.011","article-title":"The cancer-immunity cycle: indication, genotype, and immunotype","volume":"56","author":"Mellman","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2026.117485_bb0035","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev-immunol-041015-055254","article-title":"The biology and underlying mechanisms of cross-presentation of exogenous antigens on MHC-I molecules","volume":"35","author":"Cruz","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.117485_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101848","article-title":"Antigen cross-presentation by dendritic cells: a critical axis in cancer immunotherapy","volume":"71","author":"Moussion","year":"2024","journal-title":"Semin. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2026.117485_bb0045","first-page":"1063","article-title":"Cutting edge: phagosome-associated autophagosomes containing antigens and proteasomes drive TAP-independent cross-presentation","volume":"212","author":"Sengupta","year":"2024","journal-title":"Journal of immunology (Baltimore, Md.\u202f: 1950)"},{"issue":"2","key":"10.1016\/j.intimp.2026.117485_bb0050","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2567.2012.03558.x","article-title":"The pathway of cross-presentation is influenced by the particle size of phagocytosed antigen","volume":"136","author":"Mant","year":"2012","journal-title":"Immunology"},{"issue":"5","key":"10.1016\/j.intimp.2026.117485_bb0055","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117485_bb0060","doi-asserted-by":"crossref","DOI":"10.1038\/cti.2016.22","article-title":"Toll-like receptors: the swiss army knife of immunity and vaccine development","volume":"5","author":"Dowling","year":"2016","journal-title":"Clin. Transl. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2026.117485_bb0065","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/nm.3409","article-title":"Key roles of adjuvants in modern vaccines","volume":"19","author":"Reed","year":"2013","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.117485_bb0070","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.intimp.2026.117485_bb0075","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0031-6997(25)06712-2","article-title":"The biological fate of reserpine","volume":"28","author":"Stitzel","year":"1976","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2026.117485_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1092852917000621","article-title":"Mechanism of action of vesicular monoamine transporter 2 (VMAT2) inhibitors in tardive dyskinesia: reducing dopamine leads to less \u201cgo\u201d and more \u201cstop\u201d from the motor striatum for robust therapeutic effects","volume":"23","author":"Stahl","year":"2018","journal-title":"CNS Spectr."},{"issue":"1","key":"10.1016\/j.intimp.2026.117485_bb0085","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41422-023-00906-z","article-title":"Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines","volume":"34","author":"Wang","year":"2024","journal-title":"Cell Res."},{"key":"10.1016\/j.intimp.2026.117485_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156002","article-title":"Reserpine, a novel N6-methyladenosine regulator, reverses Lenvatinib resistance in hepatocellular carcinoma","volume":"135","author":"Zhao","year":"2024","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.intimp.2026.117485_bb0095","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41590-024-02068-5","article-title":"The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer","volume":"26","author":"He","year":"2025","journal-title":"Nat. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2026.117485_bb0100","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144225","article-title":"Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies","volume":"131","author":"Lu","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.intimp.2026.117485_bb0105","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41590-026-02419-4","article-title":"Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8(+) Tcells in lymph nodes","volume":"27","author":"Lai","year":"2026","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117485_bb0110","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41590-022-01141-1","article-title":"A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance","volume":"23","author":"Huang","year":"2022","journal-title":"Nat. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2026.117485_bb0115","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41591-019-0522-3","article-title":"Clonal replacement of tumor-specific T cells following PD-1 blockade","volume":"25","author":"Yost","year":"2019","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.117485_bb0120","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/eji.201041040","article-title":"PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo","volume":"41","author":"de Graaf","year":"2011","journal-title":"Eur. J. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2026.117485_bb0125","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrclinonc.2016.206","article-title":"Proteasome inhibitors in cancer therapy","volume":"14","author":"Manasanch","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"14","key":"10.1016\/j.intimp.2026.117485_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20143379","article-title":"Cellular responses to proteasome inhibition: molecular mechanisms and beyond","volume":"20","author":"Albornoz","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2026.117485_bb0135","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","article-title":"Understanding the tumor immune microenvironment (TIME) for effective therapy","volume":"24","author":"Binnewies","year":"2018","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.117485_bb0140","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41573-018-0007-y","article-title":"Approaches to treat immune hot, altered and cold tumours with combination immunotherapies","volume":"18","author":"Galon","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7","key":"10.1016\/j.intimp.2026.117485_bb0145","first-page":"3163","article-title":"\u03b22-Adrenoreceptor agonist inhibits antigen cross-presentation by dendritic cells","volume":"190","author":"Herv\u00e9","year":"2013","journal-title":"Journal of immunology (Baltimore, Md.\u202f: 1950)"},{"issue":"5","key":"10.1016\/j.intimp.2026.117485_bb0150","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41568-021-00339-z","article-title":"Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion","volume":"21","author":"Jhunjhunwala","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"10","key":"10.1016\/j.intimp.2026.117485_bb0155","doi-asserted-by":"crossref","first-page":"8131","DOI":"10.1007\/s00432-023-04737-8","article-title":"Cancer immune escape: the role of antigen presentation machinery","volume":"149","author":"Kallingal","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.intimp.2026.117485_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1661545","article-title":"Infiltration characteristics and regulatory mechanisms of CD8(+) T lymphocytes in solid tumors: spatial distribution, biological functions, and interactions with the immune microenvironment","volume":"16","author":"Ouyang","year":"2025","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2026.117485_bb0165","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1124\/pr.114.010397","article-title":"Regulation of the dopamine and vesicular monoamine transporters: pharmacological targets and implications for disease","volume":"67","author":"German","year":"2015","journal-title":"Pharmacol. Rev."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926013329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926013329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:23:14Z","timestamp":1791465794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926013329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":33,"alternative-id":["S1567576926013329"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117485","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reserpine enhances dendritic cell cross-presentation and strengthens CD8+ T cell-mediated antitumor immunity","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117485","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"117485"}}